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Kurt R Zinn et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(1), 49-57 (2014-08-01)
The use of receptor-targeted antibodies conjugated to fluorophores is actively being explored for real-time imaging of disease states; however, the toxicity of the bioconjugate has not been assessed in non-human primates. To this end, the in vivo toxicity and pharmacokinetics
Jacqueline A Bonds et al.
PloS one, 10(6), e0131266-e0131266 (2015-06-23)
Presenilin-1 (PS1), the catalytic core of the aspartyl protease γ-secretase, regulates adult neurogenesis. However, it is not clear whether the role of neurogenesis in hippocampal learning and memory is PS1-dependent, or whether PS1 loss of function in adult hippocampal neurogenesis
Alex J Wadley et al.
European journal of applied physiology, 115(8), 1757-1767 (2015-03-31)
This study investigated the impact of intensified training (IT) and carbohydrate (CHO) supplementation on resting and exercise-induced oxidative stress. Male cyclists (n = 13, mean ± SD: age 25 ± 6 years; [Formula: see text] 72 ± 5 ml/kg/min) undertook
Malgorzata M Brzóska et al.
Chemico-biological interactions, 229, 132-146 (2015-02-07)
It was investigated, in a female rat model of low and moderate lifetime human exposure to cadmium (Cd), whether polyphenols from Aronia melanocarpa berries (chokeberry; AMP) may offer protection from this heavy metal-induced disorders in bone metabolism. For this purpose
Alessandro Morais Saviano et al.
Journal of AOAC International, 98(5), 1267-1275 (2015-11-04)
The aim of this study was to develop, optimize, and validate a microplate bioassay for relative potency determination of linezolid in pharmaceutical samples using quality-by-design and design space approaches. In addition, a procedure is described for estimating relative potency uncertainty
Baoyu Zhao et al.
PloS one, 9(12), e115872-e115872 (2014-12-30)
Peptides are attracting increasing interest as protease inhibitors. Here, we demonstrate a new inhibitory mechanism and a new type of exosite interactions for a phage-displayed peptide library-derived competitive inhibitor, mupain-1 (CPAYSRYLDC), of the serine protease murine urokinase-type plasminogen activator (uPA).
Yujie Chang et al.
PloS one, 10(11), e0142952-e0142952 (2015-11-19)
Lysine is the most limiting essential amino acid for animal nutrition in maize grains. Expression of naturally lysine-rich protein genes can increase the lysine and protein contents in maize seeds. AtMAP18 from Arabidopsis thaliana encoding a microtubule-associated protein with high-lysine
Janne Hakkarainen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(9), 3806-3816 (2015-05-29)
Hydroxysteroid (17β)-dehydrogenase type 1 (HSD17B1) catalyzes the conversion of low active 17-ketosteroids, androstenedione (A-dione) and estrone (E1) to highly active 17-hydroxysteroids, testosterone (T) and E2, respectively. In this study, the importance of HSD17B1 in ovarian estrogen production was determined using
Johannes Bertsch et al.
Journal of bacteriology, 197(9), 1681-1689 (2015-03-04)
The methylenetetrahydrofolate reductase (MTHFR) of acetogenic bacteria catalyzes the reduction of methylene-THF, which is highly exergonic with NADH as the reductant. Therefore, the enzyme was suggested to be involved in energy conservation by reducing ferredoxin via electron bifurcation, followed by
Ganapathi Raj Murugesan et al.
Journal of the science of food and agriculture, 95(12), 2521-2527 (2014-11-05)
Efficacy of a multi-strain direct-fed microbial product (PoultryStar(®) ME; PS) and a xylanase enzyme product on the dietary energy utilization efficiency and resulting performance in broiler chickens was evaluated. Apart from performance parameters, cecal and serum metabolites and activities of
So Ri Kim et al.
Theranostics, 5(12), 1343-1362 (2015-10-31)
IL-17 is a cytokine mainly from IL-17-producing T cells, which are one of subsets of CD4+ T cells and play a role in adaptive immune system. Recent studies have demonstrated that IL-17A can act rapidly as an innate immune responder
Annette Ives et al.
Nature communications, 6, 6555-6555 (2015-03-25)
Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by a rapid increase
Marcus Fischer et al.
The Journal of biological chemistry, 290(45), 27113-27123 (2015-09-08)
Tripartite ATP-independent periplasmic (TRAP) transporters are secondary transporters that have evolved an obligate dependence on a substrate-binding protein (SBP) to confer unidirectional transport. Different members of the DctP family of TRAP SBPs have binding sites that recognize a diverse range
Helene Blanchard et al.
Neurochemical research, 40(11), 2293-2303 (2015-09-26)
Brain serotonergic signaling is coupled to arachidonic acid (AA)-releasing calcium-dependent phospholipase A2. Increased brain serotonin concentrations and disturbed serotonergic neurotransmission have been reported in the Flinders Sensitive Line (FSL) rat model of depression, suggesting that brain AA metabolism may be
Maxim B Prigozhin et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(26), 7966-7971 (2015-06-17)
Fast protein folding involves complex dynamics in many degrees of freedom, yet microsecond folding experiments provide only low-resolution structural information. We enhance the structural resolution of the five-helix bundle protein λ6-85 by engineering into it three fluorescent tryptophan-tyrosine contact probes.
Regulatory link between steryl ester formation and hydrolysis in the yeast Saccharomyces cerevisiae.
Birgit Ploier et al.
Biochimica et biophysica acta, 1851(7), 977-986 (2015-02-28)
Steryl esters and triacylglycerols are the major storage lipids of the yeast Saccharomyces cerevisiae. Steryl esters are formed in the endoplasmic reticulum by the two acyl-CoA:sterol acyltransferases Are1p and Are2p, whereas steryl ester hydrolysis is catalyzed by the three steryl
Yuanhong Shan et al.
Journal of chromatography. A, 1375, 101-109 (2014-12-17)
To develop a novel hybrid monolithic column based on pentafluorobenzyl imidazolium bromide ionic liquid, a new ionic liquid monomer was synthesized from 1-vinylimidazole and pentafluorobenzyl bromide. By employing a facile one-step copolymerization of polyhedral-oligomeric-silsesquioxane-type (POSS) cross-linking agent and the home-made
David W Koenig
Journal of cosmetic science, 65(2), 89-101 (2014-05-07)
Development of more effective products for cleansing the skin of microorganisms is enhanced by improved understanding of the mechanisms of attachment, as well as potential removal strategies. This paper describes an in vitro method for use of the cationic exchanger
Rishil J Kathawala et al.
Chinese journal of cancer, 34(3), 115-120 (2015-05-13)
ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells. Cabazitaxel is a
Yoshiya Yamamura et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(4), 353-360 (2015-03-31)
1. Chlorzoxazone (CLZ) is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans. Although in CLZ 6-hydroxylation several CYPs are responsible, previous studies have presented the monophasicity of the reaction in
Adrian M Gospodarek et al.
Journal of chromatography. A, 1371, 204-219 (2014-12-03)
In hydrophobic interaction chromatography (HIC), interactions between buried hydrophobic residues and HIC surfaces can cause conformational changes that interfere with separations and cause yield losses. This paper extends our previous investigations of protein unfolding in HIC chromatography by identifying protein
Claire M Hull et al.
AMB Express, 4, 64-64 (2014-11-18)
Microbial biotechnology and biotransformations promise to diversify the scope of the biorefinery approach for the production of high-value products and biofuels from industrial, rural and municipal waste feedstocks. In addition to bio-based chemicals and metabolites, microbial biomass itself constitutes an
Liming Yang et al.
International journal of molecular sciences, 16(10), 24791-24819 (2015-10-23)
Drought stress decreases crop growth, yield, and can further exacerbate pre-harvest aflatoxin contamination. Tolerance and adaptation to drought stress is an important trait of agricultural crops like maize. However, maize genotypes with contrasting drought tolerances have been shown to possess
Chikako Sakaguchi et al.
Regulatory toxicology and pharmacology : RTP, 69(3), 338-347 (2014-05-14)
The objective of this clinical study was to investigate changes in levels of biomarkers of exposure (BOEs) in healthy Japanese male smokers who switched to a prototype heated cigarette (HC). This was a controlled, semi-randomized, open-label, residential study conducted in
Alexandra Jammer et al.
Journal of experimental botany, 66(18), 5531-5542 (2015-05-24)
The analysis of physiological parameters is important to understand the link between plant phenotypes and their genetic bases, and therefore is needed as an important element in the analysis of model and crop plants. The activities of enzymes involved in
Neha Khandelwal et al.
Colloids and surfaces. B, Biointerfaces, 130, 84-92 (2015-04-25)
Recombinant expression of Capsicum annuum proteinase inhibitors (CanPI-13) and its application via synthetic carrier for the crop protection is the prime objective of our study. Herein, we explored proteinase inhibitor peptide immobilization on silica based nanospheres and rods followed by
Dhweeja Dasarathy et al.
Journal of chromatography. A, 1418, 77-82 (2015-10-03)
A new spiral tube assembly was designed to improve the column capacity and partition efficiency for protein separation. This spiral tube assembly has greater column capacity than the original tubing because of an increase in radial grooves from 4 to
Jonathan Collins et al.
Journal of industrial microbiology & biotechnology, 42(7), 1011-1026 (2015-04-29)
Emulsion stability plays a crucial role for mass transfer and downstream processing in organic-aqueous bioprocesses based on whole microbial cells. In this study, emulsion stability dynamics and the factors determining them during two-liquid phase biotransformation were investigated for stereoselective styrene
Ranjith N Kumavath et al.
Current protein & peptide science, 16(8), 775-781 (2015-05-12)
Ammonia lyase belongs to the family of enzymes that catalyzes the deamination of amino acids. Depending on the relative activity towards the substrates, L-tryptophan ammonia lyase converts L-tryptophan to indole 3-acrylic acid and ammonia. Here, we isolated, purified, and characterized
Iain M McIntyre et al.
Forensic science international, 251, 195-201 (2015-04-29)
Non-toxic postmortem trazodone tissue (liver) concentrations have not been previously described. Liver trazodone concentrations were compared to peripheral blood and central blood concentrations in 19 medical examiner cases. Postmortem blood specimens were initially screened for alcohol and simple volatiles, drugs
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