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Sampa Maiti et al.
Talanta, 141, 116-121 (2015-05-13)
A new, simple, rapid and selective spectrophotometric method has been developed for detection and estimation of butanol in fermentation broth. The red colored compound, produced during reduction of diquat-dibromide-monohydrate with 2-mercaptoethanol in aqueous solution at high pH (>13), becomes purple
Guohua Gong et al.
American journal of physiology. Heart and circulatory physiology, 309(7), H1166-H1177 (2015-08-16)
Mitochondrial respiration through electron transport chain (ETC) activity generates ATP and reactive oxygen species in eukaryotic cells. The modulation of mitochondrial respiration in vivo or under physiological conditions remains elusive largely due to the lack of appropriate approach to monitor
Anindya Sarkar et al.
The Journal of biological chemistry, 290(35), 21615-21628 (2015-07-03)
Heat shock protein 90 (hsp90) drives heme insertion into the β1 subunit of soluble guanylate cyclase (sGC) β1, which enables it to associate with a partner sGCα1 subunit and mature into a nitric oxide (NO)-responsive active form. We utilized fluorescence
Ljiljana Djekic et al.
International journal of pharmaceutics, 490(1-2), 180-189 (2015-05-24)
Suitability of liquid lecithin (i.e., solution of lecithin in soy bean oil with ∼ 60% w/w of phospholipids) for formation of gels, upon addition of water solution of poloxamer 407, was investigated, and formulated systems were evaluated as carriers for
Joana Fernandes et al.
PloS one, 9(6), e99958-e99958 (2014-06-25)
Transient global cerebral ischemia induces profound changes in the transcriptome of brain cells, which is partially associated with the induction or repression of genes that influence the ischemic response. However, the mechanisms responsible for the selective vulnerability of hippocampal neurons
Randy W Purves et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 1-7 (2015-01-02)
Acyl coenzyme A (acyl-CoA) thioesters are important intermediates in cellular metabolism and being able to distinguish among them is critical to fully understanding metabolic pathways in plants. Although significant advances have been made in the identification and quantification of acyl-CoAs
Daniel T Radoff et al.
eLife, 3 (2014-11-11)
The presynaptic protein complexin (CPX) is a critical regulator of synaptic vesicle fusion, but the mechanisms underlying its regulatory effects are not well understood. Its highly conserved central helix (CH) directly binds the ternary SNARE complex and is required for
Thiago C Genaro-Mattos et al.
Biochemistry, 54(18), 2841-2850 (2015-04-14)
Lipid peroxidation is a well-known process that has been implicated in many diseases. Recent evidence has shown that mitochondrial cholesterol levels are increased under specific conditions, making it an important target for peroxidation inside the mitochondria. Cholesterol peroxidation generates, as
Pradipta Tokdar et al.
Indian journal of microbiology, 55(2), 184-193 (2015-03-26)
Coenzyme Q10 (CoQ10) is a blockbuster nutraceutical molecule which is often used as an oral supplement in the supportive therapy for cardiovascular diseases, cancer and neurodegenerative diseases. It is commercially produced by fermentation process, hence constructing the high yielding CoQ10
Silke Beermann et al.
PloS one, 9(9), e107481-e107481 (2014-09-23)
Histamine (HA) is recognized by its target cells via four G-protein-coupled receptors, referred to as histamine H1-receptor (H1R), H2R, H3R, and H4R. Both H1R and H4R exert pro-inflammatory functions. However, their signal transduction pathways have never been analyzed in a
Sung-Hyun Kang et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(7), 773-780 (2015-02-17)
Intravesical administration of the cytotoxic drug doxorubicin is a common treatment for superficial carcinoma of the bladder, but it is associated with significant urological adverse effects. The aim of this study was to identify doxorubicin-induced changes in the local mechanisms
A Troshchynsky et al.
Genes and immunity, 16(6), 388-398 (2015-06-05)
Human terminal deoxynucleotidyl transferase (hTdT) is a DNA polymerase that functions to generate diversity in the adaptive immune system. Here, we focus on the function of naturally occurring single-nucleotide polymorphisms (SNPs) of hTdT to evaluate their role in genetic-generated immune
Chuanshan Zhang et al.
Parasitology research, 113(10), 3745-3757 (2014-07-21)
Smad family proteins are essential cellular mediators of the transforming growth factor-β superfamily. In the present study, we identified two members of the Smad proteins, Smad8 and Smad4 homologues (termed as EgSmadE and EgSmadD, respectively), from Echinococcus granulosus, the causative
Stephanie A Shumar et al.
PloS one, 10(6), e0130013-e0130013 (2015-06-09)
Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (PanK) isoforms. PanK initiates the synthesis of coenzyme A
Su Mei Wu et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 187, 202-213 (2015-05-31)
The present study seeks to detect oxidative damage and to compare anti-oxidative responses among liver, gills and brain of adult zebrafish that were cooled from 28 °C (control) to 12 °C (treatment) for 0-24 h. The lipid peroxidation of liver
Elżbieta Sikora et al.
Colloids and surfaces. B, Biointerfaces, 126, 541-545 (2015-01-27)
The skin permeation of forskolin, a diterpene isolated from Coleus forsholii, was studied using oil in water (O/W) emulsions as delivery formulations and also an oil solution for comparative purposes. Two forskolin-loaded emulsions of water/Brij 72:Symperonic A7/Miglyol 812:Isohexadecane, at 0.075
Renata Bocian et al.
Hippocampus, 25(11), 1393-1406 (2015-03-31)
Previous in vivo data suggested that orexin neuropeptides (ORX(A) and ORX(B) ) synthetized in hypothalamic neurons were involved in the mechanism of generation of the hippocampal formation theta rhythm. Surprisingly, this suggestion has never been directly proved by experiments using
Erica J Rubin et al.
Antimicrobial agents and chemotherapy, 59(4), 2051-2061 (2015-01-22)
In Salmonella enterica, PmrD is a connector protein that links the two-component systems PhoP-PhoQ and PmrA-PmrB. While Escherichia coli encodes a PmrD homolog, it is thought to be incapable of connecting PhoPQ and PmrAB in this organism due to functional
Mahmoud S Sharaf et al.
Free radical biology & medicine, 84, 142-153 (2015-04-07)
Zinc and calcium have highly interwoven functions that are essential for cellular homeostasis. Here we first present a novel real-time flow cytometric technique to measure mitochondrial redox state and show it is modulated by zinc and calcium, individually and combined.
Yan Geng et al.
Applied microbiology and biotechnology, 97(7), 2851-2858 (2012-10-30)
Antrodia camphorata is a well-known Chinese medicinal mushroom that protects against diverse health-related conditions. Submerged fermentation of A. camphorata is an alternative choice for the effective production of bioactive metabolites, but the effects of nutrition and environment on mycelial morphology
Deepesh Nagarajan et al.
BMC biochemistry, 16, 18-18 (2015-08-13)
Computational protein design is a rapidly maturing field within structural biology, with the goal of designing proteins with custom structures and functions. Such proteins could find widespread medical and industrial applications. Here, we have adapted algorithms from the Rosetta software
Lei Wan et al.
Journal of integrative plant biology, 56(7), 622-634 (2014-01-24)
Katanin, a microtubule-severing enzyme, consists of two subunits: the catalytic subunit P60, and the regulatory subunit P80. In several species, P80 functions in meiotic spindle organization, the flagella biogenesis, the neuronal development, and the male gamete production. However, the P80
Cheanyeh Cheng et al.
Journal of chromatography. A, 1380, 1-10 (2015-01-08)
An online solid-phase microextraction coupled liquid chromatography-electrospray ionization-ion trap mass spectrometry was developed for the analysis of trace R- and S-4-phenyl-2-butanol (R- and S-pbol) in salt rich cell culture of Saccharomyces cerevisiae catalyzed stereoselective reduction of 4-pheny-2-butanone (pbone). A Supel-Q
Limei Liu et al.
Antioxidants & redox signaling, 21(11), 1571-1581 (2013-12-18)
Although uncoupling protein 2 (UCP2) negatively regulates intracellular reactive oxygen species (ROS) production and protects vascular function, its participation in vascular benefits of drugs used to treat cardiometabolic diseases is largely unknown. This study investigated whether UCP2 and associated oxidative
Frédéric Bigey et al.
Current biology : CB, 31(4), 722-732 (2020-12-11)
Production of leavened bread dates to the second millennium BCE. Since then, the art of bread making has developed, yet the evolution of bread-associated microbial species remains largely unknown. Nowadays, leavened bread is made either by using a pure commercial
Expression, purification and identification of Pla a1 in a codon-optimized Platanus pollen allergen.
Yun Liu et al.
Molecular medicine reports, 12(2), 2197-2202 (2015-04-23)
The present study aimed to express, purify and identify the major allergen gene, Pla a1, in Platanus pollen. According to previous studies, the major gene sequences of the Pla a1 allergen were obtained and codon optimization and synthesis of the
Ronald P M Gonçalves et al.
Shock (Augusta, Ga.), 42(5), 415-423 (2014-07-09)
The aim of the present study was to investigate the existence of gender-related differences in the profile of changes that occur in cardiac functionality during endotoxic shock. For this, both male and female Wistar rats received a single injection of
Kirsi Penttinen et al.
PloS one, 10(5), e0125366-e0125366 (2015-05-09)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal calcium release from sarcoplasmic reticulum. Dantrolene, an inhibitor of sarcoplasmic Ca(2+) release
Zeljka Car et al.
Chemical biology & drug design, 84(4), 393-401 (2014-03-29)
Structural alterations of the aglycon portions of α-mannosides influence their inhibitory potency toward type 1-fimbriated Escherichia coli. The aim of our work was to prepare and explore inhibitory properties of novel mannosylated N-aryl-substituted 3-hydroxypyridine-4-ones because they possess needed structural characteristics
Marco Pistolozzi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 968, 69-78 (2014-01-30)
A series of novel tocainide analogues were characterized for their HSA and RSA binding, by using high-performance liquid affinity chromatography (HPLAC) and circular dichroism (CD). In this HPLAC study, HSA and RSA were covalently immobilized to the silica matrix of
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