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Thomas Jank et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(7), 2789-2802 (2015-03-19)
The bacterial toxin Photorhabdus asymbiotica toxin (PaTox) modifies Rho proteins by tyrosine GlcNAcylation and heterotrimeric Gα proteins by deamidation. Inactivation of Rho proteins results in F-actin disassembly in host cells. Here, we analyzed the subcellular distribution of PaTox and show
Nan Nan et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 53(9), 943-949 (2014-01-01)
Phage infection could seriously influence cell growth and metabolism in the fermentation of 1,3-propanediol from glycerol by Klebsiella pneumoniae. Isolation of the Klebsiella pneumoniae phage and research on its physiological characteristics would be of great significance. A K. pneumoniae phage
Jordi Loscos et al.
International ophthalmology, 35(5), 693-699 (2015-01-31)
The aim was to report the results of deep sclerectomy (DS) with supraciliary hema implant and the influence of the surgical complications on intraocular pressure (IOP). Forty-eight eyes of 41 patients with open angle glaucoma (OAG), who underwent DS with
Kumiko Takemori et al.
Life sciences, 120, 48-53 (2014-12-03)
To determine the prophylactic effects of an elastin peptide derived from the bulbus arteriosus of bonitos and prolylglycine (PG), a degradation product of elastin peptide, on vascular dysfunction in spontaneously hypertensive rats (SHRs). Male 15-week-old SHR/Izm rats were fed without
Zhiyuan Shi et al.
Tissue engineering. Part A, 21(15-16), 2186-2194 (2015-05-09)
To investigate the efficacy of recombinant adeno-associated virus (rAAV)-human telomerase reverse transcriptase (hTERT)-transducted nucleus pulposus cells (NPCs) in disc degeneration process in a canine disc degeneration model. The intervertebral disc degeneration of lumbar (L) 1-2, L3-4, and L5-6, from 12
Faiyaz Shakeel et al.
Food chemistry, 180, 244-248 (2015-03-15)
The solubility of vanillin in ten different environmentally benign solvents namely water, ethanol, ethylene glycol (EG), ethyl acetate (EA), isopropanol (IPA), propylene glycol (PG), polyethylene glycol-400 (PEG-400), Transcutol, butanol-1 and butanol-2 was measured and correlated at T=(298-318)K. The resulting experimental
Nan Deng et al.
BMC immunology, 15, 57-57 (2014-12-10)
To understand the role of genetic factors on chromosome 1 in the regulation of spontaneous arthritis in mice deficient in IL-1 receptor antagonist protein (IL_1RA), we previously used speed congenic breeding to transfer the QTL region from DBA/1(-/-) mice that
Naila El Kechai et al.
International journal of pharmaceutics, 487(1-2), 187-196 (2015-04-18)
The aim of this work was to thoroughly study the effect of liposomes on the rheological and the syringeability properties of hyaluronic acid (HA) hydrogels intended for the local administration of drugs by injection. Whatever the characteristics of the liposomes
Twishi Gulati et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(12), 1769-1775 (2015-07-03)
Our laboratory has demonstrated that bone morphogenetic protein 13 prevented the effects of annular injury in an ovine model, maintaining intervertebral disc height, cell numbers and increasing extracellular matrix production compared to degenerated controls. The present study sought to examine
Kazumasa Hirata et al.
International journal of pharmaceutics, 477(1-2), 416-420 (2014-10-12)
Skin penetration enhancers (SPEs) are commonly employed in pharmaceutical and personal care products. These compounds transiently alter the barrier properties of the skin and we have previously investigated the effects of specific SPEs on skin barrier function in vivo. In
C Neubauer et al.
Geobiology, 13(5), 443-453 (2015-04-30)
The sedimentary record of molecular fossils (biomarkers) can potentially provide important insights into the composition of ancient organisms; however, it only captures a small portion of their original lipid content. To interpret what remains, it is important to consider the
F Mousseau et al.
Langmuir : the ACS journal of surfaces and colloids, 31(26), 7346-7354 (2015-06-16)
We report on the interaction of pulmonary surfactant composed of phospholipids and proteins with nanometric alumina (Al2O3) in the context of lung exposure and nanotoxicity. We study the bulk properties of phospholipid/nanoparticle dispersions and determine the nature of their interactions.
P Siafaka et al.
Journal of materials science. Materials in medicine, 26(12), 275-275 (2015-11-07)
The aim of this study was the preparation of novel polyester nanoparticles based on folic acid (FA)-functionalized poly(ethylene glycol)-poly(propylene succinate) (PEG-PPSu) copolymer and loaded with the new anticancer drug ixabepilone (IXA). These nanoparticles may serve as a more selective (targeted)
Bin-Xian Zhang et al.
Tissue engineering. Part A, 21(9-10), 1611-1620 (2015-01-28)
Salivary gland hypofunction often results from a number of causes, including the use of various medications, radiation for head and neck tumors, autoimmune diseases, diabetes, and aging. Since treatments for this condition are lacking and adult salivary glands have little
Torbjørn Olshøj Jensen et al.
Journal of industrial microbiology & biotechnology, 39(5), 709-717 (2012-01-04)
Clostridium pasteurianum can utilize glycerol as the sole carbon source for the production of butanol and 1,3-propanediol. Crude glycerol derived from biodiesel production has been shown to be toxic to the organism even in low concentrations. By examination of different
A Gore et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(2), 301-310 (2015-05-10)
Eye exposure to the extremely toxic organophosphorus sarin results in long-term miosis and visual impairment. As current treatment using atropine or homatropine eye drops may lead to considerable visual side effects, alternative combined treatments of intramuscular (im) oximes (16.8 µmol/kg, im)
Karol Kadlec et al.
Talanta, 147, 44-49 (2015-11-26)
The novel approach for hydroxyapatite (HA) surface characterization was proposed. The main aim of this investigation was to estimate surface properties of HA as a biomaterial in real system i.e. in simulated body fluid (SBF). One of the method, which
R K Saxena et al.
Biotechnology advances, 27(6), 895-913 (2009-08-12)
1,3-Propanediol, a valuable bifunctional molecule, can be produced from renewable resources using microorganisms. It has several promising properties for many synthetic reactions, particularly for polymer and cosmetic industries. By virtue of being a natural product, relevant biochemical pathways can be
Julie Wang et al.
Circulation, 132(20), 1909-1919 (2015-09-30)
Although vascular smooth muscle cell (VSMC) proliferation is implicated in atherogenesis, VSMCs in advanced plaques and cultured from plaques show evidence of VSMC senescence and DNA damage. In particular, plaque VSMCs show shortening of telomeres, which can directly induce senescence.
Tao Tu et al.
PloS one, 10(9), e0135413-e0135413 (2015-09-04)
Intramolecular mobility and conformational changes of flexible loops have important roles in the structural and functional integrity of proteins. The Achaetomium sp. Xz8 endo-polygalacturonase (PG8fn) of glycoside hydrolase (GH) family 28 is distinguished for its high catalytic activity (28,000 U/mg).
Luiz F Ferrari et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(15), 6107-6116 (2015-04-17)
Hyperalgesic priming, a form of neuroplasticity in nociceptors, is a model of the transition from acute to chronic pain in the rat, which involves signaling from the site of an acute tissue insult in the vicinity of the peripheral terminal
Yu Liu et al.
Physical chemistry chemical physics : PCCP, 17(12), 8258-8265 (2015-03-04)
Thin films of molecular gels formed in a confined space have potential applications in transdermal delivery, artificial skin, molecular electronics, etc. The microstructures and properties of thin gel films can be significantly different from those of their bulk counterparts. However
Lijuan Zheng et al.
Journal of chromatographic science, 53(4), 633-640 (2014-09-14)
Baizhu Shaoyao San (BSS) is a famous traditional Chinese medicinal prescription, which is composed of Rhizome atractylodis macrocephalae, Radix Paeoniae Alba, Pericarpium Citri Reticulatae and Radix Saposhnikovia. In this study, a simple and sensitive high-performance liquid chromatography coupled with diode
Michal Holčapek et al.
Journal of chromatography. A, 1377, 85-91 (2014-12-30)
A novel normal-phase (NP) ultrahigh-performance liquid chromatography-mass spectrometry (UHPLC/MS) method is developed for a separation and quantitation of nonpolar lipid classes occurring in human plasma, erythrocytes and plasma lipoprotein fractions. The baseline class separation of cholesteryl esters (CE), cholesterol, triacylglycerols
Lufang Chen et al.
Molecular medicine reports, 12(5), 6879-6886 (2015-09-10)
Nearly one quarter of patients with colorectal carcinoma (CRC) were diagnosed at an advanced stage. Under these circumstances, radical resection of the tumor is the best strategy to enhance the five-year survival rate. However, up to 50% of post-operative patients
Sarunya Tuntiyasawasdikul et al.
International journal of pharmaceutics, 478(2), 486-495 (2014-12-09)
The aim of this study was to design and develop a suitable monolithic drug-in-adhesive type patch of methoxyflavones from Kaempferia parviflora (K. parviflora) using acrylic polymer Durotak(®) 87-2852. The absence of interaction between components in K. parviflora extract and the
N Hassler et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 26(1), 339-352 (2014-10-16)
Raman microspectroscopic analysis of iliac crest from patients that were treated with alendronate (ALN) for 10 years revealed minimal, transient alterations in bone material properties confined to actively forming bone surfaces compared to patients that were on ALN for 5 years. These
Muktak Aklujkar et al.
BMC genomics, 13, 690-690 (2012-12-12)
The bacterium Pelobacter carbinolicus is able to grow by fermentation, syntrophic hydrogen/formate transfer, or electron transfer to sulfur from short-chain alcohols, hydrogen or formate; it does not oxidize acetate and is not known to ferment any sugars or grow autotrophically.
Stud. Nat. Prod. Chem., 13, 53-53 (1993)
Jilagamazhi Fu et al.
Applied microbiology and biotechnology, 99(13), 5583-5592 (2015-05-24)
Biodiesel production-derived waste glycerol (WG) was previously investigated as potential carbon source for medium chain length polyhydroxyalkanoate (mcl-PHA) production by Pseudomonas putida LS46. In this study, we evaluated the effect of impurities in the WG on P. putida LS46 physiology
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