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Andrew Curtright et al.
PloS one, 10(1), e0116766-e0116766 (2015-01-15)
Acute and chronic pain conditions are often debilitating, inflicting severe physiological, emotional and economic costs and affect a large percentage of the global population. However, the development of therapeutic analgesic agents based primarily on targeted drug development has been largely
M T Ventura et al.
Journal of biological regulators and homeostatic agents, 27(2), 589-594 (2013-07-09)
Corticosteroids are therapeutic drugs widely used in cases of allergic, inflammatory and autoimmune diseases, but sometimes allergic hypersensitivity reactions have been reported as a rare adverse effect of the corticosteroids themselves. Moreover, glucocorticoids can induce gastric lesions; thats why they
Sudhir K Yadav et al.
Biochimica et biophysica acta, 1830(6), 3776-3786 (2013-03-26)
The gastro-intestinal disorders, induced by the NSAIDs including indomethacin (IND) remain unresolved medical problems. Herein, we disclose allylpyrocatechol (APC) as a potential agent against IND-gastropathy and rationalize its action mechanistically. Mice were pre-treated with APC for 1h followed by IND
V A Zolotarev et al.
Bulletin of experimental biology and medicine, 154(4), 415-418 (2013-03-15)
Proton pump inhibitors were shown to affect the sensitivity of the gastric mucosa to chemical agents. This effect is associated with inhibition of proton back-diffusion and increase in the permeability of the gastric epithelium. We studied the effect of omeprazole
Paul A Gurbel et al.
American heart journal, 165(2), 176-182 (2013-01-29)
A common regimen for patients requiring dual-antiplatelet therapy who are at risk for gastrointestinal complications is the synchronous administration of enteric-coated (EC) aspirin, a proton pump inhibitor, and clopidogrel, although proton pump inhibitors have the potential for pharmacodynamic interaction with
Horacio Reyes-Vivas et al.
Antimicrobial agents and chemotherapy, 58(12), 7072-7082 (2014-09-17)
Giardiasis is highly prevalent in the developing world, and treatment failures with the standard drugs are common. This work deals with the proposal of omeprazole as a novel antigiardial drug, focusing on a giardial glycolytic enzyme used to follow the
Kazuhiro Shiizaki et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1690-1697 (2014-07-26)
Omeprazole (OME), a proton pump inhibitor used to treat gastritis, is also an aryl hydrocarbon receptor (AhR) activator. OME activates AhR in human hepatocytes and hepatoma cells, but not in mice in vivo or in vitro. We recently discovered that
Adrian G McNicholl et al.
Gut, 63(2), 244-249 (2013-05-15)
No trial has compared non-bismuth quadruple 'sequential' and 'concomitant' regimens in settings with increasing clarithromycin rates. The study aims to compare the effectiveness and safety of these therapies for Helicobacter pylori treatment. Prospective randomised clinical trial in 11 Spanish hospitals.
Meng-Hooi Shu et al.
BMC complementary and alternative medicine, 13, 61-61 (2013-03-19)
Gracilaria changii (Xia et Abbott) Abbott, Zhang et Xia, a red algae commonly found in the coastal areas of Malaysia is traditionally used for foods and for the treatment of various ailments including inflammation and gastric ailments. The aim of
Is omeprazole helpful in the management of children with reflux oesophagitis?
Lizy A Varughese et al.
Archives of disease in childhood, 87(1), 78-80 (2002-06-29)
Yuan Zhang et al.
Die Pharmazie, 70(1), 47-54 (2015-05-16)
Polygonum multiflorum is a traditional Chinese medicinal herb used in clinical medicine to nourish the liver and kidney. However, in recent years, there have been increased reports of clinical adverse reactions associated with Polygonum multiflorum preparations, especially due to liver
M Espinosa Bosch et al.
Journal of pharmaceutical and biomedical analysis, 44(4), 831-844 (2007-05-29)
Omeprazole, a gastric acid pump inhibitor, dose-dependently controls gastric acid secretion; the drug has greater antisecretory activity than histamine H(2)-receptor antagonists. Omeprazole has been determined in formulations and biological fluids by a variety of methods such as spectrophotometry, high-performance liquid
Yehia El-Garem et al.
Urology, 84(6), 1347-1350 (2014-11-30)
To assess the effect of treatment of seminal Helicobacter pylori in infertile asthenozoospermic men. In all, 223 infertile asthenozoospermic men were consecutively selected. They were subjected to history taking, clinical examination, semen analysis, and estimation of H pylori IgA antibodies
Kazuhiro Shiizaki et al.
Molecular pharmacology, 85(2), 279-289 (2013-11-23)
Omeprazole (OME) induces the expression of genes encoding drug-metabolizing enzymes, such as CYP1A1, via activation of the aryl hydrocarbon receptor (AhR) both in vivo and in vitro. However, the precise mechanism of OME-mediated AhR activation is still under investigation. While
[Comment of the Delphi Care editors on Critical evaluation of interaction screening software available in pharmacies].
Daniel Duh et al.
Journal de pharmacie de Belgique, (4)(4), 14-15 (2013-01-29)
[Recent topics on important drugs for H. pylori eradication: Omeprazole].
Hiromi Kataoka et al.
Nihon rinsho. Japanese journal of clinical medicine, 63 Suppl 11, 333-337 (2005-12-21)
Michael A Schumacher et al.
The Journal of physiology, 593(8), 1809-1827 (2015-01-22)
An in vitro approach to study gastric development is primary mouse-derived epithelium cultured as three-dimensional spheroids known as organoids. We have devised two unique gastric fundic-derived organoid cultures: model 1 for the expansion of gastric fundic stem cells, and model
A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole.
Lars Olbe et al.
Nature reviews. Drug discovery, 2(2), 132-139 (2003-02-04)
Luigi Dall'Olmo et al.
PloS one, 9(11), e112862-e112862 (2014-11-22)
Chronic gastro-duodenal reflux in the esophagus is a major risk for intestinal metaplasia and Barrett's adenocarcinoma. A role for chronic use of proton pump inhibitor (PPI) in the increased incidence of esophageal adenocarcinoma in Western countries has been previously suggested.
Z Liu et al.
Drug research, 63(7), 370-375 (2013-04-06)
The present study was conducted to describe the pharmacokinetic profile of immediate-release compound omeprazole capsule and compare it with the enteric-coated formulation under fasting and fed condition.This study was designed to phase I, open-label, randomized, 3-part clinical trial. 12 subjects
Heyam Mohamed Ali Sidahmed et al.
PloS one, 10(3), e0121060-e0121060 (2015-03-24)
Zingiber zerumbet Smith is a perennial herb, broadly distributed in many tropical areas. In Malaysia, it's locally known among the Malay people as "lempoyang" and its rhizomes, particularly, is widely used in traditional medicine for the treatment of peptic ulcer
Anne M Hanneken et al.
Investigative ophthalmology & visual science, 54(2), 1485-1489 (2013-01-24)
Visual hallucinations (VHs) occur in macular degeneration patients with poor vision but normal cognitive function. The underlying mechanisms are poorly understood. We report the identification of pharmaceutical agents that enhance VH and use these agents to examine the contribution of
Shohda A El-Maraghy et al.
Chemico-biological interactions, 229, 26-35 (2015-02-01)
The present study investigated the gastroprotective effect of crocin in ethanol-induced gastric injury in rats. Rats were allocated into a normal group, an ulcer group, a crocin-treated group, an ulcer group pretreated with crocin, and an ulcer group pretreated with
Yuki Kondo et al.
Drug metabolism and pharmacokinetics, 29(3), 237-243 (2013-12-18)
The use of human induced pluripotent stem (iPS) cells would be of great value for a variety of applications involving drug development studies. Several reports have been published on the differentiation of human iPS cells into hepatocyte-like cells; however, the
N Inui et al.
Clinical pharmacology and therapeutics, 94(6), 702-708 (2013-08-27)
Cytochrome P450 (CYP) 1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A are major factors involved in the metabolism of clinically prescribed drugs. Because the time course after drug treatment discontinuation has received little attention, we aimed to clarify the chronological changes of
Yasuhiro Uno et al.
Biochemical pharmacology, 91(2), 242-248 (2014-07-19)
CYP2C19 (formerly known as CYP2C75), highly homologous to human CYP2C19, has been identified in cynomolgus and rhesus macaques, non-human primate species widely used in drug metabolism studies. CYP2C19 is predominantly expressed in liver and encodes a functional drug-metabolizing enzyme. Genetic
Nicholas I Cutfield et al.
The New Zealand dental journal, 108(4), 140-147 (2013-03-13)
To provide information about the most common medications listed as being taken by dental patients presenting to an outpatient setting at a tertiary institution and to establish a list of the most common medications for review for the general dental
I B Angotoeva et al.
Vestnik otorinolaringologii, (3)(3), 52-55 (2013-07-28)
The objective of the present study was to attract attention of practitioners to the possibility of involvement of pharyngel tonsils in the pathological process in the patients presenting with gastroesophageal reflux. Two clinical cases are reported to illustrate the possibility
Lassina Badolo et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(2), 177-187 (2014-09-04)
1. Regulation of hepatic metabolism or transport may lead to increase in drug clearance and compromise efficacy or safety. In this study, cryopreserved human hepatocytes were used to assess the effect of 309 compounds on the activity and mRNA expression
Jamshid Vafaeimanesh et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 25(1), 53-57 (2014-01-18)
To compare a triple-therapy regimen based on change of antibiotic (azithromycin and clarithromycin) for the eradication of Helicobacter pylori in hemodialysis (HD) patients, we studied in a prospective, randomized, double-blinded clinical trial 39 patients who had dyspepsia and showed two
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