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Tinsay A Woreta et al.
The Medical clinics of North America, 98(1), 1-16 (2013-11-26)
The routine use of serum biochemical tests allows for the detection of acute and chronic liver injury before the onset of symptoms. These tests consist of markers of hepatocellular injury (aminotransferases and APs); tests of liver metabolism (total bilirubin); and
Leilei Pan et al.
Toxicology letters, 225(1), 34-42 (2013-12-05)
Although fluoride is known to stimulate bone formation, the underlying mechanisms are not fully understood. Recent studies have implicated the Wnt/β-catenin pathway as a major signaling cascade in bone biology. Our earlier studies highlighted a probable role of canonical Wnt
Maira Souza Oliveira et al.
Toxicology letters, 224(3), 380-386 (2013-12-03)
Doxorubicin (dox) is an effective chemotherapeutic agent that leads to cardiotoxicity. An alternative treatment for dox-cardiotoxicity is autologous mesenchymal stem cells (MSCs) transplantation. It remains unclear if dox has deleterious effects on MSCs from subjects under chemotherapy, therefore this study
Yang Lei et al.
Experimental cell research, 323(1), 198-208 (2014-01-23)
Vascular calcification can be categorized into two different types. Intimal calcification related to atherosclerosis and elastin-specific medial arterial calcification (MAC). Osteoblast-like differentiation of vascular smooth muscle cells (VSMCs) has been shown in both types; however, how this relates to initiation
M D McKee et al.
Journal of dental research, 92(8), 721-727 (2013-05-23)
Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood. Tissue-nonspecific alkaline phosphatase (TNAP, ALPL) regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix; mice without TNAP
E Varga et al.
Experimental cell research, 322(2), 335-344 (2014-02-25)
One goal of research using induced pluripotent stem cell (iPSC) is to generate patient-specific cells which can be used to obtain multiple types of differentiated cells as disease models. Minimally or non-integrating methods to deliver the reprogramming genes are considered
Qian Xiao et al.
Hepatology (Baltimore, Md.), 60(6), 2091-2098 (2014-08-16)
Coffee may have hepatoprotective effects and higher coffee consumption has been associated inversely with levels of liver enzymatic markers. However, it is unclear whether decaffeinated coffee is also associated with liver enzymes. The study population included 27,793 participants, age 20
V Ia Berezovs'kyĭ et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(2), 47-51 (2013-07-05)
Our purpose was to investigate the oxygen partial pressure changes on the osteometric and biochemical markers of bone tissue in rats. It was shown that breathing of altered gas mixture did not change the mass, general length, sagittal diameter and
Eva-Maria Katzenmaier et al.
Anticancer research, 34(10), 5429-5438 (2014-10-03)
The physiological compound sodium butyrate can induce differentiation in colon cancer cells in vitro. Due to the role of galectins in growth control we explored its effect on this network beyond galectins-1 and -3, with deliberate consideration of the status
Biochemistry. Trigger factor flexibility.
Martin Gamerdinger et al.
Science (New York, N.Y.), 344(6184), 590-591 (2014-05-09)
Aja Aravamudhan et al.
Journal of biomedical nanotechnology, 9(4), 719-731 (2013-04-30)
Scaffold based bone tissue engineering (BTE) has made great progress in regenerating lost bone tissue. Materials of natural and synthetic origin have been used for scaffold fabrication. Scaffolds derived from natural polymers offer greater bioactivity and biocompatibility with mammalian tissues
Timothy M Chlon et al.
Journal of virology, 88(19), 11315-11326 (2014-07-18)
DNA repair plays a crucial role in embryonic and somatic stem cell biology and cell reprogramming. The Fanconi anemia (FA) pathway, which promotes error-free repair of DNA double-strand breaks, is required for somatic cell reprogramming to induced pluripotent stem cells
Masafumi Tomita et al.
Toxicology, 319, 63-68 (2014-03-04)
There is a close relationship between the central nervous system activity and bone metabolism. Therefore, methamphetamine (METH), which stimulates the central nervous system, is expected to affect bone turnover. The aim of this study was to investigate the role of
Ryosuke Yamaguchi et al.
Rheumatology (Oxford, England), 53(12), 2191-2195 (2014-06-25)
The aim of this study was to compare the levels of bone and cartilage metabolism markers in the synovial fluid of the hip joint between patients with secondary OA due to osteonecrosis of the femoral head (ONFH), rapidly destructive arthrosis
Studies on calf-intestinal alkaline phosphatase. I. Chromatographic purification, microheterogeneity and some other properties of the purified enzyme.
L ENGSTROM
Biochimica et biophysica acta, 52, 36-48 (1961-09-02)
Fabiano Ribeiro Cirano et al.
The Journal of oral implantology, 40(6), 655-659 (2014-12-17)
This study analyzed the role of recombinant human bone morphogenetic protein 2 (rhBMP-2) and recombinant human bone morphogenetic protein 7 (rhBMP-7) in the adhesion and differentiation of rat osteoblast-like (osteo-1) cells cultured on chemically modified titanium surfaces. Osteo-1 cells were
Alexandra M Roch et al.
Annals of surgery, 260(4), 680-688 (2014-09-10)
As such, the natural history of MPD-involved IPMN is poorly understood. The high-risk of malignancy associated with main pancreatic duct (MPD)-involved intraductal papillary mucinous neoplasm (IPMN) has been established by surgical series. The International Consensus Guidelines recommend surgical resection of
Jun Murotsuki
Clinical calcium, 23(12), 1784-1788 (2013-12-03)
Three types of fetal therapy of skeletal dysplasias, as enzyme replacement, in utero stem cell transplantation, and gene therapy, are reviewed. Clinical trial of recombinant ALP for infantile hypophosphatasia has already started in Japan. In future, such enzyme replacement therapy
Zhao Shifang et al.
Journal of biomedical nanotechnology, 10(7), 1313-1319 (2014-05-09)
The aim of this study was to deposit simvastatin-hydroxyapatite (sim-HA) coatings on titanium surfaces by an electrochemical process and evaluate osteoprogenitor cell responses to sim-HA-coated surfaces. Simvastatin was prepared onto titanium surfaces with varying concentration (10(-7), 10(-6), 10(-5) and 10(-4)
Kanakaraju Kaliannan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 7003-7008 (2013-04-10)
Metabolic syndrome comprises a cluster of related disorders that includes obesity, glucose intolerance, insulin resistance, dyslipidemia, and fatty liver. Recently, gut-derived chronic endotoxemia has been identified as a primary mediator for triggering the low-grade inflammation responsible for the development of
Ilhan Bayhan et al.
The Journal of reproductive medicine, 58(7-8), 319-323 (2013-08-21)
To assess the association between leptin levels and bone mineral density (BMD) and bone metabolism markers in postmenopausal women taking strontium ranelate. In this longitudinal uncontrolled study, postmenopausal osteoporotic women were administered strontium ranelate and categorized into 1 of 2
Si Chen et al.
Toxicology, 322, 78-88 (2014-05-29)
Sertraline is used for the treatment of depression, and is also used for the treatment of panic, obsessive-compulsive, and post-traumatic stress disorders. Previously, we have demonstrated that sertraline caused hepatic cytotoxicity, with mitochondrial dysfunction and apoptosis being underlying mechanisms. In
Yuki Matsushita et al.
The Journal of biological chemistry, 288(27), 19973-19985 (2013-05-09)
CCN3, a member of the CCN protein family, inhibits osteoblast differentiation in vitro. However, the role of CCN3 in bone regeneration has not been well elucidated. In this study, we investigated the role of CCN3 in bone regeneration. We identified
Douglas C Bauer et al.
JAMA internal medicine, 174(7), 1126-1134 (2014-05-07)
Discontinuation of bisphosphonate therapy after 3 to 5 years is increasingly considered, but methods to monitor fracture risk after discontinuation have not been established. To test methods of predicting fracture risk among women who have discontinued alendronate therapy after 4
Kh Iu Nedoshytko
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 154-162 (2014-02-01)
The state of antioxidant system and fatty acid composition of lipids in the liver tissues of rats of different sex at the ethanol and tetracycline action and at the influence of biologically active additives (BAA) "Alpha + Omega" at a
Alkaline phosphatase of milk. 2. Purification of the enzyme.
R K MORTON
The Biochemical journal, 55(5), 795-800 (1953-12-01)
T Kajikawa et al.
Journal of dental research, 93(4), 400-405 (2014-01-24)
PLAP-1/asporin is an extracellular matrix protein that is predominantly expressed in the human periodontal ligament (PDL) and has an aspartic acid (D) repeat polymorphism in its N-terminal region. In this study, we hypothesized that the D repeat polymorphism of PLAP-1/asporin
Samir K Gupta et al.
Journal of acquired immune deficiency syndromes (1999), 64(3), 279-283 (2013-11-28)
We performed a randomized controlled trial in 30 HIV-infected participants to either continue tenofovir/emtricitabine/efavirenz (Continuation Group) or switch to tenofovir/emtricitabine/raltegravir (Switch Group) for 24 weeks. There were no significant differences in the changes in flow-mediated dilation, 25(OH) vitamin D, or
N Kurtoglu-Aksoy et al.
Clinical and experimental obstetrics & gynecology, 41(2), 149-153 (2014-05-02)
Premature ovarian failure (POF) is the cessation of ovarian function before the age of 40. The loss of ovarian function, whether premature or not, has an overwhelming impact on female skeletal health, leading to an increased risk of developing osteoporosis
Asim F Choudhri et al.
The Journal of nutrition, 144(12), 1920-1927 (2014-10-25)
Despite advances in nutritional support and intensive care, preterm infants are at higher risk of compromised neurodevelopment. This study evaluated the contribution of total parenteral nutrition (PN) to compromised neurodevelopment after preterm birth. Preterm pigs were provided PN or enteral
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