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M Fukahori et al.
Chemical & pharmaceutical bulletin, 44(12), 2335-2337 (1996-12-01)
The effects of the structures of non-ionic surfactants on the uptake of butyl p-hydroxybenzoate (BP) into Escherichia coli cells and its antibacterial activity were systematically studied using polyoxyethylene alkyl ethers (PAEs) possessing various oxyethylene and hydrocarbon chain lengths. The uptake
Maria E N P Ribeiro et al.
International journal of pharmaceutics, 436(1-2), 631-635 (2012-07-31)
The aim of this study was to investigate the potential of selected Brij non-ionic surfactants for enhancing the solubility of poorly water-soluble drugs. Griseofulvin was selected as a model drug candidate enabling comparisons to be made with the solubilisation capacities
S Rahima Benhabbour et al.
Journal of controlled release : official journal of the Controlled Release Society, 158(1), 63-71 (2011-11-01)
Lipid-based oil-filled nanoparticles (NPs) with a high concentration of surface-chelated nickel (Ni-NPs) were successfully prepared using a Brij 78-NTA-Ni conjugate synthesized with Brij 78 (Polyoxyethylene (20) stearyl ether) and nitrilotriacetic acid (NTA). The facile incorporation of the Brij 78-NTA-Ni conjugate
L Realini et al.
Journal of clinical microbiology, 35(11), 2791-2794 (1997-11-14)
We report on the influences of polyoxyethylene stearate (POES), PANTA, and pH on primary cultures of Mycobacterium genavense in BACTEC vials. As a model for primary cultures from tissue, seven different strains first isolated from AIDS patients (five from Switzerland
Genki Akanuma et al.
FEMS microbiology letters, 339(1), 48-56 (2012-11-24)
Extracellular lipase activity from Ralstonia sp. NT80 is induced significantly by fatty alcohols such as stearyl alcohol. We found that when lipase expression was induced by stearyl alcohol, a 14-kDa protein (designated EliA) was produced concomitantly and abundantly in the
S X Liu et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 11(3), 279-282 (1995-01-01)
Although sufficient amount of glucagon can be taken up into systemic circulation through ocular route, the concentration of eyedrops needed at 7.5% would be too high and the price of the doses would be too expensive to be desirable. Attempts
Jingling Tang et al.
Biomacromolecules, 14(2), 424-430 (2013-01-15)
Multidrug resistance (MDR) is a major barrier to the chemotherapy treatment of many cancers. However, some nonionic surfactants, for example, Brij, have been shown to restore the sensitivity of MDR cells to such drugs. The aim of this study was
Christian Klammt et al.
Journal of structural biology, 158(3), 482-493 (2007-03-14)
G-protein coupled receptors (GPCRs) are key elements in signal transduction pathways of eukaryotic cells and they play central roles in many human diseases. So far, most structural and functional approaches have been limited by the immense difficulties in the production
Zhengrong Cui et al.
The Journal of pharmacy and pharmacology, 54(9), 1195-1203 (2002-10-03)
Intranasal immunization offers potential forthe elicitation of effective mucosal and systemic immune responses. In this study, a previously reported novel cationic nanoparticle engineered from a microemulsion precursor was further modified, optimized and applied intranasally to mice to explore its potential
Highly enantioselective epoxidation of 2,4-diarylenones by using dimeric cinchona phase-transfer catalysts: enhancement of enantioselectivity by surfactants.
Sang-Sup Jew et al.
Angewandte Chemie (International ed. in English), 44(9), 1383-1385 (2005-01-25)
Lingyan Song et al.
Journal of colloid and interface science, 328(2), 374-384 (2008-10-17)
Patternable nanoporous silica thin films with pore sizes on multiple length scales are fabricated using preformed block copolymer/homopolymer blend films as templates. Previous work by Tirumala et al. [V.R. Tirumala, R.A. Pai, S. Agarwal, J.J. Testa, G. Bhatnagar, A.H. Romang
X Dong et al.
Drug development and industrial pharmacy, 32(8), 973-980 (2006-09-07)
Fatty alcohols are commonly used in lipid-based drug delivery systems including parenteral emulsions and solid lipid nanoparticles (NPs). The purpose of these studies was to determine whether horse liver alcohol dehydrogenase (HLADH), a NAD-dependent enzyme, could metabolize the fatty alcohols
Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations
Xiong W, et al.
Carbohydrate Polymers, 204, 89-96 (2019)
P Bogner et al.
Cell biology international, 20(11), 741-749 (1996-11-01)
Exchange of erythrocyte intracellular (i/c) K+ for extracellular (e/c) Na+ in human erythrocytes treated with sub-CMC concentrations of the non-ionic detergent Brij 58 can be stopped by reincubation in serum or albumin containing solutions. The progressive equilibration of the K+
J P Lens et al.
Journal of biomaterials science. Polymer edition, 8(12), 963-982 (1997-01-01)
Alkyl-poly(ethylene oxide) (PEO) surfactants containing a terminal hydroxyl, sulfate, or carboxylate group were grafted at the surface of poly(ethylene) (PE) samples to improve their blood compatibility. Grafting was achieved by immobilizing PEO surfactants on PE using an argon plasma treatment.
Joanna M Koziara et al.
Journal of controlled release : official journal of the Controlled Release Society, 99(2), 259-269 (2004-09-24)
Despite the advances in tumor therapy, patients with primary brain tumors and brain metastases have a very poor prognosis. Low responses to chemotherapy are mainly attributed to impermeability of the blood-brain barrier to cytotoxic agents. Paclitaxel has been shown to
Woraporn Sukhumavasi et al.
Journal of immunology (Baltimore, Md. : 1950), 181(5), 3464-3473 (2008-08-21)
TLR adaptor MyD88 activation is important in host resistance to Toxoplasma gondii during i.p. infection, but the function of this signaling pathway during oral infection, in which mucosal immunity assumes a predominant role, has not been examined. In this study
Tatsuaki Tagami et al.
Journal of controlled release : official journal of the Controlled Release Society, 161(1), 142-149 (2012-04-17)
Here we report the development of an enhanced thermosensitive formulation composed of DPPC and Brij78, loaded with doxorubicin (DOX) using a Cu²⁺ gradient and post-inserted with an additional amount of Brij78. This optimal formulation (HaT-II: Hyperthermia-activated cytoToxic) displayed significantly improved
Jigna D Patel et al.
Pharmaceutical research, 24(2), 343-352 (2006-12-21)
The purpose of these studies was to prepare nanoparticles (NPs) with a small amount of surface-chelated nickel for obtaining enhanced binding of histidine-tagged (his-tag) proteins compared to non-histidine-tagged protein binding to charged nanoparticles. NPs were prepared from oil-in-water microemulsion precursors
Tailored microcrystal growth: a facile solution-phase synthesis of gold rings.
Hyojong Yoo et al.
Advanced materials (Deerfield Beach, Fla.), 23(38), 4431-4434 (2011-10-01)
Tatsuaki Tagami et al.
Journal of controlled release : official journal of the Controlled Release Society, 152(2), 303-309 (2011-02-23)
We have developed a novel and simplified thermosensitive liposomal formulation (HaT: Hyperthermia-activated cytoToxic) composed of DPPC lipid and Brij78 (96:4, molar ratio). The HaT nanoparticles were loaded with doxorubicin (DOX) with >95% efficiency when a pH gradient method and a
N Albertson et al.
Journal of clinical microbiology, 36(5), 1232-1235 (1998-05-09)
The gastrointestinal pathogen Helicobacter pylori requires supplementation with either fetal calf serum (FCS), bovine serum albumin (BSA), or (2,6-dimethyl)-beta-cyclodextrin (CD) for growth in a complex or defined medium. Because the availability of medium in which all components were chemically defined
Y C Lee et al.
Journal of pharmaceutical sciences, 86(4), 430-433 (1997-04-01)
An ocular insert is developed for the controlled systemic delivery of insulin. Commercially available Gelfoam absorbable gelatin sponge, USP, is used in the fabrication of the ocular insert in the form of a matrix system. Two eyedrop formulations and 13
Anne Huhtala et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 19(1), 11-21 (2003-03-22)
This study was undertaken to investigate the use of the in vitro test WST-1, an assay of cell proliferation and viability, for a preliminary safety evaluation of topical ophthalmic preparations. The cytotoxicity of two surfactants, benzalkonium chloride (BAC) and polyoxyethylene-20-stearyl
Tresyl-based conjugation of protein antigen to lipid nanoparticles increases antigen immunogenicity.
Anekant Jain et al.
International journal of pharmaceutics, 401(1-2), 87-92 (2010-09-15)
The present studies were aimed at investigating the engineering of NPs with protein-conjugated-surfactant at their surface. In order to increase the immunogenicity of a protein antigen, Brij 78 was functionalized by tresyl chloride and then further reacted with the primary
Nanostructured lipid carriers as promising delivery systems for plant extracts: The case of silymarin
Piazzini V, et al.
Applied Sciences, 8(7), 1163-1163 (2018)
S O Williams et al.
Drug development and industrial pharmacy, 26(1), 71-77 (2000-04-01)
The purpose of this study was to scale up an oil/water (o/w) cream formulation containing 40% diethylene glycol monoethyl ether (DGME), developed via 300-g laboratory batches in a 2(5-2) fractional factorial design, to 7-kg batch sizes in a Brogli-10 homogenizer.
Jae-Haeng Song et al.
Drug development and industrial pharmacy, 35(8), 897-903 (2009-02-26)
The oral administration of loratadine, an antihistamine, can have a variety of adverse side effects, such as headache, fatigue, and nausea, because of the transient high blood concentration. To avoid these effects, loratadine can be administered using a transdermal drug
Wei Xiong et al.
International journal of nanomedicine, 13, 3781-3793 (2018-07-11)
Berberine (BBR) is a plant-derived benzylisoquinoline alkaloid and has been demonstrated to be a potential treatment for various chronic diseases. The poor water solubility and P-glycoprotein (Pgp)-mediated drug efflux are the main challenges for its further application in a clinical
J Q Zhang et al.
Drug delivery, 14(6), 381-387 (2007-08-19)
The study describes the development of stealth solid lipid nanoparticles (SLNs) as colloidal carriers for silibinin, a drug with very low solubility. Stealth SLNs were constituted mainly of bioacceptable and biodegradable lipids, such as stearic acid and surfactant Brij 78
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