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Nikita Mundhara et al.
Scientific reports, 9(1), 7638-7638 (2019-05-23)
Methyl-β-cyclodextrin (MCD), an established pharmacological excipient, depolymerizes the actin cytoskeleton. In this work, we investigated the effect of MCD-mediated actin depolymerization on various cellular phenotypes including traction force, cell stiffness, focal adhesions, and intracellular drug accumulation. In addition to a
Zane R Lybrand et al.
The Journal of comparative neurology, 528(3), 468-480 (2019-09-11)
The interneurons associated with rapid escape circuits are adapted for fast pathway activation and rapid conduction. An essential aspect of fast activation is the processing of sensory information with limited delays. Although aquatic annelid worms have some of the fastest
Benjamin L Hlina et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 200, 9-16 (2017-06-08)
Invasive sea lamprey (Petromyzon marinus) populations in the Great Lakes are controlled by applying the piscicide, 3-trifluoromethyl-4-nitrophenol (TFM), to infested streams with larval sea lamprey (ammocoetes). While treatment mortality is >90%, surviving lamprey, called residuals, can undermine control efforts. A
Yizhong Liu et al.
Nanotoxicology, 11(7), 846-856 (2017-09-09)
In this work, we evaluated the impact of gold nanoparticles on endothelial cell behavior and function beyond the influence on cell viability. Five types of gold nanoparticles were studied: 5 nm and 20 nm bare gold nanoparticles, 5 nm and 20 nm gold nanoparticles
Fabiana Corami et al.
Environmental science and pollution research international, 27(13), 15565-15583 (2020-02-23)
To evaluate the hazard assessment of dredging and disposal of sediments, an in-depth chemical and toxicological characterization of sediments was carried out in Venice Lagoon. The bioaccessible and mobile concentration of trace elements in superficial and deep sediments (in the
Kathryn A Rosowski et al.
Scientific reports, 8(1), 17967-17967 (2018-12-21)
Cells respond to the mechanics of their environment. Mechanical cues include extracellular matrix (ECM) stiffness and deformation, which are primarily sensed through integrin-mediated adhesions. We investigated the impact of ECM deformation on cellular forces, measuring the time-evolution of traction forces
Cori K Cahoon et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(33), E6857-E6866 (2017-08-02)
The synaptonemal complex (SC), a structure highly conserved from yeast to mammals, assembles between homologous chromosomes and is essential for accurate chromosome segregation at the first meiotic division. In Drosophila melanogaster, many SC components and their general positions within the
Rita Jurkow et al.
BMC plant biology, 20(1), 290-290 (2020-06-25)
Nanoparticles (NPs) serve various industrial and household purposes, and their increasing use creates an environmental hazard because of their uncontrolled release into ecosystems. An important aspect of the risk assessment of NPs is to understand their interactions with plants. The
Subhra P Hui et al.
Developmental cell, 43(6), 659-672 (2017-12-20)
The attenuation of ancestral pro-regenerative pathways may explain why humans do not efficiently regenerate damaged organs. Vertebrate lineages that exhibit robust regeneration, including the teleost zebrafish, provide insights into the maintenance of adult regenerative capacity. Using established models of spinal
Belinda Huerta et al.
Aquatic toxicology (Amsterdam, Netherlands), 219, 105380-105380 (2019-12-20)
Population control of invasive sea lamprey relies heavily on lampricide treatment of infested streams. The lampricide 3-trifluoromethyl-4-nitrophenol (TFM) is thought to impair mitochondrial ATP production through uncoupling oxidative phosphorylation. However, the effect of TFM on the entire electron transport chain
Sushant Kumar et al.
Cell, 180(5), 915-927 (2020-02-23)
The dichotomous model of "drivers" and "passengers" in cancer posits that only a few mutations in a tumor strongly affect its progression, with the remaining ones being inconsequential. Here, we leveraged the comprehensive variant dataset from the ICGC/TCGA Pan-Cancer Analysis
Nageshvar Patel et al.
Foods (Basel, Switzerland), 9(10) (2020-10-07)
The aim of this study was to test the predictability of a detailed mineral profile of beef using different portable near-infrared spectrometers (NIRS). These devices are rapid, chemical waste-free, cheap, nondestructive tools that can be used directly on the meat
Rosen K Rachev et al.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 67(7), 1303-1316 (2020-01-28)
Plane wave imaging (PWI) is an ultrasonic array imaging technique used in nondestructive testing, which has been shown to yield high resolution with few transmissions. Only a few published examples are available of PWI of components with nonplanar surfaces in
Rhodri L T Bevan et al.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 67(11), 2387-2401 (2020-08-04)
The multiview total focusing method (TFM) enables a region of interest within a specimen to be imaged using different ray paths and wave-mode combinations. For defects larger than the ultrasonic wavelength, different portions of the same defect may manifest in
Yvonne Aratyn-Schaus et al.
The Journal of cell biology, 212(4), 389-397 (2016-02-10)
The efficacy of cardiac cell therapy depends on the integration of existing and newly formed cardiomyocytes. Here, we developed a minimal in vitro model of this interface by engineering two cell microtissues (μtissues) containing mouse cardiomyocytes, representing spared myocardium after
Rim Timoumi et al.
Toxicology mechanisms and methods, 30(6), 438-449 (2020-04-22)
Triflumuron (TFM) is an insect growth regulator (IGR), an insecticide commonly used over the world. It is known for its several toxic manifestations, such as reprotoxicity, immunotoxicity and hematotoxicity, which could affect public health. However, studies that reveal its toxic
Laura Marastoni et al.
Scientific reports, 10(1), 18839-18839 (2020-11-04)
In several cultivation areas, grapevine can suffer from Fe chlorosis due to the calcareous and alkaline nature of soils. This plant species has been described to cope with Fe deficiency by activating Strategy I mechanisms, hence increasing root H+ extrusion
Obesity and Risk of Nonalcoholic Fatty Liver Disease: A Comparison of Bioelectrical Impedance Analysis and Conventionally-Derived Anthropometric Measures.
Maya Balakrishnan et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 15(12), 1965-1967 (2017-06-24)
L V Magnussen et al.
Andrology, 5(5), 946-953 (2017-09-16)
The purpose of the study was to evaluate whether testosterone replacement therapy improves muscle mechanical and physical function in addition to increasing lean leg mass and total lean body mass in aging men with type 2 diabetes and lowered bio-available
Thalita Fialho da Rocha et al.
European journal of nutrition, 56(5), 1983-1991 (2016-06-09)
Evaluate the association between alcohol consumption and body adiposity. We analyzed cross-sectional data from a longitudinal investigation (Pró-Saúde Study), comprising a sample of 514 civil servants of both sexes (35-64 years). Daily alcohol consumption (wine, beer, and other alcoholic drinks) over
Erminia Conti et al.
Environmental science and pollution research international, 24(21), 17642-17650 (2017-06-11)
Behavioral ecotoxicology has become very important in the short time since a change in behavior is very often the first response to environmental altered conditions. We investigated the influence of trace metal intake on the spatial orientation performances of the
Luís B Sardinha et al.
Pediatric obesity, 12(5), 373-379 (2016-06-04)
The amount of time children spend in sedentary behaviours may have adverse health effects. To examine the substitution effects of displacing a fixed duration of sedentary time with physical activity (PA) on children's body composition. We included 386 children (197
Simone L Otto et al.
Brain structure & function, 224(2), 829-846 (2018-12-06)
Disruption in cholinergic signaling has been linked to many environmental and/or pathological conditions known to modify adult neurogenesis. The α7 nAChRs are in the family of cys-loop receptor channels which have been shown to be neuroprotective in adult neurons and
Bas Vriens et al.
Environmental science & technology, 51(19), 10943-10953 (2017-07-04)
The number and quantities of trace elements used in industry, (high-tech) consumer products, and medicine are rapidly increasing, but the resulting emissions and waste streams are largely unknown. We assessed the concentrations of 69 elements in digested sewage sludge and
Neal I Callaghan et al.
Communications biology, 3(1), 229-229 (2020-05-13)
Primary adult cardiomyocyte (aCM) represent the mature form of myocytes found in the adult heart. However, culture of aCMs in particular is challenged by poor survival and loss of phenotype, rendering extended in vitro experiments unfeasible. Here, we establish murine
Lauren M Styczynski et al.
Neuroscience letters, 720, 134764-134764 (2020-01-21)
Early life administration of vincristine (VNC), commonly used to treat pediatric leukemia, evokes peripheral neuropathy and mechanical pain hypersensitivity in rats that lasts into adolescence. However, the degree to which VNC-evoked neuropathic pain persists throughout adulthood has yet to be
J H Erasmus et al.
The Science of the total environment, 703, 134738-134738 (2019-11-16)
South Africa is the world's main supplier of Pt. The Bushveld Igneous Complex in South Africa contains 75% of the world's Pt resources. Mining of this precious metal requires large volumes of water for production and removal of waste products.
Nikita Mundhara et al.
The Biochemical journal, 478(1), 179-196 (2020-12-22)
Human body temperature limits below 40°C during heat stroke or fever. The implications of prolonged exposure to the physiologically relevant temperature (40°C) on cellular mechanobiology is poorly understood. Here, we have examined the effects of heat stress (40°C for 72 h
Vladimir R Djordjevic et al.
Environment international, 128, 353-361 (2019-05-12)
Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to investigate the role of
Pedro J Benito et al.
Journal of applied physiology (Bethesda, Md. : 1985), 118(8), 1006-1013 (2015-02-28)
The aim of the present study was to compare the effects of different physical activity programs, in combination with a hypocaloric diet, on anthropometric variables and body composition in obese subjects. Ninety-six obese (men: n = 48; women: n =
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