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J P Wery et al.
Nature, 352(6330), 79-82 (1991-07-04)
Phospholipases A2 (PLA2s) may be grouped into distinct families of proteins that catalyse the hydrolysis of the 2-acyl bond of phospholipids and perform a variety of biological functions. The best characterized are the small (relative molecular mass approximately 14,000) calcium-dependent
Nathan A Ungerleider et al.
Endocrinology, 154(6), 2025-2033 (2013-03-28)
The development of insulin resistance is tightly linked to fatty liver disease and is considered a major health concern worldwide, although their mechanistic relationship remains controversial. Activin has emerging roles in nutrient homeostasis, but its metabolic effects on hepatocytes remain
Hiroaki Chiba et al.
The Journal of biological chemistry, 279(13), 12890-12897 (2004-01-08)
Psoriasis is a common skin disease characterized by hyperplastic regenerative epidermal growth and infiltration of immunocytes. The etiology of psoriasis is unknown, although several genetic and cellular factors have been elucidated. To find new psoriasis-related genes, we have cloned cDNAs
Iu I Kravtsov et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(3), 69-71 (2013-04-25)
The effect of glatiramer acetate on the structure of the lipid phase of cell membranes of red blood cells, the status of lipid peroxidation and antioxidant defense system in patients with relapsing forms of multiple sclerosis. It is shown that
Inactivation of crotoxin by group-specific reagents.
H FRAENKEL-CONRAT et al.
Biochimica et biophysica acta, 5(1), 98-104 (1950-03-01)
J D Sharp et al.
The Journal of biological chemistry, 266(23), 14850-14853 (1991-08-15)
Phospholipases A2 (PLA2s) play a key role in inflammatory processes through production of precursors of eicosanoids and platelet-activating factor. Recently, we described the purification of a novel approximately 100-kDa cytosolic PLA2 (cPLA2) from human monoblast U937 cells that is activated
Z Ma et al.
The Journal of biological chemistry, 274(14), 9607-9616 (1999-03-27)
An 85-kDa Group VI phospholipase A2 enzyme (iPLA2) that does not require Ca2+ for catalysis has recently been cloned from three rodent species. A homologous 88-kDa enzyme has been cloned from human B-lymphocyte lines that contains a 54-amino acid insert
Sheng Hua et al.
Biochimica et biophysica acta, 1831(6), 1146-1157 (2013-03-19)
Constitutive phosphorylation of protein kinase B (AKT) is a common feature of cancer caused by genetic alteration in the phosphatase and tensin homolog (PTEN) gene and is associated with poor prognosis. This study determined the role of cytosolic phospholipase A2α
H M Verheij et al.
Biochimica et biophysica acta, 747(1-2), 93-99 (1983-09-14)
The complete amino acid sequence of phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) from human pancreas was determined. The protein consists of a single polypeptide chain of 125 amino acids and has a molecular weight of 14003. The chain is cross-linked
A study of the purification and properties of the phospholipase A of Crotalus admanteus venom.
K SAITO et al.
Biochemistry, 1, 521-532 (1962-05-25)
S Hara et al.
Journal of biochemistry, 104(3), 326-328 (1988-09-01)
The amino acid composition and partial NH2-terminal amino acid sequence of an extracellular phospholipase A2 in human rheumatoid synovial fluid were determined. The predominant amino acids in the phospholipase A2 were cysteine, glycine, arginine, and lysine, suggesting that it is
Xiao-Yan Pang et al.
The Journal of biological chemistry, 287(42), 35260-35274 (2012-08-28)
Adipose phospholipase A(2) (AdPLA or Group XVI PLA(2)) plays an important role in the onset of obesity by suppressing adipose tissue lipolysis. As a consequence, AdPLA-deficient mice are resistant to obesity induced by a high fat diet or leptin deficiency.
Christine Sers et al.
Oncogene, 21(18), 2829-2839 (2002-04-26)
H-rev107-1 is a growth inhibitory RAS target gene capable of suppressing anchorage independent growth in vitro and in vivo. Using a tumour tissue array with 241 matched tumour and normal tissue cDNA pools, we found down-regulation of H-REV107-1 in 7
Petra C Kienesberger et al.
Journal of lipid research, 50 Suppl, S63-S68 (2008-11-26)
The human genome expresses nine patatin-like phospholipase domain containing proteins (PNPLA1-9). Members of this family share a protein domain discovered initially in patatin, the most abundant protein of the potato tuber. Patatin is a lipid hydrolase with an unusual folding
René P Zahedi et al.
Journal of proteome research, 7(2), 526-534 (2007-12-20)
Beside their main physiological function in hemostasis, platelets are also highly involved in pathological processes, such as atherothrombosis and inflammation. During hemostasis, binding of adhesive substrates to tyrosine-kinase-linked adhesion receptors and/or soluble agonists to G-protein coupled receptors leads to a
R M Kramer et al.
The Journal of biological chemistry, 264(10), 5768-5775 (1989-04-05)
We have purified a human non-pancreatic phospholipase A2 that is present in platelets and is enriched in rheumatoid synovial fluid. The enzyme is calcium-dependent, has a pH optimum of 8-10, and shows a striking preference for substrate presented in the
E Valentin et al.
Biochemical and biophysical research communications, 279(1), 223-228 (2000-12-09)
Mammalian-secreted phospholipases A(2) (sPLA(2)) form a diverse family of at least nine enzymes that hydrolyze phospholipids to release free fatty acids and lysophospholipids. We report here the cloning and characterization of human group IIF sPLA(2) (hGIIF sPLA(2)). The full-length cDNA
Mélissa Dussoyer et al.
Journal of proteomics, 251, 104397-104397 (2021-10-23)
A striking feature of skin organization is that the extracellular matrix (ECM) occupies a larger volume than the cells. Skin ECM also directly contributes to aging and most cutaneous diseases. In recent years, specific ECM enrichment protocols combined with in
J D Sharp et al.
The Journal of biological chemistry, 269(37), 23250-23254 (1994-09-16)
The Ca(2+)-sensitive cytosolic phospholipase A2 (cPLA2) displays both a phospholipase A2 and a lysophospholipase activity. Numerous hydrolases, including lipases, catalyze the hydrolysis of ester bonds by means of an active site triad of amino acids that includes a serine or
Koji Morishita et al.
The journal of trauma and acute care surgery, 75(5), 767-774 (2013-10-26)
Gut-derived mediators are carried via mesenteric lymph duct into systemic circulation after trauma/hemorrhagic shock (T/HS), thus leading to acute lung injury (ALI)/multiple-organ dysfunction syndrome. Phospholipase A2 (PLA(2)) is a key enzyme for the production of lipid mediators in posthemorrhagic shock
Makoto Murakami et al.
The Journal of biological chemistry, 278(12), 10657-10667 (2003-01-11)
Here we report cellular arachidonate (AA) release and prostaglandin (PG) production by novel classes of secretory phospholipase A(2)s (sPLA(2)s), groups III and XII. Human group III sPLA(2) promoted spontaneous AA release, which was augmented by interleukin-1, in HEK293 transfectants. The
Milleporin-1, a new phospholipase A2 active protein from the fire coral Millepora platyphylla nematocysts.
Radwan FF and Aboul-Dahab HM
Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 139(4), 267-272 (2004)
Shunchen Qiu et al.
Biochemical and biophysical research communications, 441(2), 453-456 (2013-12-29)
Human non-pancreatic secretory phospholipase A2 (hnpsPLA2) is a group IIA phospholipase A2 which plays an important role in the innate immune response. This enzyme was found to exhibit bactericidal activity toward Gram-positive bacteria, but not Gram-negative ones. Though native hnpsPLA2
Reply: limits of Mendelian randomization analyses in selection of secretory phospholipase A2-IIA as a valid therapeutic target for prevention of cardiovascular disease.
Michael V Holmes et al.
Journal of the American College of Cardiology, 63(9), 943-943 (2013-12-10)
Stephen J Nicholls et al.
JAMA, 311(3), 252-262 (2013-11-20)
Secretory phospholipase A2 (sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2 inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes is unknown. To determine the effects of sPLA2 inhibition with varespladib
Ladeana W Hillier et al.
Nature, 434(7034), 724-731 (2005-04-09)
Human chromosome 2 is unique to the human lineage in being the product of a head-to-head fusion of two intermediate-sized ancestral chromosomes. Chromosome 4 has received attention primarily related to the search for the Huntington's disease gene, but also for
Bogeon Yun et al.
The Journal of biological chemistry, 289(3), 1491-1504 (2013-12-04)
Perturbation of calcium signaling that occurs during cell injury and disease, promotes cell death. In mouse lung fibroblasts A23187 triggered mitochondrial permeability transition pore (MPTP) formation, lactate dehydrogenase (LDH) release, and necrotic cell death that were blocked by cyclosporin A
Solution structure of porcine pancreatic phospholipase A2.
van der Berg B
The Embo Journal, 14(17), 4123-4131 (1995)
Shareef Khateeb et al.
American journal of human genetics, 79(5), 942-948 (2006-10-13)
Infantile neuroaxonal dystrophy (INAD) is an autosomal recessive progressive neurodegenerative disease that presents within the first 2 years of life and culminates in death by age 10 years. Affected individuals from two unrelated Bedouin Israeli kindreds were studied. Brain imaging
A G Börsch-Haubold et al.
The Journal of biological chemistry, 273(8), 4449-4458 (1998-03-21)
The present study identifies the phosphorylation sites of the 85-kDa cytosolic phospholipase A2 (cPLA2) in human platelets and HeLa cells. Tryptic digests of 32P-phosphorylated and -immunoprecipitated cPLA2 were analyzed by microbore high performance liquid chromatography and two-dimensional phosphopeptide mapping against
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