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显示 1-30 共 743 条结果 关于 "P9541" 范围 论文
Raúl Pérez-Ortuño et al.
Analytical and bioanalytical chemistry, 407(28), 8463-8473 (2015-09-08)
A straightforward, high-throughput method was developed and fully validated for the simultaneous determination of the specific tobacco biomarkers nicotine and its main metabolite cotinine in a wide dynamic range and supporting the most common human biological matrices (urine, oral fluid
Medha Priyadarshini et al.
Islets, 7(2), e1045182-e1045182 (2015-06-20)
The short chain fatty acid (SCFA) receptor (free fatty acid receptor-3; FFAR3) is expressed in pancreatic β cells; however, its role in insulin secretion is not clearly defined. Here, we examined the role of FFAR3 in insulin secretion. Using islets
Niketkumar Patel et al.
Pharmaceutical development and technology, 20(4), 442-457 (2014-01-29)
Freshly excised rat skin and side-by-side permeation cells were used to study the effect of electronic and formulation variables on transdermal iontophoretic delivery of tacrine. Current strength at 0.1-0.3 mA was observed to be the driving force resulting in tacrine
Surabhi Khandige et al.
PLoS pathogens, 11(8), e1005109-e1005109 (2015-08-21)
Uropathogenic Escherichia coli (UPEC) are capable of occupying physiologically distinct intracellular and extracellular niches within the urinary tract. This feat requires the timely regulation of gene expression and small RNAs (sRNAs) are known to mediate such rapid adjustments in response
Ahmed Sadik et al.
Cell, 182(5), 1252-1270 (2020-08-21)
Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. The context specificity of AHR target genes has so far impeded systematic investigation of AHR activity and its upstream enzymes across human cancers. A
Christopher J Konop et al.
ACS chemical neuroscience, 6(6), 855-870 (2015-03-31)
Neuropeptides are known to have dramatic effects on neurons and synapses; however, despite extensive studies of the motorneurons in the parasitic nematode Ascaris suum, their peptide content had not yet been described. We determined the peptide content of single excitatory
Chun-Xiao Li et al.
Parasites & vectors, 8, 325-325 (2015-06-13)
Aedes aegypti is an important vector for dengue virus and thus has been targeted with pyrethroid insecticides in many areas of the world. As such, resistance has been detected to several of these insecticides, including in China, but the mechanisms
Oral solid potassium chloride and anticholinergic medications: a new drug interaction for an old drug?
Barbara J Zarowitz
Geriatric nursing (New York, N.Y.), 27(6), 329-333 (2006-12-19)
Nerea Fernández-Iglesias et al.
Nanoscale, 7(34), 14324-14331 (2015-08-06)
Once nanoparticles enter a biological system, it is known that their surface is instantly covered by the biomolecules present with preference to proteins. This protein corona has been a subject of numerous studies in order to reveal its composition. Besides
Iryna V Samarska et al.
PloS one, 9(5), e97196-e97196 (2014-05-14)
Cardiopulmonary bypass (CPB) may induce systemic inflammation and vascular dysfunction. Sphingosine 1-phosphate (S1P) modulates various vascular and immune responses. Here we explored whether agonists of the S1P receptors, FTY720 and SEW2871 improve vascular reactivity after CPB in the rat. Experiments
Takeaki Nagamine et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 997, 187-193 (2015-06-30)
In order to clarify the mechanism of fucoidan transport, we developed the chromatographic determination method. A size-exclusion chromatography (SEC) method for the determination of Okinawa-fucoidan using Develosil 300 Diol-5 (60×8.0mm I.D., 30nm pore-diameter) with the eluent containing 1% non-ionic detergent
Jérémy Carlier et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 70-77 (2014-12-23)
Hypoglycin A (HGA) is the toxic principle in ackee (Blighia sapida Koenig), a nutritious and readily available fruit which is a staple of the Jamaican working-class and rural population. The aril of the unripe fruit has high concentrations of HGA
Mark T Waddingham et al.
Cardiovascular diabetology, 14, 92-92 (2015-07-22)
Impaired actin-myosin cross-bridge (CB) dynamics correlate with impaired left ventricular (LV) function in early diabetic cardiomyopathy (DCM). Elevated expression and activity of Rho kinase (ROCK) contributes to the development of DCM. ROCK targets several sarcomeric proteins including myosin light chain
Robert T Dauchy et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 54(1), 40-50 (2015-02-05)
Early studies on rodents showed that short-term exposure to high-intensity light (> 70 lx) above 600 nm (red-appearing) influences circadian neuroendocrine and metabolic physiology. Here we addressed the hypothesis that long-term, low-intensity red light exposure at night (rLEN) from a
K-Y Kim et al.
Cell death & disease, 6, e1839-e1839 (2015-08-08)
Glaucoma is the leading cause of irreversible blindness and is characterized by slow and progressive degeneration of the optic nerve head axons and retinal ganglion cell (RGC), leading to loss of visual function. Although oxidative stress and/or alteration of mitochondrial
Raffaello Mazzaro et al.
ChemistryOpen, 4(3), 268-273 (2015-08-08)
Graphene-metal composites have potential as novel catalysts due to their unique electrical properties. Here, we report the synthesis of a composite material comprised of monodispersed platinum nanoparticles on high-quality graphene obtained by using two different exfoliation techniques. The material, prepared
Sebastian Hückesfeld et al.
PloS one, 10(8), e0135011-e0135011 (2015-08-08)
Motor systems can be functionally organized into effector organs (muscles and glands), the motor neurons, central pattern generators (CPG) and higher control centers of the brain. Using genetic and electrophysiological methods, we have begun to deconstruct the motor system driving
Kyoung-Yong Chun et al.
Nanoscale, 7(29), 12427-12434 (2015-07-02)
Heat-driven ionic gate nanochannels have been recently demonstrated, which exploit temperature-responsive polymer brushes based on wettability. These heat-sensing artificial nanochannels operate in a broad temperature-response boundary and fixed liquid cell environment, thereby experiencing limited system operation in the flat and
Rishil J Kathawala et al.
Chinese journal of cancer, 34(3), 115-120 (2015-05-13)
ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells. Cabazitaxel is a
Lianet Monzote et al.
Parasitology, 142(9), 1239-1248 (2015-06-02)
Nemorosone (Nem) and guttiferone A (GutA) are acyl phloroglucinol derivatives (APD) that are present in different natural products. For both compounds anti-cancer and anti-microbial properties have been reported. In particular, an anti-leishmanial activity of both compounds was demonstrated. The aim
Ezzat Naddaf et al.
Journal of separation science, 38(13), 2348-2356 (2015-05-02)
A sensitive technique to determinate naproxen in hair samples was developed using hollow-fiber micro-solid-phase combined with fluorescence spectrophotometry. The incorporation of multi-walled carbon nanotubes modified with a Keggin polyoxometalate into a silica matrix prepared by the sol-gel method was reported.
Ton Yoisungnern et al.
Scientific reports, 5, 11170-11170 (2015-06-09)
Silver nanoparticles (AgNPs) have many features that make them attractive as medical devices, especially in therapeutic agents and drug delivery systems. Here we have introduced AgNPs into mouse spermatozoa and then determined the cytotoxic effects of AgNPs on sperm function
J Spinner et al.
Journal of mass spectrometry : JMS, 49(12), 1306-1313 (2014-12-06)
Drugs deposited in human teeth are well preserved; the spectrum of toxicological investigations may therefore be supplemented by an analysis method for drugs in teeth. A liquid chromatography-electrospray ionization tandem mass spectrometry assay for the detection and quantification of basic
Eivind Valen Egeland et al.
Clinical & experimental metastasis, 32(8), 755-767 (2015-09-10)
S100A4 promotes metastasis in several types of cancer, but the involved molecular mechanisms are still incompletely described. The protein is associated with a wide variety of biological functions and it locates to different subcellular compartments, including nuclei, cytoplasm and extracellular
Joanne D Du et al.
International journal of pharmaceutics, 471(1-2), 358-365 (2014-06-01)
Targeted drug delivery to the buccal mucosa offers distinct advantages over oral delivery to the gastrointestinal tract including by-passing hepatic first-pass metabolism. However, the buccal route is often limited by low bioavailability, low drug loading and reduced residence time due
Ajeesh Koshy Cherian et al.
Neuropharmacology, 82, 41-48 (2014-03-22)
Kynurenic acid (KYNA) is a tryptophan metabolite that acts in the brain as an endogenous antagonist at multiple receptors, including glutamate and α7 nicotinic acetylcholine receptors. Increased levels of KYNA have been demonstrated in the brain of patients with a
C M Gabardo et al.
The Analyst, 140(16), 5781-5788 (2015-07-17)
Fully-integrated electro-fluidic systems with micro-/nano-scale features have a wide range of applications in lab-on-a-chip systems used for biosensing, biological sample processing, and environmental monitoring. Rapid prototyping of application-specific electro-fluidic systems is envisioned to facilitate the testing, validation, and market translation
Marcelo S da Silva et al.
Bio-protocol, 8(24), e3125-e3125 (2018-12-20)
Trypanosoma cruzi is a protozoan parasite belonging to the Trypanosomatidae family. Although the trypanosomatids multiply predominantly by clonal generation, the presence of DNA exchange in some of them has been puzzling researchers over the years, mainly because it may represent
Diana Klompstra et al.
Nature cell biology, 17(6), 726-735 (2015-05-06)
Cell contacts provide spatial cues that polarize early embryos and epithelial cells. The homophilic adhesion protein E-cadherin is required for contact-induced polarity in many cells. However, it is debated whether E-cadherin functions instructively as a spatial cue, or permissively by
Dominique Leitner et al.
Stem cell research, 41, 101617-101617 (2019-11-16)
Parkinson's disease is associated with the loss of dopaminergic neurons in the midbrain. Clinical studies investigating replacement of these neurons with in vitro-generated neurons are currently underway. However, this approach has been limited by difficulties in scaling up on-demand production
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