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Sophie Payne et al.
Developmental biology, 405(1), 82-95 (2015-06-24)
CHARGE syndrome is caused by spontaneous loss-of-function mutations to the ATP-dependant chromatin remodeller chromodomain-helicase-DNA-binding protein 7 (CHD7). It is characterised by a distinct pattern of congenital anomalies, including cardiovascular malformations. Disruption to the neural crest lineage has previously been emphasised
Ruchun Wu et al.
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 27(3), 493-501 (2011-06-10)
1,3-propanediol is an important raw material in chemical industry. Microbial conversion of glycerol or glucose into 1,3-propanediol has been given much attention due to its renewable resource, mild reaction conditions, and other advantages. It is a challenge to efficiently separate
Sarbjit S Saini et al.
The Journal of investigative dermatology, 135(1), 67-75 (2014-07-22)
ASTERIA I was a 40-week, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of subcutaneous omalizumab as add-on therapy for 24 weeks in patients with chronic idiopathic urticaria/spontaneous urticaria (CIU/CSU) who remained symptomatic despite H1 antihistamine treatment at
Marina T Tomovic et al.
Acta poloniae pharmaceutica, 72(1), 137-145 (2015-04-09)
Potentilla species have been used in traditional medicine in the treatment of different ailment, disease or malady. Potentilla reptans (P. reptans) has been scarcely studied. The aim of this study was to test antioxidant and anti-inflammatory activity of P. reptans
Jiao Song et al.
Journal of lipid research, 56(8), 1492-1500 (2015-05-30)
It is widely accepted that small-molecule drugs, despite their selectivity at primary targets, exert pharmacological effects (and safety liabilities) through a multiplicity of pathways. As such, it has proved extremely difficult to experimentally assess polypharmacology in an agnostic fashion. Profiling
Vinod Kumar et al.
Applied microbiology and biotechnology, 96(2), 373-383 (2012-06-12)
The co-production of 3-hydroxypropionic acid (3HP) and 1,3-propanediol (PDO) from glycerol was studied using the resting cells of a recombinant Klebsiella pneumoniae J2B strain that overexpresses an aldehyde dehydrogenase (KGSADH). Active biomass was produced in a mineral salt medium containing
Susi Anheuser et al.
Journal of lipid research, 56(9), 1747-1761 (2015-07-16)
Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease. It also accumulates in Niemann-Pick disease types A and B with primary storage of SM and with cholesterol in type C. Reconstitution of GM2 catabolism with β-hexosaminidase A and
Tiantian She et al.
Cancer prevention research (Philadelphia, Pa.), 8(5), 464-474 (2015-03-04)
Cancer is still the major cause of death across the world. Regular approaches cannot effectively solve the emerging problems, including drug/radiation resistance, side effects, and therapeutic ineffectiveness. Natural dietary supplements have shown effectiveness in the prevention and treatment of cancer.
Rui Weng et al.
Rapid communications in mass spectrometry : RCM, 29(16), 1491-1500 (2015-07-28)
Although serotonin deficiency is involved with various physiological disorders such as Alzheimer's disease, Parkinson's disease, schizophrenia and depression, the serotonin-dependent pathomechanisms remain poorly understood, particularly from a lipidomics perspective. This study therefore aimed to identify novel lipid biomarkers associated with
Yang Mi et al.
Journal of molecular endocrinology, 55(3), 219-229 (2015-08-27)
Gestational diabetes mellitus (GDM) is a condition commonly encountered during mid to late pregnancy with pathologic manifestations including hyperglycemia, hyperinsulinemia, insulin resistance, and fetal mal-development. The deficit and dysfunction of insulin secreting β-cells are signature symptoms for GDM. Pancreatic progenitors
Osama Abdelhakim Aly Ahmed et al.
Journal of pharmaceutical sciences, 104(6), 2062-2075 (2015-04-16)
This study is aimed at developing glimepiride (GMD) liposomal films using quality by design (QbD) and process analytical technology (PAT) principles. Risk analysis and Plackett-Burman design were utilized to evaluate formulation variables in two paths. Internal path included liposomal parameters
Arianna Crespi et al.
The Journal of investigative dermatology, 135(1), 192-201 (2014-08-02)
By means of morphological and biochemical criteria, we here provide evidence for the localization and function of premature ovarian failure, 1B (POF1B) in desmosomes. In monolayers of Caco-2 intestinal cells and in stratified HaCaT keratinocytes, endogenous POF1B colocalized with desmoplakin
Saumya Sarkar et al.
Indian journal of pharmacology, 47(5), 491-495 (2015-11-26)
This study compared the effectiveness of prophylactic administration of topical flurbiprofen 0.03% and nepafenac 0.1% in maintaining mydriasis during small incision cataract surgery (SICS). This study was a prospective, randomized, double-blind comparative study in adult cataract patients given topical flurbiprofen
E Celińska
Biotechnology advances, 28(4), 519-530 (2010-04-07)
The history of 1,3-propanediol (1,3-PD) conversion from being a specialty chemical to being a bulk chemical illustrates that the concerted effort of different metabolic engineering approaches brings the most successful results. In order to metabolically tailor the 1,3-PD production pathway
Jamile Zeni et al.
Bioprocess and biosystems engineering, 38(12), 2497-2502 (2015-09-06)
The aim of this research was the partial characterization of polygalacturonase (PG) extracts produced by a newly isolated Penicillium brasilianum and Aspergillus niger in submerged fermentation. The partial characterization of the crude enzymatic extracts showed optimum activity at pH 5.5
Krista D Buono et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(23), 8855-8865 (2015-06-13)
Neonatal hypoxia-ischemia (H-I) is the leading cause of brain damage resulting from birth complications. Studies in neonatal rats have shown that H-I acutely expands the numbers of neural precursors (NPs) within the subventricular zone (SVZ). The aim of these studies
Satoshi Ohno et al.
Journal of bioscience and bioengineering, 115(2), 221-228 (2012-10-09)
For efficient production of industrially useful metabolites by microorganisms, it is important to design metabolic networks suitable for production. For this purpose, constraint-based metabolic flux simulation is a powerful tool to predict the effect of reaction knockouts on target productivity.
Ming-Jun Tsai et al.
PloS one, 10(7), e0131026-e0131026 (2015-07-15)
Excessive production of radical oxygen species in skin is a contributor to a variety of skin pathologies. Naringenin is a potent antioxidant. The purpose of the present study was to develop elastic liposomes for naringenin topical application. Naringenin-loaded elastic liposomes
Laurent Imbert et al.
Journal of analytical toxicology, 38(9), 676-680 (2014-09-05)
A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters
Sarah N Deffit et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1446-1453 (2015-01-16)
B lymphocytes exploit macroautophagy to capture cytoplasmic and nuclear proteins within autophagosomes. Fusion of autophagosomes with lysosomes and endosomes facilitates content proteolysis, with the resulting peptides selectively binding MHC class II (MHC II) molecules, which are displayed for recognition by
Daria Szymanowska-Powałowska et al.
Applied microbiology and biotechnology, 99(7), 3179-3189 (2014-12-20)
Knowledge of tolerance of bacteria to toxic stress is important, especially for processes targeted at high final titers of product. Information on environmental limits and stress responses may help during selection of strains or design and control of processes. The
Ruijuan Gao et al.
Basic & clinical pharmacology & toxicology, 117(2), 105-116 (2015-01-24)
Gelatinases play important roles in tumour invasion and metastasis and are thus considered promising targets for cancer therapy. In this study, a new single-chain variable fragment (scFv)-based fusion protein Fv-LDP, composed of the anti-gelatinases scFv and lidamycin apoprotein (LDP), was
Judit Pogany et al.
Journal of virology, 89(10), 5714-5723 (2015-03-13)
Similar to other positive-strand RNA viruses, tombusviruses are replicated by the membrane-bound viral replicase complex (VRC). The VRC consists of the p92 virus-coded RNA-dependent RNA polymerase (RdRp), the viral p33 RNA chaperone, and several co-opted host proteins. In order to
André Engesland et al.
Journal of pharmaceutical sciences, 104(3), 1119-1127 (2015-01-06)
Cost-effective and efficient methods for permeability screening are crucial during early development of drugs, drug formulations, and cosmeceuticals. Alternatives to animal experiments are impelled for both economical and ethical reasons. The aim of this study was to determine the ability
Graham D Cole et al.
JACC. Heart failure, 2(5), 545-548 (2014-10-11)
Prescription and adherence to medical therapy for heart failure are disappointing despite convincing randomized controlled trial (RCT) evidence for angiotensin-converting enzyme inhibition, beta-blockade, and aldosterone antagonism. In this study, we report an imbalanced approach amongst clinicians, who describe focusing during
Frédéric J Veyrier et al.
PLoS genetics, 11(7), e1005338-e1005338 (2015-07-15)
Respiratory infectious diseases are the third cause of worldwide death. The nasopharynx is the portal of entry and the ecological niche of many microorganisms, of which some are pathogenic to humans, such as Neisseria meningitidis and Moraxella catarrhalis. These microbes
Megan P O'Brien et al.
Cartilage, 6(3), 174-184 (2015-07-16)
Evaluation of early compositional changes in healing articular cartilage is critical for understanding tissue repair and for therapeutic decision-making. Fourier transform infrared imaging spectroscopy (FT-IRIS) can be used to assess the molecular composition of harvested repair tissue. Furthermore, use of
Francesco Muniz-Miranda et al.
The Journal of chemical physics, 137(24), 244501-244501 (2013-01-03)
Hydrogen bond interactions strongly affect vibrational properties and frequencies, the most common consequence being a redshift of the stretching vibration involved; there are, however, few exceptions to this general trend. In previous works, we have proved the effectiveness of ab
Johannes Zuegg et al.
Nature communications, 6, 7719-7719 (2015-07-22)
The rapid rise of multi-drug-resistant bacteria is a global healthcare crisis, and new antibiotics are urgently required, especially those with modes of action that have low-resistance potential. One promising lead is the liposaccharide antibiotic moenomycin that inhibits bacterial glycosyltransferases, which
Tingting Zhang et al.
Analytical and bioanalytical chemistry, 407(21), 6543-6555 (2015-06-24)
This article describes the development of a lipidomic platform consisting of a 4000 QTRAP mass spectrometer and a self-installed sample inlet system to indentify and quantify 12 phospholipid and five sphingolipid classes from lipid-rich brain tissues of mouse, duck, and
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