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PHR1047
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关键词:'PHR1047'
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Lisa Pollaro et al.
Molecular cancer therapeutics, 14(1), 151-161 (2014-11-09)
Monoclonal antibodies have long in vivo half-lives and reach high concentrations in tumors but cannot access all regions in the tissue, whereas smaller ligands such as peptides distribute better but are limited by low concentrations due to fast renal clearance.
J L Burzotta et al.
Clinics in podiatric medicine and surgery, 6(2), 453-467 (1989-04-01)
The phenol and alcohol procedure still remains as one of the most effective and gratifying means of treatment for symptomatic ingrown nails. Most of the literature is concerned with length and manner of application and various forms of postoperative management.
Siriluck Ponsuksili et al.
Biology of reproduction, 91(6), 135-135 (2014-09-26)
Endometrial receptivity is a prerequisite for successful embryo implantation and pregnancy. Receptivity involves complex processes promoted by many transcripts that are key components of molecular pathways that depend on ovarian hormones and that contribute to shaping structural, metabolic, and communication
Ximeng Liu et al.
Current protocols in molecular biology, Chapter 2, Unit2-Unit2 (2013-04-03)
DNA isolation is a fundamental initial step for molecular genetic studies. Two quite different methodologies are described in this unit: silica spin column and phenol/chloroform extraction. Currently, the most commonly used technique is the silica-based spin column, although phenol/chloroform extraction
Tahra Mohamed Leheta et al.
The Journal of dermatological treatment, 25(2), 130-136 (2012-03-09)
Deep peeling using phenol and percutaneous collagen induction (PCI) are used in treating acne scars. To compare deep peeling using phenol and PCI combined with trichloroacetic acid (TCA) 20% in treating atrophic acne scars. 24 patients with post-acne atrophic scars
Michał Brokl et al.
Journal of chromatography. A, 1370, 216-229 (2014-12-03)
A method involving headspace solid-phase microextraction (HS-SPME) and comprehensive two-dimensional gas chromatography (GC×GC) coupled to time-of-flight mass spectrometry (TOFMS) was developed and applied to evaluate profiles of volatile compounds present in mainstream tobacco smoke particulate matter trapped on glass fiber
Aaron Goldman et al.
Nature communications, 6, 6139-6139 (2015-02-12)
Understanding the emerging models of adaptive resistance is key to overcoming cancer chemotherapy failure. Using human breast cancer explants, in vitro cell lines, mouse in vivo studies and mathematical modelling, here we show that exposure to a taxane induces phenotypic
Damian Cordoba Diaz et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(9), 1363-1367 (2013-05-04)
A phenolization approach is often chosen for treatment of ingrown toenails. Many reports describe lavage of the wound with alcohol to neutralize any residual phenol. The aim of our study was to compare the suitability and effectiveness of a solution
Callie A Cole et al.
Physical chemistry chemical physics : PCCP, 16(33), 17835-17844 (2014-07-19)
Uracil is an essential biomolecule for terrestrial life, yet its prebiotic formation mechanisms have proven elusive for decades. Meteorites have been shown to contain uracil and the interstellar abundance of aromatic species and nitrogen-containing molecules is well established, providing support
The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes.
Zhiwei Ang et al.
Scientific reports, 5, 8134-8134 (2015-01-31)
G-protein coupled receptor 43 (GPR43) recognizes short chain fatty acids and is implicated in obesity, colitis, asthma and arthritis. Here, we present the first full characterization of the GPR43 promoter and 5'-UTR. 5'-RACE of the GPR43 transcript identified the transcription
Ayla Valinezhad Orang et al.
Asian Pacific journal of cancer prevention : APJCP, 15(16), 6685-6689 (2014-08-30)
Alterations in gene expression levels or mutations of tyrosine kinases are detected in some human cancers. In this study, we examined whether serine threonine tyrosine kinase 1 (STYK1)/novel oncogene with kinase domain (NOK) is overexpressed in patients with colorectal cancer.
Changwu Yue et al.
World journal of microbiology & biotechnology, 31(4), 541-548 (2015-02-24)
The draft genome sequence of marine Streptomyces olivaceus strain FXJ 7.023 contains a cryptic Type III polyketide synthase (type III PKS) gene cluster, which is similar to the Streptomyces coelicolor THN biosynthesis gene cluster. A putative type III PKS (SoRppA)
Lina Raudone et al.
Food & function, 5(6), 1167-1174 (2014-04-05)
The mechanism of action of polyphenolic compounds is attributed to their antioxidant, anti-inflammatory, and anti-proliferative properties and their effects on subcellular signal transduction, cell cycle impairment and apoptosis. A raspberry (Rubus idaeus L.) fruit extract contains various antioxidant active compounds
Mika Lännenpää
Plant cell reports, 33(8), 1377-1388 (2014-05-06)
Overexpression of Arabidopsis AtMYB12 transcription factor greatly increases the total phenolic and flavonol content in transgenic kale leaves. Flavonoids are a diverse group of plant secondary metabolites exhibiting a number of health-promoting effects. There has been a growing interest to
Heidi M Ott et al.
Molecular cancer therapeutics, 13(12), 3062-3073 (2014-09-26)
The EZH2 methyltransferase silences gene expression through methylation of histone H3 on lysine 27 (H3K27). Recently, EZH2 mutations have been reported at Y641, A677, and A687 in non-Hodgkin lymphoma. Although the Y641F/N/S/H/C and A677G mutations exhibit clearly increased activity with
Oliver Dehus et al.
Analytical and bioanalytical chemistry, 407(6), 1673-1683 (2015-01-13)
Birch (Betula) pollen is a major cause of allergy in northern and central Europe. The allergenic potency of products for diagnosis and therapy of birch pollen allergy is adjusted nearly exclusively to the major birch pollen allergen Bet v 1.
Damir Baranasic et al.
mBio, 5(6), e01328-e01328 (2014-11-13)
Antigenic or phenotypic variation is a widespread phenomenon of expression of variable surface protein coats on eukaryotic microbes. To clarify the mechanism behind mutually exclusive gene expression, we characterized the genetic properties of the surface antigen multigene family in the
Hajer Ayari-Jeridi et al.
PloS one, 10(1), e0116615-e0116615 (2015-01-21)
Retinoblastoma, an embryonic neoplasm of retinal origin, is the most common primary intraocular malignancy in children. Somatic inactivation of both alleles of the RB1 tumor suppressor gene in a retinal progenitor cell through diverse mechanisms including genetic and epigenetic modifications
Jae H Park et al.
Journal of medicinal chemistry, 57(15), 6623-6631 (2014-07-16)
The aqueous solution structure of protoxin II (ProTx II) indicated that the toxin comprises a well-defined inhibitor cystine knot (ICK) backbone region and a flexible C-terminal tail region, similar to previously described NaSpTx III tarantula toxins. In the present study
Tzu-Yu Liu et al.
Current drug delivery, 12(1), 3-8 (2014-10-02)
Vaccine candidates for the treatment of human papillomavirus (HPV)-associated cancers are aimed to activate T-cells and induce development of cytotoxic anti-tumor specific responses. Peptide epitopes derived from HPV-16 E7 oncogenic protein have been identified as promising antigens for vaccine development.
Cuneyt Kayaalp et al.
Techniques in coloproctology, 13(3), 189-193 (2009-08-06)
Investigating minimally invasive methods for treatment of pilonidal disease, we reviewed the techniques and the results of phenol treatment of pilonidal disease in the medical literature. A Pubmed search for all English language written papers and abstracts published between January
Shun Uemura et al.
Neuroscience research, 80, 91-94 (2014-01-01)
Because genetic manipulation occasionally disrupts the expression of the neighboring genes, the chromosomal locus where the transgene has been integrated should be identified in the use of transgenic organisms. By using a new blend of thermostable DNA polymerase, we established
Jie Zhang et al.
Biotechnology for biofuels, 8, 36-36 (2015-03-13)
Clostridium cellulolyticum and other cellulolytic Clostridium strains are natural producers of lignocellulosic biofuels and chemicals via the consolidated bioprocessing (CBP) route, and systems metabolic engineering is indispensable to meet the cost-efficient demands of industry. Several genetic tools have been developed
Philipp Y Maximov et al.
Journal of medicinal chemistry, 57(11), 4569-4583 (2014-05-09)
Tamoxifen has biologically active metabolites: 4-hydroxytamoxifen (4OHT) and endoxifen. The E-isomers are not stable in solution as Z-isomerization occurs. We have synthesized fixed ring (FR) analogues of 4OHT and endoxifen as well as FR E and Z isomers with methoxy
Stephen J Glynn et al.
Organic & biomolecular chemistry, 13(13), 3887-3899 (2015-02-12)
The green tea polyphenol epigallocatechin-3-gallate (EGCG) was reported to effectively antagonize the ability of Bortezomib (BZM) to induce apoptosis in cancer cells. This interaction was attributed to the formation of a covalent adduct between a phenolic moiety of EGCG with
Eriko Sasaki et al.
Journal of medical virology, 87(4), 694-701 (2015-02-07)
The segmented nature of the rotavirus genome provides an opportunity for the virus to reassort upon co-infection of more than one rotavirus strain. Previously, two G1P[4] strains isolated from children with diarrhoea, AU64, and AU67, were shown by RNA-RNA hybridization
Ryoichi Mori et al.
The American journal of pathology, 184(9), 2465-2479 (2014-07-11)
The forkhead box O (FOXO) family has been extensively investigated in aging and metabolism, but its role in tissue-repair processes remains largely unknown. Herein, we clarify the molecular aspect of the FOXO family in skin wound healing. We demonstrated that
Amani M D Elahwany et al.
Acta biologica Hungarica, 64(1), 106-117 (2013-04-10)
Six isolates with phenol degrading ability were obtained from marine sediments by enrichment procedures and an isolate, AM4, was identified as Alcaligenes sp. by 16S rDNA sequencing. The Plackett-Burman design was applied to estimate the significance of culture medium components
Heather M Wilkins et al.
Human molecular genetics, 23(24), 6528-6541 (2014-07-17)
Brain bioenergetic function declines in some neurodegenerative diseases, this may influence other pathologies and administering bioenergetic intermediates could have therapeutic value. To test how one intermediate, oxaloacetate (OAA) affects brain bioenergetics, insulin signaling, inflammation and neurogenesis, we administered intraperitoneal OAA
Javier E Ramirez et al.
Food chemistry, 176, 106-114 (2015-01-28)
The HPLC profiles of six fruits endemic of the VIII region of Chile were investigated using high resolution mass analysis (HR-ToF-ESI-MS). The anthocyanin fingerprints generated for the fruits were compared and the antioxidant capacities measured by the scavenging of the
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