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Vikash Chandra Tripathi et al.
Free radical research, 54(2-3), 150-161 (2020-02-06)
The marine environment is emerging as a biodiversity resource for the discovery of natural molecules or chemical scaffolds with pharmaceutical activity. Marine microbes have a tremendous ability to sense and respond to their surroundings to survive in a stressful environment
Luitpold Fried et al.
Journal of bacteriology, 195(4), 807-815 (2012-12-12)
Escherichia coli contains 30 two-component systems (TCSs), each consisting of a histidine kinase and a response regulator. Whereas most TCSs are well characterized in this model organism, little is known about the YpdA/YpdB system. To identify YpdB-regulated genes, we compared
Nora McFadden et al.
PLoS pathogens, 7(12), e1002413-e1002413 (2011-12-17)
Small RNA viruses have evolved many mechanisms to increase the capacity of their short genomes. Here we describe the identification and characterization of a novel open reading frame (ORF4) encoded by the murine norovirus (MNV) subgenomic RNA, in an alternative
Margherita Sosio et al.
Cell chemical biology, 25(5), 540-549 (2018-03-20)
Pseudouridimycin (PUM) is a selective nucleoside-analog inhibitor of bacterial RNA polymerase with activity against Gram-positive and Gram-negative bacteria. PUM, produced by Streptomyces sp. ID38640, consists of a formamidinylated, N-hydroxylated Gly-Gln dipeptide conjugated to 5'-aminopseudouridine. We report the characterization of the
Nalini Aswath et al.
European journal of dentistry, 8(1), 79-84 (2014-06-27)
In the present study, we have investigated the genetic status of CTSC gene in a HMS subject, who along with her parents belonged to non-Jewish South Indian Dravidian community. Genomic deoxyribonucleic acid isolated from the peripheral blood of the subject
Alexandra Mant et al.
Channels (Austin, Tex.), 7(4), 288-302 (2013-06-29)
Acid-sensitive, two-pore domain potassium channels, K(2P)3.1 and K(2P)9.1, are implicated in cardiac and nervous tissue responses to hormones, neurotransmitters and drugs. K(2P)3.1 and K(2P)9.1 leak potassium from the cell at rest and directly impact membrane potential. Hence altering channel number
Vernon K Ward et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(26), 11050-11055 (2007-06-22)
Noroviruses are the major cause of nonbacterial gastroenteritis in humans. These viruses have remained refractory to detailed molecular studies because of the lack of a reverse genetics system coupled to a permissive cell line for targeted genetic manipulation. There is
Karen Olsson-Francis et al.
Applied and environmental microbiology, 76(7), 2115-2121 (2010-02-16)
Many cyanobacteria are known to tolerate environmental extremes. Motivated by an interest in selecting cyanobacteria for applications in space, we launched rocks from a limestone cliff in Beer, Devon, United Kingdom, containing an epilithic and endolithic rock-dwelling community of cyanobacteria
Prolactin inhibits a major tumor-suppressive function of wild type BRCA1.
Chen KH and Walker Am
Cancer Letters, 375(2), 293-302 (2016)
Constant V Edi et al.
PLoS genetics, 10(3), e1004236-e1004236 (2014-03-22)
Malaria control relies heavily on pyrethroid insecticides, to which susceptibility is declining in Anopheles mosquitoes. To combat pyrethroid resistance, application of alternative insecticides is advocated for indoor residual spraying (IRS), and carbamates are increasingly important. Emergence of a very strong
Elena Baldascino et al.
Frontiers in physiology, 8, 1001-1001 (2018-01-13)
The gastric ganglion is the largest visceral ganglion in cephalopods. It is connected to the brain and is implicated in regulation of digestive tract functions. Here we have investigated the neurochemical complexity (through in silico gene expression analysis and immunohistochemistry)
Cassandra M Barrett et al.
International journal of molecular sciences, 21(2) (2020-01-18)
A persistent challenge for mammalian cell engineering is the undesirable epigenetic silencing of transgenes. Foreign DNA can be incorporated into closed chromatin before and after it has been integrated into a host cell's genome. To identify elements that mitigate epigenetic
Puja Yadav et al.
Nucleic acids research, 44(2), 718-729 (2015-11-04)
Highly transcribed guanine-run containing sequences, in Saccharomyces cerevisiae, become unstable when topoisomerase I (Top1) is disrupted. Topological changes, such as the formation of extended RNA:DNA hybrids or R-loops or non-canonical DNA structures including G-quadruplexes has been proposed as the major
Charles S Cockell et al.
The ISME journal, 5(10), 1671-1682 (2011-05-20)
An epilithic microbial community was launched into low Earth orbit, and exposed to conditions in outer space for 548 days on the European Space Agency EXPOSE-E facility outside the International Space Station. The natural phototroph biofilm was augmented with akinetes
Bhuminathan Swamikannu et al.
Asian Pacific journal of cancer prevention : APJCP, 14(5), 2743-2746 (2013-06-28)
Dilantin sodium (phenytoin) is an antiepileptic drug, which is routinely used to control generalized tonic clonic seizure and partial seizure episodes. A few case reports of oral squamous cell carcinomas arising from regions of phenytoin induced gingival overgrowth (GO), and
Apiruck Watthanasurorot et al.
PLoS pathogens, 7(6), e1002062-e1002062 (2011-06-23)
The Down syndrome cell adhesion molecule, also known as Dscam, is a member of the immunoglobulin super family. Dscam plays an essential function in neuronal wiring and appears to be involved in innate immune reactions in insects. The deduced amino
Margaret A Owegi et al.
The Journal of biological chemistry, 281(40), 30001-30014 (2006-08-08)
Vacuolar proton-translocating ATPase pumps consist of two domains, V(1) and V(o). Subunit d is a component of V(o) located in a central stalk that rotates during catalysis. By generating mutations, we showed that subunit d couples ATP hydrolysis and proton
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