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关键词:'N6876'
显示 1-30 共 715 条结果 关于 "N6876" 范围 论文
Merve Erdem et al.
Pediatric hematology and oncology, 32(3), 182-192 (2014-09-24)
Human ether-a-go-go related gene (herg) encoding HERG K(+) channel has been demonstrated in many previous studies with its association to cell cycle progression and growth in tumor cells. The upregulated expression of HERG K+ channels was determined in different tumor
Pui San Wong et al.
Pharmacological research, 91, 29-35 (2014-12-03)
Oxygenation with 95%O2 is routinely used in organ bath studies. However, hyperoxia may affect tissue responses, particularly in studies which involve reactive oxygen species (ROS). Here, the effects of the antioxidant, Tiron, were investigated under different gassing conditions in the
Shaotong Zhu et al.
The Journal of biological chemistry, 290(34), 20761-20773 (2015-07-03)
Complex I (NADH:ubiquinone oxidoreductase) is a multisubunit, membrane-bound enzyme of the respiratory chain. The energy from NADH oxidation in the peripheral region of the enzyme is used to drive proton translocation across the membrane. One of the integral membrane subunits
Weihe Zhang et al.
Journal of medicinal chemistry, 57(16), 7031-7041 (2014-07-30)
We previously reported a potent small molecule Mer tyrosine kinase inhibitor UNC1062. However, its poor PK properties prevented further assessment in vivo. We report here the sequential modification of UNC1062 to address DMPK properties and yield a new potent and
Ning Li et al.
Planta, 241(3), 591-602 (2014-11-17)
NADPH oxidase AtrbohD an d AtrbohF negatively modulate lateral root development by changing the peroxidase activity and increasing the local generation of superoxide in primary roots of Arabidopsis in an auxin-independent manner. NADPH oxidase subunits AtrbohD and AtrbohF play pivotal
Renata V Tiradentes et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 38(7), 471-477 (2015-03-06)
Renovascular hypertension is characterized by increased renal sympathetic activity, angiotensin II and by endothelial dysfunction. The purpose of this study was to determine the role of renal sympathetic nerve activity (RSNA) in mediating the anti-hypertensive effects of aliskiren (ALSK) and
Koji Shibasaki et al.
Biochemical and biophysical research communications, 458(1), 168-173 (2015-02-01)
Compartmentalization of neuronal function is achieved via specifically localized clustering of ion channels in discrete subcellular membrane domains. Transient receptor potential (TRP) channels exhibit highly variable cellular and subcellular patterns of expression. We previously revealed that the thermo-sensor TRPV4 (activated
Wen-Guang Shi et al.
Journal of hazardous materials, 362, 275-285 (2018-09-23)
To shed light on physiological mechanisms underlying abscisic-acid (ABA)-mediated lead (Pb) uptake, translocation and detoxification, we exposed Populus × canescens saplings to either 0 or 3 mM Pb2+ in combination with either 0 or 10 μM exogenous ABA. Pb was taken up
Chunyeh Chen et al.
Journal of bioscience and bioengineering, 120(4), 387-395 (2015-03-31)
Much attention has been paid to biosurfactants produced using microorganisms, but little direct evidence for the development of natural biosurfactants combined with Chinese medicinal herbs are available. We investigated the emulsification and antioxidation of biosurfactant extracts from Chinese medicinal herb
Nora E Szabo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5233-5246 (2015-04-04)
Spinal cord neurons respond to peripheral noxious stimuli and relay this information to higher brain centers, but the molecules controlling the assembly of such pathways are poorly known. In this study, we use the intersection of Lmx1b and Hoxb8::Cre expression
Helen Mokhtar et al.
Vaccine, 32(50), 6828-6837 (2014-05-23)
The porcine reproductive and respiratory syndrome virus (PRRSV) is a rapidly evolving and diversifying pathogen necessitating the development of improved vaccines. Immunity to PRRSV is not well understood although there are data suggesting that virus-specific T cell IFN-γ responses play
Expression of the endothelial lipase gene in murine embryos and reproductive organs.
Lindegaard ML et al.
Journal of Lipid Research, 46, 439-439 (2005)
Swati Rawat et al.
Journal of molecular biology, 427(5), 1023-1037 (2014-05-23)
The transmembrane (TM) helices of most type II single-span membrane proteins (S-SMPs) of Escherichia coli occur near the N-terminus, where the cell's targeting mechanisms can readily identify it as it emerges from the ribosome. However, the TM helices of a
Kuttikkadan A Rony et al.
International journal of medicinal mushrooms, 17(6), 521-531 (2015-09-10)
Phellinus rimosus is a parasitic host specific polypore mushroom with profound antioxidant, antihepatotoxic, anti-inflammatory, antitumor, and antimutagenic activities. This study investigated the hypoglycemic and hypolipidemic activities of the wood-inhabiting polypore mushroom Ph. Rimosus in streptozotocin (STZ)-induced diabetic rats. Diabetes was
Su-Mi Woo et al.
Molecules and cells, 38(7), 604-609 (2015-06-13)
The active metabolite of vitamin D such as 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) is a well-known key regulatory factor in bone metabolism. However, little is known about the potential of vitamin D as an odontogenic inducer in human dental pulp cells (HDPCs)
Birgit Hegner Satir et al.
Cell biology international, 39(2), 136-145 (2014-07-22)
Parafusin (PFUS), a 63 kDa protein first discovered in the eukaryote Paramecium and known for its role in apicomplexan exocytosis, provides a model for the common origin of cellular systems employing scaffold proteins for targeting and signaling. PFUS is closely related
Yujie Chang et al.
PloS one, 10(11), e0142952-e0142952 (2015-11-19)
Lysine is the most limiting essential amino acid for animal nutrition in maize grains. Expression of naturally lysine-rich protein genes can increase the lysine and protein contents in maize seeds. AtMAP18 from Arabidopsis thaliana encoding a microtubule-associated protein with high-lysine
Su-Chen Ho et al.
Molecules (Basel, Switzerland), 19(11), 17697-17714 (2014-11-05)
The anti-neuroinflammatory capacities of raw and steamed garlic extracts as well as five organosulfur compounds (OSCs) were examined in lipopolysaccharide (LPS)-stimulated BV2 microglia. According to those results, steaming pretreatment blocked the formation of alliinase-catalyzed OSCs such as allicin and diallyl
Saida Haider et al.
Life sciences, 124, 110-119 (2015-02-01)
D-Galactose (D-gal) induced accelerated senescence has been used to develop an aging model for brain. Previously, long term administration of a wide range of doses has been used for this purpose. In the present study we investigate whether short term
Brynn N Akerberg et al.
Developmental biology, 407(1), 158-172 (2015-06-24)
The formation of intricately organized aortic and pulmonic valves from primitive endocardial cushions of the outflow tract is a remarkable accomplishment of embryonic development. While not always initially pathologic, developmental semilunar valve (SLV) defects, including bicuspid aortic valve, frequently progress
Crystal W Burke et al.
Journal of virology, 89(7), 3568-3583 (2015-01-16)
Respiratory paramyxoviruses such as respiratory syncytial virus (RSV) and human parainfluenza virus type 1 (HPIV1) to HPIV4 infect virtually all children by the age of 2 to 5 years, leading to partial but incomplete protection from reinfection. Here, we used
Jalaluddin M Ashraf et al.
International journal of biological macromolecules, 51(4), 604-611 (2012-07-04)
Reactions of reducing sugars with free amino groups of proteins can form advanced glycation end products (AGEs). While the formation of nucleoside AGEs has been studied in detail, no extensive work has been carried out to assess DNA Amadori and
Ci-Hai Zhang et al.
International journal of biological macromolecules, 79, 681-686 (2015-06-09)
Glycyrrhiza uralensis, an important Chinese medicine, has a long history of use in China. In this study, three water-soluble polysaccharides fractions (GUPs-1, GUPs-2 and GUPs-3) were isolated and purified from the root of G. uralensis by DEAE-52 and Sephadex G-100
Yanfen Ma et al.
Microbes and infection, 17(6), 440-450 (2015-04-23)
Chagas disease caused by Trypanosoma cruzi is a major neglected tropical parasitic disease. The pathogenesis of this infection remains disputable. There is no suitable vaccine for the prevention. Attenuated live vaccines can provide strong protection against infection; however, there are
Jesica Raineri et al.
Plant cell reports, 34(12), 2065-2080 (2015-08-08)
Arabidopsis transgenic plants expressing the sunflower transcription factor HaWRKY76 exhibit increased yield and tolerance to drought and flood stresses. The genetic construct containing HaWRKY76 is proposed as a potential biotechnological tool to improve crops. Water deficit and water excess are
Joanna Simińska et al.
Plant physiology and biochemistry : PPB, 96, 209-216 (2015-08-25)
Storage proteins of cereal seeds are processed during accumulation and degraded during germination primarily by cysteine proteinases. One of the mechanisms controlling the activity of these enzymes is the synthesis of specific inhibitors named phytocystatins. Here we present the complete
Łukasz Bułdak et al.
Experimental and therapeutic medicine, 17(4), 2861-2869 (2019-03-25)
GLP-1 agonists such as exenatide and liraglutide are novel drugs for the treatment of diabetes and obesity. While improvements in glycemic control can rely on an incretin effect, the mechanisms behind the loss of weight following therapy have yet to
HuaPing Li et al.
Cancer cell international, 15, 52-52 (2015-06-09)
Aberrant expression of heparanase (Hpa) is associated with apoor prognosis in ovarian and cervical cancer patients. Inhibitors of Hpa can prevent the growth and metastasis of malignant tumor cells, and suramin may be such a compound that has strong anti-proliferative
Soham Mitra et al.
Scientific reports, 5, 13949-13949 (2015-09-15)
The MPTP mediated neurodegeneration in substantia nigra has been well studied, but not the status of frontal cortex. The novelty of the present study is to explore the sex difference of frontal cortex during MPTP intoxication and to investigate the
Saman Ahmad et al.
Human immunology, 74(1), 23-27 (2012-10-18)
Incubation of proteins with glucose lead to their non-enzymatic glycation ultimately resulting in the formation of advanced glycation end products (AGEs) in vivo. AGEs alter unique three dimensional structures of various plasma proteins such as IgG. The role of oxidative
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