P9622

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Pristane-induced granulocyte recruitment promotes phenotypic conversion of macrophages and protects against diffuse pulmonary hemorrhage in Mac-1 deficiency.

Yiqin Shi et al.

Journal of immunology (Baltimore, Md. : 1950), 193(10), 5129-5139 (2014-10-05)

Diffuse pulmonary hemorrhage (DPH) is an uncommon but critical complication of systemic lupus erythematosus. Peritoneal administration of 2,6,10,14-tetramethylpentadecane (pristane) can recapitulate a lupus-like syndrome in mice, which can develop into DPH within a few weeks, especially in C57BL/6 mice. Mac-1

Transgenic mice expressing human FcgammaRIIa have enhanced sensitivity to induced autoimmune arthritis as well as elevated Th17 cells.

Nicholas C Van de Velde et al.

Immunology letters, 130(1-2), 82-88 (2009-12-17)

The major human Fc receptor, huFcgammaRIIa, is implicated in the development of autoimmune arthritis in humans but until recently has not been studied in mouse models. We evaluated potential roles of FcgammaRIIa by using transgenic mice expressing the receptor. We

Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice.

Christine M Coquery et al.

PloS one, 9(7), e102284-e102284 (2014-07-11)

Despite increased frequencies of neutrophils found in autoimmune diseases such as systemic lupus erythematosus (SLE), how they contribute to disease pathogenesis and the mechanisms that affect the accumulation of neutrophils are poorly understood. The aim of this study was to

Alpha-melanocyte stimulating hormone ameliorates disease activity in an induced murine lupus-like model.

D A C Botte et al.

Clinical and experimental immunology, 177(2), 381-390 (2014-03-29)

Alpha-melanocyte stimulating hormone (α-MSH) is a neuropeptide exhibiting anti-inflammatory activity in experimental models of autoimmune diseases. However, no studies thus far have examined the effects of α-MSH on systemic lupus erythematosus (SLE). This study aimed to determine the effects of

Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin.

Rahul D Pawar et al.

Clinical immunology (Orlando, Fla.), 154(1), 49-65 (2014-06-28)

The onset of autoantibodies in systemic autoimmunity can be the result of a breakdown in tolerance at multiple checkpoints. Genetic, hormonal, and immunological factors can combine with environmental influences to accelerate the onset of disease and aggravate disease outcome. Here

Activation of rheumatoid factor-specific B cells is antigen dependent and occurs preferentially outside of germinal centers in the lupus-prone NZM2410 mouse model.

Allison Sang et al.

Journal of immunology (Baltimore, Md. : 1950), 193(4), 1609-1621 (2014-07-13)

AM14 rheumatoid factor (RF) B cells in the MRL/lpr mice are activated by dual BCR and TLR7/9 ligation and differentiate into plasmablasts via an extrafollicular (EF) route. It was not known whether this mechanism of activation of RF B cells

Effects of pristane alone or combined with chloroquine on macrophage activation, oxidative stress, and TH1/TH2 skewness.

Qiufang Ouyang et al.

Journal of immunology research, 2014, 613136-613136 (2014-08-20)

We investigated the protective role of chloroquine against pristane-induced macrophage activation, oxidative stress, and Th1/Th2 skewness in C57BL/6J mice. Those mice were treated with pristane alone or combined with chloroquine. Hematological and biochemical parameters, macrophage phagocytic function, the oxidant/antioxidant index

Dysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupus.

Allison Sang et al.

PloS one, 9(8), e102151-e102151 (2014-08-06)

The breakdown in tolerance of autoreactive B cells in the lupus-prone NZM2410-derived B6.Sle1.Sle2.Sle3 (TC) mice results in the secretion of autoantibodies. TC dendritic cells (DCs) enhance B cell proliferation and antibody secretion in a cytokine-dependent manner. However, the specific cytokine

No evidence of pathogenic involvement of cathelicidins in patient cohorts and mouse models of lupus and arthritis.

D Kienhöfer et al.

PloS one, 9(12), e115474-e115474 (2014-12-24)

Apart from their role in the immune defence against pathogens evidence of a role of antimicrobial peptides (AMPs) in autoimmune diseases has accumulated in the past years. The aim of this project was to examine the functional impact of the

Hes1 attenuates type I IFN responses via VEGF-C and WDFY1.

Fei Ning et al.

The Journal of experimental medicine, 216(6), 1396-1410 (2019-04-25)

Induction of type I interferons (IFNs) is critical for eliciting competent immune responses, especially antiviral immunity. However, uncontrolled IFN production contributes to pathogenesis of autoimmune and inflammatory diseases. We found that transcription factor Hes1 suppressed production of type I IFNs

KIAA1114, a full-length protein encoded by the trophinin gene, is a novel surface marker for isolating tumor-initiating cells of multiple hepatocellular carcinoma subtypes.

Sae Won Kim et al.

Oncotarget, 5(5), 1226-1240 (2014-04-10)

Identification of novel biomarkers for tumor-initiating cells (TICs) is of critical importance for developing diagnostic and therapeutic strategies against cancers. Here we identified the role of KIAA1114, a full-length translational product of the trophinin gene, as a distinctive marker for

Resveratrol possesses protective effects in a pristane-induced lupus mouse model.

Zhuo-Long Wang et al.

PloS one, 9(12), e114792-e114792 (2014-12-17)

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of autoantibodies. To date, no therapy has been found to satisfactorily treat SLE. SIRT1 deficiency results in the development of an autoimmune syndrome in mice, including a

Bmal1 is an essential regulator for circadian cytosolic Ca²⁺ rhythms in suprachiasmatic nucleus neurons.

Masayuki Ikeda et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12029-12038 (2014-09-05)

The hypothalamic suprachiasmatic nucleus (SCN) plays a pivotal role in the mammalian circadian clock system. Bmal1 is a clock gene that drives transcriptional-translational feedback loops (TTFLs) for itself and other genes, and is expressed in nearly all SCN neurons. Despite

Comparative in vitro and in vivo assessment of toxin neutralization by anti-tetanus toxin monoclonal antibodies.

Mehdi Yousefi et al.

Human vaccines & immunotherapeutics, 10(2), 344-351 (2013-10-16)

Tetanus is caused by the tetanus neurotoxin (TeNT), a 150 kDa single polypeptide molecule which is cleaved into an active two-chain molecule composed of a 50 kDa N-terminal light (L) and a 100 kDa C-terminal heavy (H) chains. Recently, extensive

Correlation of the levels of DNA-binding inhibitor Id3 and regulatory T cells with SLE disease severity.

Chen Liu et al.

Journal of autoimmunity, 113, 102498-102498 (2020-06-17)

E proteins, a subset of basic helix-loop-helix (bHLH) proteins, are transcription activators and their functions are inhibited by DNA-binding inhibitor (Id) 1-4. Studies have shown that Treg levels are decreased in Id3 knockout mice. Mice over-expressing Id1 in CD4 T

Housekeeping gene stability in pristane-induced arthritis and antigen-induced pulmonary inflammation of rats.

Congshan Jiang et al.

Inflammation research : official journal of the European Histamine Research Society ... [et al.], 58(9), 601-609 (2009-04-10)

Aim of this study is to explore the expression stability of 12 commonly used housekeeping genes in inflammation condition. Two rat models, pristane-induced arthritis (PIA) and antigen-induced pulmonary inflammation (AIPI) were established and reverse transcription-PCR was performed from rat spleens

A monoclonal antibody against neem leaf glycoprotein recognizes carcinoembryonic antigen (CEA) and restricts CEA expressing tumor growth.

Arnab Das et al.

Journal of immunotherapy (Hagerstown, Md. : 1997), 37(8), 394-406 (2014-09-10)

Carcinoembryonic antigen (CEA) is one of the promising tumor antigens mainly associated with carcinoma of the colon, lung, breast, etc. and received wide attention for cancer immunotherapy. Neem leaf glycoprotein (NLGP), an effective immunomodulator, is able to generate humoral and

Positional identification of RT1-B (HLA-DQ) as susceptibility locus for autoimmune arthritis.

Sabrina Haag et al.

Journal of immunology (Baltimore, Md. : 1950), 194(6), 2539-2550 (2015-02-13)

Rheumatoid arthritis (RA) is associated with amino acid variants in multiple MHC molecules. The association to MHC class II (MHC-II) has been studied in several animal models of RA. In most cases these models depend on T cells restricted to

Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus.

Sudesh Pawaria et al.

Journal of immunology (Baltimore, Md. : 1950), 193(7), 3288-3295 (2014-08-26)

Systemic lupus erythematosus (SLE) is a type I IFN (IFN-I)-driven autoimmune disorder with exaggerated B and Th cell responses. Th17 cells, a recently identified Th cell subset, have been strongly implicated in the pathogenesis of SLE. Because IFN-I suppresses the

IL-17 promotes murine lupus.

Gil Amarilyo et al.

Journal of immunology (Baltimore, Md. : 1950), 193(2), 540-543 (2014-06-13)

The proinflammatory activity of IL-17-producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we provide direct evidence for a role of IL-17 in the pathogenesis of systemic lupus erythematosus (SLE). The induction of

Dual B cell immunotherapy is superior to individual anti-CD20 depletion or BAFF blockade in murine models of spontaneous or accelerated lupus.

WeiYu Lin et al.

Arthritis & rheumatology (Hoboken, N.J.), 67(1), 215-224 (2014-10-11)

To determine whether a combination of B cell depletion and BAFF blockade is more effective than monotherapy in treating models of spontaneous or accelerated systemic lupus erythematosus (SLE) in (NZB × NZW)F1 mice. Clinical parameters such as disease progression-free survival

An essential role of caspase 1 in the induction of murine lupus and its associated vascular damage.

J Michelle Kahlenberg et al.

Arthritis & rheumatology (Hoboken, N.J.), 66(1), 152-162 (2014-01-23)

Systemic lupus erythematosus (SLE) is a systemic autoimmune syndrome associated with organ damage and an elevated risk of cardiovascular disease resulting from activation of both innate and adaptive immune pathways. Recently, increased activation of the inflammasome machinery in SLE has

Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment.

Nikaïa Smith et al.

Science advances, 5(7), eaav9019-eaav9019 (2019-07-17)

Type I interferons are highly potent cytokines essential for self-protection against tumors and infections. Deregulations of type I interferon signaling are associated with multiple diseases that require novel therapeutic options. Here, we identified the small molecule, IT1t, a previously described

Assessment of the translational value of mouse lupus models using clinically relevant biomarkers.

Andrew T Bender et al.

Translational research : the journal of laboratory and clinical medicine, 163(6), 515-532 (2014-01-28)

Lupus is an autoimmune disease with a poorly understood etiology that manifests with a diverse pathology. This heterogeneity has been a challenge to clinical drug development efforts. A related difficulty is the uncertain translational power of animal models used for

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