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Robert W P Glowacki et al.
Cell host & microbe, 27(1), 79-92 (2020-01-07)
Efficient nutrient acquisition in the human gut is essential for microbial persistence. Although polysaccharides have been well-studied nutrients for the gut microbiome, other resources such as nucleic acids and nucleosides are less studied. We describe several ribose-utilization systems (RUSs) that
Virayu Suthiphasilp et al.
Heliyon, 7(2), e06180-e06180 (2021-03-06)
Four new compounds, (+)-(2S)-desmosdumosone (1), (+)-(2R)-7,8-dimethoxy-5-hydroxyflavanone (7), (+)-(2R)-7-methoxychamanetin (9), and (+)-(1'R,2'R)-phebalosin (18), and 25 known compounds were isolated from the twig and leaf extracts of Desmos dumosus. Compounds (±)-7 and (±)-9 were isolated as racemates and their enantiomers were separated by chiral
Celia Bustos-Brito et al.
Molecules (Basel, Switzerland), 25(8) (2020-04-25)
The aerial parts of Salvia cinnabarina afforded two undescribed labdane diterpenoids 1 and 2 (malonylcommunol and 6β-hydroxy-trans-communic acid) along with two known labdane diterpenoids, trans-communic acid (3) and trans-communol (4). Additionally, seven known metabolites were also isolated; two isopimarane diterpenoids
Mezna Saleh Altowyan et al.
Molecules (Basel, Switzerland), 24(12) (2019-06-28)
Inhibition of α-amylase and α-glucosidase by specified synthetic compounds during the digestion of starch helps control post-prandial hyperglycemia and could represent a potential therapy for type II diabetes mellitus. A new series of spiroheterocyclic compounds bearing oxindole/benzofuran/pyrrolidine/thiazolidine motifs were synthesized
Hyeong-U Son et al.
Biomolecules, 9(12) (2019-12-11)
To determine the mechanism of action of the effects of phytoalexins in soybeans, we analyzed α-glucosidase inhibition kinetics using Michaelis-Menten plots and Lineweaver-Burk plots. The results showed that the type of inhibition with glyceollin was competitive, that of genistein was
Adolfo Andrade-Cetto et al.
Evidence-based complementary and alternative medicine : eCAM, 2021, 6625009-6625009 (2021-01-29)
The onset of type 2 diabetes (T2D) is a consequence of the progressive loss of adequate β-cell insulin secretion, which frequently occurs under a background of insulin resistance. Currently, nearly 13 million Mexicans are living with diabetes. Moreover, due to
Oxana B Kazakova et al.
Molecules (Basel, Switzerland), 25(20) (2020-10-24)
A series of two new and twenty earlier synthesized branched extra-amino-triterpenoids obtained by the direct coupling of betulinic/betulonic acids with polymethylenpolyamines, or by the cyanoethylation of lupane type alcohols, oximes, amines, and amides with the following reduction were evaluated for
Héctor Cedeño et al.
Molecules (Basel, Switzerland), 24(23) (2019-11-28)
Gaiadandendron punctatum G.Don. (violeta de campo) is a plant used in traditional medicine by the Saraguro people, an ancient indigenous group that lives in southern Ecuador. From samples collected in the region, six glycoside flavonoids, five with quercetin and one
Suphongphan Srisurichan et al.
Phytochemistry, 106, 197-206 (2014-07-24)
Eight pregnane-type steroidal glycosides substituted with ortho-acetate groups were isolated from the methanolic extract of the pericarp of Gymnema griffithii fruits, and named gymnemogriffithosides A-H. Their structures were determined by spectroscopic analysis (one and two dimensional nuclear magnetic resonance, high
Hyeong-U Son et al.
Biomedical reports, 1(4), 624-628 (2014-03-22)
Cudrania tricuspidata (CT) is a type of add-value beneficial plant. The aim of the present study was to determine the components of CT that inhibit α-glucosidase activity. Roots, leaves and stems of the plants were obtained and several subgroups were
Yinan Zhang et al.
Molecules (Basel, Switzerland), 26(4) (2021-03-07)
Our previous study found that desmethylxanthohumol (1) inhibited α-glucosidase in vitro. Recently, further investigations revealed that dehydrocyclodesmethylxanthohumol (2) and its dimer analogue rottlerone (3) exhibited more potent α-glucosidase inhibitory activity than 1. The aim of this study was to synthesize
Kirana P Mugaranja et al.
Heliyon, 6(7), e04392-e04392 (2020-07-17)
A phenolic rich fraction purified from Simarouba glauca leaves was effective in alpha glucosidase inhibition. The purified fraction named 'fraction-14' had shown significant inhibition of yeast alpha glucosidase enzyme activity (IC50 = 2.4 ± 0.4 μg/mL) when compared to anti-diabetic
Issis Quispe-Fuentes et al.
Journal of food science and technology, 57(6), 2241-2250 (2020-05-21)
The aim of this study is to determine the effects of different drying methods, including freeze drying (FD), convective drying, sun drying, infrared drying and vacuum drying (VD), on the chemical composition and microstructure of maqui berries as well as
Jang Hoon Kim et al.
Bioorganic chemistry, 87, 803-809 (2019-04-13)
Eight anthocyanidin derivatives (1-8) were evaluated as potential inhibitors of the catalysis of α-glucosidase. Among them, compounds 4 and 8 had the highest levels of inhibitory activity at 100 μM (IC50 values of 14.4 ± 0.1 and 29.7 ± 1.2 μM) and acted in a dose-dependent
Parham Taslimi
Archiv der Pharmazie, 353(11), e2000210-e2000210 (2020-09-03)
In this study, the acetophenone derivatives 1-6 were found to be effective inhibitor molecules for α-glycosidase, human carbonic anhydrases I and II (hCA I/II), and acetylcholinesterase (AChE), with Ki values in the range of 167.98 ± 25.06 to 304.36 ± 65.45 µM for α-glycosidase, 555.76 ± 56.07
P S Unnikrishnan et al.
Pharmacognosy magazine, 11(Suppl 4), S511-S515 (2016-03-26)
In the continuing search for safe and efficient antidiabetic drug, marine algae become important source which provide several compounds of immense therapeutic potential. Alpha-amylase, alpha-glucosidase inhibitors, and antioxidant compounds are known to manage diabetes and have received much attention recently.
Hyeong-U Son et al.
Biomedical reports, 1(4), 624-628 (2014-03-22)
Cudrania tricuspidata (CT) is a type of add-value beneficial plant. The aim of the present study was to determine the components of CT that inhibit α-glucosidase activity. Roots, leaves and stems of the plants were obtained and several subgroups were
Sae Rom Park et al.
Food chemistry, 257, 128-134 (2018-04-07)
α-Glucosidase is an enzyme that plays a key role in raising blood sugar level and is considered a good target for developing drugs to treat type 2 diabetes. This study was performed to evaluate the inhibition of the catalytic reaction
Fabiola A López-Huerta et al.
Bioorganic chemistry, 100, 103919-103919 (2020-05-18)
Chemical investigation of the aerial parts of Cnidoscolus spinosus resulted in the isolation of relatively infrequent hopane-type triterpenes, 3β-acetoxy-hop-22(29)-ene (1), first reported here as natural product, together with 3-oxo-hop-22(29)-ene (2), and 3β-hydroxy-hop-22(29)-ene (3). β-Amyrin palmitate and three phytosterols were also
Malose J Mphahlele et al.
Bioorganic chemistry, 97, 103702-103702 (2020-03-09)
Series of 7-aryl- (3a-f), 7-arylvinyl- (3g-k) and 7-(arylethynyl)-5-bromo-3-methylindazoles (4a-f) have been evaluated through enzymatic assay in vitro for inhibitory effect against α-glucosidase activity and for antioxidant potential through the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Compounds 3a-k and 4a-f showed significant
Jaegoo Kim et al.
World journal of microbiology & biotechnology, 34(11), 167-167 (2018-11-02)
Candida albicans is a major invasive pathogen, and the development of strains resistant to conventional antifungal agents has been reported in recent years. We evaluated the antifungal activity of 44 compounds against Candida strains. Magnoflorine showed the highest growth inhibitory
Erick P Gutiérrez-Grijalva et al.
Food research international (Ottawa, Ont.), 116, 676-686 (2019-02-06)
Different oregano species have been traditionally used as infusions in folk medicine. Oregano medicinal properties, such as antioxidant and anti-inflammatory, have been partially attributed to its polyphenolic content. However, information regarding bioaccessibility of oregano polyphenols is limited. Cell-based antioxidant activity
Sajjad Esmaeili et al.
Bioorganic chemistry, 88, 102972-102972 (2019-05-13)
Dipyridamole (DP) elevates cyclic Adenosine Monophosphate (cAMP) levels in platelets, erythrocytes, and endothelial cells and also blocks adenosine reuptake. It is used to dilate blood vessels in people with peripheral arterial disease and coronary artery disease (CAD). The flexible backbone
Cuiling Zhong et al.
Nature communications, 11(1), 6330-6330 (2020-12-12)
Endothelial cell (EC) metabolism is thought to be one of the driving forces for angiogenesis. Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular EC, with an
Justyna Skoczek et al.
Food chemistry, 294, 231-237 (2019-05-28)
A fully mechanized Arduino-controlled multi-pumping flow analysis system and procedure for the determination of β-galactosidase activity are proposed. The applied bioanalytical method is based on the determination of p-nitrophenol formed in the course of enzyme-catalyzed hydrolysis of p-nitrophenyl-galactopyranosides. The photometric
Bita Amiri et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 138, 105040-105040 (2019-08-11)
Antibiotics are effective drugs that are used to treat infectious diseases either by killing bacteria or slowing down their growth. The well-adapted structural features of antibiotics for the inhibition/activation of enzymes include several available hydrogen bond (H-bond) acceptors and donors
Andrea L Ball et al.
Journal of enzyme inhibition and medicinal chemistry, 23(1), 131-135 (2008-03-18)
Glycosidases perform a wide range of functions in physiology and pathology, and are potential targets for the treatment of diseases such as influenza, cancer, AIDS and diabetes. This paper reports a convenient discontinuous colourimetric assay for the measurement of glycosidase
Sangeun Park et al.
Bioorganic & medicinal chemistry letters, 21(8), 2441-2444 (2011-03-15)
We constructed a library of sugar-dipeptide conjugate to find out the best complementary against hydrophobic pocket of α-glucosidase. The best substrate showed 150-fold improved K(m) value relative p-acetaminophenyl-α-D-glucopyranoside for α-glucosidase from Bacillus stearothermophillus. Using information from the complementary, we synthesized
Faryal Chaudhry et al.
Bioorganic chemistry, 82, 267-273 (2018-11-06)
Herein, substituted imidazole-pyrazole hybrids (2a-2n) were prepared via a multi component reaction employing pyrazole-4-carbaldehydes (1a-1d), ammonium acetate, benzil and arylamines as reactants. All the new compounds were characterized through their spectral and elemental analyses. Further these compounds were tested against
Elmira F Khusnutdinova et al.
Bioorganic chemistry, 88, 102957-102957 (2019-05-12)
A series of nineteen nitrogen-containing lupane triterpenoids was obtained by modification of C2, C3, C20 and C28 positions of betulonic acid and their α-glucosidase inhibiting activity was investigated. Being a leader compound from our previous study, 2,3-indolo-betulinic acid was used
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