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Belgin Sever et al.
International journal of biological macromolecules, 163, 1970-1988 (2020-09-16)
Alzheimer's disease (AD) is a complex, predominant, and progressive form of dementia. The treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of cholinergic replacement by acetylcholinesterase (AChE) inhibitors in AD treatment has been well-documented so
Clemente Capasso et al.
Journal of enzyme inhibition and medicinal chemistry, 27(6), 892-897 (2012-07-19)
A new carbonic anhydrase (CA, EC 4.2.1.1) from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 was identified and characterized. The bacterial carbonic anhydrase gene was expressed in Escherichia coli yielding an active enzyme, which was purified in large amounts. The recombinant
Novel Redox-Dependent Esterase Activity (EC 3.1.1.2) for DJ-1: Implications for Parkinson's Disease.
Emmanuel Vázquez-Mayorga et al.
International journal of molecular sciences, 17(8) (2016-08-25)
Mutations the in human DJ-1 (hDJ-1) gene are associated with early-onset autosomal recessive forms of Parkinson's disease (PD). hDJ-1/parkinsonism associated deglycase (PARK7) is a cytoprotective multi-functional protein that contains a conserved cysteine-protease domain. Given that cysteine-proteases can act on both
Jay E Mellon
Toxins, 7(8), 3257-3266 (2015-08-22)
Several atoxigenic Aspergillus flavus isolates, including some being used as biocontrol agents, and one toxigenic isolate were surveyed for the ability to produce extracellular xylanolytic and pectinolytic hydrolases. All of the tested isolates displayed good production of endoxylanases when grown
Haibo Xu et al.
Food chemistry, 188, 439-445 (2015-06-05)
An acidic cutinase (TtcutB) from Thielavia terrestris CAU709 was purified to apparent homogeneity with 983 Um g(-1) specific activity. The molecular mass of the enzyme was estimated to be 27.3 and 27.9 kDa by SDS-PAGE and gel filtration, respectively. A
Chengliang Zhang et al.
International immunopharmacology, 24(2), 153-158 (2014-12-17)
Liver plays a central role in xenobiotics metabolism, thus affecting the in vivo disposition and therapeutic effects of drugs. Carboxylesterases (CESs), with the main isoforms CES1 and CES2, are important in the metabolism of ester-type prodrugs. However, influences of immunological
Michelle R Baker et al.
Biochemistry research international, 2011, 739712-739712 (2011-09-16)
Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect of preconditioning. We preincubated human serum albumin with isoflurane, dialyzed to release agent, and assessed protein conformation. Susceptibility to chemical modification by methylglyoxal and
Cristobal Narvaez et al.
Chemosphere, 135, 75-82 (2015-04-29)
Inhibition of blood esterase activities by organophosphate (OP) pesticides has been used as a sensitive biomarker in birds. Furthermore, compared to mammalian vertebrates, less is known about the role of these enzyme activities in the digestive tracts of non-mammalian vertebrates
Julie Boucher et al.
Analytical biochemistry, 478, 73-81 (2015-03-25)
Protein glycation is a ubiquitous process involved in vascular complications observed in diabetes. Glyoxal (GO), an intracellular reactive oxoaldehyde that is one of the most potent glycation agents, readily reacts with amines present on proteins to produce the lysine-derived adduct
Eva Ramírez et al.
Journal of agricultural and food chemistry, 62(39), 9569-9575 (2014-09-12)
The main Spanish table olive varieties supplied by different olive cooperatives were investigated for their polyphenol compositions and the endogenous enzymes involved in their transformations during two growing seasons. Olives of the Manzanilla variety had the highest concentration in total
Justin J Miller et al.
eLife, 10 (2021-07-20)
Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However, many carboxy ester promoieties are rapidly hydrolyzed by
Immunomodulatory, antiglycation and anti-ulcerative properties of Ruellia squarrosa Fenzl Acanthaceae
Afzal K, et al.
Tropical Journal of Pharmaceutical Research, 16(8), 1751-1755 (2017)
Yoshihiro Tokudome et al.
Annals of dermatology, 27(3), 269-274 (2015-06-18)
Reconstructed human epidermal culture skin models have been developed for cosmetic and pharmaceutical research. This study evaluated the total and carboxyl esterase activities (i.e., Km and Vmax , respectively) and localization in two reconstructed human epidermal culture skin models (LabCyte
E Björklund et al.
British journal of pharmacology, 161(7), 1512-1526 (2010-08-26)
Drugs used clinically usually have a primary mechanism of action, but additional effects on other biological targets can contribute to their effects. A potentially useful additional target is the endocannabinoid metabolizing enzyme monoacylglycerol lipase (MGL). We have screened a range
Preparation of Dental Resins Resistant to Enzymatic and Hydrolytic Degradation in Oral Environments.
Andres Gonzalez-Bonet et al.
Biomacromolecules, 16(10), 3381-3388 (2015-09-12)
The short average service life of traditional dental composite restorative materials and increasing occurrence of secondary caries adjacent to composite restorations and sealants are necessitating the development of new, longer lasting compositions. Novel monomers and their polymers, reinforcing fillers, and
Gabriela Fernandes et al.
The journal of adhesive dentistry, 22(3), 265-274 (2020-05-22)
To investigate whether dental adhesives modified with polyacrylic acid copper iodide particles could inhibit esterase activity in vitro and the copper release rate from resin matrices, as well as the correlation between the two variables. Different concentrations of copper iodide
Joanne L Porter et al.
ACS chemical biology, 10(2), 611-621 (2014-11-25)
The ease with which enzymes can be adapted from their native roles and engineered to function specifically for industrial or commercial applications is crucial to enabling enzyme technology to advance beyond its current state. Directed evolution is a powerful tool
Arna Runarsdottir et al.
Journal of molecular biology, 401(3), 451-464 (2010-07-06)
Glutathione transferases (GSTs) are known as promiscuous enzymes capable of catalyzing the conjugation of glutathione with a broad range of electrophilic substrates. A previous study based on recombinant chimeras derived from human GST M1-1 and GST M2-2 demonstrated the formation
Xinwen Wang et al.
Biological & pharmaceutical bulletin, 38(2), 292-297 (2015-03-10)
Patients with coronary artery disease often receive concurrent treatment with clopidogrel and a hydroxymethylglutaryl (HMG)-CoA reductase inhibitor medication. Accordingly, potential drug-drug interactions associated with the concomitant use of these agents present an area of concern. Both CYP enzymes and carboxylesterase
Johannes Martin Kisch et al.
Chembiochem : a European journal of chemical biology, 15(13), 1911-1919 (2014-07-22)
Biofilms are matrix-encapsulated cell aggregates that cause problems in technical and health-related areas; for example, 65 % of all human infections are biofilm associated. This is mainly due to their ameliorated resistance against antimicrobials and immune systems. Pseudomonas aeruginosa, a biofilm-forming
Michael Salcius et al.
Journal of biomolecular screening, 19(6), 917-927 (2014-02-21)
Bioactive small molecules are an invaluable source of therapeutics and chemical probes for exploring biological pathways. Yet, significant hurdles in drug discovery often come from lacking a comprehensive view of the target(s) for both early tool molecules and even late-stage
Paolo Ascenzi et al.
Biochemical and biophysical research communications, 424(3), 451-455 (2012-07-10)
Human serum albumin (HSA) displays esterase activity reflecting multiple irreversible chemical modifications rather than turnover. Here, kinetics of the pseudo-enzymatic hydrolysis of 4-nitrophenyl acetate (NphOAc) are reported. Under conditions where [HSA]≥ 5×[NphOAc] and [NphOAc]≥ 5×[HSA], the HSA-catalyzed hydrolysis of NphOAc
Tzvetan Mihaylov et al.
Inorganic chemistry, 51(18), 9619-9628 (2012-09-08)
The mechanism of p-nitrophenyl acetate (pNPA) hydrolysis promoted by vanadate ions was investigated utilizing both density functional theory and ab initio methods. In accordance with experiments, suggesting pure hydrolytic ester bond cleavage involving a nucleophilic addition in the rate-limiting transition
Bapi Gorain et al.
SpringerPlus, 3, 666-666 (2014-01-01)
Telescopium telescopium, a marine mollusc collected from Sundarban mangrove, belongs to the largest mollusca phylum in the world and exudes a blue secretion when stimulated mechanically. The blue secretion was found to metabolize (preferentially) para-amino benzoic acid, a substrate for
Hanna Gustafsson et al.
Colloids and surfaces. B, Biointerfaces, 100, 22-30 (2012-07-04)
Immobilization of enzymes usually improves the recyclability and stability and can sometimes also improve the activity compared to enzymes free in solution. Mesoporous silica is a widely studied material as host for immobilized enzymes because of its large internal surface
Ramón Alberto Batista-García et al.
PloS one, 9(8), e105893-e105893 (2014-08-28)
A moderate halophile and thermotolerant fungal strain was isolated from a sugarcane bagasse fermentation in the presence of 2 M NaCl that was set in the laboratory. This strain was identified by polyphasic criteria as Aspergillus caesiellus. The fungus showed
Akın Akıncıoğlu et al.
Bioorganic & medicinal chemistry, 21(6), 1379-1385 (2013-02-12)
Sulfamides represent an important class of biologically active compounds. A series of novel sulfamides were synthesized from 1-aminoindanes, 1-aminotetralin, 2-aminoindanes and 2-aminotetralin via the reactions of free amines, benzyl alcohol and chlorosulfonyl isocyanate (CSI) followed by hydrogenolysis of the obtained
Hamada Mohamed Ibrahim et al.
Molecules (Basel, Switzerland), 16(5), 3723-3739 (2011-05-06)
1,2,3-Triazolo[4,5-b]pyridines and pyrazolo[4,3-b]pyridines can be readily prepared via cyanoacetylation reactions of 5-amino-1,2,3-triazoles 1a,b and 4-amino- pyrazole 2 followed by subsequent cyclization of the formed cyanoacetamides. Reactions of amines 1a,b with a mixture of p-nitrophenylacetic acid and acetic anhydride under microwave
Yu Cheng Zhu et al.
Pesticide biochemistry and physiology, 122, 15-21 (2015-06-15)
Fall armyworm (FAW) is a damaging pest of many economic crops. Long-term use of chemical control prompted resistance development to many insecticide classes. Many populations were found to be significantly less susceptible to major Bt toxins expressed in transgenic crops.
Conformer selection and intensified dynamics during catalytic turnover in chymotrypsin.
Peter Liuni et al.
Angewandte Chemie (International ed. in English), 51(38), 9666-9669 (2012-09-01)
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