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L Cupillard et al.
The Journal of biological chemistry, 272(25), 15745-15752 (1997-06-20)
Secretory phospholipases A2 (sPLA2s) represent a rapidly expanding family of structurally related enzymes found in mammals as well as in insect and snake venoms. In this report, a cDNA coding for a novel sPLA2 has been isolated from human fetal
The site of attack of phospholipase (lecithinase) A on lecithin: a re-evaluation. Position of fatty acids on lecithins and triglycerides.
D J HANAHAN et al.
The Journal of biological chemistry, 235, 1917-1923 (1960-07-01)
Amit Kumar Khan et al.
Polymers, 12(4) (2020-04-26)
In this work, we have used low-molecular-weight (PEG12-b-PCL6, PEG12-b-PCL9 or PEG16-b-PLA38; MW, 1.25-3.45 kDa) biodegradable block co-polymers to construct nano- and micron-scaled hybrid (polymer/lipid) vesicles, by solvent dispersion and electroformation methods, respectively. The hybrid vesicles exhibit physical properties (size, bilayer
E Valentin et al.
The Journal of biological chemistry, 275(11), 7492-7496 (2000-03-14)
Venom and mammalian secreted phospholipases A(2) (sPLA(2)s) have been associated with numerous physiological, pathological, and toxic processes. So far, structurally related group I and II sPLA(2)s have been found in vertebrates such as mammals and snakes, whereas group III sPLA(2)s
Adrian Hohl et al.
Human gene therapy methods, 28(5), 268-276 (2017-08-16)
Adenoviral vector production for therapeutic applications is a well-established routine process. However, current methods for measurement of adenovirus particle titers as a quality characteristic require highly purified virus preparations. While purified virus is typically obtained in the last step of
Saikumari Y Krishnaiah et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(5), 2066-2073 (2013-02-13)
The phospholipase A2 (PLA2)activity of phosphorylated peroxiredoxin 6 (Prdx6) is required for activation of NADPH oxidase (NOX2). We investigated the interaction of Prdx6 with p67(phox) and its effect on NOX2 activity. With the use of specific antibodies, coimmunoprecipitation of p67(phox)
C Song et al.
The Journal of biological chemistry, 274(24), 17063-17067 (1999-06-08)
We have isolated a cDNA encoding a 1012-amino acid polypeptide cPLA2-beta, that has significant homology with cPLA2-alpha in both the calcium-dependent lipid binding domain as well as in the catalytic domain. Transient expression of cPLA2-beta cDNA in COS cells results
K Husmann et al.
Oncogene, 17(10), 1305-1312 (1998-10-15)
The H-rev107 tumour suppressor was isolated as a gene specifically expressed in rat fibroblasts resistant toward malignant transformation by the activated HRAS gene (Sers et al., 1997; Hajnal et al., 1994). Here we describe the human homologue of the rat
Increased serum phospholipase A2 activity after non-heart-beating donor liver transplantation and association with ischemia-reperfusion injury.
Monbaliu DR
The Journal of Surgical Research, 151(1), 125-131 (2009)
Panagiotis I Sergouniotis et al.
American journal of human genetics, 89(6), 782-791 (2011-12-06)
Flecked-retina syndromes, including fundus flavimaculatus, fundus albipunctatus, and benign fleck retina, comprise a group of disorders with widespread or limited distribution of yellow-white retinal lesions of various sizes and configurations. Three siblings who have benign fleck retina and were born
S G Gregory et al.
Nature, 441(7091), 315-321 (2006-05-20)
The reference sequence for each human chromosome provides the framework for understanding genome function, variation and evolution. Here we report the finished sequence and biological annotation of human chromosome 1. Chromosome 1 is gene-dense, with 3,141 genes and 991 pseudogenes
Joyce Solomons et al.
Developmental medicine and child neurology, 56(4), 386-389 (2014-03-19)
Infantile neuroaxonal dystrophy (INAD) is a rare autosomal recessive neurodegenerative disorder caused by mutations in the phospholipase A2 group 6 (Pla2G6) gene. Affected individuals usually present between the ages of 6 months and 2 years with rapid cognitive and motor
PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron.
Neil V Morgan et al.
Nature genetics, 38(7), 752-754 (2006-06-20)
Neurodegenerative disorders with high brain iron include Parkinson disease, Alzheimer disease and several childhood genetic disorders categorized as neuroaxonal dystrophies. We mapped a locus for infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation (NBIA) to chromosome 22q12-q13 and
I B Pryvrots'ka et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 124-136 (2014-02-01)
In an experimental model of acute pancreatitis (AP) in rats no alteration in leukocyte's viability was found by flow cytometry as compared to control. After 1 day of AP production of reactive oxygen forms in granulocytes was increased more than
Milena Sokolowska et al.
The Journal of biological chemistry, 289(7), 4470-4488 (2013-12-25)
Hyaluronan (HA) is the major glycosaminoglycan in the extracellular matrix. During inflammation, there is an increased breakdown of HA, resulting in the accumulation of low molecular weight (LMW) HA and activation of monocytes and macrophages. Eicosanoids, derived from the cytosolic
John E Collins et al.
Genome biology, 5(10), R84-R84 (2004-10-06)
We have developed a systematic approach to generating cDNA clones containing full-length open reading frames (ORFs), exploiting knowledge of gene structure from genomic sequence. Each ORF was amplified by PCR from a pool of primary cDNAs, cloned and confirmed by
I Dunham et al.
Nature, 402(6761), 489-495 (1999-12-11)
Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and
Sean A Beausoleil et al.
Nature biotechnology, 24(10), 1285-1292 (2006-09-12)
Data analysis and interpretation remain major logistical challenges when attempting to identify large numbers of protein phosphorylation sites by nanoscale reverse-phase liquid chromatography/tandem mass spectrometry (LC-MS/MS) (Supplementary Figure 1 online). In this report we address challenges that are often only
R Grataroli et al.
European journal of biochemistry, 122(1), 111-117 (1982-02-01)
Upon tryptic activation of pure human prophospholipase A2, a heptapeptide is released from the N-terminal part of the protein yielding active phospholipase A2 (EC 3.1.1.4). Both the kinetics of the activation process and the amino acid sequence of the activation
J J Seilhamer et al.
DNA (Mary Ann Liebert, Inc.), 5(6), 519-527 (1986-12-01)
Oligonucleotide probes synthesized using the published protein sequence for porcine pancreatic phospholipase A2 (PLA2; Puijk et al., 1977), were used to screen a cDNA library made from porcine pancreas. One resulting clone which encoded the entire porcine PLA2 enzyme was
Antibodies: taking the sting out.
Yvonne Bordon
Nature reviews. Immunology, 13(12), 843-843 (2013-11-10)
Intae Lee et al.
The Journal of pharmacology and experimental therapeutics, 345(2), 284-296 (2013-03-12)
1-Hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol (MJ33) is a fluorinated phospholipid analog that inhibits the phospholipase A2 (PLA2) activity of peroxiredoxin 6 (Prdx6). Prdx6 PLA2 activity is required for activation of NADPH oxidase 2 and subsequent generation of reactive oxygen species (ROS). In vitro, MJ33
I-Ta Lee et al.
Biochemical pharmacology, 85(7), 954-964 (2013-01-16)
Vascular smooth muscle cells (VSMCs) that function as synthetic units play important roles in cardiovascular diseases. Extracellular nucleotides, such as ATP, have been shown to act via activation of P2 purinoceptors implicated in various inflammatory diseases, we hypothesized that extracellular
K W Underwood et al.
The Journal of biological chemistry, 273(34), 21926-21932 (1998-08-15)
We report the cloning and characterization of a novel membrane-bound, calcium-independent PLA2, named cPLA2-gamma. The sequence encodes a 541-amino acid protein containing a domain with significant homology to the catalytic domain of the 85-kDa cPLA2 (cPLA2-alpha). cPLA2-gamma does not contain
Coro Paisan-Ruiz et al.
Annals of neurology, 65(1), 19-23 (2008-06-24)
Although many recessive loci causing parkinsonism dystonia have been identified, these do not explain all cases of the disorder. We used homozygosity mapping and mutational analysis in three individuals from two unrelated families who presented with adult-onset levodopa-responsive dystonia-parkinsonism, pyramidal
Joel Martin et al.
Nature, 432(7020), 988-994 (2004-12-24)
Human chromosome 16 features one of the highest levels of segmentally duplicated sequence among the human autosomes. We report here the 78,884,754 base pairs of finished chromosome 16 sequence, representing over 99.9% of its euchromatin. Manual annotation revealed 880 protein-coding
B Rydqvist et al.
Acta physiologica Scandinavica, 130(2), 299-305 (1987-06-01)
Neurotoxicity of an isolated fraction (V) of the venom from the snake Agkistrodon halys (Pallas) was studied on the crayfish stretch receptor using a two-electrode voltage-clamp technique. The toxin was previously shown to have less phospholipase A2 activity but to
Teal S Hallstrand et al.
Pulmonary pharmacology & therapeutics, 25(6), 432-437 (2013-01-17)
Alterations in the airway epithelium have been associated with the development of asthma in elite athletes and in subjects that are susceptible to exercise-induced bronchoconstriction (EIB). The syndrome of EIB refers to acute airflow obstruction that is triggered by a
New generation of drugs may treat diverse array of allergic/inflammatory diseases.
Jonny Patience
Immunotherapy, 4(11), 1093-1093 (2013-01-19)
Jesper V Olsen et al.
Cell, 127(3), 635-648 (2006-11-04)
Cell signaling mechanisms often transmit information via posttranslational protein modifications, most importantly reversible protein phosphorylation. Here we develop and apply a general mass spectrometric technology for identification and quantitation of phosphorylation sites as a function of stimulus, time, and subcellular
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