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Vasiliy M Petrov et al.
The Journal of biological chemistry, 277(36), 33041-33048 (2002-06-28)
DNA polymerase (gp43) of phage T4 plays two biological roles, one as an essential DNA binding replication enzyme and the other as an mRNA-specific autogenous translational repressor. Binding of T4 gp43 to its mRNA target (translational operator RNA) interferes with
Sandra Thiemann et al.
The Journal of biological chemistry, 290(37), 22662-22677 (2015-07-29)
During inflammation, dendritic cells emigrate from inflamed tissue across the lymphatic endothelium into the lymphatic vasculature and travel to regional lymph nodes to initiate immune responses. However, the processes that regulate dendritic cell tissue egress and migration across the lymphatic
Zheng Fu et al.
Cell reports, 28(1), 159-171 (2019-07-04)
Regulatory T cells (Tregs) are pivotal for immune suppression. Cellular metabolism is important for Treg homeostasis and function. However, the exact role of mitochondrial respiration in Tregs remains elusive. Mitochondrial transcription factor A (Tfam) is essential for mitochondrial respiration and controls
Gopal Kushawah et al.
Developmental cell, 54(6), 805-817 (2020-08-10)
Early embryonic development is driven exclusively by maternal gene products deposited into the oocyte. Although critical in establishing early developmental programs, maternal gene functions have remained elusive due to a paucity of techniques for their systematic disruption and assessment. CRISPR-Cas13
Jemina Lehto et al.
Cancers, 13(6) (2021-04-04)
The C-X3-C motif chemokine receptor 1 (CX3CR1, fractalkine receptor) is associated with neoplastic transformation, inflammation, neurodegenerative diseases and aging, and the small molecule inhibitor KAND567 targeting CX3CR1 (CX3CR1i) is evaluated in clinical trials for acute systemic inflammation upon SARS-CoV-2 infections.
Alison A Staton et al.
Nature protocols, 6(12), 2035-2049 (2011-12-03)
MicroRNAs (miRNAs) regulate gene expression by pairing with complementary sequences in the 3' untranslated regions (UTRs) of transcripts. Although the molecular mechanism underlying miRNA biogenesis and activity is becoming better understood, determining the physiological role of the interaction of an
Ava Vila-Leahey et al.
Oncoimmunology, 5(7), e1151591-e1151591 (2016-09-14)
Histamine receptor 2 (H2) antagonists are widely used clinically for the control of gastrointestinal symptoms, but also impact immune function. They have been reported to reduce tumor growth in established colon and lung cancer models. Histamine has also been reported
Nuno-Valério Silva et al.
Frontiers in cell and developmental biology, 9, 674749-674749 (2021-06-22)
Inflammatory bowel diseases (IBD) with chronic infiltration of immune cells in the gastrointestinal tract are common and largely incurable. The therapeutic targeting of IBD has been hampered by the complex causality of the disease, with environmental insults like cholesterol-enriched Western
Alberto Balderas et al.
Neurochemistry international, 73, 139-145 (2013-11-12)
Glutamate, the major excitatory amino acid, activates a wide variety of signal transduction cascades. Ionotropic and metabotropic glutamate receptors are critically involved in long-term synaptic changes, although recent findings suggest that the electrogenic Na(+)-dependent glutamate transporters, responsible for its removal
Valerio Matozzo et al.
Fish & shellfish immunology, 45(2), 528-533 (2015-05-20)
The cuttlefish Sepia officinalis is an important fishery resource in the Northern Adriatic Sea (Italy). During reproduction, fertilised eggs are released by adult females in coastal waters and embryo development can take over two months. During this period, embryos rely
Claus Hedegaard et al.
FEBS open bio, 3, 411-420 (2013-11-20)
Synapsin 1 (SYN1) is a phosphoprotein involved in nerve signal transmission. The porcine SYN1 promoter orthologue was cloned and characterized to provide a means of expressing a transgene specifically in neurons. The nucleotide sequence of the promoter displayed a high
Nora Grahl et al.
PLoS pathogens, 11(8), e1005133-e1005133 (2015-09-01)
Candida albicans is both a major fungal pathogen and a member of the commensal human microflora. The morphological switch from yeast to hyphal growth is associated with disease and many environmental factors are known to influence the yeast-to-hyphae switch. The
Fränze Progatzky et al.
Nature communications, 5, 5864-5864 (2014-12-24)
Prolonged ingestion of a cholesterol- or saturated fatty acid-enriched diet induces chronic, often systemic, auto-inflammatory responses resulting in significant health problems worldwide. In vivo information regarding the local and direct inflammatory effect of these dietary components in the intestine and
Cyril Sobolewski et al.
The Journal of pharmacology and experimental therapeutics, 355(2), 308-328 (2015-09-04)
Cyclooxygenase-2 (COX-2) is an essential regulator of cancer promotion and progression. Extensive efforts to target this enzyme have been developed to reduce growth of cancer cells for chemopreventive and therapeutic reasons. In this context, cyclooxygenase-2 inhibitors present interesting antitumor effects.
Teresa Lee et al.
The Journal of biological chemistry, 289(33), 22798-22814 (2014-07-06)
DHX9 is an ATP-dependent DEXH box helicase with a multitude of cellular functions. Its ability to unwind both DNA and RNA, as well as aberrant, noncanonical polynucleotide structures, has implicated it in transcriptional and translational regulation, DNA replication and repair
Arabella Young et al.
BMC cancer, 14, 808-808 (2014-11-06)
Radiotherapy is a chosen treatment option for prostate cancer patients and while some tumours respond well, up to 50% of patients may experience tumour recurrence. Identification of functionally relevant predictive biomarkers for radioresponse in prostate cancer would enable radioresistant patients
Jo-Il Kim et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2427-2436 (2014-10-11)
The solid matrices used for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) enable the analysis of small molecules by preventing fragmentations of organic matrix molecules in the low mass-to-charge ratio (m/z) range. In this work, a nylon nanoweb with TiO(2)
Kun Shan et al.
Experimental eye research, 197, 108107-108107 (2020-06-13)
Pathological ocular angiogenesis commonly results in visual impairment or even blindness. Unveiling the mechanisms of pathological angiogenesis is critical to identify the regulators and develop effective targeted therapies. Here, we used corneal neovascularization (CNV) model to investigate the mechanism of
Jingjing Wei et al.
International journal of molecular medicine, 36(5), 1384-1392 (2015-09-24)
Emphysema is a serious disease of the respiratory system and is associated with inflammation and oxidative stress. Heme oxygenase-1 (HO-1), a rate-limiting enzyme involved in heme biosynthesis, exerts potent anti-inflammatory, antioxidant, anti-apoptotic and anti‑proliferative effects in various diseases. In the
Anja Täuber et al.
International journal of pharmaceutics, 489(1-2), 73-82 (2015-04-22)
Fungal infections of skin and/or nails are common diseases resulting in major challenges in topical treatment. Therefore, the objective of the present study was to develop a dermal formulation targeting both tinea pedis and onychomycosis. The antifungal agent ciclopirox olamine
Zhuo-Chen Ma et al.
Nature communications, 11(1), 4536-4536 (2020-09-12)
Natural musculoskeletal systems have been widely recognized as an advanced robotic model for designing robust yet flexible microbots. However, the development of artificial musculoskeletal systems at micro-nanoscale currently remains a big challenge, since it requires precise assembly of two or
Line Mygland et al.
iScience, 24(7), 102807-102807 (2021-08-03)
Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for the antiproliferative effect of tankyrase inhibition (TNKSi). The TNKS1/2-specific
Marcus D Goncalves et al.
Science (New York, N.Y.), 363(6433), 1345-1349 (2019-03-23)
Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS
Hendrik Manner et al.
Surgical endoscopy, 29(7), 1888-1896 (2014-10-09)
A prerequisite for endoscopic treatment (ET) of not only mucosal, but also submucosal early adenocarcinoma of the esophagus (EAC) would be a rate of lymph node (LN) metastasis below the mortality rate of esophagectomy (2-5%). The aim of the present
Ying Liu et al.
Biosensors & bioelectronics, 64, 43-50 (2014-09-06)
Inflammatory cytokines are secreted by immune cells in response to infection or injury. Quantification of multiple cytokines in parallel may help with disease diagnosis by illuminating inflammatory pathways related to disease onset and progression. This paper describes development of an
Verena Resch et al.
AMB Express, 4, 30-30 (2014-06-21)
The Michael hydratase - alcohol dehydrogenase (MhyADH) from Alicycliphilus denitrificans was previously identified as a bi-functional enzyme performing a hydration of α,β-unsaturated ketones and subsequent oxidation of the formed alcohols. The investigations of the bi-functionality were based on a spectrophotometric
Tsiry Rasamiravaka et al.
PloS one, 10(7), e0132791-e0132791 (2015-07-18)
Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in biofilm formation. One of the active compounds has been isolated and
Haiyun Chen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(11), 1230-1236 (2014-08-31)
Schizophyllum commune (SC) is widely consumed by Chinese, especially in southern part of China. The aim of the present study was to assess the extract of SC on vascular tone and the mechanisms involved. Experiments were performed on aorta of
Sawsan Almohammed et al.
The journal of physical chemistry letters, 10(8), 1878-1887 (2019-03-30)
Semiconductor-graphene oxide-based surface-enhanced Raman spectroscopy substrates represent a new frontier in the field of surface-enhanced Raman spectroscopy (SERS). However, the application of graphene oxide has had limited success because of the poor Raman enhancement factors that are achievable in comparison
Monika Dabrzalska et al.
International journal of pharmaceutics, 492(1-2), 266-274 (2015-06-29)
Dendrimers due to their unique architecture may play an important role in drug delivery systems including chemotherapy, gene therapy and recently, photodynamic therapy as well. We investigated two dendrimer-photosensitizer systems in context of potential use of these systems in photodynamic
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