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O1008
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Liliana M R Silva et al.
Parasitology research, 114(1), 113-124 (2014-10-24)
Eimeria arloingi infections can cause severe haemorrhagic enteritis in young goat kids, thereby leading to high economic losses in goat industry worldwide. We aimed to isolate a new E. arloingi strain and establish a suitable in vitro culture system for
Jin Han et al.
ACS nano, 9(3), 2805-2819 (2015-02-18)
Electrophysiological phenotype development and paracrine action of mesenchymal stem cells (MSCs) are the critical factors that determine the therapeutic efficacy of MSCs for myocardial infarction (MI). In such respect, coculture of MSCs with cardiac cells has windowed a platform for
Ryo Sawamura et al.
Biochemical and biophysical research communications, 458(2), 387-391 (2015-02-07)
Clarification of the mechanism of chickens' taste sense will provide meaningful information for creating and improving new feedstuff for chickens, because the character of taste receptors in oral tissues affects feeding behavior in animals. Although fatty acids are partly recognized
Olesya Yarema et al.
ACS nano, 9(11), 11134-11142 (2015-09-16)
Ternary I-III-VI nanocrystals, such as silver indium selenide (AISe), are candidates to replace cadmium- and lead-based chalcogenide nanocrystals as efficient emitters in the visible and near IR, but, due to challenges in controlling the reactivities of the group I and
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Jaiyanth Daniel et al.
PloS one, 9(12), e114877-e114877 (2014-12-10)
Latent infection with dormant Mycobacterium tuberculosis is one of the major reasons behind the emergence of drug-resistant strains of the pathogen worldwide. In its dormant state, the pathogen accumulates lipid droplets containing triacylglycerol synthesized from fatty acids derived from host
R K Dutta et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 48(8), 871-878 (2013-03-15)
The toxicity effect due to chronic exposure of ZnO nanoparticles (NPs) was systematically studied by repeatedly treating different lower concentrations of ZnO nanoparticles with culture media of E. coli strain. The chronic exposure of ZnO NPs of concentrations below minimum
Akira Kotani et al.
Journal of pharmaceutical and biomedical analysis, 97, 47-53 (2014-05-13)
The effects of hyperglycemia on the pharmacokinetics of valproic acid (VPA) were examined by time-concentration profiles of plasma VPA accompanied with blood glucose (BG) changing. In addition, time-concentration profiles of plasma free fatty acids (FFAs) were also obtained to examine
Sumita Mishra et al.
The Journal of clinical investigation, 131(21) (2021-10-08)
Central obesity with cardiometabolic syndrome (CMS) is a major global contributor to human disease, and effective therapies are needed. Here, we show that cyclic GMP-selective phosphodiesterase 9A inhibition (PDE9-I) in both male and ovariectomized female mice suppresses preestablished severe diet-induced
Federica Bigucci et al.
Drug development and industrial pharmacy, 41(6), 1017-1025 (2014-06-12)
The aim of this study was to evaluate the capacity of cellulose films enriched with oleic acid and polysorbate 80 to enhance the transdermal permeation of propranolol hydrochloride. Polymeric films were prepared by casting and drying aqueous solutions of hydroxypropylmethylcellulose
Yasutaka Kuwahara et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(2), 380-389 (2016-11-26)
One-pot reaction involving Pd-catalyzed H
Jason Nardella et al.
Archives of biochemistry and biophysics, 579, 73-84 (2015-06-04)
The gypsy moth utilizes a pheromone, (7R,8S)-2-methyl-7,8-epoxyoctadecane, for mate location. The pheromone is detected by sensory hairs (sensilla) on the antennae of adult males. Sensilla contain the dendrites of olfactory neurons bathed in lymph, which contains pheromone binding proteins (PBPs).
Neslihan Ustündağ-Okur et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 204-215 (2014-08-12)
The objective of this study was to explore the potential of the nanostructured lipid carriers (NLCs) modified with chitosan oligosaccharide lactate (COL) for topical ocular application. Ofloxacin (OFX) loaded NLCs were prepared by microemulsion or high shear homogenization methods. For
Saurabh Vig et al.
Cell cycle (Georgetown, Tex.), 14(14), 2274-2284 (2015-05-07)
Calreticulin (CRT) is an endoplasmic reticulum (ER) resident calcium binding protein that is involved in several cellular activities. Transcriptome analyses in CRT knockdown HepG2 cells revealed 253 altered unique genes and subsequent in silico protein-protein interaction network and MCODE clustering
Zizwe A Chase et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(46), 16541-16546 (2015-09-26)
The state of Ni supported on HZSM-5 zeolite, silica, and sulfonated carbon was studied during aqueous-phase catalysis of phenol hydrodeoxygenation using in situ extended X-ray absorption fine structure spectroscopy. On sulfonated carbon and HZSM-5 supports, NiO and Ni(OH)2 were readily
Elizabeth Cocks et al.
Pharmaceutical research, 31(8), 2000-2009 (2014-02-20)
This work investigates the feasibility of delivering large (≈ 25 μm) porous poly (lactide-co-glycolide) (PLGA) microparticles containing a model protein via pressurised metered dose inhaler (pMDI). Porous PLGA microparticles were prepared by modified double emulsion method as pMDI suspension based systems
Takuya Kitamura et al.
The Biochemical journal, 465(1), 79-87 (2014-10-07)
Aldehyde dehydrogenases (ALDHs) catalyse the conversion of toxic aldehydes into non-toxic carboxylic acids. Of the 21 ALDHs in mice, it is the ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 and ALDH3B3) that are responsible for the removal of lipid-derived aldehydes.
Stephanie Phan et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 117-124 (2015-07-28)
Lipid-based formulations are gaining interest for use as drug delivery systems for poorly water-soluble drug compounds. During digestion, the lipolysis products self-assemble with endogenous surfactants in the gastrointestinal tract to form colloidal structures, enabling enhanced drug solubilisation. Although earlier studies
Ronak Savla et al.
Pharmaceutical research, 31(12), 3487-3502 (2014-06-13)
Design and synthesis of a tumor responsive nanoparticle-based system for imaging and treatment of various cancers. Manganese oxide nanoparticles (Mn3O4 NPs) were synthesized and modified with LHRH targeting peptide or anti-melanoma antibodies (cancer targeting moieties) and a MMP2 cleavable peptide
Luciana Balboa et al.
Clinical science (London, England : 1979), 129(4), 319-330 (2015-04-11)
Circulating monocytes (Mo) play an essential role in the host immune response to chronic infections. We previously demonstrated that CD16(pos) Mo were expanded in TB (tuberculosis) patients, correlated with disease severity and were refractory to dendritic cell differentiation. In the
Pamela J McFie et al.
Biochimica et biophysica acta, 1841(9), 1318-1328 (2014-06-24)
Acyl CoA:diacylglycerol acyltransferase-2 (DGAT2) is an integral membrane protein that catalyzes the synthesis of triacylglycerol (TG). DGAT2 is present in the endoplasmic reticulum (ER) and also localizes to lipid droplets when cells are stimulated with oleate. Previous studies have shown
Eriel Martínez et al.
Nature communications, 7, 13823-13823 (2016-12-09)
The oxygenation of unsaturated fatty acids by dioxygenases occurs in all kingdoms of life and produces physiologically important lipids called oxylipins. The biological roles of oxylipins have been extensively studied in animals, plants, algae and fungi, but remain largely unidentified
Feng Zhu et al.
ACS nano, 9(3), 2948-2959 (2015-02-11)
Organometallic halide perovskites CH3NH3PbX3 (X = I, Br, Cl) have quickly become one of the most promising semiconductors for solar cells, with photovoltaics made of these materials reaching power conversion efficiencies of near 20%. Improving our ability to harness the
Yi-Hsin Tseng et al.
Autophagy, 10(1), 20-31 (2013-11-23)
The thyroid hormone, T 3, regulates cell growth, differentiation and development through binding to the nuclear thyroid hormone receptor (THR), a member of the steroid/TR superfamily of ligand-dependent transcriptional factors. T 3 modulates lipid metabolism in liver, although the detailed
Hao Wang et al.
Scientific reports, 5, 17088-17088 (2015-11-27)
Triple-doped (Yb(3+)/Er(3+)/Tm(3+)) KMnF3 nanocubes with uniform sizes of 250 nm were synthesized by a facile hydrothermal route using the oleic acid as the capping agent. It was found that these nanocubes can simultaneously exhibited four-color (blue, green, red and NIR)
Rachael Dangarembizi et al.
Natural product communications, 8(3), 411-414 (2013-05-18)
Aloe ferox is an important medicinal plant in Southern Africa whose seeds could be useful as a source of oil. The fatty acid composition of A. ferox seed oil was determined using gas chromatography. The physicochemical properties of the oil
U Goebel et al.
British journal of anaesthesia, 113(3), 474-483 (2014-04-04)
Whereas the effects of various inspiratory ventilatory modifications in lung injury have extensively been studied, those of expiratory ventilatory modifications are less well known. We hypothesized that the newly developed flow-controlled expiration (FLEX) mode provides a means of attenuating experimental
Simon Hammann et al.
Analytical and bioanalytical chemistry, 407(30), 9019-9028 (2015-10-07)
Triacylglycerols represent the major part (>90%) in most plant oils and have to be eliminated, when the minor compounds such as phytosterols or tocopherols should be analyzed. Here, we used an all liquid-liquid chromatographic technique, countercurrent chromatography (CCC), to fractionate
Lianjiang Tan et al.
Carbohydrate polymers, 157, 325-334 (2016-12-19)
As a naturally-abundant biopolymer, chitosan (CS) exhibit pH-sensitive structural transformation within a narrow pH range. Integrating hydrophobic groups to CS molecules gives modified CS polymers with more adjustable pH responsiveness. In this paper, near-infrared (NIR) photoluminescent Ag
Sławomir Oszwałdowski et al.
Journal of chromatography. A, 1412, 139-150 (2015-08-25)
Capillary electrophoresis coupled with contactless conductivity detector was applied to characterize BGE/segment/segment/BGE and BGE/segment/electrolyte/segment/BGE systems, where segment is the phase of mixed micelles migrating surrounded by BGE and composition of the first segment≠second segment. It was established that both systems
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