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[Penicillamine-induced myasthenia gravis].
H Nishida et al.
Ryoikibetsu shokogun shirizu, (36)(36), 351-353 (2001-10-13)
Curtis R Chong et al.
Journal of medicinal chemistry, 50(22), 5524-5527 (2007-10-09)
The antiarthritis drug D-penicillamine (D-PEN) catalyzes zinc(II) transfer from carboxypeptidase A to chelators such as thionein and EDTA at a rate constant up to 400-fold faster than the uncatalyzed release. Once D-PEN releases zinc(II) from enzyme stronger chelators can tightly
Gursimran Chandhok et al.
PloS one, 9(6), e98809-e98809 (2014-06-04)
Mutations in the copper (Cu) transporter gene ATP7B, the primary cause of Wilson disease (WD), result in high liver Cu and death of hepatocytes. Cu chelators and zinc salts are the two most important drugs used in the treatment of
Charles Banliat et al.
International journal of molecular sciences, 21(15) (2020-07-31)
Oviduct fluid extracellular vesicles (oEVs) have been proposed as bringing key molecules to the early developing embryo. In order to evaluate the changes induced by oEVs on embryo phospholipids, fresh bovine blastocysts developed in vitro in the presence or absence
T Litwin et al.
Neurologia i neurochirurgia polska, 47(5), 502-506 (2013-10-30)
The authors present the case of a 19-year-old patient with Wilson disease (WD) who developed symptoms of acute focal dystonia of the left hand (a 'starfish' hand presentation) shortly after treatment with the tricyclic antidepressant clomipramine. The diagnosis of WD
Paria Pashazadeh-Panahi et al.
Journal of molecular recognition : JMR, 33(5), e2828-e2828 (2020-02-27)
In this study, d-penicillamine-functionalized graphene quantum dots (DPA-GQD) has been synthesized, which significantly increases the fluorescence intensity of GQD. We used this simple fluorescent probe for metal ions detection in human plasma samples. Designed DPA-GQD respond to Hg2+ , Cu2+
D L Phelps et al.
The Cochrane database of systematic reviews, (1)(1), CD001073-CD001073 (2001-05-02)
Retinopathy of prematurity remains a common problem. A low rate of this disorder was unexpectedly observed among infants treated with intravenous d-penicillamine to prevent hyperbilirubinemia. This observation led to the investigation of its use to prevent retinopathy of prematurity. To
Lucía Martí-Prats et al.
Psychopharmacology, 232(19), 3597-3606 (2015-07-15)
Previous experiments in our laboratory have shown that D-penicillamine (DP) (acetaldehyde sequestering agent) is able to block the increase in ethanol consumption observed after a period of imposed deprivation (the so-called alcohol deprivation effect (ADE)), using a non-operant paradigm in
Takeki Uehara et al.
Molecular nutrition & food research, 54(2), 218-227 (2009-12-31)
Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to
Diego F Carrillo-González et al.
Tropical animal health and production, 52(5), 2559-2565 (2020-05-23)
The in vitro embryo production industry in the actual world presents some difficulties related to low embryonic production rates, a problem that could be associated with in vitro culture conditions that differed from the in vivo (oviductal) conditions, mainly related
Benedetto Natalini et al.
Methods in molecular biology (Clifton, N.J.), 970, 191-208 (2013-01-04)
Chiral ligand-exchange chromatography (CLEC) first described in the late 1960s to early 1970s by Davankov and Rogozhin can be still considered as an elective choice for the direct enantioseparation of compounds endowed with chelating moieties. Among the numerous chelating species
R Gotti et al.
Journal of chromatography. A, 844(1-2), 361-369 (2000-01-15)
The ability of capillary zone electrophoresis in the development of analytical methods devoted to the quality control of the thiol drug penicillamine is shown. Using 50 mM phosphate running buffer (pH 2.5), good quantitations of underivatized penicillamine and its disulfide
Seyedeh Missagh Jalali et al.
Toxicology and industrial health, 33(6), 512-518 (2017-01-11)
This study was performed to assess hepatotoxicity and alterations in liver antioxidant defence in acute lead (Pb) exposure and the protective effects of silymarin in comparison to D-penicillamine in rats. Forty eight Albino rats were divided in eight groups and
Vera Kuznetsova et al.
Nanomaterials (Basel, Switzerland), 10(8) (2020-08-14)
Nowadays, multiplex analysis is very popular, since it allows to detect a large number of biomarkers simultaneously. Traditional multiplex analysis is usually based on changes of photoluminescence (PL) intensity and/or PL band spectral positions in the presence of analytes. Using
Hon-Lok Tang et al.
Clinical nephrology, 79(4), 326-329 (2013-03-30)
Mercury is a known cause of nephrotic syndrome and the underlying renal pathology in most of the reported cases was membranous nephropathy. We describe here 4 cases of minimal change disease following exposure to mercury-containing skin lightening cream for 2
Sebastian J Sciegienka et al.
Free radical biology & medicine, 108, 354-361 (2017-04-09)
D-penicillamine (DPEN), a copper chelator, has been used in the treatment of Wilson's disease, cystinuria, and rheumatoid arthritis. Recent evidence suggests that DPEN in combination with biologically relevant copper (Cu) concentrations generates H
Maria A Saracino et al.
Talanta, 103, 355-360 (2012-12-04)
D-penicillamine is a thiol drug mainly used for Wilson's disease, rheumatoid arthritis and cystinuria. Adverse effects during normal use of the drug are frequent and may include skin lesions. To evaluate its toxic effects in clinical cases an original method
A copper for your thoughts.
Robert A Coates
Journal of insurance medicine (New York, N.Y.), 43(2), 112-115 (2012-08-11)
Kessarin Ngamdee et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 211, 313-321 (2018-12-24)
A highly selective circular dichroism sensor based on cysteamine-capped cadmium sulfide quantum dots (Cys-CdS QDs) was successfully developed for the determination of Cu2+. Basically, the Cys-CdS QDs are not active in circular dichroism spectroscopy. However, the circular dichroism probe (DPA@Cys-CdS
Y Gong et al.
Alimentary pharmacology & therapeutics, 24(11-12), 1535-1544 (2007-01-09)
D-Penicillamine is used for patients with primary biliary cirrhosis due to its ability to decrease hepatic copper and modulate the immune response. The results on effects of D--penicillamine in randomized-clinical trials of primary biliary cirrhosis patients are inconsistent. To systematically
Wenge Jiang et al.
Nature communications, 10(1), 2318-2318 (2019-05-28)
Since Pasteur first successfully separated right-handed and left-handed tartrate crystals in 1848, the understanding of how homochirality is achieved from enantiomeric mixtures has long been incomplete. Here, we report on a chirality dominance effect where organized, three-dimensional homochiral suprastructures of
Ding-Bang Chen et al.
PloS one, 7(5), e37709-e37709 (2012-05-26)
Wilson disease (WD) is characterized by the accumulation of copper arising from a mutation in the ATP7B gene. Penicillamine (PA) makes 10-50% of the patients with neurologic symptoms neurologically worse at the early stage of administration. The aim of this
A Boehler et al.
The European respiratory journal, 9(6), 1317-1319 (1996-06-01)
D-penicillamine-associated bronchiolitis obliterans (BO) is a rare but well-known pulmonary complication in patients with rheumatoid arthritis or progressive systemic sclerosis. It has been assumed that in most, if not all cases, BO is a complication of the underlying disease rather
Stephen Chan et al.
Food chemistry, 199, 185-194 (2016-01-19)
Various food constituents have been proposed as disease-modifying agents for Alzheimer's disease (AD), due to epidemiological evidence of their beneficial effects, and for their ability to ameliorate factors linked to AD pathogenesis, namely by: chelating iron, copper and zinc; scavenging
J Karpinski et al.
American journal of nephrology, 17(6), 528-532 (1997-01-01)
Therapeutic use of D-penicillamine has been associated with a range of adverse effects. We present a patient with scleroderma, treated with D-penicillamine for 5 years, who developed severe renal failure due to rapidly progressive glomerulonephritis with both crescents and subepithelial
Ana Gomes et al.
Bioorganic & medicinal chemistry, 15(18), 6027-6036 (2007-07-13)
2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of
E Carlos Rodriguez-Merchan
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 51(6), 772-776 (2012-07-13)
Hemophilia is an inherited recessive, sex-linked bleeding disorder. The lack of sufficient coagulation factor VIII produces hemophilia A, and the lack of factor IX causes hemophilia B. The prevention and treatment of the disease requires intravenous infusion of the deficient
Danuta Gillner et al.
Bioorganic & medicinal chemistry letters, 19(22), 6350-6352 (2009-10-14)
The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) is a critical bacterial enzyme for the construction of the bacterial cell wall. A screen biased toward compounds containing zinc-binding groups (ZBG's) including thiols, carboxylic acids, boronic acids, phosphonates and hydroxamates has delivered a
D E Furst et al.
Scandinavian journal of rheumatology, 30(4), 189-191 (2001-10-02)
Based on open studies. D-penicillamine (DPA) has been used for the treatment of systemic sclerosis (SSc) but we believe the controlled trial of this drug in SSc does not support its use to treat this disease. Open trials are inevitably
M L Schilsky
Current gastroenterology reports, 3(1), 54-59 (2001-02-15)
New options are available for the medical treatment of patients with Wilson's disease. Penicillamine is no longer the treatment of choice, as there is a growing experience with safer and more effective alternatives. Trientine may be the best choice for
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