搜索范围
M9281
应用筛选条件
关键词:'M9281'
显示 1-30 #N/A 2224 条结果 关于 "M9281" 范围 论文
Hui Liu et al.
Journal of leukocyte biology, 108(1), 253-266 (2020-04-10)
Berberine (BBR) is an isoquinoline alkaloid extracted from several commonly used Chinese herbs. Our previous studies demonstrated BBR-mediated alleviation of lung injury due to inflammation and decrease in the mortality of mice with influenza viral pneumonia. The recent argument of
Yung-Ting Hsiao et al.
Environmental toxicology (2018-05-03)
Gefitinib has been used for cancer patients and curcumin (CUR), demethoxycurcumin (DMC), or bisdemethoxycurcumin (BDMC) also shown to induce cancer cell apoptosis. However, no report shows the combination of gefitinib with, CUR, DMC, or BDMC induce cell apoptosis and autophagy
Yunzhao Chen et al.
Cancer research, 80(11), 2175-2189 (2020-02-19)
Esophageal squamous cell carcinoma (ESCC) is one of the deadliest malignant diseases. Multiple studies with large clinic-based cohorts have revealed that variations of phospholipase C epsilon 1 (PLCE1) correlate with esophageal cancer susceptibility. However, the causative role of PLCE1 in
Xiaohuan Zhang et al.
Life sciences, 264, 118664-118664 (2020-11-01)
Etoposide-induced protein 2.4 (EI24) is an autophagy-associated protein and acts as a tumor suppressor. However, its role in tissue fibrosis remains unknown. Herein, a downregulation of EI24 levels in the lungs from mouse pulmonary fibrosis (PF) model and lung epithelial
Zonghao Tang et al.
Frontiers in cell and developmental biology, 8, 619924-619924 (2021-02-05)
During the luteinization after ovulation in mammalian ovary, the containing cells undergo an energy consuming function re-determination process to differentiate into luteal cells under avascular environment. Previous evidences have delineated the contribution of autophagy to the cell differentiation and the
Liwen Zheng et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 65(6), 1014-1020 (2017-06-22)
The aim of this study is to investigate the role of tumor necrosis factor-α (TNF-α) in apoptosis and autophagy of mouse osteoblast MC3T3-E1 cells, as well as the crosstalk between autophagy and apoptosis. Mouse osteoblast MC3T3-E1 cells were cultured in
Yunseo Woo et al.
Oncology letters, 13(5), 3579-3585 (2017-05-23)
Angiotensin II receptor blockers (ARBs) are anti-hypertensive drugs that competitively inhibit the binding of angiotensin II to its receptor, resulting in blood vessel dilation and the reduction of blood pressure. These antagonists are also known as sartans, and are a
Xiangli Bai et al.
Autophagy, 16(6), 1111-1129 (2019-08-27)
Diabetes is a recognized high-risk factor for the development of atherosclerosis, in which macroautophagy/autophagy is emerging to play essential roles. The retention of low-density lipoprotein (LDL) particles in subendothelial space following transcytosis across the endothelium is the initial step of
Hui-Yun Hwang et al.
Autophagy, 17(10), 2783-2799 (2020-10-31)
Macroautophagy/autophagy (hereafter autophagy), the process of mass degradation of unnecessary elements within the cell, is often dysregulated in many diseases such as cancer, atherosclerosis, and neurodegenerative diseases. Hence, autophagy modulating agents have a great potential to be therapeutic agents for
Yi-Chia Wu et al.
International journal of molecular sciences, 20(14) (2019-07-25)
Mitochondrial dysfunction is associated with cardiovascular diseases and diabetes. Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling, and the abnormal proliferation, apoptosis and migration of pulmonary arterial smooth muscle cells (PASMCs). The glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide
Shuyan Wang et al.
Current neurovascular research, 17(5), 644-651 (2020-11-07)
To investigate the role of autophagy in the tight junction of human brain endothelial cells during hypoxia and ischemia. Endothelial cells play an important role in the initiation, progression and recovery from ischemic stroke. The role of autophagy on human
Baoming Xie et al.
Autophagy, 17(4), 925-947 (2020-03-12)
Macroautophagy/autophagy plays an essential role in cellular responses to pathogens. However, the precise mechanisms and signaling pathways that modulate cellular autophagy in classical swine fever virus (CSFV)-infected host cells have not been confirmed. In this study, we showed that CSFV
Wenjing Zhou et al.
Cell cycle (Georgetown, Tex.), 16(1), 73-81 (2016-11-15)
Tumors are comprised of malignant cancer cells and stromal cells which constitute the tumor microenvironment (TME). Previous studies have shown that cancer associated fibroblast (CAF) in TME is an important promoter of tumor initiation and progression. However, the underlying molecular
Tomohisa Ito et al.
International journal of oncology, 53(2), 503-514 (2018-05-31)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and cold plasma-stimulated medium (PSM) are promising novel anticancer tools due to their strong anticancer activities and high tumor-selectivity. The present study demonstrated that PSM and TRAIL may trigger autophagy in human malignant melanoma and osteosarcoma
Kyle Caution et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 18(4), 491-500 (2019-02-10)
Autophagy is a highly regulated, biological process that provides energy during periods of stress and starvation. This conserved process also acts as a defense mechanism and clears microbes from the host cell. Autophagy is impaired in Cystic Fibrosis (CF) patients
Ya-Ya Xie et al.
Molecular and cellular biochemistry, 443(1-2), 181-191 (2017-12-24)
Rheumatoid arthritis (RA) is a degenerative joint disease that is caused by multiple pathogenic factors. However, the precise etiology of RA is still unknown. Our previous studies demonstrated that acid-sensing ion channel 1a (ASIC1a)-mediated articular chondrocyte apoptosis played a key
Jia-Bin Nian et al.
Cell cycle (Georgetown, Tex.), 19(10), 1132-1142 (2020-04-17)
Nasal epithelial cells are the first barrier against allergen infiltration in allergic rhinitis (AR), and the relationship between nasal epithelial cells and mast cell-mediated hypersensitivity remains unclear. This study aimed to investigate the possible association between allergen-challenged nasal epithelial cells
Bowen Yu et al.
Frontiers in pharmacology, 11, 1087-1087 (2020-08-09)
Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, AsIII) has been reported to induce cytotoxicity in breast cancer cells. We recently demonstrated that AsIII
Dipanwita Das Mukherjee et al.
Biochimica et biophysica acta. Molecular cell research, 1867(10), 118762-118762 (2020-06-06)
Microtubules, the key components of the eukaryotic cytoskeleton and mitotic spindle, are one of the most sought-after targets for cancer chemotherapy, especially due to their indispensible role in mitosis. Cervical cancer is a prevalent malignancy among women of developing countries
Marcin Luty et al.
Cancers, 11(1) (2019-01-16)
Metronomic agents reduce the effective doses and adverse effects of cytostatics in cancer chemotherapy. Therefore, they can enhance the treatment efficiency of drug-resistant cancers. Cytostatic and anti-angiogenic effects of fenofibrate (FF) suggest that it can be used for the metronomic
Xiaomiao Zhang et al.
Archives of biochemistry and biophysics, 672, 108061-108061 (2019-07-30)
Autophagy exerts a dual role in promoting cell death or survival. Recent studies have shown that it may play an important role in lipopolysaccharide (LPS)-induced acute lung injury (ALI). It was also suggested that angiotensin converting enzyme 2 (ACE2) may
You-Zhi Xu et al.
Oncology reports, 35(4), 2081-2088 (2016-02-06)
Cancer cells activate autophagy in response to anticancer therapies. Autophagy induction is a promising therapeutic approach to treat cancer. In a previous study, YL4073 inhibited the growth of liver cancer and induced liver cancer cell apoptosis. Here, we demonstrated the
Xiaodong Shu et al.
Cell death & disease, 10(8), 577-577 (2019-08-03)
Although multiple hypotheses had been proposed to clarify the causes of depression, the accurate pathogenesis and effective treatment of depression still need to be solved. Pathological change of astrocytes has been recognized to play a pivotal role in depression. Fluoxetine
Sheng Zhang et al.
Molecular neurobiology, 53(1), 83-94 (2014-11-19)
β-asarone, a major component of Acorus tatarinowii Schott, has positive effects in neurodegeneration disease, however, its effect on the Parkinson's disease (PD) remains unclear. In this study, the effects of β-asarone on behavioral tests, neurotransmitters, tyrosine hydroxylase (TH), and α-synuclein
Hui Miao et al.
Drug design, development and therapy, 14, 4845-4854 (2020-11-19)
MicroRNAs play important roles in testicular development and spermatogenesis. Previous research has indicated that the level of miR-200a was significantly upregulated in patients with different spermatogenic impairments. However, the mechanism by which miR-200a regulated spermatogenic impairments remains unclear. Leydig cells
Sihyung Wang et al.
Experimental & molecular medicine, 49(9), e380-e380 (2017-09-25)
Tumor necrosis factor-inducible gene 6 protein (TSG-6) has recently been shown to protect the liver from acute damage. However, the mechanism underlying the effect of TSG-6 on the liver remains unclear. Autophagy is a catabolic process that targets cell components
Suraiya Saleem et al.
The Journal of biological chemistry, 292(7), 2571-2585 (2016-12-25)
Amyloid-β (Aβ)-induced neuron death is considered central to the pathogenesis of Alzheimer's disease (AD). Among several death modalities, autophagy and apoptosis play important roles in Aβ-induced neuron death suggesting that there may be regulatory mechanisms that initiate both cell death
Feng Zhang et al.
Investigative ophthalmology & visual science, 60(7), 2743-2752 (2019-06-28)
To evaluate the potential antifibrotic effect of rosiglitazone (RSG), a peroxisome proliferator-activated receptor γ (PPARγ)-selective agonist, on subconjunctival fibrosis in a rabbit model of glaucoma filtration surgery (GFS) in vivo, and to investigate the underlying mechanisms in human Tenon's fibroblasts
Armelle T Mbaveng et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 76, 153261-153261 (2020-06-20)
The discovery of novel phytochemicals represents a reasonable approach to fight malignancies, especially those which are resistant to standard chemotherapy. We evaluated the cytotoxic potential of a naturally occurring N-acetylglycoside of oleanolic acid, aridanin, on 18 cancer cell lines, including
S100A8 transported by SEC23A inhibits metastatic colonization via autocrine activation of autophagy.
Zhiwei Sun et al.
Cell death & disease, 11(8), 650-650 (2020-08-20)
Metastasis is the main cause of failure of cancer treatment. Metastatic colonization is regarded the most rate-limiting step of metastasis and is subjected to regulation by a plethora of biological factors and processes. On one hand, regulation of metastatic colonization
1/75