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Karolien Gellynck et al.
Experimental biology and medicine (Maywood, N.J.), 240(4), 446-457 (2014-10-12)
Continuous glucose monitoring (CGM) is crucial in diabetic care. Long-term CGM systems however require an accurate sensor as well as a suitable measuring environment. Since large intravenous sensors are not feasible, measuring inside the interstitial fluid is considered the best
Shradha Basi-Chipalu et al.
Applied and environmental microbiology, 81(10), 3419-3429 (2015-03-15)
Lantibiotics are ribosomally synthesized antimicrobial peptides with substantial posttranslational modifications. They are characterized by the unique amino acids lanthionine and methyllanthionine, which are introduced by dehydration of Ser/Thr residues and linkage of the resulting dehydrated amino acids with Cys residues.
C A Moore et al.
Toxicology letters, 229(1), 257-264 (2014-06-10)
Organophosphates (OPs) are widely used in agriculture. Many studies have investigated the capability of personal protective equipment (PPE) to reduce chemical exposure; however, investigations into the protective effect of 'every-day' clothing are rare. The purpose of this study was to
Paul Holvoet et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 77, 22-33 (2015-01-03)
There is a close interaction between Type 2 Diabetes, obesity and liver disease. We have studied the effects of the two most abundant Stevia-derived steviol glycosides, stevioside and rebaudioside A, and their aglycol derivative steviol on liver steatosis and the
Anton Iliuk et al.
International journal of mass spectrometry, 377, 744-753 (2015-05-09)
Tandem mass spectrometry (MS/MS) has enabled researchers to analyze complex biological samples since the original concept inception. It facilitates the identification and quantification of modifications within tens of thousands of proteins in a single large-scale proteomic experiment. Phosphorylation analysis, as
Claudia Borst et al.
Methods in molecular biology (Clifton, N.J.), 970, 363-375 (2013-01-04)
Chiral separation by means of cyclodextrins has a long-standing tradition in capillary electrophoresis techniques. Here we present a chiral method utilizing the recently introduced microemulsion electrokinetic chromatography. The microemulsion consisting of 1.0% SDS, 4.0% 1-butanol, 3.0% 2-propanol, 0.5% ethylacetate, and
Protein tyrosine phosphatase 1B (PTP1B) is involved in the defective erythropoietic function of carbamylated erythropoietin.
María Eugenia Chamorro et al.
The international journal of biochemistry & cell biology, 61, 63-71 (2015-02-11)
Mehdi Najar et al.
Cytotherapy, 16(9), 1220-1228 (2014-07-30)
Adult human subcutaneous adipose tissue harbors a multipotent stem cell population, the so-called human adipose tissue-derived mesenchymal stromal cells (AT-MSCs). These cells are able to differentiate in vitro into various cell types and possess immunomodulatory features. Yet procedures to obtain
Jelle De Vos et al.
Journal of chromatography. A, 1360, 164-171 (2014-08-17)
To increase detection sensitivity in liquid chromatography, a generic post-column refocusing strategy has been developed to enrich (target) analytes prior to detection. In this strategy, after separation on the analytical column, the analytes are led to a trap column preferably
Annie Girard et al.
Reproductive biology and endocrinology : RB&E, 13, 17-17 (2015-04-17)
The physiological state of the dominant follicle is important as it may be linked to the competence of the oocyte within. The objective of this study was to analyze, by transcriptomic analysis, the changes occurring in granulosa cells from dominant
Jiali Gu et al.
Applied microbiology and biotechnology, 99(4), 1709-1718 (2014-08-12)
Methyl (R)-o-chloromandelate (R-CMM) is an intermediate for the platelet aggregation inhibitor clopidogrel. Its preparation through enzymatic resolution of the corresponding ester has been hindered by the lack of an enzyme with satisfying enantioselectivity and activity. In the present work, we
Wei Lei et al.
Reproduction (Cambridge, England), 148(6), 607-621 (2014-09-26)
The mouse model has greatly contributed to understanding molecular mechanisms involved in the regulation of progesterone (P4) plus estrogen (E)-dependent blastocyst implantation process. However, little is known about contributory molecular mechanisms of the P4-only-dependent blastocyst implantation process that occurs in
Tian-Ren Li et al.
Nature communications, 5, 5500-5500 (2014-11-22)
Through nearly 50 years of development, sulphur ylides have been established as versatile and powerful reagents for the construction of carbocycles and heterocycles. Despite advances, two important and yet elusive bottlenecks continue to inhibit the advancement of this chemistry: a
Effective, low-cost, simple, disposable cooling tool for patient comfort in common dermatologic procedures.
Doris M Hexsel et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(9), 1402-1404 (2013-05-23)
Liana Tsenova et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 34(9), 716-726 (2014-05-17)
Treatment of chronic inflammatory diseases with tumor necrosis factor alpha (TNF-α) antagonists has been associated with increased risk of tuberculosis (TB). We examined the usefulness of the rabbit model of active pulmonary TB for studying the impact of the human
Izaskun Valdivielso et al.
Food chemistry, 173, 709-717 (2014-12-04)
Carotenoids and tocopherols from botanical species abundant in Atlantic mountain grasslands were simultaneously extracted using one-step solid-liquid phase. A single n-hexane/2-propanol extract containing both types of compounds was injected twice under two different sets of HPLC conditions to separate the
Marina Makrecka et al.
Molecular and cellular biochemistry, 395(1-2), 1-10 (2014-06-01)
In the heart, a nutritional state (fed or fasted) is characterized by a unique energy metabolism pattern determined by the availability of substrates. Increased availability of acylcarnitines has been associated with decreased glucose utilization; however, the effects of long-chain acylcarnitines
Dominik Duscher et al.
Scientific reports, 4, 7144-7144 (2014-11-22)
Advanced age is associated with an increased risk of vascular morbidity, attributable in part to impairments in new blood vessel formation. Mesenchymal stem cells (MSCs) have previously been shown to play an important role in neovascularization and deficiencies in these
Cheng-Yen Kao et al.
Helicobacter, 19(6), 443-454 (2014-08-12)
Motility mediated by the flagella of Helicobacter pylori has been shown to be required for normal colonization and is thought to be important for the bacteria to move toward the gastric mucus in niches adjacent to the epithelium. Barnard et
Eugene Cho et al.
Oncology reports, 33(3), 1459-1464 (2014-12-20)
The neuron-restrictive silencer factor/repressor element 1-silencing transcription factor (NRSF/REST) was originally discovered as a transcriptional repressor of neuronal genes in non-neuronal cells. However, it was recently reported to be abundantly expressed in several types of aggressive cancer cells, as well
Weilin Liu et al.
Food chemistry, 175, 16-24 (2015-01-13)
This study examined the stability of liposomes loaded with negatively charged protein (bovine serum albumin, BSA) during in vitro digestion. Zeta-potential and morphology measurements confirmed that BSA-loaded liposomes were successfully prepared, with an encapsulation efficiency of around 34%. The encapsulated
Mona Freidin et al.
Experimental neurology, 263, 339-349 (2014-12-03)
X-linked Charcot-Marie-Tooth disease (CMT1X) is an inherited peripheral neuropathy caused by mutations in GJB1, the human gene for Connexin32 (Cx32). This present study uses Ilumina Ref8-v2 BeadArray to examine the expression profiles of injured and uninjured sciatic nerves at 5
Cédric Pisani et al.
BMC genomics, 16, 315-315 (2015-04-22)
The toxicity of manufactured fumed silica nanoparticles (NPs) remains poorly investigated compared to that of crystalline silica NPs, which have been associated with lung diseases after inhalation. Amorphous silica NPs are a raw material for manufactured nanocomposites, such as cosmetics
In vitro and in vivo toxicological studies of V nerve agents: molecular and stereoselective aspects.
Georg Reiter et al.
Toxicology letters, 232(2), 438-448 (2014-12-03)
In vitro inhibition data of cholinesterases (ChEs) and reactivation with HI 6 are presented for separated VX and VR enantiomers with high purity (enantiomer excess >99.999%). Inhibition rate constants for (-)-VR were fourfold higher than for (-)-VX. Marked higher stereoselectivity
K P Goetz et al.
Nature communications, 5, 5642-5642 (2014-12-04)
The crystalline structure of organic materials dictates their physical properties, but while significant research effort is geared towards understanding structure-property relationships in such materials, the details remain unclear. Many organic crystals exhibit transitions in their electrical properties as a function
David R Barnidge et al.
Journal of proteome research, 13(11), 5198-5205 (2014-08-20)
We previously described a microLC-ESI-Q-TOF MS method for identifying monoclonal immunoglobulins in serum and then tracking them over time using their accurate molecular mass. Here we demonstrate how the same methodology can be used to identify and characterize polyclonal immunoglobulins
Ana M Ferreira et al.
Human mutation, 35(12), 1514-1523 (2014-09-19)
Microsatellite instability (MSI) in tumors results in an accumulation of mutations in (target) genes. Previous studies suggest that the profile of target genes differs according to tumor type. This paper describes the first genome-wide search for target genes for mismatch
A W Jones et al.
Forensic science international, 37(4), 277-285 (1988-06-01)
Headspace gas chromatography was used to determine the concentration of ethanol and methanol in blood samples from 519 individuals suspected of drinking and driving in Sweden where the legal alcohol limit is 0.50 mg/g in whole blood (11 mmol/l). The
László Pál et al.
Immunopharmacology and immunotoxicology, 37(2), 193-201 (2015-02-19)
A large volume of alcoholic beverages containing aliphatic alcohols is consumed worldwide. Previous studies have confirmed the presence of ethanol-induced immunosuppression in heavy drinkers, thereby increasing susceptibility to infectious diseases. However, the aliphatic alcohols contained in alcoholic beverages might also
B P Kaistha et al.
British journal of cancer, 111(9), 1780-1787 (2014-08-20)
Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies with an overall 5-year survival rate of <5%. Despite significant advances in treatment of the disease during the past decade, the median survival rate (∼6 months) has hardly improved
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