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显示 1-30 共 672 条结果 关于 "O1008" 范围 论文
Liliya Vinarova et al.
Food & function, 6(4), 1319-1330 (2015-03-17)
Quillaja saponin extracts are known to reduce plasma cholesterol levels in humans. Here we study the mechanism of this effect with Quillaja Dry saponin extract (QD). In vitro model of triglyceride lipolysis is used to quantify the effect of QD
Hilda A Ayala-Bravo et al.
Pharmaceutical research, 20(8), 1267-1273 (2003-09-02)
The purpose of this work was to 1) investigate the effect of sucrose esters (sucrose oleate and sucrose laureate in water or in Transcutol, TC) on the stratum corneum (SC) barrier properties in vivo and 2) examine the impact of
Konstanze Steiner et al.
Toxicology and applied pharmacology, 280(3), 534-542 (2014-09-15)
Cyanobacterial blooms have an impact on the aquatic ecosystem due to the production of toxins (e.g. microcystins, MCs), which constrain fish health or even cause fish death. However the toxicokinetics of the most abundant toxin, microcystin-LR (MC-LR), are not yet
Leslie S Hamachi et al.
Chemical science, 10(26), 6539-6552 (2019-08-02)
We report a method to control the composition and microstructure of CdSe1-x S x
Juan L Benedé et al.
Talanta, 147, 246-252 (2015-11-26)
In this work, a new approach that combines the advantages of stir bar sorptive extraction (SBSE) and dispersive solid phase extraction (DSPE), i.e. stir bar sorptive-dispersive microextraction (SBSDµE), is employed as enrichment and clean-up technique for the sensitive determination of
Wusigale et al.
Journal of agricultural and food chemistry, 68(1), 340-350 (2019-12-25)
Folic acid, a synthetic form of folate, is a water-soluble vitamin that is essential during periods of rapid cell division and growth. However, it decomposes upon ultraviolet irradiation to form inactive photoproducts. In this study, the protective effect and mechanisms
Chun-Yan Song et al.
Journal of gastroenterology and hepatology, 30(2), 405-412 (2014-08-05)
Sophocarpine, a tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L., has been documented that it can suppress pro-inflammatory cytokines synthesis in alleviating nonalcoholic steatohepatitis (NASH) in vivo. Toll-like receptor 4 (TLR4) is a pattern recognition receptor whose activation results in
Justin I Odegaard et al.
Cell metabolism, 7(6), 496-507 (2008-06-05)
Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin resistance and type 2 diabetes. While inflammatory activation of resident hepatic macrophages potentiates insulin resistance, the functions of alternatively activated Kupffer cells in metabolic disease remain unknown. Here we show
Abdul Bari et al.
Journal of microencapsulation, 32(1), 54-60 (2014-08-05)
The objective of the present study was to improve solubility, dissolution rate and therapeutic efficacy of a BCS Class II drug, glibenclamide by using oral self nano emulsifying powder. The powder was prepared by adsorbing the mixture of oil, surfactant
Yuko Nagamura et al.
BMC complementary and alternative medicine, 14, 256-256 (2014-07-21)
Rikkunshito is a traditional Japanese herbal medicine that is used to treat appetite loss associated with cancer and other disorders. The formulation contains various constituents that influence cell signaling, and rikkunshito may accordingly affect human homeostasis through multiple regulatory pathways
Alexandra Rogue et al.
Toxicology and applied pharmacology, 276(1), 73-81 (2014-02-19)
Although non-alcoholic fatty liver disease (NAFLD) is currently the most common form of chronic liver disease there is no pharmacological agent approved for its treatment. Since peroxisome proliferator-activated receptors (PPARs) are closely associated with hepatic lipid metabolism, they seem to
Ram Jee Sharma et al.
Natural product communications, 10(6), 969-976 (2015-07-23)
Eugenia jambolana, commonly known as 'jamun' or Indian blackberry, is an important source of bioactive compounds. All parts of the plant like stem bark, leaves, flower, fruit pulp and seeds are traditionally used for many diseases. Metabolite profiling in medicinally
R Valjakka-Koskela et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 11(4), 343-350 (2000-10-18)
The aim of this study was to determine if transdermal penetration of levosimendan, a novel positive inotropic drug, could be enhanced and controlled by formulation modifications. Penetration of levosimendan across human epidermis in vitro was determined using abdominal excised skin
Michael C Rudolph et al.
Journal of lipid research, 55(6), 1052-1065 (2014-04-29)
Thyroid hormone responsive protein Spot 14 has been consistently associated with de novo fatty acid synthesis activity in multiple tissues, including the lactating mammary gland, which synthesizes large quantities of medium chain fatty acids (MCFAs) exclusively via FASN. However, the
Song Ye et al.
Dalton transactions (Cambridge, England : 2003), 44(35), 15583-15590 (2015-08-06)
The pH value plays an important role in controlling the crystallization process and microstructure of the final products in the synthesis of nanocrystals with a solvothermal method. This work reported the effect of the mother solution pH value on the
L Jordaens et al.
Theriogenology, 84(6), 899-910 (2015-06-30)
Elevated non-esterified fatty acids (NEFAs) have been recognized as an important link between lipolytic metabolic conditions and impaired fertility in high-yielding dairy cows. However, NEFA effects on the oviductal micro-environment currently remain unknown. We hypothesize that elevated NEFAs may contribute
Elizabeth Cocks et al.
Drug development and industrial pharmacy, 41(3), 522-528 (2014-03-22)
The effect of suspension stabilizers, internal aqueous phase volume and polymer amount were investigated for the production of protein loaded poly(d,l lactide-co-glycolide) (PLGA) microparticles suitable for pulmonary drug delivery. PLGA microparticles were produced adopting water-in-oil-in-water (W/O/W) solvent evaporation technique and were
James C S Ho et al.
The Journal of biological chemistry, 288(24), 17460-17471 (2013-05-01)
Long-chain fatty acids are internalized by receptor-mediated mechanisms or receptor-independent diffusion across cytoplasmic membranes and are utilized as nutrients, building blocks, and signaling intermediates. Here we describe how the association of long-chain fatty acids to a partially unfolded, extracellular protein
Mehmet Oguz Gok et al.
Molecular biology of the cell, 33(1), ar11-ar11 (2021-11-25)
The asymmetric distribution of phospholipids in membranes is a fundamental principle of cellular compartmentalization and organization. Phosphatidylethanolamine (PE), a nonbilayer phospholipid that contributes to organelle shape and function, is synthesized at several subcellular localizations via semiredundant pathways. Previously, we demonstrated
Cédric Montigny et al.
The Journal of biological chemistry, 289(49), 33850-33861 (2014-10-11)
Sarcolipin (SLN) is a regulatory peptide present in sarcoplasmic reticulum (SR) from skeletal muscle of animals. We find that native rabbit SLN is modified by a fatty acid anchor on Cys-9 with a palmitic acid in about 60% and, surprisingly
Karen L Sweazea et al.
Zoology (Jena, Germany), 116(2), 85-89 (2013-02-07)
Plasma glucose and ketone concentrations are much higher in birds than in humans and birds exhibit resistance to insulin-mediated glucose uptake into muscle. Therefore, birds may offer a model in which to examine the effects of high plasma glucose and
Paul A Turner et al.
Tissue engineering. Part A, 21(11-12), 1837-1847 (2015-03-18)
To improve treatment of obesity, a contributing factor to multiple systemic and metabolic diseases, a better understanding of metabolic state and environmental stress at the cellular level is essential. This work presents development of a three-dimensional (3D) in vitro model
Pegah Moradi Khaniabadi et al.
Photodiagnosis and photodynamic therapy, 31, 101896-101896 (2020-06-26)
Theranostic agents can combine photosensitizers and contrast agents into a single unit for photothermal therapy (PTT) and magnetic resonance imaging (MRI). The possibility of treating and diagnosing malignant cancers without any ionizing radiation could become an option. This study investigates
Jilite Wang et al.
Bioscience, biotechnology, and biochemistry, 79(3), 456-461 (2014-11-07)
Dietary plant protein is well known to reduce serum cholesterol levels. Rice bran is a by-product of rice milling and is a good source of protein. The present study examined whether feeding rats a high-cholesterol diet containing 10% rice bran
Pablo J Giraudi et al.
Experimental and molecular pathology, 98(1), 85-92 (2014-12-24)
Non-alcoholic fatty liver disease is characterized by an initial accumulation of triglycerides that can progress to non-alcoholic steatohepatitis, which can ultimately evolve to cirrhosis and hepatocellular carcinoma. Hepatic stellate cells play a key role in liver fibrogenesis by an increased
Mika Hilvo et al.
International journal of cancer, 134(7), 1725-1733 (2013-10-12)
Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic
Nathalie Nicod et al.
The Journal of nutritional biochemistry, 26(2), 165-172 (2014-12-04)
High-density lipoproteins (HDLs) are atheroprotective because of their role in reverse cholesterol transport. The intestine is involved in this process because it synthesizes HDL, removes cholesterol from plasma and excretes it into the lumen. We investigated the role of selected
C Carrillo et al.
Nutricion hospitalaria, 27(6), 1860-1865 (2013-04-17)
The beneficial effects of oleic acid in cancer processes can no longer be doubted, but little is known about the mechanisms of action behind this phenomenon. The aim of the present review is to clarify whether oleic acid has an
Marta Corzo-Martínez et al.
Food & function, 11(1), 813-823 (2020-01-15)
This work studies the effect of enzymatic glycerolysis on digestibility and bioaccessibility of ratfish liver oil (RLO) rich in alkylglycerols (AKGs), as well as the capability of the glycerolysis product (GP) to act as lipid-based delivery system (LBDS) for a
A I Figueroa et al.
Nanotechnology, 24(15), 155705-155705 (2013-03-23)
We present radio frequency transverse susceptibility (TS) measurements on oleic acid-coated and SiO2-coated Fe3-xO4 magnetite nanoparticles. The effects of the type of coating on the interparticle interactions and magnetic anisotropy are evaluated for two different particle sizes in powder samples.
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