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P5515
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Ivan D Tarandovskiy et al.
PloS one, 8(2), e55688-e55688 (2013-02-14)
Thrombin generation assay is a convenient and widely used method for analysis of the blood coagulation system status. Thrombin generation curve (TGC) is usually bell-shaped with a single peak, but there are exceptions. In particular, TGC in platelet-rich plasma (PRP)
Adalet Demir et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47(6), 974-983 (2014-09-05)
Donor to recipient (D/R) matching in lung transplantation (LTx) is usually directed by blood group (identity or compatibility) and predicted total lung capacity (pTLC) based on height and age. Other donor (D) and recipient (R) characteristics such as cytomegalovirus (CMV)
Alexander C Ford et al.
The American journal of gastroenterology, 108(10), 1566-1574 (2013-06-12)
There has been no definitive synthesis of the evidence for any benefit of available pharmacological therapies in opioid-induced constipation (OIC). We conducted a systematic review and meta-analysis to address this deficit. We searched MEDLINE, EMBASE, EMBASE Classic, and the Cochrane
Yasuyuki Takai et al.
Investigative ophthalmology & visual science, 54(4), 3065-3071 (2013-04-13)
To report the efficacy of systemic prostaglandin E1 (PGE1) monotherapy for treating acute central retinal artery occlusion (CRAO). The best-corrected visual acuity (BCVA) and side effects were evaluated retrospectively in 10 consecutive eyes (nine patients; mean age, 61.3 years) with
Katsuko Shiraya et al.
The Journal of biological chemistry, 285(29), 22141-22151 (2010-05-08)
We identified a novel prostaglandin (PG)-specific organic anion transporter (OAT) in the OAT group of the SLC22 family. The transporter designated OAT-PG from mouse kidney exhibited Na(+)-independent and saturable transport of PGE(2) when expressed in a proximal tubule cell line
Beatriz Gras-Miralles et al.
Clinical interventions in aging, 8, 191-200 (2013-02-27)
Chronic constipation is a common disorder in the general population, with higher prevalence in the elderly, and is associated with worse quality of life and with greater health care utilization. Lubiprostone is an intestinal type-2 chloride channel activator that increases
Giordano Pula et al.
Arteriosclerosis, thrombosis, and vascular biology, 30(12), 2631-2638 (2010-10-05)
Micromolar concentrations of the proangiogenic metabolite deoxyribose-1-phosphate (dRP) were detected in platelet supernatants by mass spectrometry. In this study, we assessed whether the release of dRP by platelets stimulates endothelial cell migration and angiogenesis. Protein-free supernatants from thrombin-stimulated platelets increased
Xiao-Gang Wang et al.
The Journal of organic chemistry, 78(18), 9488-9493 (2013-08-21)
We report herein for the first time the enantioselective synthesis of 8-aza-PGE1. The synthesis used the cross olefin metathesis reaction to connect the 5-vinyl-γ-lactam subunit, prepared from (R)-malic acid via the Ley's sulfone-based α-amidalkylation protocol (dr = 6.8:1), with the
Yasuyuki Hara et al.
The Journal of surgical research, 184(2), 1134-1142 (2013-05-22)
To resolve the shortage of donors associated with liver transplantation, the potential uncontrolled non-heart-beating donor (UNHBD) pool is expected to increase. However, warm ischemia-reperfusion injury leads to inferior survival in transplantation using the grafts from UNHBD compared with those from
Mohammed Makkawi et al.
Thrombosis and haemostasis, 114(5), 1004-1019 (2015-08-08)
P2Y12 receptor is required for sustained activation of integrin αIIbβ3, irreversible platelet aggregation and thrombus stabilisation. Tetraspanin superfamily member CD151 associates with integrin αIIbβ3 and plays critical roles in regulation of thrombus growth and stability in vivo. The possible functional
Marc Dufour et al.
Biochemical and biophysical research communications, 451(4), 587-591 (2014-08-17)
The inflammatory prostaglandin E2 (PGE2) cytokine plays a key role in the development of colon cancer. Several studies have shown that PGE2 directly induces the growth of colon cancer cells and furthermore promotes tumor angiogenesis by increasing the production of
S F de Stoppelaar et al.
Journal of thrombosis and haemostasis : JTH, 13(9), 1709-1720 (2015-07-17)
Beside their role in hemostasis, platelets serve as sentinel cells in host defense during infection. In sepsis, platelets have been implicated in both beneficial (antibacterial) and detrimental responses (thrombosis and organ damage). Toll-like receptors and their common adaptor, myeloid differentiation
J G Ray
Transplantation, 66(4), 476-483 (1998-09-12)
To assess whether prostaglandin E1 analogs have a role in either reducing renal allograft rejection or improving renal function among both transplant and nontransplant patients. Studies were identified through Ovid MEDLINE between 1981 and December 1997 using multiple MeSH headings
Heidi A Trau et al.
Biology of reproduction, 92(1), 15-15 (2014-11-08)
Rapid angiogenesis occurs as the ovulatory follicle is transformed into the corpus luteum. To determine if luteinizing hormone (LH)-stimulated prostaglandin E2 (PGE2) regulates angiogenesis in the ovulatory follicle, cynomolgus macaques received gonadotropins to stimulate multiple follicular development and chorionic gonadotropin
Mikkel Fode et al.
BJU international, 112(7), 998-1008 (2013-07-06)
The pathophysiology of erectile dysfunction after radical prostatectomy (RP) is believed to include neuropraxia, which leads to temporarily reduced oxygenation and subsequent structural changes in penile tissue. This results in veno-occlusive dysfunction, therefore, penile rehabilitation programmes focus on tissue oxygenation.
A Creutzig et al.
VASA. Zeitschrift fur Gefasskrankheiten, 33(3), 137-144 (2004-10-06)
The relevance of Prostaglandin El (PGE,) in the treatment of peripheral arterial occlusive disease stage III and IV was to be evaluated for the first time by a meta-analysis. Altogether, 643 patients were analyzed from seven randomized, controlled PGE1 studies
[Intracavernous injection test by prostaglandin E1].
Toshikazu Otani
Nihon rinsho. Japanese journal of clinical medicine, 60 Suppl 6, 173-177 (2002-08-09)
Jae Hong Im et al.
Bio-protocol, 7(4), e2132-e2132 (2017-02-20)
Platelets and coagulation have long been known to be essential for metastasis in experimental models. In order to study the interactions between tumor cells, platelets and endothelium, we have adapted methods used in coagulation research for the isolation of platelets
Martina H Lundberg Slingsby et al.
Haematologica (2021-02-12)
Antisense oligonucleotides (ASOs) are DNA-based, disease-modifying drugs. Clinical trials with 2'-O-methoxyethyl (2'MOE) ASOs have reported dose- and sequencespecific lowering of platelet counts according to two phenotypes. Phenotype 1 is a moderate (but not clinically severe) drop in platelet count. Phenotype
Michael Berner et al.
The journal of sexual medicine, 9(12), 3089-3107 (2012-10-24)
As yet, a summary of research evidence concerning the efficacy of psychological treatment in male sexual dysfunction is lacking. Our systematic review gives an overview of the efficacy of psychosocial interventions in all male sexual dysfunctions. Main outcome measures included
Renata N Gomes et al.
Lipids in health and disease, 11, 171-171 (2012-12-13)
In many types of cancer, prostaglandin E2 (PGE2) is associated with tumour related processes including proliferation, migration, angiogenesis and apoptosis. However in gliomas the role of this prostanoid is poorly understood. Here, we report on the proliferative, migratory, and apoptotic
W Blogowski et al.
Journal of biological regulators and homeostatic agents, 26(3), 429-438 (2012-10-05)
Postoperative decline of renal function remains a common and unpredictable complication after abdominal aortic aneurysm (AAA) reconstruction. The oxidative stress that occurs during perioperative ischemia/reperfusion injury (I/R) may contribute to the development of this complication. In this study, the influence
Kevin A Lidberg et al.
Scientific reports, 11(1), 4722-4722 (2021-02-27)
CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expression and hypertension, however, most investigators have
J R Sheu et al.
British journal of pharmacology, 127(5), 1206-1212 (1999-08-24)
PMC, a potent alpha-tocopherol derivative, dose-dependently (5-25 microM) inhibited the ATP-release reaction and platelet aggregation in washed human platelets stimulated by agonists (collagen and ADP). PMC also dose-dependently inhibited the intracellular Ca2+ mobilization, whereas it did not inhibit phosphoinositide breakdown
Mélanie Abonnenc et al.
Blood transfusion = Trasfusione del sangue, 13(2), 255-264 (2014-11-05)
The Intercept Blood SystemTM (Cerus) is used to inactivate pathogens in platelet concentrates (PC). The aim of this study was to elucidate the extent to which the Intercept treatment modifies the functional properties of platelets. A two-arm study was conducted
R Urciuoli et al.
The Cochrane database of systematic reviews, (2)(2), CD001784-CD001784 (2004-04-24)
Erectile dysfunction (ED), the inability to achieve or maintain an erection sufficient for satisfactory sexual activity, is one of the most common sexual dysfunctions in men. ED may have a dramatic impact on the quality of life of many men
[Prostaglandin E1: results and perspectives in clinical practice].
N G Guseva
Klinicheskaia meditsina, 79(2), 4-10 (2001-06-23)
Claire M Ervin et al.
Reviews on recent clinical trials, 8(1), 9-22 (2012-11-08)
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders and it is characterized by episodes of abdominal pain and altered bowel functions. The specific bowel disturbances of diarrhea, constipation or an alternation between the two defines the
Tongyun Chen et al.
The Journal of thoracic and cardiovascular surgery, 147(4), 1362-1367 (2013-11-21)
To compare the therapeutic efficacy of recombinant human brain natriuretic peptide and prostaglandin E1 in the treatment of pulmonary hypertension after mitral valve replacement. Sixty patients with postoperative pulmonary hypertension were divided randomly into 3 groups that received saline, prostaglandin
Prostaglandin E1 and its analog misoprostol inhibit human CML stem cell self-renewal via EP4 receptor activation and repression of AP-1
Li F, et al.
Cell Stem Cell, 21(3), 359-373 (2017)
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