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T M Lilley et al.
Oecologia, 175(3), 811-823 (2014-05-20)
Harmful reactive oxygen species (ROS) produced during metabolism and immune responses are neutralized in part by a powerful enzymatic antioxidant system. Inter-species variability in the baseline activity of antioxidant enzymes may be explained by a variety of life history traits.
Marta Rysz et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1345-1352 (2015-06-11)
Genes coding for cytochrome P450 are regulated by endogenous hormones such as the growth hormone, corticosteroids, thyroid, and sex hormones. Secretion of these hormones is regulated by the respective hypothalamus-pituitary-secretory organ axes. Since the brain sends its serotonergic projections from
Juhyun Kim et al.
Archives of pharmacal research, 37(11), 1464-1476 (2013-10-10)
The purpose of this study was to better understand why para-halogen modifications of S-3-(4-halophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl) propionamide selective androgen receptor modulators (SARMs) had the opposite of expected effects on total clearance, in which electron-withdrawing groups generally protect benzene ring from hydroxylation. We
Hiromi I Wettersten et al.
Cancer research, 75(12), 2541-2552 (2015-05-09)
Kidney cancer [or renal cell carcinoma (RCC)] is known as "the internist's tumor" because it has protean systemic manifestations, suggesting that it utilizes complex, nonphysiologic metabolic pathways. Given the increasing incidence of this cancer and its lack of effective therapeutic
Peter Tsvetkov et al.
The Journal of biological chemistry, 289(16), 11272-11281 (2014-03-07)
The 26S proteasome is the end point of the ubiquitin- and ATP-dependent degradation pathway. The 26S proteasome complex (26S PC) integrity and function has been shown to be highly dependent on ATP and its homolog nucleotides. We report here that
Wei Yu et al.
PloS one, 9(5), e98044-e98044 (2014-05-29)
Diabetic cardiomyopathy (DCM) suggests a direct cellular insult to myocardium. Apoptosis is considered as one of the hallmarks of DCM. Oxidative stress plays a key role in the pathogenesis of DCM. In this study, we explored the prevention of myocardial
Xin Deng et al.
Journal of bacteriology, 196(14), 2499-2513 (2014-04-29)
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from human pathogens Staphylococcus aureus and Pseudomonas aeruginosa can be readily inhibited by reactive oxygen species (ROS)-mediated direct oxidation of their catalytic active cysteines. Because of the rapid degradation of H2O2 by bacterial catalase, only steady-state but
Wenyi Hua et al.
Bioanalysis, 7(12), 1471-1482 (2015-07-15)
Quantitation of CAM H4 in biological matrix has been a challenge due to low concentrations, instability and the existence of four CAM diastereomers. Historically, either inactive clopidogrel acid or CAM diastereomers without separation were measured for exposure and PK parameters.
Olof Björnberg et al.
Archives of biochemistry and biophysics, 564, 164-172 (2014-09-27)
Three protein disulfide reductases of the thioredoxin superfamily from the industrially important Gram-positive Lactococcus lactis (LlTrxA, LlTrxD and LlNrdH) are compared to the "classical" thioredoxin from Escherichia coli (EcTrx1). LlTrxA resembles EcTrx1 with a WCGPC active site motif and other
Carole Hénique et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6), 2473-2483 (2015-02-26)
Adult skeletal muscle is a dynamic, remarkably plastic tissue, which allows myofibers to switch from fast/glycolytic to slow/oxidative types and to increase mitochondrial fatty acid oxidation (mFAO) capacity and vascularization in response to exercise training. mFAO is the main muscle
Yinhang Yu et al.
International immunopharmacology, 25(1), 74-82 (2015-01-21)
It has been demonstrated that circulating FGF21 levels are elevated in the serum and synovial fluid of patients with rheumatoid arthritis (RA). The aim of this study is to investigate efficacy of FGF21 for treatment of RA and the molecular
Kyra J Barnes et al.
European journal of clinical pharmacology, 70(9), 1097-1106 (2014-06-24)
To investigate the potential inhibitory effects of uremic toxins on the major human hepatic drug-metabolising cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes in vitro. Benzyl alcohol, p-cresol, indoxyl sulfate, hippuric acid and a combination of the four uremic toxins were
Yi-Fan Xu et al.
Molecular systems biology, 9, 665-665 (2013-05-15)
Nucleotide degradation is a universal metabolic capability. Here we combine metabolomics, genetics and biochemistry to characterize the yeast pathway. Nutrient starvation, via PKA, AMPK/SNF1, and TOR, triggers autophagic breakdown of ribosomes into nucleotides. A protein not previously associated with nucleotide
Dev Churamani et al.
The Biochemical journal, 453(1), 147-151 (2013-05-03)
TPCs (two-pore channels) are NAADP (nicotinic acid-adenine dinucleotide phosphate)-sensitive Ca2+-permeable ion channels expressed on acidic organelles. In the present study we show that deletion of the N-terminal region redirects TPC1 to the ER (endoplasmic reticulum). The introduction of fluorophores at
Jacob M Riveron et al.
BMC genomics, 15, 817-817 (2014-09-28)
Pyrethroid resistance in the major malaria vector Anopheles funestus is rapidly expanding across Southern Africa. It remains unknown whether this resistance has a unique origin with the same molecular basis or is multifactorial. Knowledge of the origin, mechanisms and evolution
Eun Young Kim et al.
Biochemical and biophysical research communications, 441(1), 77-82 (2013-10-19)
Previously, we identified proteins showing a differential acetylation pattern during adipogenic differentiation. Here, we examined the role of malate dehydrogenase 2 (MDH2) acetylation in the adipogenesis of 3T3-L1 preadipocytes. The acetylation level of MDH2 showed a dramatic increase during adipogenesis.
Bevan P Gang et al.
Cancer biology & therapy, 15(11), 1533-1541 (2014-12-09)
Deregulated metabolism is gaining recognition as a hallmark of cancer cells, and is being explored for therapeutic potential. The Warburg effect is a metabolic phenotype that occurs in 90% of tumors, where glycolysis is favored despite the presence of oxygen.
Danilo M Daloso et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(11), E1392-E1400 (2015-02-04)
Plant mitochondria have a fully operational tricarboxylic acid (TCA) cycle that plays a central role in generating ATP and providing carbon skeletons for a range of biosynthetic processes in both heterotrophic and photosynthetic tissues. The cycle enzyme-encoding genes have been
Dean Fraga et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 187, 85-101 (2015-05-20)
Phosphagen kinases (PKs) are well-studied enzymes involved in energy homeostasis in a wide range of animal, protozoan, and even some bacterial species. Recent genome efforts have allowed comparative work on the PKs to extend beyond the biochemistry of individual proteins
Zhe-Yi Hu et al.
Rapid communications in mass spectrometry : RCM, 28(11), 1285-1292 (2014-04-25)
Clopidogrel (CLO) is a prodrug used to prevent ischemic events in patients undergoing percutaneous coronary intervention or with myocardial infarction. A previous study found ethyl clopidogrel (ECLO) is formed by transesterification of CLO when incubated with alcohol in human liver
Jocelyn Kauny et al.
Biochimica et biophysica acta, 1837(6), 792-801 (2014-01-28)
We measured the kinetics of light-induced NADPH formation and subsequent dark consumption by monitoring in vivo its fluorescence in the cyanobacterium Synechocystis PCC 6803. Spectral data allowed the signal changes to be attributed to NAD(P)H and signal linearity vs the
Jun-ichi Akutsu et al.
Extremophiles : life under extreme conditions, 19(6), 1077-1085 (2015-08-21)
Mannosylglycerate is known as a compatible solute, and plays important roles for salinity adaptation and high temperature stability of microorganisms. In the gene cluster for the mannosylglycerate biosynthetic pathway predicted from the genomic data of Pyrococcus horikoshii OT3, the PH0925
Klaske van Norren et al.
Journal of cachexia, sarcopenia and muscle, 6(3), 253-268 (2015-09-25)
In rodent models, caloric restriction (CR) with maintenance of adequate micronutrient supply has been reported to increase lifespan and to reduce age-induced muscle loss (sarcopenia) during ageing. In the present study, we further investigated effects of CR on the onset
Hydrogen peroxide generation in the vacuoles of red beet root cells.
E V Pradedova et al.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 449, 106-109 (2013-05-09)
Huybrecht T'jollyn et al.
The AAPS journal, 17(6), 1376-1387 (2015-07-26)
This paper focuses on the retrospective evaluation of physiologically based pharmacokinetic (PBPK) techniques used to mechanistically predict clearance throughout pediatric life. An intravenous tramadol retrograde PBPK model was set up in Simcyp® using adult clearance values, qualified for CYP2D6, CYP3A4
Xiaochun Li et al.
Nature, 517(7532), 104-107 (2014-10-14)
Sterols are essential biological molecules in the majority of life forms. Sterol reductases including Δ(14)-sterol reductase (C14SR, also known as TM7SF2), 7-dehydrocholesterol reductase (DHCR7) and 24-dehydrocholesterol reductase (DHCR24) reduce specific carbon-carbon double bonds of the sterol moiety using a reducing
Ming Xu et al.
Biochimica et biophysica acta, 1833(12), 3228-3236 (2013-10-08)
Autophagic flux is an important process during autophagy maturation in coronary arterial myocytes (CAMs). Here, we defined the role and molecular mechanism of the motor protein dynein in the regulation of autophagic flux in CAMs. In mouse CAMs, dynein protein
Marie Pereira et al.
Cell reports, 28(2), 498-511 (2019-07-11)
Iron is an essential metal that fine-tunes the innate immune response by regulating macrophage function, but an integrative view of transcriptional and metabolic responses to iron perturbation in macrophages is lacking. Here, we induced acute iron chelation in primary human
Effects of long-acting somatostatin analogues on redox systems in rat lens in experimental diabetes.
Sirilaksana Kunjara et al.
International journal of experimental pathology, 95(2), 95-100 (2014-03-08)
The effects of long-acting somatostatin analogues, angiopeptin (AGP) and Sandostatin (SMS), on the early decline in the lens content of glutathione (GSH), ATP and NADPH and increase in sorbitol were studied in STZ diabetic rats, and comparison was made with
Piyanuch Wonganan et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1191-1201 (2014-04-26)
HC-04 cells were evaluated as an in vitro model for mechanistic study of changes in the function of hepatic CYP3A during virus infection. Similar to in vivo observations, infection with a first generation recombinant adenovirus significantly inhibited CYP3A4 catalytic activity
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