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Steven R Caliari et al.
Scientific reports, 6, 21387-21387 (2016-02-26)
Tissue fibrosis contributes to nearly half of all deaths in the developed world and is characterized by progressive matrix stiffening. Despite this, nearly all in vitro disease models are mechanically static. Here, we used visible light-mediated stiffening hydrogels to investigate
C R Hansen et al.
Xenobiotica; the fate of foreign compounds in biological systems, 10(4), 257-263 (1980-04-01)
1. Residues of the lampricides 14C-Bayer 73 (2',5-dichloro-4'-nitrosalicylanilide) and 14C-TFM (3-trifluoromethyl-4-nitrophenol) were absorbed from aqueous sublethal concn. by aquatic larvae of the midge Chironomus tentans. 2. Toxicant residues were widely distributed during early hours of exposure, but later and during
Georgios Pavlou et al.
ACS nano, 14(6), 7121-7139 (2020-05-21)
Among the eukaryotic cells that navigate through fully developed metazoan tissues, protozoans from the Apicomplexa phylum have evolved motile developmental stages that move much faster than the fastest crawling cells owing to a peculiar substrate-dependent type of motility, known as
Rim Timoumi et al.
Journal of biochemical and molecular toxicology, 34(8), e22504-e22504 (2020-04-01)
Insect growth regulator insecticides are a new class of pesticides, commonly used around the world to control insect damages. Among those compounds, we focused our interest on triflumuron (TFM), which is less toxic than other conventional insecticides. However, not much
Dnyandev G Gadhave et al.
Drug development and industrial pharmacy, 45(5), 839-851 (2019-02-01)
Multiple sclerosis (MS) is one of the most severe autoimmune disorder of the central nervous system (CNS). The present research work was aimed to formulate and investigate teriflunomide (TFM)-loaded intranasal (i.n.) nanostructured lipid carriers (NLC) for the treatment of multiple
L E Gyllenhammer et al.
International journal of obesity (2005), 40(4), 601-606 (2015-10-08)
Puberty is a period defined by large changes in adipose tissue accumulation and distribution; however, longitudinal patterns of ectopic fat development have not been shown. We have previously shown significant declines in beta-cell function (BCF) across puberty and hypothesize that
Hongwei Hu et al.
Sensors (Basel, Switzerland), 18(6) (2018-06-08)
The ultrasonic phased array total focusing method (TFM) has the advantages of full-range dynamic focusing and high imaging resolution, but the problem of long imaging time limits its practically industrial applications. To reduce the imaging calculation demand of TFM, the
Eduardo Lopez Villaverde et al.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 64(9), 1336-1344 (2017-04-10)
In this paper, defects in a high density polyethylene pipe are imaged with the total focusing method. The viscoelastic attenuation of this material greatly reduces the signal level and leads to a poor signal-to-noise ratio (SNR) due to electronic noise.
Michael A Boogaard et al.
Environmental toxicology and chemistry, 34(7), 1634-1641 (2015-03-03)
The present study evaluated the risk of 12-h exposures of the lampricide 3-trifluoromethyl-4-nitrophenol (TFM) to multiple life stages of the federally endangered snuffbox (Epioblasma triquetra) and its primary host fish the common logperch (Percina caprodes) as well as a surrogate
Andrzej Kalisz et al.
Scientific reports, 9(1), 5416-5416 (2019-04-02)
This study investigated if genetic diversity among cauliflower cultivars (white 'Xenia' F1, green 'Vitaverde' F1, purple 'Graffiti' F1, orange 'Sunset' F1, romanesco 'Celio' F1) and transplant chilling are reflected in the content of 17 elements in mature curds. Transplants at
Daniel E P Gomez et al.
NeuroImage, 218, 116783-116783 (2020-05-16)
Temporally independent functional modes (TFMs) are functional brain networks identified based on their temporal independence. The rationale behind identifying TFMs is that different functional networks may share a common anatomical infrastructure yet display distinct temporal dynamics. Extracting TFMs usually require
Evy Aerts et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 108(5), 2180-2191 (2020-01-17)
Porous titanium fiber mesh (TFM) is considered a suitable scaffold material for bone reconstruction. Also, TFM can be used to cover the surface of bone-anchored devices, that is, orthopedic or dental implants. The titanium fiber size has an effect of
Oana Birceanu et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 153(3), 342-349 (2010-12-22)
The toxicity of 3-trifluoromethyl-4-nitrophenol (TFM) appears to be due to a mismatch between ATP supply and demand in lamprey, depleting glycogen stores and starving the nervous system of ATP. The cause of this TFM-induced ATP deficit is unclear. One possibility
Hanen Samouda et al.
Pediatric diabetes, 21(5), 758-765 (2020-05-18)
Visceral adipose tissue (VAT) accumulation is a major cardiometabolic risk factor, associated with increased inflammation. Oxidative stress (OS) is also associated with inflammation and cardiometabolic issues, yet mainly through general obesity. Both OS and obesity were linked to vitamin D
Steve Gutreuter et al.
Environmental toxicology and chemistry, 26(9), 1978-1986 (2007-08-21)
Predictors of the percentile lethal/effective concentration/dose are commonly used measures of efficacy and toxicity. Typically such quantal-response predictors (e.g., the exposure required to kill 50% of some population) are estimated from simple bioassays wherein organisms are exposed to a gradient
Sushant Kumar et al.
Cell, 180(5), 915-927 (2020-02-23)
The dichotomous model of "drivers" and "passengers" in cancer posits that only a few mutations in a tumor strongly affect its progression, with the remaining ones being inconsequential. Here, we leveraged the comprehensive variant dataset from the ICGC/TCGA Pan-Cancer Analysis
Nageshvar Patel et al.
Foods (Basel, Switzerland), 9(10) (2020-10-07)
The aim of this study was to test the predictability of a detailed mineral profile of beef using different portable near-infrared spectrometers (NIRS). These devices are rapid, chemical waste-free, cheap, nondestructive tools that can be used directly on the meat
Rim Timoumi et al.
Toxicology mechanisms and methods, 30(6), 438-449 (2020-04-22)
Triflumuron (TFM) is an insect growth regulator (IGR), an insecticide commonly used over the world. It is known for its several toxic manifestations, such as reprotoxicity, immunotoxicity and hematotoxicity, which could affect public health. However, studies that reveal its toxic
Yvonne Aratyn-Schaus et al.
The Journal of cell biology, 212(4), 389-397 (2016-02-10)
The efficacy of cardiac cell therapy depends on the integration of existing and newly formed cardiomyocytes. Here, we developed a minimal in vitro model of this interface by engineering two cell microtissues (μtissues) containing mouse cardiomyocytes, representing spared myocardium after
Timothy F Miles et al.
eLife, 7 (2018-06-09)
Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink' to facilitate evasion of host immune responses. To probe the molecular basis of US28's unique ligand cross-reactivity, we deep-sequenced CX3CL1 chemokine
Obesity and Risk of Nonalcoholic Fatty Liver Disease: A Comparison of Bioelectrical Impedance Analysis and Conventionally-Derived Anthropometric Measures.
Maya Balakrishnan et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 15(12), 1965-1967 (2017-06-24)
Laura Marastoni et al.
Scientific reports, 10(1), 18839-18839 (2020-11-04)
In several cultivation areas, grapevine can suffer from Fe chlorosis due to the calcareous and alkaline nature of soils. This plant species has been described to cope with Fe deficiency by activating Strategy I mechanisms, hence increasing root H+ extrusion
Simon Dinehart et al.
Environmental toxicology and chemistry, 39(8), 1599-1607 (2020-05-18)
3-Trifluoromethyl-4-nitrophenol (TFM) has been used for more than 60 yr to control the invasive parasitic sea lamprey (Petromyzon marinus) in the Great Lakes Basin (USA/Canada). In the early 1990s, researchers reported that TFM induced vitellogenin in fish and that TFM was
Thalita Fialho da Rocha et al.
European journal of nutrition, 56(5), 1983-1991 (2016-06-09)
Evaluate the association between alcohol consumption and body adiposity. We analyzed cross-sectional data from a longitudinal investigation (Pró-Saúde Study), comprising a sample of 514 civil servants of both sexes (35-64 years). Daily alcohol consumption (wine, beer, and other alcoholic drinks) over
Lauren M Styczynski et al.
Neuroscience letters, 720, 134764-134764 (2020-01-21)
Early life administration of vincristine (VNC), commonly used to treat pediatric leukemia, evokes peripheral neuropathy and mechanical pain hypersensitivity in rats that lasts into adolescence. However, the degree to which VNC-evoked neuropathic pain persists throughout adulthood has yet to be
Erminia Conti et al.
Environmental science and pollution research international, 24(21), 17642-17650 (2017-06-11)
Behavioral ecotoxicology has become very important in the short time since a change in behavior is very often the first response to environmental altered conditions. We investigated the influence of trace metal intake on the spatial orientation performances of the
Cori K Cahoon et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(33), E6857-E6866 (2017-08-02)
The synaptonemal complex (SC), a structure highly conserved from yeast to mammals, assembles between homologous chromosomes and is essential for accurate chromosome segregation at the first meiotic division. In Drosophila melanogaster, many SC components and their general positions within the
L V Magnussen et al.
Andrology, 5(5), 946-953 (2017-09-16)
The purpose of the study was to evaluate whether testosterone replacement therapy improves muscle mechanical and physical function in addition to increasing lean leg mass and total lean body mass in aging men with type 2 diabetes and lowered bio-available
Kathryn A Rosowski et al.
Scientific reports, 8(1), 17967-17967 (2018-12-21)
Cells respond to the mechanics of their environment. Mechanical cues include extracellular matrix (ECM) stiffness and deformation, which are primarily sensed through integrin-mediated adhesions. We investigated the impact of ECM deformation on cellular forces, measuring the time-evolution of traction forces
Simone L Otto et al.
Brain structure & function, 224(2), 829-846 (2018-12-06)
Disruption in cholinergic signaling has been linked to many environmental and/or pathological conditions known to modify adult neurogenesis. The α7 nAChRs are in the family of cys-loop receptor channels which have been shown to be neuroprotective in adult neurons and
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