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Zhe Han et al.
Journal of cellular physiology, 234(4), 4179-4190 (2018-08-28)
Sendai virus strain Tianjin, a novel genotype of Sendai virus, has been proven to possess potent antitumor effect on certain cancer cell types although inactivated by ultraviolet (UV). This study was carried out to investigate the in vitro anticancer properties
Meihua Shan et al.
Free radical biology & medicine, 110, 432-443 (2017-06-26)
The objective of this study was to examine the effect of autophagy on stress-induced M2 macrophage polarization in the tumor microenvironment of breast cancer and to determine whether the underlying mechanism was related to the reactive oxygen species (ROS)/ERK and
Caterina Miceli et al.
Nature cell biology, 22(9), 1091-1102 (2020-09-02)
Organs and cells must adapt to shear stress induced by biological fluids, but how fluid flow contributes to the execution of specific cell programs is poorly understood. Here we show that shear stress favours mitochondrial biogenesis and metabolic reprogramming to
Shuai Ji et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 83, 153478-153478 (2021-02-11)
Protection of pancreatic islet cells against dysfunction or death by regulating autophagy is considered to be an effective method for treatment of type 2 diabetes mellitus (T2DM). Morus alba leaves (mulberry leaves), a popular herbal medicine, have been used for
Ji Li et al.
International immunopharmacology, 91, 107275-107275 (2020-12-29)
Periodontitis is a common chronic disease. Osteoclast differentiation contributes to alveolar bone resorption which is a distinct phenomenon during periodontitis. Syndecan 4 (SDC4), a member of the syndecan family, was found to be highly expressed during periodontitis. However, little is
Yajing Liu et al.
Scientific reports, 10(1), 18515-18515 (2020-10-30)
Several literature has shown that salinomycin (Sal) is able to kill various types of cancer cells through different signaling pathways. However, its effect on melanoma has seldom been reported. We examined the anti-cancer efficacy of Sal in melanoma cell lines
Xiao-Long Huang et al.
Anti-cancer drugs, 28(6), 596-602 (2017-04-22)
The role of autophagy in the anticancer activity of gemcitabine (GEM) in bladder cancer is unclear. The aim of this study is to determine whether GEM activates autophagy, the role of autophagy in the anticancer activity of GEM, and the
Cong Han et al.
Veterinary research, 51(1), 61-61 (2020-05-10)
Hsp40/DnaJ family proteins play important roles in the infection process of various viruses. Porcine DNAJB6 (pDNAJB6) is a major member of this family, but its role in modulating the replication of porcine circovirus type 2 (PCV2) is still unclear. In
Lin Wang et al.
International journal of oncology, 56(5), 1162-1174 (2020-04-23)
ADAM metallopeptidase domain 12 (ADAM12) has been demonstrated to mediate cell proliferation and apoptosis resistance in several types of cancer cells. However, the effect of ADAM12 silencing on the proliferation and apoptosis of choriocarcinoma cells remains unknown. The present study
Yong-Xun Jin et al.
Zygote (Cambridge, England), 24(1), 31-41 (2014-12-17)
The mitochondrial genome is maternally inherited in animals, despite the fact that paternal mitochondria enter oocytes during fertilization. Autophagy and ubiquitin-mediated degradation are responsible for the elimination of paternal mitochondria in Caenorhabditis elegans; however, the involvement of these two processes
Kunpeng Liu et al.
American journal of cancer research, 10(1), 78-94 (2020-02-18)
Papillary thyroid carcinoma (PTC) is the most common cancer of the endocrine system, which is usually associated with a favorable therapeutic response and prognosis. However, metastatic spreading occurs in around 5% of the PTC patients. Identification of molecular markers could
Jie Mei et al.
Human reproduction (Oxford, England), 30(7), 1677-1689 (2015-05-16)
What mechanism is involved in regulating the autophagy of endometrial stromal cells (ESCs), and does it participate in the pathogenesis of endometriosis? CXCL12 down-regulates secretory phase ESC autophagy. mTOR (mammalian target of rapamycin), the major negative regulator of autophagy, is
In Young Kim et al.
Biochemical pharmacology, 162, 41-54 (2018-12-12)
Although the proteasome inhibitor (PI) bortezomib (Btz) is in current clinical use as a front-line treatment for multiple myeloma, its clinical efficacy in solid tumors has not been satisfactory. Here, we show that loperamide (Lop), an antidiarrheal drug, effectively sensitizes
Yongjian Li et al.
International journal of molecular medicine, 40(5), 1405-1414 (2017-09-28)
Caffeine has been identified to have beneficial effects against chronic liver diseases, particularly liver fibrosis. Many studies have reported that caffeine ameliorates liver fibrosis by directly inducing hepatic stellate cell (HSC) apoptosis; however, the molecular mechanisms involved in this process remain
Hee Young Kwon et al.
Archives of toxicology, 92(1), 241-257 (2017-07-06)
Hepatocellular carcinoma (HCC) is one of the most fatal malignancies with high mortality worldwide. Here the underlying antitumor mechanism of gallotannin was elucidated in HCC cells. Gallotannin suppressed viability and colony formation, increased subG
Mei-Juan Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 648-662 (2020-01-10)
Histone deacetylases 3 (HDAC3) modulates the acetylation state of histone and non-histone proteins and could be a powerful regulator of the inflammatory process in stroke. Inflammasome activation is a ubiquitous but poorly understood consequence of acute ischemic stroke. Here, we
Daniela Laura Papademetrio et al.
Targeted oncology, 9(2), 123-134 (2013-04-17)
Pancreatic cancer is an aggressive disease. Its incidence has increased over the last two decades. It is currently the fourth cause of death among cancers in the western world. Unfortunately, systemic chemotherapy still relies on just a few drugs which
Kuang-Yao Chen et al.
PLoS neglected tropical diseases, 14(6), e0008290-e0008290 (2020-06-02)
Angiostrongyliasis is induced by the nematode Angiostrongylus cantonensis and leads to eosinophilic meningitis and meningoencephalitis in humans. Excretory-secretory products (ESPs) are important investigation targets for studying the relationship between hosts and nematodes. These products assist worms in penetrating the blood-brain
Huandi Liu et al.
Journal of medical virology (2022-09-28)
Hydrogen sulfide (H2 S) is a redox gasotransmitter. It has been shown that H2 S has a key role in host antiviral defense by inhibiting interleukin production and S-sulfhydrating Keap1 lead to Nrf2/ARE pathway activation. However, it is yet unclear
Ying Fu et al.
Frontiers in pharmacology, 13, 918732-918732 (2022-06-17)
Autophagy, a highly conserved catabolic pathway in eukaryotic cells, contributes to the maintenance of the homeostasis and function of the kidney. Upon acute kidney injury (AKI), autophagy is activated in renal tubular cells to act as an intrinsic protective mechanism.
Zhipeng Du et al.
Journal of cellular physiology, 234(8), 13867-13877 (2019-01-31)
We previously reported that Xiaotan Sanjie (XTSJ) decoction can prevent the progression of gastric cancer in vitro and in vivo. Pinelliae rhizome (PR), one component of XTSJ decoction, has an inhibitory effect on the growth and proliferation of tumor cells.
Zili Zhang et al.
Cell death & disease, 8(6), e2886-e2886 (2017-06-16)
Autophagy and cellular senescence are stress responses essential for homeostasis. Therefore, they may represent new pharmacologic targets for drug development to treat diseases. In this study, we sought to evaluate the effect of dihydroartemisinin (DHA) on senescence of activated hepatic
Mihwa Kim et al.
Autophagy, 13(1), 149-168 (2016-10-19)
Recent progress in chemotherapy has significantly increased its efficacy, yet the development of chemoresistance remains a major drawback. In this study, we show that GFRA1/GFRα1 (GDNF family receptor α 1), contributes to cisplatin-induced chemoresistance by regulating autophagy in osteosarcoma. We
Li Fang et al.
Experimental cell research, 322(2), 290-301 (2014-01-16)
Podocyte apoptosis is a major factor inducing podocyte depletion that predicts the progressive course of glomerulosclerosis. However, the molecular mechanisms underlying podocyte apoptosis are still not well understood. Autophagy is a lysosomal degradation system involving the degradation and recycling of
Yucel Aydin et al.
The American journal of pathology, 188(10), 2339-2355 (2018-08-04)
Liver cirrhosis is an independent risk factor for hepatocellular carcinoma (HCC). The mechanisms that contribute to HCC development in the cirrhotic microenvironment are unknown. We found that HCC grown in the highly stressed cirrhotic microenvironment undergoes autophagy switching from a
Meng Shen et al.
Oncology reports, 34(1), 359-367 (2015-05-26)
Breast cancer is one of the most common cancers affecting women worldwide. Conventional chemotherapy is still one of the major approaches to the treatment of breast cancer. Autophagy, also termed as type II programmed cell death (PCD), exhibits either a
Yini Wu et al.
Cardiology journal, 24(4), 409-418 (2017-02-16)
The effect of sevoflurane on the doxorubicin-induced myocardial injury was explored by investigating the phosphorylation states of proteins in phosphatidylinositol 3-kinase (PI3K)/Akt/mam-malian target of rapamycin (mTOR) signaling pathway. Myocardial injury rat models were induced by doxorubicin and evenly assigned into
Meng Wang et al.
The Journal of pharmacy and pharmacology, 69(6), 743-752 (2017-03-08)
Inhibition of autophagy has been increasingly recognized as a potential therapeutic approach against cancer. Our previous reports showed that Astragaloside II improves hepatic cancer cells resistance by downregulating MDR1 and P-gp .The purpose of this study was to further investigated
Yang Yang et al.
Oncology reports, 41(5), 3100-3110 (2019-04-13)
The pleiotropic effects of hyperthermia on cancer cells have been well documented, and microwave hyperthermia (MWHT) has been widely applied for multifarious cancer treatment. However, the mechanisms underlying the anticancer effect of MWHT combined with gemcitabine (GEM) remain poorly understood.
Zi-Wei Liu et al.
Viruses, 12(1) (2019-12-22)
Enterovirus 71 (EV71) is the main pathogen that causes severe hand, foot, and mouth disease with fatal neurological complications. However, its neurovirulence mechanism is still unclear. Candidate virulence sites were screened out at structural protein VP1, but the function of
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