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N5535
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显示 1-30 #N/A 388 条结果 关于 "N5535" 范围 论文
Ashish Kumar Sharma et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 15(4), 410-418 (2013-02-12)
The objective of this article is to investigate the combination of telmisartan with vildagliptin therapy versus monotherapy of vildagliptin and telmisartan on diabetic nephropathy in type 2 diabetes mellitus rats. In adult rats streptozotocin (65 mg/kg) and nicotinamide (110 mg/kg)
Johannes Trapp et al.
Journal of medicinal chemistry, 49(25), 7307-7316 (2006-12-08)
NAD+-dependent histone deacetylases, sirtuins, cleave acetyl groups from lysines of histones and other proteins to regulate their activity. Identification of potent selective inhibitors would help to elucidate sirtuin biology and could lead to useful therapeutic agents. NAD+ has an adenosine
Xiao-bin Lv et al.
Scientific reports, 5, 17940-17940 (2015-12-15)
SUN2, a key component of LINC (linker of nucleoskeleton and cytoskeleton) complex located at the inner nuclear membrane, plays unknown role in lung cancer. We found that SUN2 expression was decreased in lung cancer tissue compared with paired normal tissues
Yusuke Kobayashi et al.
Kekkaku : [Tuberculosis], 88(9), 671-675 (2013-12-05)
A 66-year-old man with hepatocellular carcinoma (HCC) and suspicion of lung metastasis consulted us because of an abnormal chest shadow as seen on a radiograph. He had been treated with sorafenib for 2 months. A chest CT scan showed cavitating
Meihua Zheng et al.
Molecular and cellular biochemistry, 393(1-2), 59-67 (2014-04-15)
The present study was designed to investigate the effect of hydrogen sulfide on cellular senescence of human umbilical vascular endothelial cells (HUVECs CC-2517) and its underlying mechanism. The premature senescence-like phenotype HUVECs (the fourth passage) was induced by treatment with
Justin W Ady et al.
Surgery, 156(2), 263-269 (2014-06-25)
Sorafenib is the standard systemic therapy for unresectable or recurrent hepatocellular carcinoma (HCC) but adds minimal increase in survival. Therefore, there is a great need to develop novel therapies for advanced or recurrent HCC. One emerging field of cancer treatment
Elisa Corritore et al.
Cellular reprogramming, 16(6), 456-466 (2014-12-02)
β-Cell replacement therapy is a promising field of research that is currently evaluating new sources of cells for clinical use. Pancreatic epithelial cells are potent candidates for β-cell engineering, but their large-scale expansion has not been evidenced yet. Here we
Christian J Lemmerhirt et al.
ChemMedChem, 10(2), 368-379 (2014-11-14)
Openers of neuronal voltage-gated potassium channels (KV ) are of interest as therapeutic agents for treating pain (flupirtine) and epilepsy (retigabine). In an effort to better understand the mechanisms of action and toxicity of flupirtine, we synthesized nine novel analogues
Marie-Hélène Massicotte et al.
European journal of endocrinology, 170(4), 575-582 (2014-01-16)
Tyrosine kinase inhibitors (TKIs) are used to treat patients with advanced thyroid cancers. We retrospectively investigated the efficacy of TKIs administered outside of clinical trials in metastatic sites or locally advanced thyroid cancer patients from five French oncology centers. THERE
M Verdú et al.
Journal of animal science, 93(6), 3018-3033 (2015-06-27)
A total of 240 Holstein bulls (121 ± 2.0 kg initial BW; 99 ± 1.0 d of age), from 2 consecutive fattening cycles, were randomly allocated in 1 of 6 pens and assigned to 1 of the 3 treatments consisting
Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma.
Philippe Bahadoran et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e324-e326 (2013-05-30)
Jinmi Lee et al.
Cell stress & chaperones, 19(5), 649-656 (2014-01-22)
Accumulation of excess hepatic lipids contributes to insulin resistance and liver disease associated with endoplasmic reticulum (ER) stress. Exendin-4 is an agonist of the glucagon-like peptide 1 receptor and plays a role in improving insulin resistance and liver disease by
Sang Woo Lee et al.
Biochemical and biophysical research communications, 464(4), 1178-1184 (2015-07-26)
Activin A, which is a signaling molecule similar to Nodal, rapidly promotes endoderm induction of both embryonic stem (ES) cells and MSCs. Protocols for hepatic induction exhibit differences in efficiency and reproducibility depending on the specific methods or sources of
Erin M Kropp et al.
Stem cells translational medicine, 4(5), 483-493 (2015-04-03)
The tumorigenic potential of human pluripotent stem cells (hPSCs) is a major limitation to the widespread use of hPSC derivatives in the clinic. Here, we demonstrate that the small molecule STF-31 is effective at eliminating undifferentiated hPSCs across a broad
Jessica Walter et al.
Journal of clinical research in pediatric endocrinology, 6(2), 93-99 (2014-06-17)
The vision of potential autologous cell therapy for the cure of diabetes encourages ongoing research. According to a previously published protocol for the generation of insulin-producing cells from human monocytes, we analyzed whether the addition of growth factors could increase
Aaron T Wecksler et al.
Cancer chemotherapy and pharmacology, 75(1), 161-171 (2014-11-22)
Sorafenib (Nexavar®) is currently the only FDA-approved small molecule targeted therapy for advanced hepatocellular carcinoma. The use of structural analogues and derivatives of sorafenib has enabled the elucidation of critical targets and mechanism(s) of cell death for human cancer lines.
Ayelet Lenz et al.
PloS one, 9(11), e112914-e112914 (2014-11-14)
In vitro expansion of adult human islet β cells is an attractive solution for the shortage of tissue for cell replacement therapy of type 1 diabetes. Using a lineage tracing approach we have demonstrated that β-cell-derived (BCD) cells rapidly dedifferentiate
Paola Bonfanti et al.
Stem cells and development, 24(15), 1766-1778 (2015-05-01)
A comparative analysis of mouse and human pancreatic development may reveal common mechanisms that control key steps as organ morphogenesis and cell proliferation and differentiation. More specifically, understanding beta cell development remains an issue, despite recent progress related to their
Final report of phase II study of sorafenib, cytarabine and idarubicin for initial therapy in younger patients with acute myeloid leukemia.
F Ravandi et al.
Leukemia, 28(7), 1543-1545 (2014-02-04)
Hien Lau et al.
Islets, 12(3), 41-58 (2020-05-28)
The use of pancreata from pre-weaned piglets has the potential to serve as an unlimited alternative source of islets for clinical xenotransplantation. As pre-weaned porcine islets (PPIs) are immature and require prolonged culture, we developed an islet maturation media (IMM)
L Claret et al.
Clinical pharmacology and therapeutics, 95(4), 446-451 (2014-01-21)
The motesanib phase III MONET1 study failed to show improvement in overall survival (OS) in non-small cell lung cancer, but a subpopulation of Asian patients had a favorable outcome. We performed exploratory modeling and simulations based on MONET1 data to
Yoshinao Soma et al.
International journal of dermatology, 44(3), 197-202 (2005-04-06)
Certain moisturizers can improve skin barrier function in atopic dermatitis. The effect of topical nicotinamide on atopic dry skin is unknown. We examined the effect of topical nicotinamide on atopic dry skin and compared the results with the effect of
Dorte E Kristensen et al.
The Journal of physiology, 593(8), 2053-2069 (2015-02-03)
AMP-activated protein kinase (AMPK) is a regulator of energy homeostasis during exercise. Studies suggest muscle fibre type-specific AMPK expression. However, fibre type-specific regulation of AMPK and downstream targets during exercise has not been demonstrated. We hypothesized that AMPK subunits are
Qiang You et al.
International journal of molecular medicine, 36(3), 833-838 (2015-07-03)
Apoptosis inhibitor of macrophages (AIM/cluster of differentiation 5 antigen-like/soluble protein α) has been shown to inhibit cellular apoptosis; however, the underlying molecular mechanism has not been elucidated. Using yeast two‑hybrid screening, the present study uncovered that AIM binds to insulin‑like
Aurélie Lenglet et al.
Drugs in R&D, 13(3), 165-173 (2013-09-04)
Hyperphosphatemia in chronic kidney disease (CKD) has been associated with elevated cardiovascular morbidity and mortality. Serum phosphate control remains a cornerstone of the clinical management of patients with CKD, in order to both attenuate the progression of secondary hyperparathyroidism or
Howard Safran et al.
American journal of clinical oncology, 38(1), 1-4 (2013-05-08)
To assess the activity and toxicity of lenalidomide for patients with advanced hepatocellular cancer (HCC) previously treated with sorafenib. Patients with advanced HCC who progressed on or were intolerant to sorafenib were eligible. Patients received lenalidomide 25 mg orally for
Hossein A Hamed et al.
Journal of cellular physiology, 230(1), 131-139 (2014-06-10)
The present studies were to determine whether the multi-kinase inhibitor sorafenib or its derivative regorafenib interacted with the ERBB1/ERBB2 inhibitor lapatinib to kill CNS tumor cells. In multiple CNS tumor cell types sorafenib and lapatinib interacted in a greater than
Ming-Chung Lin et al.
International journal of molecular sciences, 16(6), 12092-12107 (2015-05-30)
Prolonged treatment with a large dose of propofol may cause diffuse cellular cytotoxicity; however, the detailed underlying mechanism remains unclear, particularly in vascular endothelial cells. Previous studies showed that a propofol overdose induces endothelial injury and vascular barrier dysfunction. Regarding
Wenjun Yan et al.
BMC medical genomics, 8, 52-52 (2015-08-19)
p53 is a tumor suppressor that contributes to the host immune response against viral infections in addition to its well-established protective role against cancer development. In response to influenza A virus (IAV) infection, p53 is activated and plays an essential
Luise Maute et al.
Journal of cancer research and clinical oncology, 140(5), 823-827 (2014-02-22)
Renal cell carcinoma (RCC) is the most common renal tumor and accounts for nearly 3 % of adult cancers. In the recent years, seven new targeted agents have been approved changing the treatment in metastatic RCC dramatically. So far, however
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