搜索范围
o3129
应用筛选条件
关键词:'o3129'
显示 1-30 #N/A 211 条结果 关于 "o3129" 范围 论文
Jiqing Liu et al.
Developmental and comparative immunology, 107, 103657-103657 (2020-02-25)
As a multifunctional protein, cyclophilin A (CypA) plays an important role in cell apoptosis. In our previous work, we found that CypA from Apostichopus japonicus (AjCypA), as a cofactor, could modulate nuclear translocation of NF-κB. However, the immune function of
Annachiara Scalzone et al.
Frontiers in bioengineering and biotechnology, 8, 712-712 (2020-07-23)
Nature provides biomaterials that tend to be effective to control both their adhesive and cohesive properties. A catecholamine motif found in the marine mussels, the mytilus edulis foot protein, can play adhesiveness and cohesiveness. Particularly, acidic pH drives catechol (Cat)
Siyuan Feng et al.
Frontiers in microbiology, 11, 413-413 (2020-04-09)
There is growing evidence that GreA aids adaptation to stressful environments in various bacteria. However, the functions of GreA among mycobacteria remain obscure. Here, we report on cellular consequences following deletion of greA gene in Mycobacterium spp. The greA mutant
Vanessa Piechotta et al.
The Cochrane database of systematic reviews, 2019(11) (2019-11-26)
Multiple myeloma is a bone marrow-based hematological malignancy accounting for approximately two per cent of cancers. First-line treatment for transplant-ineligible individuals consists of multiple drug combinations of bortezomib (V), lenalidomide (R), or thalidomide (T). However, access to these medicines is
Jun-Cheng Guo et al.
Psychiatry investigation, 15(4), 407-412 (2018-03-20)
To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD). A total of 300 patients with sporadic PTSD and 150 healthy subjects (the control group) were selected according to
Yan Gao et al.
Environmental pollution (Barking, Essex : 1987), 230, 469-478 (2017-07-09)
Bacterial communities in rivers receiving untreated domestic wastewater may show specific spatial assemblage patterns due to a wide range of physicochemical conditions created by periodic algal bloom. However, there are significant gaps in understanding environmental forces that drive changes in
Rosa Purgatorio et al.
ChemMedChem, 16(3), 589-598 (2020-11-07)
Different Mannich base derivatives have been studied with the aim of addressing the poor aqueous solubility of the recently disclosed 6-phenethyl-2,3,4,5-tetrahydroazepino[4,3-b]indol-1(6H)-one (1), a human butyrylcholinesterase inhibitor (hBChE, IC50 13 nM) and protective agent in NMDA-induced neurotoxicity, in in vivo assays. The N-(4-methylpiperazin-1-yl)methyl
Sheng-Qiang Fan et al.
Environmental science & technology, 54(1), 297-305 (2019-12-04)
This work developed a novel Membrane Granular Sludge Reactor (MGSR) equipped with a gas permeable membrane module for efficient methane delivery to cultivate nitrate/nitrite dependent anaerobic methane oxidation (n-DAMO) microorganisms in granular sludge. As proof of concept, the MGSR was
H Chu et al.
Journal of applied microbiology, 125(2), 554-563 (2018-04-21)
This study investigates pinewood nematode's impacts on root mycoflora of Pinus tabulaeformis. The biomass, colonization rate, community structure and diversity of root-associated fungi were investigated in pinewood nematode-infected and nematode-noninfected P. tabulaeformis. The results indicated that the roots of P.
Meiyao Wang et al.
BMC genomics, 21(1), 410-410 (2020-06-20)
Coilia nasus (C. nasus) is an important anadromous fish species that resides in the Yangtze River of China, and has high ecological and economical value. However, wild resources have suffered from a serious reduction in population, attributed to the over-construction
Félicien Le Louedec et al.
Pharmaceuticals (Basel, Switzerland), 14(2) (2021-03-07)
Therapeutic drug monitoring of ibrutinib is based on the area under the curve of concentration vs. time (AUCIBRU) instead of trough concentration (Cmin,ss) because of a limited accumulation in plasma. Our objective was to identify a limited sampling strategy (LSS)
Ji Won Park et al.
Free radical biology & medicine, 121, 149-156 (2018-05-02)
Nitric oxide (NO) is an essential signaling molecule in the body, regulating numerous biological processes. Beside its physiological roles, NO affects drug metabolism by modulating the activity and/or expression of cytochrome P450 enzymes. Previously, our lab showed that NO generation
Gang Wang et al.
Viruses, 11(4) (2019-04-03)
Transmissible gastroenteritis virus (TGEV) is the etiologic agent of transmissible gastroenteritis in pigs, and the N-terminal domain of TGEV spike protein is generally recognized as both the virulence determinant and enteric tropism determinant. Here, we assembled a full-length infectious cDNA
Katrine Bugge et al.
Structure (London, England : 1993), 26(5), 734-746 (2018-04-17)
Communication within cells relies on a few protein nodes called hubs, which organize vast interactomes with many partners. Frequently, hub proteins are intrinsically disordered conferring multi-specificity and dynamic communication. Conversely, folded hub proteins may organize networks using disordered partners. In
Jidong Liang et al.
Chemosphere, 266, 128984-128984 (2020-11-26)
DNA-stable isotope probing (SIP) with 13C labeled phenanthrene (PHE) as substrate was used to identify specific bacterial degraders during natural attenuation (NA) and bioaugmentation (BA) in petroleum contaminated soil. BA, with the addition of a bacterial suspension mixture named GZ
Giulio Poli et al.
Frontiers in chemistry, 6, 229-229 (2018-07-05)
Herein we present the algorithm and performance assessment of our newly developed conformer generator iCon that was implemented in LigandScout 4.0. Two data sets of high-quality X-ray structures of drug-like small molecules originating from the Protein Data Bank (200 ligands)
Songqing Wu et al.
PloS one, 11(1), e0147855-e0147855 (2016-01-28)
Monochamus alternatus Hope is the main vector in China of the Pine Wilt Disease caused by the pine wood nematode Bursaphelenchus xylophilus. Although chemical control is traditionally used to prevent pine wilt disease, new strategies based in biological control are
Duban García et al.
Environmental science and pollution research international, 27(27), 33890-33902 (2020-06-17)
The search for renewable fuels or components which may improve or replace fossil fuels is an important step towards a sustainable future. In particular, the pine oleoresin produced by conifer trees, which is composed by turpentine oil and non-volatile rosin
Meraj A Khan et al.
Scientific reports, 7, 41749-41749 (2017-02-09)
Neutrophils are short-lived innate immune cells. These cells respond quickly to stimuli, and die within minutes to hours; the relevance of DNA transcription in dying neutrophils remains an enigma for several decades. Here we show that the transcriptional activity reflects
Guokun Yang et al.
Journal of molecular endocrinology, 58(4), 179-191 (2017-03-12)
CTRP9 is a member of the C1q/TNF-related protein (CTRP) superfamily and has been studied in mammals, whereas the comparative studies of CTRP9 in non-mammalian species are still absent. In this study
Keith T Schmidt et al.
Cancer chemotherapy and pharmacology, 86(4), 475-486 (2020-09-09)
NLG207 (formerly CRLX101) is a nanoparticle-drug conjugate (NDC) of the potent topoisomerase I inhibitor, camptothecin (CPT). The present study sought to characterize the complex pharmacokinetics (PK) of NLG207 and better describe CPT release from nanoparticles using a population PK (popPK)
Yuan Liang et al.
International journal of food microbiology, 290, 184-192 (2018-10-23)
The regulatory gene (aflR) encodes AflR, a positive regulator of transcriptional pathway that activates aflatoxin biosynthesis. It has been demonstrated in our laboratory that L-Asp-L-Asn (DN) extracted from Bacillus megaterium inhibited the growth of Aspergillus flavus. We fused gene encoding
V Gopalaswamy et al.
Nature, 565(7741), 581-586 (2019-02-01)
Focusing laser light onto a very small target can produce the conditions for laboratory-scale nuclear fusion of hydrogen isotopes. The lack of accurate predictive models, which are essential for the design of high-performance laser-fusion experiments, is a major obstacle to
Jing Yuan et al.
PLoS genetics, 15(2), e1007934-e1007934 (2019-02-12)
Ovules contain the female gametophytes which are fertilized during pollination to initiate seed development. Thus, the number of ovules that are produced during flower development is an important determinant of seed crop yield and plant fitness. Mutants with pleiotropic effects
Muting Yan et al.
The Science of the total environment, 631-632, 840-848 (2018-05-08)
The Three Gorges Project significantly impacted water quality and ecological balance in this area. The special engineered aquatic environment could be an important reservoir for antibiotic resistance genes (ARGs). Fifteen ARGs corresponding to three groups of antibiotics (tetracyclines, sulfonamides and
Fulin Sun et al.
Applied microbiology and biotechnology, 104(2), 775-783 (2019-11-30)
Although increasing levels of attention have been targeted towards aquaculture-associated bacteria, the bacterial community of animal intestines and its relationship with the aquaculture environment need to be further investigated. In this study, we used high-throughput sequencing to analyze the bacterial
Meenakshi Srinivasan et al.
Journal of clinical pharmacology, 59(9), 1216-1224 (2019-04-12)
The objective of the study was to develop a population pharmacokinetic model of pemetrexed and identify factors contributing to variability in exposure in Indian patients. Plasma samples were obtained from a cohort of 85 patients following 500 mg/m2 intravenous infusion
Chen Zhao et al.
PloS one, 15(11), e0241371-e0241371 (2020-11-21)
Welsh onion (Allium fistulosum L.) constitutes an important plant species cultivated in China due the benefits and applications in different areas. Moreover, nitrogen is an essential nutrient during the growth and development of plant. Here, we present the effects of
Zhiwei Ma et al.
The journal of physical chemistry. B, 125(9), 2288-2298 (2021-03-03)
Rapid identification of inhibitors for a family of proteins and prediction of ligand specificity are highly desirable for structure-based drug design. However, sequentially docking ligands into each protein target with conventional single-target docking methods is too computationally expensive to achieve
Fernanda A H Batista et al.
Journal of enzyme inhibition and medicinal chemistry, 35(1), 639-649 (2020-02-13)
Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (Hsp). These are molecular
1/8