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显示 1-30 共 85 条结果 关于 "p-916" 范围 论文
Roi Isaac et al.
The Journal of biological chemistry, 288(8), 5682-5693 (2013-01-01)
Selective serotonin reuptake inhibitors (SSRIs) are antidepressants used for the treatment of mood and anxiety disorders. Here, we demonstrate that incubation (2 h) of murine islets or Min6 β cell line with the SSRIs paroxetine, fluoxetine, or sertraline inhibited insulin-induced
David Germann et al.
Profiles of drug substances, excipients, and related methodology, 38, 367-406 (2013-05-15)
Paroxetine hydrochloride (3S-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine hydrochloride (or (-)-(3S,4R)-(4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)-phenoxy]methyl]piperidine hydrochloride), a phenylpiperidine derivative, is a selective serotonin reuptake inhibitor. Paroxetine is indicated for the treatment of depression, generalized anxiety disorder, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, and social anxiety disorder. The physicochemical
Teaching an old drug new tricks: can paroxetine ease the burden of cardiovascular disease in diabetes?
Stephen B Wheatcroft
Diabetes, 62(3), 698-700 (2013-02-23)
N Byatt et al.
Acta psychiatrica Scandinavica, 127(2), 94-114 (2012-12-18)
Conflicting data have led to controversy regarding antidepressant use during pregnancy. The objectives of this study are to i) review the risks of untreated depression and anxiety, ii) review the literature on risks of exposure to antidepressants during pregnancy, iii)
Harry G Brittain
Profiles of drug substances, excipients, and related methodology, 38, 407-421 (2013-05-15)
The polymorphic (crystal systems for which a substance can exist in structures defined by different unit cells, and where each of the forms has the same elemental composition) and solvatomorphic (systems where the crystal structures of the substance are defined
Mohamed A El-Nabarawi et al.
International journal of pharmaceutics, 443(1-2), 307-317 (2013-01-23)
Paroxetine (PAX) is the most potent serotonin reuptake blocker antidepressant clinically available. This study is aimed to reduce the side effects accompanied with the initial high plasma concentration after oral administration of PAX and fluctuations in plasma levels and also
Gordana Ristevska-Dimitrovska et al.
Psychiatria Danubina, 25(2), 123-127 (2013-06-26)
A growing body of evidence shows that brain-derived neurotrophic factor (BDNF) plays a role in depressive disorder. Serum BDNF levels are lower in depressed patients and they increase after a long course of antidepressant treatment. Our study aims to test
Michael F Grunebaum et al.
The Journal of clinical psychiatry, 74(9), 872-879 (2013-10-11)
Identifying the depression symptoms most closely associated with suicidal thoughts and which medications provide the fastest depression relief may help suicide prevention. Post hoc analysis of data from a randomized, double-blind, 8-week clinical trial of the selective serotonin reuptake inhibitor
M A Sierra-Rodriguez et al.
Seminars in ophthalmology, 28(4), 244-246 (2013-05-01)
To present a unique case of a 33-year-old woman using paroxetine who presented with acute unilateral visual loss due to chronic angle-closure glaucoma. Case report. A 33-year-old women who had been under paroxetine treatment for the past four months presented
Putting GlaxoSmithKline to the test over paroxetine.
Peter Doshi
BMJ (Clinical research ed.), 347, f6754-f6754 (2013-11-14)
[Posttraumatic stress disorder].
Ruth V Reed et al.
Praxis, 102(1), 45-48 (2013-02-07)
Neelesh Malviya et al.
Acta poloniae pharmaceutica, 70(2), 317-322 (2013-04-26)
The present study aimed to investigate the effect of ethyl acetate fraction of A. cepa bulb on mating behavior in paroxetine-induced sexually dysfunction male rats. Sexual dysfunctions such as decreased libido, delayed orgasm, difficulties in maintaining an erection, and inhibition
Steven G Potkin et al.
Journal of clinical psychopharmacology, 33(1), 3-10 (2013-01-02)
The potential for iloperidone, a D2/5-HT2A antipsychotic, to affect the heart rate-corrected QT interval (QTc) was assessed in the absence and presence of metabolic inhibitors in a randomized, open-label, multicenter study. QT interval prolongation by medications, including both conventional and
Paroxetine approval.
Suzanne M Mahon et al.
The American journal of nursing, 114(1), 10-10 (2013-12-29)
Joannie Poirier-Bisson et al.
The Journal of nervous and mental disease, 201(9), 753-759 (2013-09-03)
The aim of this study was to assess the incremental cost-effectiveness ratios (ICERs) of two brief cognitive-behavioral therapy (CBT)-based interventions and a pharmacological treatment, compared with usual care, initiated in the emergency department (ED) for individuals with panic disorder (PD)
Zenaide S do Monte et al.
Chirality, 25(4), 211-214 (2013-03-28)
A simple, rapid, and sensitive method for the analysis of paroxetine, in tablets as well as the pure drug, by circular dichroism is described. The method was validated for repeatability, linearity, limit of detection, limit of quantification, and recovery according
Zheng-Wu Peng et al.
Molecular and cellular biochemistry, 375(1-2), 105-113 (2013-01-08)
Paroxetine is a widely used antidepressant in clinic. Besides its role in inhibition of serotonin reuptake, resent studies indicate that the increase of hippocampal neurogenesis is also involved in its pharmacology. However, only limited data are available in this regard
David Pubill et al.
Neurotoxicology, 35, 41-49 (2012-12-25)
Nicotine (NIC), the main psychostimulant compound of smoked tobacco, exerts its effects through activation of central nicotinic acetylcholine receptors (nAChR), which become up-regulated after chronic administration. Recent work has demonstrated that the recreational drug 3,4-methylenedioxy-methamphetamine (MDMA) has affinity for nAChR
Jennifer C Naylor et al.
Psychiatry research, 206(2-3), 318-320 (2013-01-02)
Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era
Katarzyna Socała et al.
Pharmacological reports : PR, 64(5), 1259-1266 (2012-12-15)
Sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, has recently been reported to influence the antidepressant activity of some antidepressant drugs. The present study was undertaken to investigate the involvement of the nitric oxide/cyclic guanosine 3',5'-monophosphate/PDE5 (NO/cGMP/PDE5) signaling pathway in the
Arun V Ravindran et al.
Asian journal of psychiatry, 6(2), 157-161 (2013-03-08)
Few published studies have evaluated selective serotonin reuptake inhibitors in dysthymia without current co-morbid major depression. In this 12-week study, 40 dysthymic patients were randomly assigned to either placebo (n=19) or 20-40 mg/day of paroxetine (n=21). At endpoint, the paroxetine
Shvetank Bhatt et al.
Indian journal of experimental biology, 51(6), 435-443 (2013-08-10)
The compound 6o (at 0.5, 1 and 2 mg/kg, ip) with optimum log P and pA2 value, was subjected to forced swim test (FST) and tail suspension test (TST). The compound 6o significantly reduced the duration of immobility in mice
Ryen W White et al.
Journal of the American Medical Informatics Association : JAMIA, 20(3), 404-408 (2013-03-08)
Adverse drug events cause substantial morbidity and mortality and are often discovered after a drug comes to market. We hypothesized that Internet users may provide early clues about adverse drug events via their online information-seeking. We conducted a large-scale study
GSK paid smaller companies to delay generic versions of paroxetine, says fair trade body.
Clare Dyer
BMJ (Clinical research ed.), 346, f2566-f2566 (2013-04-24)
Yukiko Mine et al.
Journal of pharmacological sciences, 121(1), 58-66 (2012-12-22)
Although selective serotonin reuptake inhibitors (SSRIs) are widely used to treat depression, they frequently cause gastrointestinal adverse effects, such as nausea and emesis. In the present study, we investigated the anti-emetic effect of mosapride, a 5-HT(4) receptor agonist, on SSRIs-induced
Sandra Malynn et al.
Neurochemical research, 38(4), 694-704 (2013-01-23)
Pro-inflammatory cytokines have been implicated in the precipitation of depression and related disorders, and the antidepressant sensitive serotonin transporter (SERT) may be a major target for immune regulation in these disorders. Here, we focus on astrocytes, a major class of
Wei-Rong Lin et al.
Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 32(12), 1063-1069 (2013-01-11)
To compare the differences in the efficacy on agitated depression among the alliance therapy of acupuncture and seroxat, the alliance therapy of electroacupuncture and seroxat and the simple application of seroxat. One hundred and two cases were randomized into a
Akiko Mikami et al.
International journal of clinical pharmacology and therapeutics, 51(5), 374-382 (2013-01-30)
To develop a pharmacokinetic model able to describe the nonlinear pharmacokinetics of paroxetine (PRX) and to predict the drug-drug interaction between PRX and metoprolol under various dosage regimens. A pharmacokinetic model of PRX incorporating mechanism-based inhibition was developed. This model
Adam S Kamlet et al.
PloS one, 8(3), e59187-e59187 (2013-04-05)
New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of modern reactions from the stage of synthetic chemistry development to
Neil M Davies et al.
Journal of clinical epidemiology, 66(12), 1386-1396 (2013-10-01)
To investigate whether physicians' prescribing preferences were valid instrumental variables for the antidepressant prescriptions they issued to their patients. We investigated whether physicians' previous prescriptions of (1) tricyclic antidepressants (TCAs) vs. selective serotonin reuptake inhibitors (SSRIs) and (2) paroxetine vs.
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