CN
Search Within
P5869
应用筛选条件
关键词:'P5869'
显示 1-30 共 157 条结果 关于 "P5869" 范围 论文
Jungju Kim et al.
Tissue engineering and regenerative medicine, 18(3), 387-397 (2021-01-09)
Three-dimensional (3D) in vitro cultures recapitulate the physiological microenvironment and exhibit high concordance with in vivo conditions. Improving co-culture models with different kind of cell types cultured on a 3D scaffold can closely mimic the in vivo environment. In this
Tae Chul Moon et al.
PloS one, 9(9), e108595-e108595 (2014-10-01)
PGD₂ has long been implicated in allergic diseases. Recent cloning of a second PGD₂ receptor, DP2 (also known as CRTh2), led to a greater understanding of the physiological and pathophysiological implications of PGD₂. PGD₂ signaling through DP1 and DP2 mediates
J Filipowska et al.
Biomedical materials (Bristol, England), 9(6), 065001-065001 (2014-10-21)
In this study, 3D porous bioactive composite scaffolds were produced and evaluated for their physico-chemical and biological properties. Polymer poly-L-lactide-co-glycolide (PLGA) matrix scaffolds were modified with sol-gel-derived bioactive glasses (SBGs) of CaO-SiO2-P2O5 systems. We hypothesized that SBG incorporation into PLGA
Sheila J Semaan et al.
Molecular and cellular endocrinology, 401, 84-97 (2014-12-17)
Puberty is governed by the secretion of gonadotropin releasing hormone (GnRH), but the roles and identities of upstream neuropeptides that control and time puberty remain poorly understood. Indeed, how various reproductive neural gene systems change before and during puberty, and
Jessica Mayeux et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 1955-1963 (2015-07-26)
Tight control of B cell differentiation into plasma cells (PCs) is critical for proper immune responses and the prevention of autoimmunity. The Ets1 transcription factor acts in B cells to prevent PC differentiation. Ets1(-/-) mice accumulate PCs and produce autoantibodies.
Alexander S Kauffman et al.
Endocrinology, 155(6), 2222-2232 (2014-03-25)
Age-related LH surge dysfunction in middle-aged rats is characterized, in part, by reduced responsiveness to estradiol (E2)-positive feedback and reduced hypothalamic kisspeptin neurotransmission. Vasoactive intestinal peptide (VIP) neurons in the suprachiasmatic nucleus project to hypothalamic regions that house kisspeptin neurons.
Cheng-Hung Chen et al.
American journal of physiology. Cell physiology, 309(9), C600-C607 (2015-08-21)
Endothelial cell migration is a fundamental process during angiogenesis and, therefore, a point of intervention for therapeutic strategies aimed at controlling pathologies involving blood vessel growth. We sought to determine the role of the gap junction protein connexin 43 (Cx43)
Shalini V Gohil et al.
Journal of biomedical materials research. Part A, 102(12), 4568-4580 (2014-03-29)
The aim of the study is use of transgenic fluorescent protein reporter mouse models to understand the cellular processes in recombinant human bone morphogenetic protein-2 (rhBMP-2) mediated bone formation. Bilateral parietal calvarial bone defects in Col3.6Topaz transgenic fluorescent osteoblast reporter
Julia T Warren et al.
Journal of cellular biochemistry, 116(11), 2476-2483 (2015-04-14)
The interaction between Receptor Activator of NF-κB Ligand (RANKL) and its receptor RANK is essential for the differentiation and bone resorbing capacity of the osteoclast. Osteoprotegerin (OPG), a soluble homodimer, acts as a decoy receptor for RANKL and thus inhibits
Helen M McGuire et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5123-5135 (2015-10-23)
The selection of affinity-matured Ab-producing B cells is supported by interactions with T follicular helper (Tfh) cells. In addition to cell surface-expressed molecules, cytokines produced by Tfh cells, such as IL-21 and IL-4, provide B cell helper signals. In this
Sarah Louise Dombernowsky et al.
Nature communications, 6, 7518-7518 (2015-06-26)
The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the cell surface, a key step underlying epithelial development, growth and tumour progression. However, mechanisms acutely controlling ADAM17 cell-surface availability to modulate the extent of ErbB ligand release are poorly
Bianca Kloos et al.
Cell communication and signaling : CCS, 13, 40-40 (2015-09-16)
Pasteurella multocida toxin (PMT) is a potent inducer of osteoclast formation. Pigs suffering from an infection with toxigenic Pasteurella multocida strains develop atrophic rhinitis characterised by a loss of turbinate bones and conchae. However, on the molecular level the process
Bakytzhan Bakhautdin et al.
Biochemical and biophysical research communications, 453(4), 722-727 (2014-10-11)
Ceruloplasmin (Cp) is a copper-containing ferroxidase with potent antioxidant activity. Cp is expressed by hepatocytes and activated macrophages and has been known as physiologic inhibitor of myeloperoxidase (MPO). Enzymatic activity of MPO produces anti-microbial agents and strong prooxidants such as
Zhong-ping Ma et al.
Cell and tissue research, 361(2), 467-476 (2015-03-07)
Osteoporosis (OP) often increases the risk of bone fracture and other complications and is a major clinical problem. Previous studies have found that high blood pressure is associated with bone formation abnormalities, resulting in increased calcium loss. We have investigated
Rahul D Pawar et al.
Clinical immunology (Orlando, Fla.), 154(1), 49-65 (2014-06-28)
The onset of autoantibodies in systemic autoimmunity can be the result of a breakdown in tolerance at multiple checkpoints. Genetic, hormonal, and immunological factors can combine with environmental influences to accelerate the onset of disease and aggravate disease outcome. Here
Alene Kast et al.
PLoS genetics, 11(5), e1005005-e1005005 (2015-05-15)
Cytoplasmic virus like elements (VLEs) from Kluyveromyces lactis (Kl), Pichia acaciae (Pa) and Debaryomyces robertsiae (Dr) are extremely A/T-rich (>75%) and encode toxic anticodon nucleases (ACNases) along with specific immunity proteins. Here we show that nuclear, not cytoplasmic expression of
Mohammed Wahiduzzaman et al.
Immunologic research, 62(2), 189-197 (2015-05-02)
Human papillomaviruses (HPVs) are prerequisite for the development of cervical cancer, with HPV16 and HPV18 being the most prevalent. Despite the fact that two prophylactic vaccines against HPVs are in the market, wide-scale application of the vaccine in developing countries
Jia Guo et al.
PloS one, 9(6), e99224-e99224 (2014-06-11)
Streptomyces avermitilis is an important bacterial species used for industrial production of avermectins, a family of broad-spectrum anthelmintic agents. We previously identified the protein SAV576, a TetR family transcriptional regulator (TFR), as a downregulator of avermectin biosynthesis that acts by
P M Zakas et al.
Journal of thrombosis and haemostasis : JTH, 13(1), 72-81 (2014-10-16)
The formation of neutralizing antibodies (inhibitors) directed against human coagulation factor VIII (hFVIII) is a life-threatening pathogenic response that occurs in 20-30% of severe congenital hemophilia A patients and 0.00015% of the remaining population (i.e. acquired hemophilia A). Interspecies amino
Lingbing Zhang et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 38(4), 137-144 (2015-04-04)
Loss of antitumor response to repeated chemotherapy is a major cause of treatment failure in cancer patients. The development of acquired drug resistance is thought to come primarily from changes in tumor cells, and not host response to the tumor.
X Liu et al.
Parasite immunology, 36(11), 594-604 (2014-07-22)
Scabies is an ectoparasitic infestation by the mite Sarcoptes scabiei. Although commonly self-limiting, a fraction of patients develop severely debilitating crusted scabies. The immune mechanisms underlying the development of crusted scabies are unclear, and undertaking longitudinal infection studies in humans
Delfo D'Alessandro et al.
Biomedical materials (Bristol, England), 9(4), 045007-045007 (2014-07-17)
In this study, we performed a complete histologic analysis of constructs based on large diameter ( >100 μm) poly-L-lactic acid (PLLA) microfibers obtained via dry-wet spinning and rat Mesenchymal Stromal Cells (rMSCs) differentiated towards the osteogenic lineage, using acrylic resin embedding.
Takeo Nitta et al.
International journal of clinical and experimental pathology, 7(8), 4913-4921 (2014-09-10)
The role of autophagy in cholangiocarcinoma is poorly understood. This study investigated its involvement in cholangiocarcinoma, focusing on carcinoma cell invasion and prognostic significance using cholangiocarcinoma cell lines, CCKS1 and HuCCT1, and human tissues of hilar and extrahepatic cholangiocarcinoma. Nutrient
W Yang et al.
European cells & materials, 27, 350-364 (2014-06-11)
In the context of skeletal tissue development and repair, endochondral ossification has inspired a new approach to regenerate bone tissue in vivo using a cartilage intermediate as an osteoinductive template. The aim of this study was to investigate the behavior
Nicolas A Giraldo et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(13), 3031-3040 (2015-02-18)
Clear cell renal cell carcinoma (ccRCC) has shown durable responses to checkpoint blockade therapies. However, important gaps persist in the understanding of its immune microenvironment. This study aims to investigate the expression and prognostic significance of immune checkpoints in primary
Jun-Kyum Kim et al.
Cancer letters, 353(2), 194-200 (2014-08-01)
The invasiveness of glioblastoma is a major cause of poor prognosis and relapse. However, the molecular mechanism controlling glioma cell invasion is poorly understood. Here, we report that receptor activator of nuclear factor kappa-B (NFκB) ligand (RANKL) promotes glioma cell
Sigridur Jonsdottir et al.
Veterinary immunology and immunopathology, 166(1-2), 8-21 (2015-05-26)
Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of midges (Culicoides spp.). IgE-mediated reactions are often involved in the pathogenesis of this disease. IBH does not occur in Iceland due to the absence of Culicoides
Liu Sun et al.
PloS one, 10(7), e0132525-e0132525 (2015-07-07)
The LIM homeobox family protein Lhx5 plays important roles in forebrain development in the vertebrates. The lhx5 gene exhibits complex temporal and spatial expression patterns during early development but its transcriptional regulation mechanisms are not well understood. Here, we have
Rui Ge et al.
Journal of virology, 89(15), 7696-7706 (2015-05-15)
Zebrafish (Danio rerio) is a unique potential model animal for dissecting innate immune signaling. Here we demonstrate that herpes simplex virus 1 (HSV-1) could infect zebrafish at its different developmental stages and trigger the expression of type I interferons (IFNs)
Guro K Bårnes et al.
Clinical and vaccine immunology : CVI, 22(7), 697-705 (2015-05-01)
We developed and evaluated a rapid and simple multiplex microsphere assay for the quantification of specific IgG and IgA antibodies against meningococcal serogroup A, C, W, and Y capsular polysaccharides in serum and saliva. Meningococcal polysaccharides were conjugated to distinct
1/6