N3786

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The M segment of the 2009 pandemic influenza virus confers increased neuraminidase activity, filamentous morphology, and efficient contact transmissibility to A/Puerto Rico/8/1934-based reassortant viruses.

Patricia J Campbell et al.

Journal of virology, 88(7), 3802-3814 (2014-01-17)

The 2009 H1N1 lineage represented the first detection of a novel, highly transmissible influenza A virus genotype: six gene segments originated from the North American triple-reassortant swine lineage, and two segments, NA and M, derived from the Eurasian avian-like swine

Antigenic and receptor binding properties of enterovirus 68.

Tadatsugu Imamura et al.

Journal of virology, 88(5), 2374-2384 (2013-12-29)

Increased detection of enterovirus 68 (EV68) among patients with acute respiratory infections has been reported from different parts of the world in the late 2000s since its first detection in pediatric patients with lower-respiratory-tract infections in 1962. However, the underlying

Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase.

J A Cabezas

The Biochemical journal, 278 ( Pt 1), 311-312 (1991-08-15)

IL-17-producing B cells combat parasites.

Beatriz León et al.

Nature immunology, 14(5), 419-421 (2013-04-20)

A novel influenza virus neuraminidase inhibitor AV5027.

Alexandre V Ivachtchenko et al.

Antiviral research, 100(3), 698-708 (2014-01-15)

A medium-sized focused library of novel Oseltamivir structural analogues with promising antiviral activity was successfully synthesized using a combinatorial approach. The synthesized compounds were then thoroughly evaluated in neuraminidase- and cell-based assays. As a result, (3R,4R,5S)-4-(2,2-difluoroacetylamino)-5-amino-3-(1-ethyl-propoxy)-cyclohex-1-enecarboxylic acid (AV5027) was identified

[Efficacy of anti-neuraminidase drugs application during and after an influenza pandemic].

N V Breslav et al.

Voprosy virusologii, 58(1), 28-32 (2013-06-22)

The emergent 2009 A(H1N1) pandemic brought into acute focus the problem of choosing the most effective anti-influenza drugs for successive influenza infection spreading control. Oseltamivir and zanamivir, influenza virus neuraminidase inhibitors (NAIs), were recommended by the WHO experts for the

Chemistry, metabolism, and biological functions of sialic acids.

R Schauer

Advances in carbohydrate chemistry and biochemistry, 40, 131-234 (1982-01-01)

Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the presence of mutation R289K.

Chinh Tran-To Su et al.

BMC bioinformatics, 14 Suppl 16, S7-S7 (2014-02-26)

Since late March 2013, there has been another global health concern with a sudden wave of flu infections by a novel strain of avian influenza A (H7N9) virus in China. To-date, there have been more than 100 infections with 23

Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues.

Yi Zhang et al.

Journal of medicinal chemistry, 56(7), 2948-2958 (2013-03-28)

In the past two decades, human neuraminidases (human sialidases, hNEUs) have been found to be involved in numerous pathways in biology. The development of selective and potent inhibitors of these enzymes will provide critical tools for glycobiology, help to avoid

Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors.

Christopher J Vavricka et al.

Nature communications, 4, 1491-1491 (2013-02-21)

Development of novel influenza neuraminidase inhibitors is critical for preparedness against influenza outbreaks. Knowledge of the neuraminidase enzymatic mechanism and transition-state analogue, 2-deoxy-2,3-didehydro-N-acetylneuraminic acid, contributed to the development of the first generation anti-neuraminidase drugs, zanamivir and oseltamivir. However, lack of

Development of a surveillance scheme for equine influenza in the UK and characterisation of viruses isolated in Europe, Dubai and the USA from 2010-2012.

Alana L Woodward et al.

Veterinary microbiology, 169(3-4), 113-127 (2014-02-01)

Equine influenza viruses are a major cause of respiratory disease in horses worldwide and undergo antigenic drift. Several outbreaks of equine influenza occurred worldwide during 2010-2012, including in vaccinated animals, highlighting the importance of surveillance and virus characterisation. Virus isolates

Identification of critical residues in the hemagglutinin and neuraminidase of influenza virus H1N1pdm for vaccine virus replication in embryonated chicken eggs.

Weijia Wang et al.

Journal of virology, 87(8), 4642-4649 (2013-02-15)

In 2009, we successfully produced a high-yield live attenuated H1N1pdm A/California/7/2009 vaccine (CA/09 LAIV) by substitution of three residues (K119E, A186D, and D222G) in the hemagglutinin (HA) protein. Since then, we have generated and evaluated additional H1N1pdm vaccine candidates from

Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin is independent of the viral neuraminidase.

Longping V Tse et al.

Journal of virology, 87(9), 5161-5169 (2013-03-02)

Influenza virus is well recognized to modulate host tropism and pathogenesis based on mutations in the proteolytic cleavage site of the viral hemagglutinin (HA), which activates HA and exposes the fusion peptide for membrane fusion. Instead of the conventional trypsin-mediated

[Immunization with live attenuated A/H5N1 vaccine protects guinea pigs from reinfection].

M V Sergeeva et al.

Voprosy virusologii, 58(6), 36-39 (2014-04-30)

Cold-adapted influenza virus A/HK/1/68/162/35(H3N2) was developed as unified donor of attenuation and high reproductive capacity forvaccine strains. The reassortant of this donor with surface antigens of highly pathogenic strain Alchicken/Astana/6/05 (H5N1) was tested in guinea pigs as a live or

[Evolution of influenza A(H3N2) virus from 2007 to 2012].

Voprosy virusologii, 58(6), 27-31 (2014-04-30)

The results of the genetic studies of influenza viruses make it possible to understand their evolution and recommendations for vaccine strains content. In this work, the data of complete sequence of the HA, NA, and M2-protein for 34 strains of

Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.

Daniela A Bermejo et al.

Nature immunology, 14(5), 514-522 (2013-04-09)

Here we identified B cells as a major source of rapid, innate-like production of interleukin 17 (IL-17) in vivo in response to infection with Trypanosoma cruzi. IL-17(+) B cells had a plasmablast phenotype, outnumbered cells of the TH17 subset of

The evolutionary dynamics of influenza A virus adaptation to mammalian hosts.

S Bhatt et al.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368(1614), 20120382-20120382 (2013-02-06)

Few questions on infectious disease are more important than understanding how and why avian influenza A viruses successfully emerge in mammalian populations, yet little is known about the rate and nature of the virus' genetic adaptation in new hosts. Here

Molecular evolution of the haemagglutinin-neuraminidase gene in human parainfluenza virus type 3 isolates from children with acute respiratory illness in Yamagata prefecture, Japan.

Katsumi Mizuta et al.

Journal of medical microbiology, 63(Pt 4), 570-577 (2014-01-28)

We conducted detailed genetic analyses of the haemagglutinin-neuraminidase (HN) gene in 272 human parainfluenza virus type 3 (HPIV3) isolates from children with acute respiratory illness during the period 2002-2009 in Yamagata prefecture, Japan. A phylogenetic tree reconstructed by the Bayesian

Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A.

Dennis Schade et al.

Journal of medicinal chemistry, 57(3), 759-769 (2014-01-16)

With the emergence of oseltamivir-resistant influenza viruses and in view of a highly pathogenic flu pandemic, it is important to develop new anti-influenza agents. Here, the development of neuraminidase (NA) inhibitors that were designed to overcome resistance mechanisms along with

Reassortment patterns of avian influenza virus internal segments among different subtypes.

Lu Lu et al.

BMC evolutionary biology, 14, 16-16 (2014-01-25)

The segmented RNA genome of avian Influenza viruses (AIV) allows genetic reassortment between co-infecting viruses, providing an evolutionary pathway to generate genetic innovation. The genetic diversity (16 haemagglutinin and 9 neuraminidase subtypes) of AIV indicates an extensive reservoir of influenza

[Peculiarity of reassortment of current wild type influenza viruses with master donor viruses for live influenza vaccine].

I V Kiseleva et al.

Voprosy virusologii, 58(5), 26-31 (2014-03-20)

The live attenuated influenza vaccine (LAIV) currently licensed in Russia consists of the reassortant viruses with hemagglutinin (HA) and neuraminidase (NA) gene segments from the circulating wild-type viruses and the six internal protein-encoding gene segments from cold-adapted master donor viruses

In situ molecular identification of the influenza A (H1N1) 2009 Neuraminidase in patients with severe and fatal infections during a pandemic in Mexico City.

Rodolfo Ocadiz-Delgado et al.

BMC infectious diseases, 13, 20-20 (2013-01-19)

In April 2009, public health surveillance detected an increased number of influenza-like illnesses in Mexico City's hospitals. The etiological agent was subsequently determined to be a spread of a worldwide novel influenza A (H1N1) triple reassortant. The purpose of the

Modulation of an ectodomain motif in the influenza A virus neuraminidase alters tetherin sensitivity and results in virus attenuation in vivo.

Victor H Leyva-Grado et al.

Journal of molecular biology, 426(6), 1308-1321 (2014-01-02)

We previously demonstrated that ectodomain residue Asp286 in N2 neuraminidase (NA; Asp268 in N1 NA) present in budding-capable NA proteins contributes to productive NA plasma membrane transport partly by mediating escape from tetherin restriction [Yondola MA, Fernandes F, Belicha-Villanueva A

Neuraminidase inhibitors for influenza: a review and public health perspective in the aftermath of the 2009 pandemic.

Charles R Beck et al.

Influenza and other respiratory viruses, 7 Suppl 1, 14-24 (2013-02-12)

The objectives of this study were to: (1) reflect on key stages in the discovery, development and pre-pandemic use of neuraminidase inhibitors (NAIs), (2) summarise the evidence of NAI effectiveness for treatment and prophylaxis of seasonal influenza prior to the

Differential transport of Influenza A neuraminidase signal anchor peptides to the plasma membrane.

Andreas Max Ernst et al.

FEBS letters, 587(9), 1411-1417 (2013-03-26)

Influenza A Neuraminidase is essential for virus release from the cell surface of host cells. Given differential structures of the N-terminal sequences including the transmembrane domains of neuraminidase subtypes, we investigated their contribution to transport and localization of subtypes N1

A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013.

E Takashita et al.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 19(1) (2014-01-18)

Six influenza A(H1N1)pdm09 viruses were detected in Sapporo, Japan, between November and December 2013. All six viruses possessed an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir. No epidemiological link among the six cases could

[Active neuraminidase constituents of Polygonum cuspidatum against influenza A(H1N1) influenza virus].

Kao-Tan Chen et al.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(20), 3068-3073 (2013-01-15)

To isolate and identify active neuraminidase constituents of Polygonum cuspidatum against influenza A (H1N1) influenza virus. On the basis of the bioassay-guided fractionation,such chromatographic methods as silica gel, sephadex LH-20 and HPLC were adopted to isolate active constituents of extracts

[Evaluation of the anti-neuraminidase antibodies in clinical trials of the live influenza vaccine of the A(H5N2) subtype].

T A Smolonogina et al.

Voprosy virusologii, 58(6), 31-35 (2014-04-30)

In the current study, we evaluated the neuraminidase-inhibition (NI) antibodies among volunteers during the phase I and phase II of the clinical trials of a monovalent live attenuated influenza vaccine (LAIV) A/17/duck/ Potsdam/86/92(H5N2). The reassortant influenza virus RN2/57-human A(H7N2) containing

Genetic ancestor of external antigens of pandemic influenza A/H1N1 virus.

Ramaiah Arunachalam et al.

Interdisciplinary sciences, computational life sciences, 4(4), 282-290 (2013-01-29)

The aim of the present investigation was to discover the genetic relationships of 2009 pandemic novel influenza A/H1N1 virus (NIV) external antigens Hemagglutinin (HA) and Neuraminidase (NA) with other influenza viruses by performing phylogenetic, comparative and statistical analyses. Phylogenetic trees

Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis.

Warren G Lewis et al.

The Journal of biological chemistry, 288(17), 12067-12079 (2013-03-13)

Bacterial vaginosis (BV) is a polymicrobial imbalance of the vaginal microbiota associated with reproductive infections, preterm birth, and other adverse health outcomes. Sialidase activity in vaginal fluids is diagnostic of BV and sialic acid-rich components of mucus have protective and

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