MSQC3

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关键词:'MSQC3'

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Mass Spectrometry-Based Method Targeting Ig Variable Regions for Assessment of Minimal Residual Disease in Multiple Myeloma.

Carlo O Martins et al.

The Journal of molecular diagnostics : JMD, 22(7), 901-911 (2020-04-18)

Multiple myeloma is a systemic malignancy of monoclonal plasma cells that accounts for 10% of hematologic cancers. With development of highly effective therapies for multiple myeloma, minimal residual disease (MRD) assessment has emerged as an important end point for management

Development and validation of an LC-MS/MS method for simultaneous quantification of co-administered trastuzumab and pertuzumab.

Sandor Schokker et al.

mAbs, 12(1), 1795492-1795492 (2020-08-04)

Given the increasing use of combination therapy with multiple monoclonal antibodies (mAbs), there is a clinical need for multiplexing assays. For the frequently co-administered anti-human epidermal growth factor receptor 2 (HER2) mAbs trastuzumab and pertuzumab, we developed a high-throughput and

Quantitation of intact monoclonal antibody in biological samples: comparison of different data processing strategies.

Xi Qiu et al.

Bioanalysis, 10(13), 1055-1067 (2018-07-05)

Sample extraction using immuno-affinity capture coupled with LC-high-resolution mass spectrometer has recently emerged as a novel approach for the determination of concentrations of large molecules at intact level in biological matrix. In the current work, different data processing strategies for

Automated Antibody De Novo Sequencing and Its Utility in Biopharmaceutical Discovery.

K Ilker Sen et al.

Journal of the American Society for Mass Spectrometry, 28(5), 803-810 (2017-01-21)

Applications of antibody de novo sequencing in the biopharmaceutical industry range from the discovery of new antibody drug candidates to identifying reagents for research and determining the primary structure of innovator products for biosimilar development. When murine, phage display, or

Generic automated method for liquid chromatography-multiple reaction monitoring mass spectrometry based monoclonal antibody quantitation for preclinical pharmacokinetic studies.

Qian Zhang et al.

Analytical chemistry, 86(17), 8776-8784 (2014-07-11)

Quantitation of therapeutic monoclonal antibodies (mAb) using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for pharmacokinetic (PK) studies is becoming an essential complement to traditional antibody-based ligand binding assays (LBA). Here we show an automated method to perform LC-MS/MS-based quantitation, with IgG1

Top-down LC-MS quantitation of intact denatured and native monoclonal antibodies in biological samples.

Liyun Zhang et al.

Bioanalysis, 10(13), 1039-1054 (2018-06-29)

The requirements for developing antibody biotherapeutics benefit from understanding the nature and relevant aspects of the entire molecule. The method presented herein employs on-line multidimensional LC-quadrupole time-of-flight (QTOF)-MS for the quantitative determination of an antibody isolated from biological samples while

Generic MS-based method for the bioanalysis of therapeutic monoclonal antibodies in nonclinical studies.

Noritaka Hashii et al.

Bioanalysis, 12(4), 231-243 (2020-02-25)

Aim: A generic bioanalytical method was developed to quantify therapeutic IgG1 monoclonal antibodies (mAbs) in mouse sera by combining an easy sample preparation method with LC/MS using selected reaction monitoring. Materials & methods: Rituximab and trastuzumab were used as model

Automated Antibody De Novo Sequencing and Its Utility in Biopharmaceutical Discovery.

Sen K I, et al.

Journal of the American Society For Mass Spectrometry, 28(5), 803-810 (2017)

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