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Matthias B Stope et al.
Oncology reports, 32(6), 2380-2386 (2014-09-19)
Drug resistance minimizes the effects of prostate cancer (PC) chemotherapy with docetaxel and is generally considered to be associated with the expression of heat shock protein (HSP) 27 including various cytoprotective pathways. In the present study, we investigated the effects
J Y Huh et al.
International journal of obesity (2005), 38(12), 1538-1544 (2014-03-13)
Irisin is a recently identified exercise-induced myokine suggested to induce browning of white adipocytes. Deficiency of myostatin, and thus stimulation of muscle growth, has also been reported to induce irisin and its precursor FNDC5 expression in muscle and drive the
Myrna Virreira et al.
The international journal of biochemistry & cell biology, 43(1), 10-13 (2010-11-09)
Pancreatic β-cells originate from gut endoderm during development. Pancreatic endocrine cells represent about 10% of the mature pancreatic cells, and β-cells represent the majority of endocrine cells. β-cells secrete insulin in response to elevation of nutrient concentrations. Insulin maintains glucose
Jennifer C Bailey et al.
Immunology, 143(4), 679-691 (2014-07-06)
CD1d-mediated lipid antigen presentation activates a subset of innate immune lymphocytes called invariant natural killer T (NKT) cells that, by virtue of their potent cytokine production, bridge the innate and adaptive immune systems. Transforming growth factor (TGF-β) is a known
Hong-Bo Wang et al.
Nature communications, 6, 6240-6240 (2015-02-12)
Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein for infection of both
K O Tokarchuk et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 25-31 (2013-05-30)
We investigated the changes in the forms of plasma iron and participation of aldehydes in the development of oxidative stress under glycerol-induced rhabdomyolysis in rats. Rhabdomyolysis was caused by intramuscular injection of 50% glycerol in the dose 10 ml/kg. We
Moonhee Lee et al.
Neurobiology of aging, 36(1), 42-52 (2014-08-30)
Neuroinflammation is hypothesized to be a major driving force behind Alzheimer's disease (AD) pathogenesis. This hypothesis predicts that activated microglial cells can stimulate neurons to produce excessive amounts of β-amyloid protein (Aβ₁₋₄₂) and tau. The excess Aβ₁₋₄₂ forms extracellular deposits
Brandon S Brown et al.
Cancer biology & therapy, 15(7), 851-861 (2014-04-24)
Systemic chemotherapeutics remain the standard of care for most malignancies even though they frequently suffer from narrow therapeutic index, poor serum solubility, and off-target effects. In this study, we have encapsulated etoposide, a topoisomerase inhibitor effective against a wide range
Diana F Lázaro et al.
PLoS genetics, 10(11), e1004741-e1004741 (2014-11-14)
Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Furthermore, mutations in the gene encoding for ASYN are associated with familial and sporadic forms of PD, suggesting
Keijiro Hara et al.
Cancer letters, 356(2 Pt B), 496-505 (2014-10-11)
The effect of the third member of the Dickkopf family (DKK3) in the Wnt pathway in glioblastoma remains unclear. We first demonstrated the non-specific interaction of Wnt3a and Wnt5a with the receptors LRP6 and ROR2 and the up-regulation of the
T Ehtezazi et al.
Drug development and industrial pharmacy, 41(2), 279-291 (2013-11-21)
Conventional suspension pressurized metered dose inhalers (pMDIs) suffer not only from delivering small amounts of a drug to the lungs, but also the inhaled dose scatters all over the lung regions. This results in much less of the desired dose
Semih Can Akıncılar et al.
FEBS letters, 589(9), 974-984 (2015-03-10)
Besides its canonical function of catalyzing the formation of telomeric repeats, many groups have recently reported non-canonical functions of hTERT in particular, and telomerase in general. Regulating transcription is the central basis of non-canonical functions of telomerase. However, unlike reverse
Petra Booij et al.
Environmental science & technology, 48(14), 8003-8011 (2014-06-14)
Because of large-scale production and use of an increasing diversity of chemicals in modern society, estuarine and coastal waters may be contaminated with numerous substances. Some of these compounds have the potential to affect microalgae at the base of the
Amir Bein et al.
Pediatric research, 77(5), 649-655 (2015-02-11)
Necrotizing enterocolitis (NEC), a common intestinal disease affecting premature infants, is a major cause of morbidity and mortality. Previous reports indicate an upregulation of intestinal matrix metalloproteinases (MMPs) activity that may play key roles on the higher permeability of the
Peter Draxler et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12015-12028 (2014-09-05)
Sensory nerve fibers differ not only with respect to their sensory modalities and conduction velocities, but also in their relative roles for pain hypersensitivity. It is presently largely unknown which types of sensory afferents contribute to various forms of neuropathic
Vineela Chukkapalli et al.
Virology, 476, 168-179 (2014-12-30)
Combinations of direct-acting antivirals (DAAs) against the hepatitis C virus (HCV) have the potential to revolutionize the HCV therapeutic regime. An integral component of DAA combination therapies is HCV NS5A inhibitors. It has previously been proposed that NS5A DAAs inhibit
Urea cycle disorder drug approved.
Malini Guha
Nature biotechnology, 31(4), 274-274 (2013-04-09)
Eytan R Barnea et al.
PloS one, 9(7), e100263-e100263 (2014-07-02)
Endogenous PIF, upon which embryo development is dependent, is secreted only by viable mammalian embryos, and absent in non-viable ones. Synthetic PIF (sPIF) administration promotes singly cultured embryos development and protects against their demise caused by embryo-toxic serum. To identify
Cayo Almeida et al.
Pain, 156(3), 504-513 (2015-02-18)
Treatment of neuropathic pain is a clinical challenge likely because of the time-dependent changes in many neurotransmitter systems, growth factors, ionic channels, membrane receptors, transcription factors, and recruitment of different cell types. Conversely, an increasing number of reports have shown
Nguyen H Tran et al.
Chemical Society reviews, 42(24), 9454-9479 (2013-09-18)
Presently there is a glut of glycerol as the by-product of biofuel production and it will grow as production increases. The conundrum is how we can consume this material and convert it into a more useful product. One potential route
Wen Qin et al.
Chembiochem : a European journal of chemical biology, 15(18), 2747-2753 (2014-10-30)
Macrolactins (MLNs) have unique structural patterns containing a 24-membered ring lactone and diverse bioactivities. The MLN skeleton is biosynthesized via a trans-acyl transferase (AT) type I polyketide synthase (PKS) pathway, but the tailoring steps are still unknown. Herein, we report
Shweta Mishra et al.
PloS one, 10(1), e0116611-e0116611 (2015-01-31)
New Delhi metallo β-lactamases are one of the most significant emerging resistance determinants towards carbapenem drugs. Their persistence and adaptability often depends on their genetic environment and linkage. This study reports a unique and novel arrangement of blaNDM-1 gene within
K V Dmitruk et al.
TSitologiia i genetika, 47(6), 3-21 (2014-01-21)
Until recently, the methylotrophic yeast was not considered as a potential producer of biofuels, particularly of ethanol from lignocellulosic hydrolysates. The first work published 10 years ago reveals the ability of thermotolerant methylotrophic yeast Hansenula polymorpha to ferment xylose--one of
Clara Pereira et al.
Experimental cell research, 333(1), 73-79 (2015-03-03)
Mutations in Parkin, an E3 ubiquitin ligase, are associated to autosomal recessive Parkinson's disease (PD). Parkin has been mainly implicated, along with Pink1, in mitochondrial autophagy in response to stress. In this study, a yeast model was developed to analyse
Hannelore Rücker et al.
Organic & biomolecular chemistry, 13(10), 3040-3047 (2015-01-27)
Inflammatory signaling pathways orchestrate the cellular response to infection and injury. These pathways are known to be modulated by compounds that alkylate cysteinyl thiols. One class of phytochemicals with strong thiol alkylating activity is the chalcones. In this study we
Xin Zheng et al.
Journal of virology, 89(9), 4786-4797 (2015-01-30)
Angiopoietin-1 (ANGPT-1) is a secreted glycoprotein that was first characterized as a ligand of the Tie2 receptor. In a previous study using microarray analysis, we found that the expression of ANGPT-1 was upregulated in Kaposi's sarcoma-associated herpesvirus (KSHV)-infected primary effusion
Franziska Barthel et al.
Anesthesiology, 121(1), 160-169 (2014-03-07)
Dysfunction of spinal glycinergic neurotransmission is a major pathogenetic factor in neuropathic pain. The synaptic glycine concentration is controlled by the two glycine transporters (GlyT) 1 and 2. GlyT inhibitors act antinociceptive in various animal pain models when applied as
H Craig Heller et al.
Neurobiology of learning and memory, 116, 162-171 (2014-12-03)
Down syndrome (DS) has an incidence of about 1/700 births, and is therefore the most common cause of cognitive and behavioral impairments in children. Recent studies on mouse models of DS indicate that a number of pharmacotherapies could be beneficial
Hicham Benabdelkamel et al.
Molecular and cellular endocrinology, 401, 142-154 (2014-12-17)
Overweight (OW) and obese individuals are considered to be graded parts of the scale having increasing weight as a common feature. They may not, however, be part of the same continuum and may differ metabolically. In this study we applied
D Brouard et al.
Vox sanguinis, 108(2), 197-204 (2014-12-04)
The last two decades have seen major developments in genotyping assays to facilitate the procurement of red blood cell units to alloimmunized patients. To make genotyping faster, simpler and less costly, a nanotechnology approach based on metal/silica fluorescent nanoparticles and
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