NA1111

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Structure, transcription, and variability of metazoan mitochondrial genome: perspectives from an unusual mitochondrial inheritance system.

Fabrizio Ghiselli et al.

Genome biology and evolution, 5(8), 1535-1554 (2013-07-25)

Despite its functional conservation, the mitochondrial genome (mtDNA) presents strikingly different features among eukaryotes, such as size, rearrangements, and amount of intergenic regions. Nonadaptive processes such as random genetic drift and mutation rate play a fundamental role in shaping mtDNA:

Components from the Human c-myb Transcriptional Regulation System Reactivate Epigenetically Repressed Transgenes.

Cassandra M Barrett et al.

International journal of molecular sciences, 21(2) (2020-01-18)

A persistent challenge for mammalian cell engineering is the undesirable epigenetic silencing of transgenes. Foreign DNA can be incorporated into closed chromatin before and after it has been integrated into a host cell's genome. To identify elements that mitigate epigenetic

Bacteria-Induced Dscam Isoforms of the Crustacean, Pacifastacus leniusculus.

Apiruck Watthanasurorot et al.

PLoS pathogens, 7(6), e1002062-e1002062 (2011-06-23)

The Down syndrome cell adhesion molecule, also known as Dscam, is a member of the immunoglobulin super family. Dscam plays an essential function in neuronal wiring and appears to be involved in innate immune reactions in insects. The deduced amino

Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics.

Margherita Sosio et al.

Cell chemical biology, 25(5), 540-549 (2018-03-20)

Pseudouridimycin (PUM) is a selective nucleoside-analog inhibitor of bacterial RNA polymerase with activity against Gram-positive and Gram-negative bacteria. PUM, produced by Streptomyces sp. ID38640, consists of a formamidinylated, N-hydroxylated Gly-Gln dipeptide conjugated to 5'-aminopseudouridine. We report the characterization of the

Heterozygous Ile453Val codon mutation in exon 7, homozygous single nucleotide polymorphisms in intron 2 and 5 of cathepsin C are associated with Haim-Munk syndrome.

Nalini Aswath et al.

European journal of dentistry, 8(1), 79-84 (2014-06-27)

In the present study, we have investigated the genetic status of CTSC gene in a HMS subject, who along with her parents belonged to non-Jewish South Indian Dravidian community. Genomic deoxyribonucleic acid isolated from the peripheral blood of the subject

Acid sensitive background potassium channels K2P3.1 and K2P9.1 undergo rapid dynamin-dependent endocytosis.

Alexandra Mant et al.

Channels (Austin, Tex.), 7(4), 288-302 (2013-06-29)

Acid-sensitive, two-pore domain potassium channels, K(2P)3.1 and K(2P)9.1, are implicated in cardiac and nervous tissue responses to hormones, neurotransmitters and drugs. K(2P)3.1 and K(2P)9.1 leak potassium from the cell at rest and directly impact membrane potential. Hence altering channel number

Lack of RING finger domain (RFD) mutations of the c-cbl gene in oral squamous cell carcinomas in Chennai, India.

Senthilnathan Rajendran et al.

Asian Pacific journal of cancer prevention : APJCP, 14(2), 1073-1075 (2013-04-30)

In normal cells, activated epidermal growth factor receptor (EGFR) molecules are subjected to ubiquitination-mediated proteasome degradation pathway by c-Cbl, an ubiquitin ligase that checks uncontrolled proliferation. Hence expression of wild type c-Cbl molecule is essential to keep this degradation machinery

Lack of mutation in p53 and H-ras genes in phenytoin induced gingival overgrowth suggests its non cancerous nature.

Bhaskar Jayaraman et al.

Asian Pacific journal of cancer prevention : APJCP, 13(11), 5535-5538 (2013-01-16)

There have been case reports of oral squamous cell carcinoma arising from gingival overgrowth induced by phenytoin--an antiepileptic drug. However, a detailed analysis for the presence of mutations in p53 and ras genes, which are the two most frequently mutated

Prolactin inhibits a major tumor-suppressive function of wild type BRCA1.

Chen KH and Walker Am

Cancer Letters, 375(2), 293-302 (2016)

Isolation of novel extreme-tolerant cyanobacteria from a rock-dwelling microbial community by using exposure to low Earth orbit.

Karen Olsson-Francis et al.

Applied and environmental microbiology, 76(7), 2115-2121 (2010-02-16)

Many cyanobacteria are known to tolerate environmental extremes. Motivated by an interest in selecting cyanobacteria for applications in space, we launched rocks from a limestone cliff in Beer, Devon, United Kingdom, containing an epilithic and endolithic rock-dwelling community of cyanobacteria

Identification of a domain in the V0 subunit d that is critical for coupling of the yeast vacuolar proton-translocating ATPase.

Margaret A Owegi et al.

The Journal of biological chemistry, 281(40), 30001-30014 (2006-08-08)

Vacuolar proton-translocating ATPase pumps consist of two domains, V(1) and V(o). Subunit d is a component of V(o) located in a central stalk that rotates during catalysis. By generating mutations, we showed that subunit d couples ATP hydrolysis and proton

Evaluation of the Saccharomyces cerevisiae ADH2 promoter for protein synthesis.

K Michael Lee et al.

Yeast (Chichester, England), 22(6), 431-440 (2005-04-26)

The Saccharomyces cerevisiae ADH2 promoter (P(ADH2)) is repressed several hundred-fold in the presence of glucose; transcription is initiated once the glucose in the medium is exhausted. The promoter can thus be utilized for effective regulation of recombinant gene expression in

Attempts to Construct an Enlarged pUC19 via Insertion of HindIII-digested Coliphage ? DNA

Muhamed Amirie

Journal of Experimental Microbiology and Immunology, 18, 96-101 (2014)

The Antimicrobial Effect of Pomegranate Peel Extract versus Chlorhexidine in High Caries Risk Individuals Using Quantitative Real-Time Polymerase Chain Reaction: A Randomized Triple-Blind Controlled Clinical Trial.

Benoy Jacob et al.

International journal of dentistry, 2021, 5563945-5563945 (2021-09-14)

The aim of the present study was to compare the antibacterial effectiveness of chlorhexidine and PPE oral rinse on S. mutans, Lactobacilli, and Veillonella, in clinical salivary samples of patients with advanced stages of dental caries at baseline and two

Recombinant l-glutaminase obtained from Geobacillus thermodenitrificans DSM-465: characterization and in silico elucidation of conserved structural domains.

Luqman Shah et al.

RSC advances, 9(8), 4258-4267 (2019-02-01)

Glutaminase (GLS) is an enzyme essential for amino acid metabolism; in particular, it acts as a catalyst in glutaminolysis, a reaction exploited by the malignant cells to meet the nutrient requirements for their accelerated growth and proliferation. Via regulating the

Evaluation of combined efficacy of photodynamic therapy using indocyanine green photosensitizer and non-surgical periodontal therapy on clinical and microbial parameters in the management of chronic periodontitis subjects: A randomized split-mouth design.

Kanchana Sukumar et al.

Photodiagnosis and photodynamic therapy, 31, 101949-101949 (2020-08-10)

The clinical efficacy of multiple applications of Photodynamic therapy (PDT) needs to be better investigated for the management of chronic periodontitis subjects. The aim of this study was to evaluate the clinical and antimicrobial efficacy of multiple application of PDT

Ketamine exerts a protective role in a cell-based model of major depressive disorder via the inhibition of apoptosis and inflammation and activation of the Krebs cycle.

Wenfei Zhang et al.

Bosnian journal of basic medical sciences, 20(1), 44-55 (2019-06-20)

Major depressive disorder (MDD) is one of the most common psychiatric disorders characterized by major depressive episodes. Although great efforts have been made to develop antidepressant drugs that target the monoaminergic system, these drugs are effective in only approximately 50%

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