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Ivan D Tarandovskiy et al.
PloS one, 8(2), e55688-e55688 (2013-02-14)
Thrombin generation assay is a convenient and widely used method for analysis of the blood coagulation system status. Thrombin generation curve (TGC) is usually bell-shaped with a single peak, but there are exceptions. In particular, TGC in platelet-rich plasma (PRP)
Mikkel Fode et al.
BJU international, 112(7), 998-1008 (2013-07-06)
The pathophysiology of erectile dysfunction after radical prostatectomy (RP) is believed to include neuropraxia, which leads to temporarily reduced oxygenation and subsequent structural changes in penile tissue. This results in veno-occlusive dysfunction, therefore, penile rehabilitation programmes focus on tissue oxygenation.
Adalet Demir et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 47(6), 974-983 (2014-09-05)
Donor to recipient (D/R) matching in lung transplantation (LTx) is usually directed by blood group (identity or compatibility) and predicted total lung capacity (pTLC) based on height and age. Other donor (D) and recipient (R) characteristics such as cytomegalovirus (CMV)
Alexander C Ford et al.
The American journal of gastroenterology, 108(10), 1566-1574 (2013-06-12)
There has been no definitive synthesis of the evidence for any benefit of available pharmacological therapies in opioid-induced constipation (OIC). We conducted a systematic review and meta-analysis to address this deficit. We searched MEDLINE, EMBASE, EMBASE Classic, and the Cochrane
Mélanie Abonnenc et al.
Blood transfusion = Trasfusione del sangue, 13(2), 255-264 (2014-11-05)
The Intercept Blood SystemTM (Cerus) is used to inactivate pathogens in platelet concentrates (PC). The aim of this study was to elucidate the extent to which the Intercept treatment modifies the functional properties of platelets. A two-arm study was conducted
Martina H Lundberg Slingsby et al.
Haematologica (2021-02-12)
Antisense oligonucleotides (ASOs) are DNA-based, disease-modifying drugs. Clinical trials with 2'-O-methoxyethyl (2'MOE) ASOs have reported dose- and sequencespecific lowering of platelet counts according to two phenotypes. Phenotype 1 is a moderate (but not clinically severe) drop in platelet count. Phenotype
Yasuyuki Takai et al.
Investigative ophthalmology & visual science, 54(4), 3065-3071 (2013-04-13)
To report the efficacy of systemic prostaglandin E1 (PGE1) monotherapy for treating acute central retinal artery occlusion (CRAO). The best-corrected visual acuity (BCVA) and side effects were evaluated retrospectively in 10 consecutive eyes (nine patients; mean age, 61.3 years) with
Mohammed Makkawi et al.
Thrombosis and haemostasis, 114(5), 1004-1019 (2015-08-08)
P2Y12 receptor is required for sustained activation of integrin αIIbβ3, irreversible platelet aggregation and thrombus stabilisation. Tetraspanin superfamily member CD151 associates with integrin αIIbβ3 and plays critical roles in regulation of thrombus growth and stability in vivo. The possible functional
Marc Dufour et al.
Biochemical and biophysical research communications, 451(4), 587-591 (2014-08-17)
The inflammatory prostaglandin E2 (PGE2) cytokine plays a key role in the development of colon cancer. Several studies have shown that PGE2 directly induces the growth of colon cancer cells and furthermore promotes tumor angiogenesis by increasing the production of
Yasuyuki Hara et al.
The Journal of surgical research, 184(2), 1134-1142 (2013-05-22)
To resolve the shortage of donors associated with liver transplantation, the potential uncontrolled non-heart-beating donor (UNHBD) pool is expected to increase. However, warm ischemia-reperfusion injury leads to inferior survival in transplantation using the grafts from UNHBD compared with those from
Prostaglandin E1 use during neonatal transfer: potential beneficial role in persistent pulmonary hypertension of the newborn.
Neelam Gupta et al.
Archives of disease in childhood. Fetal and neonatal edition, 98(2), F186-F188 (2012-12-14)
Raymond A Costabile et al.
Expert opinion on pharmacotherapy, 9(8), 1421-1429 (2008-05-14)
Erectile dysfunction is a disease affecting millions of men over the age of 40. Alprostadil, a synthetic form of prostaglandin E(1), was introduced almost three decades ago, and is today considered an alternative treatment for erectile dysfunction. The purpose of
[Efficacy and perspectives of use of vasaprostan (prostaglandin E1) in rheumatology].
N G Gusev
Terapevticheskii arkhiv, 74(5), 85-88 (2002-06-29)
[Prostaglandin E1, E2 and their metabolites].
H Shio
Nihon rinsho. Japanese journal of clinical medicine, 57 Suppl, 724-727 (2000-01-15)
Leah Armon et al.
Fertility and sterility, 102(3), 885-890 (2014-07-27)
To characterize the nature of the human oocyte-derived chemoattractant. Laboratory in vitro study. Academic research institute. Ten healthy sperm donors. Oocyte-conditioned media from women undergoing IVF treatment because of male factor infertility. Sperm samples were processed by the migration-sedimentation technique. Oocyte-conditioned
Marcello Gomide et al.
The Journal of thoracic and cardiovascular surgery, 146(5), 1146-1151 (2013-10-17)
Preoperative comorbidities (PCMs) are known risk factors for Norwood stage I (NW1). We tested the hypothesis that short-term bilateral pulmonary arterial banding (bPAB) before NW1 could improve the prognosis of these high-risk patients. From January 2006 to October 2011, 17
Prostaglandins and thromboxanes.
B Samuelsson et al.
Annual review of biochemistry, 47, 997-1029 (1978-01-01)
A P Lea et al.
Drugs & aging, 8(1), 56-74 (1996-01-01)
Intracavernous alprostadil (synthetic prostaglandin E1) is a vasodilating agent which acts by relaxing the smooth muscles of the corpus cavernosum and by increasing the diameter of cavernous arteries; this leads to erection. Following intracavernous administration, alprostadil is either locally metabolised
J Defize et al.
Gut, 30(6), 774-781 (1989-06-01)
The actions of hydrochloric acid, natural PGE1, PGE2 and a synthetic commercial PGE1 preparation, Enisoprost (Searle) on pepsinogen synthesis and secretion were studied in canine chief cell monolayer cultures. Hydrochloric acid, applied directly to the apical surface of chief cells
Alprostadil in impotence.
M J Artoux et al.
DICP : the annals of pharmacotherapy, 25(4), 363-366 (1991-04-01)
O Gottschalk et al.
Scandinavian journal of rheumatology, 43(5), 356-363 (2014-05-16)
The use of statins in the prevention and treatment of cardiovascular diseases is well established. Their use as anti-inflammatory and immunomodulatory agents in the treatment of rheumatoid arthritis (RA) has also been investigated, with several clinical and experimental studies indicating
[Intracavernous injection test by prostaglandin E1].
Toshikazu Otani
Nihon rinsho. Japanese journal of clinical medicine, 60 Suppl 6, 173-177 (2002-08-09)
J G Ray
Transplantation, 66(4), 476-483 (1998-09-12)
To assess whether prostaglandin E1 analogs have a role in either reducing renal allograft rejection or improving renal function among both transplant and nontransplant patients. Studies were identified through Ovid MEDLINE between 1981 and December 1997 using multiple MeSH headings
Heidi A Trau et al.
Biology of reproduction, 92(1), 15-15 (2014-11-08)
Rapid angiogenesis occurs as the ovulatory follicle is transformed into the corpus luteum. To determine if luteinizing hormone (LH)-stimulated prostaglandin E2 (PGE2) regulates angiogenesis in the ovulatory follicle, cynomolgus macaques received gonadotropins to stimulate multiple follicular development and chorionic gonadotropin
Michael Berner et al.
The journal of sexual medicine, 9(12), 3089-3107 (2012-10-24)
As yet, a summary of research evidence concerning the efficacy of psychological treatment in male sexual dysfunction is lacking. Our systematic review gives an overview of the efficacy of psychosocial interventions in all male sexual dysfunctions. Main outcome measures included
Jae Hong Im et al.
Bio-protocol, 7(4), e2132-e2132 (2017-02-20)
Platelets and coagulation have long been known to be essential for metastasis in experimental models. In order to study the interactions between tumor cells, platelets and endothelium, we have adapted methods used in coagulation research for the isolation of platelets
Katsuko Shiraya et al.
The Journal of biological chemistry, 285(29), 22141-22151 (2010-05-08)
We identified a novel prostaglandin (PG)-specific organic anion transporter (OAT) in the OAT group of the SLC22 family. The transporter designated OAT-PG from mouse kidney exhibited Na(+)-independent and saturable transport of PGE(2) when expressed in a proximal tubule cell line
A Creutzig et al.
VASA. Zeitschrift fur Gefasskrankheiten, 33(3), 137-144 (2004-10-06)
The relevance of Prostaglandin El (PGE,) in the treatment of peripheral arterial occlusive disease stage III and IV was to be evaluated for the first time by a meta-analysis. Altogether, 643 patients were analyzed from seven randomized, controlled PGE1 studies
J R Sheu et al.
British journal of pharmacology, 127(5), 1206-1212 (1999-08-24)
PMC, a potent alpha-tocopherol derivative, dose-dependently (5-25 microM) inhibited the ATP-release reaction and platelet aggregation in washed human platelets stimulated by agonists (collagen and ADP). PMC also dose-dependently inhibited the intracellular Ca2+ mobilization, whereas it did not inhibit phosphoinositide breakdown
Beatriz Gras-Miralles et al.
Clinical interventions in aging, 8, 191-200 (2013-02-27)
Chronic constipation is a common disorder in the general population, with higher prevalence in the elderly, and is associated with worse quality of life and with greater health care utilization. Lubiprostone is an intestinal type-2 chloride channel activator that increases
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