PHR1117

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关键词:'PHR1117'

显示 1-30 共 137 条结果关于 "PHR1117" 范围论文

Safety assessment of butylated hydroxyanisole and butylated hydroxytoluene as antioxidant food additives.

G M Williams et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 37(9-10), 1027-1038 (1999-10-29)

Butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) are widely used antioxidant food additives. They have been extensively studied for potential toxicities. This review details experimental studies of genotoxicity and carcinogenicity which bear on cancer hazard assessment of exposure to humans.

Peroxidative permeabilization of liposomes induced by cytochrome c/cardiolipin complex.

Alexander M Firsov et al.

Biochimica et biophysica acta, 1848(3), 767-774 (2014-12-09)

Interaction of cytochrome c with mitochondrial cardiolipin converting this electron transfer protein into peroxidase is accepted to play an essential role in apoptosis. Cytochrome c/cardiolipin peroxidase activity was found here to cause leakage of carboxyfluorescein, sulforhodamine B and 3-kDa (but

Chemical profile and biological activities of Veronica thymoides subsp. pseudocinerea.

Abdulselam Ertas et al.

Pharmaceutical biology, 53(3), 334-339 (2014-10-22)

In Turkey, Veronica species (Plantaginaceae) have been used as a diuretic and for wound healing in traditional medicine. To examine the fatty acid and essential oil profiles, the antioxidant, anticholinesterase, antimicrobial, and DNA damage effects of Veronica thymoides P.H. Davis

Quantification of F2-isoprostanes as a reliable index of oxidative stress in vivo using gas chromatography-mass spectrometry (GC-MS) method.

Wei Liu et al.

Free radical biology & medicine, 47(8), 1101-1107 (2009-08-04)

Free radical-induced lipid peroxidation has been implicated in a number of human diseases including atherosclerosis, cancer, and neurodegenerative diseases. F(2)-Isoprostanes (IsoPs) are isomers of prostaglandin PGF(2alpha) that are generated in vivo from the free radical-initiated peroxidation of arachidonic acid independent

Butylated hydroxytoluene analogs: synthesis and evaluation of their multipotent antioxidant activities.

Wageeh A Yehye et al.

Molecules (Basel, Switzerland), 17(7), 7645-7665 (2012-06-27)

A computer-aided predictions of antioxidant activities were performed with the Prediction Activity Spectra of Substances (PASS) program. Antioxidant activity of compounds 1, 3, 4 and 5 were studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and lipid peroxidation assays to verify the predictions obtained

Development and evaluation of chitosan and chitosan/Kollicoat® Smartseal 30 D film-coated tablets for colon targeting.

Michael Drechsler et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 807-815 (2014-10-11)

The aim of the present study was to develop film-coated tablets which release a minor amount of the active pharmaceutical ingredient (API) into the stomach and small intestine, yet show a sharp increase of drug release in the colon. Tablets

Butylated hydroxytoluene (BHT): a review.

H Babich

Environmental research, 29(1), 1-29 (1982-10-01)

Phytochemical profiles, antioxidant activities of functional herb Abrus cantoniensis and Abrus mollis.

Mei Yang et al.

Food chemistry, 177, 304-312 (2015-02-11)

It has been claimed that consumptions of Abrus cantoniensis (AC) and Abrus mollis (AM) as folk beverages and soups are good to cleanse liver toxicants and prevent liver diseases. There is scant information on the phytochemical profiles and antioxidant activities

Rapid modification of the insect elicitor N-linolenoyl-glutamate via a lipoxygenase-mediated mechanism on Nicotiana attenuata leaves.

Arjen VanDoorn et al.

BMC plant biology, 10, 164-164 (2010-08-11)

Some plants distinguish mechanical wounding from herbivore attack by recognizing specific constituents of larval oral secretions (OS) which are introduced into plant wounds during feeding. Fatty acid-amino acid conjugates (FACs) are major constituents of Manduca sexta OS and strong elicitors

Expedited access to vinaxanthone and chemically edited derivatives possessing neuronal regenerative effects through ynone coupling reactions.

Matthew R Chin et al.

ACS chemical neuroscience, 6(4), 542-550 (2015-01-24)

The natural product vinaxanthone has demonstrated a remarkable capability to promote nerve growth following injury or transplantation. In rats following total transection of the spinal cord delivery of vinaxanthone enhanced axonal regeneration, remyelination and angiogenesis at the site of injury

Bioaccessibility and digestive stability of carotenoids in cooked eggs studied using a dynamic in vitro gastrointestinal model.

Chamila Nimalaratne et al.

Journal of agricultural and food chemistry, 63(11), 2956-2962 (2015-03-10)

Among dietary carotenoids, lutein and zeaxanthin are known to protect against age-related macular degeneration, a leading cause of irreversible vision loss in the elderly. Egg yolk is rich in lutein and zeaxanthin, however, the effect of cooking and gastrointestinal digestion

Drug-excipient compatibility studies in binary mixtures of avobenzone.

Rita Ceresole et al.

Journal of cosmetic science, 64(5), 317-328 (2013-10-22)

During preformulation studies of cosmetic/pharmaceutical products, thermal analysis techniques are very useful to detect physical or chemical incompatibilities between the active and the excipients of interest that might interfere with safety and/or efficacy of the final product. Differential scanning calorimetry

Structure of the N-terminal segment of human retinol dehydrogenase 11 and its preferential lipid binding using model membranes.

Mustapha Lhor et al.

Biochimica et biophysica acta, 1848(3), 878-885 (2014-12-30)

Retinol dehydrogenase 11 (RDH11) has been postulated to be anchored to membranes by means of its N-terminal segment in retinal pigment epithelial (RPE) cells where it participates to the visual cycle. The analysis of the primary sequence of RDH11 revealed

Preparing amorphous hydrophobic drug nanoparticles by nanoporous membrane extrusion.

Peng Guo et al.

Nanomedicine (London, England), 8(3), 333-341 (2012-09-05)

The aim of the present study was to develop a simple and straightforward method for formulating hydrophobic drugs into nanoparticulate form in a scalable and inexpensive manner. The nanoporous membrane extrusion (NME) method was used to prepare hydrophobic drug nanoparticles.

Determination of synthetic phenolic antioxidants and relative metabolites in sewage treatment plant and recipient river by high performance liquid chromatography-electrospray tandem mass spectrometry.

Runzeng Liu et al.

Journal of chromatography. A, 1381, 13-21 (2015-01-24)

Robust analytical methods were developed for the determination of eight emerging synthetic phenolic antioxidants (SPAs) and three metabolites in sewage sludge, effluent and river water matrices. Accelerated solvent extraction was employed for the extraction of the target analytes from sludge

Comparison of lifelong and late life exercise on oxidative stress in the cerebellum.

Li Cui et al.

Neurobiology of aging, 30(6), 903-909 (2007-11-03)

Aging was associated with increased oxidation of DNA, RNA, and lipids in the cerebellum of male rats. DNA and lipid oxidation was reduced by lifelong (94 weeks) voluntary exercise on a running wheel. A reduction in cerebellar lipid oxidation, but

Simultaneous analysis of carotenoids and tocopherols in botanical species using one step solid-liquid extraction followed by high performance liquid chromatography.

Izaskun Valdivielso et al.

Food chemistry, 173, 709-717 (2014-12-04)

Carotenoids and tocopherols from botanical species abundant in Atlantic mountain grasslands were simultaneously extracted using one-step solid-liquid phase. A single n-hexane/2-propanol extract containing both types of compounds was injected twice under two different sets of HPLC conditions to separate the

Chemical constituents and biological activities of Cirsium leucopsis, C. sipyleum, and C. eriophorum.

Mehmet Boğa et al.

Zeitschrift fur Naturforschung. C, Journal of biosciences, 69(9-10), 381-390 (2015-02-26)

Two endemic Cirsium species, C. leucopsis DC. and C. sipyleum O. Schwarz, and C. eriophorum (L.) Scop. growing in Turkey were investigated to establish their secondary metabolites, fatty acid compositions, and antioxidant and anticholinesterase potentials. Spectroscopic methods were used to

Oxidative stress is a potential cost of breeding in male and female northern elephant seals.

J T Sharick et al.

Functional ecology, 29(3), 367-376 (2015-05-20)

The trade-off between current reproductive effort and survival is a key concept of life history theory. A variety of studies support the existence of this trade-off but the underlying physiological mechanisms are not well-understood. Oxidative stress has been proposed as

Optimization and validation of a chiral GC-MS method for the determination of free D-amino acids ratio in human urine: application to a gestational diabetes mellitus study.

Ma Paz Lorenzo et al.

Journal of pharmaceutical and biomedical analysis, 107, 480-487 (2015-02-14)

Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance with onset or first recognition during pregnancy. It is affecting approximately up to 14% of all pregnancies with an increasing tendency. GDM has been related to relevant short-term and long-term health

The antioxidant behaviour of melatonin and structural analogues during lipid peroxidation depends not only on their functional groups but also on the assay system.

Natalia Fagali et al.

Biochemical and biophysical research communications, 423(4), 873-877 (2012-06-21)

There is no general agreement yet on the antioxidant effect of pineal indoles against lipid peroxidation. Accordingly, the main goal of the present work was to study the antioxidant activity of melatonin (MLT), N-acetylserotonin (NAS), 5-HO-tryptophan (5HO-TRP) and 5-methoxytryptamine (5MTP)

Effects of dietary fat, butylated hydroxytoluene and propyl gallate on microsomal drug metabolism in rats.

Nutrition reviews, 40(6), 189-191 (1982-06-01)

Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages.

Jocelijn Meijerink et al.

British journal of pharmacology, 172(1), 24-37 (2014-05-02)

N-docosahexaenoylethanolamine (DHEA) is the ethanolamine conjugate of the long-chain polyunsaturated n-3 fatty acid docosahexaenoic (DHA; 22: 6n-3). Its concentration in animal tissues and human plasma increases when diets rich in fish or krill oil are consumed. DHEA displays anti-inflammatory properties

Anti-inflammatory effects of vitamin E on adjuvant-induced arthritis in rats.

Mateus Fortes Rossato et al.

Inflammation, 38(2), 606-615 (2014-08-15)

Vitamin E (vit-E) is a lipophilic antioxidant, and its anti-inflammatory activity is still not full characterized. Thus, our goal was to investigate the anti-inflammatory effect of repeated vit-E treatment in the arthritis induced by the intraplantar injection of complete Freund's

Chemical composition and free radical-scavenging, anticancer and anti-inflammatory activities of the essential oil from Ocimum kilimandscharicum.

V T de Lima et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(11), 1298-1302 (2014-08-31)

The essential oil from the leaves of Ocimum kilimandscharicum (EOOK), collected in Dourados-MS, was investigated for anticancer, anti-inflammatory and antioxidant activity and chemical composition. The essential oil was extracted by hydrodistillation, and the chemical composition was performed by gas chromatography-mass

Cryopreservation prevents iron-initiated highly unsaturated fatty acid loss during storage of human blood on chromatography paper at -20°C.

Adam H Metherel et al.

The Journal of nutrition, 145(3), 654-660 (2015-03-04)

Fingertip prick whole blood collection on chromatography paper is amenable to high-throughput fatty acid (FA) profiling for large clinical and field studies. However, sample storage is problematic because highly unsaturated FAs (HUFAs) in erythrocytes rapidly degrade in samples stored at

Structural characterization of lignin: a potential source of antioxidants guaiacol and 4-vinylguaiacol.

Mohammadali Azadfar et al.

International journal of biological macromolecules, 75, 58-66 (2015-01-21)

The structure of lignin obtained from the ozone and soaking aqueous ammonia pretreatment of wheat straw has been characterized utilizing chemical analytical methods in order to reveal its antioxidant characteristics, including attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), pyrolysis-gas chromatography/mass

A method for long term stabilisation of long chain polyunsaturated fatty acids in dried blood spots and its clinical application.

Ge Liu et al.

Prostaglandins, leukotrienes, and essential fatty acids, 91(6), 251-260 (2014-12-03)

Conventional assays of omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in humans involve venous blood collection and expensive, multi-step processes that limit their usefulness as screening tools. This study aimed to develop a capillary dried blood spot (DBS)

[Comparison of the antiradical activity of ionol, components of fresh ginger, and its extracts].

E S Alinkina et al.

Prikladnaia biokhimiia i mikrobiologiia, 48(5), 564-569 (2012-10-30)

The antiradical properties of three samples of ginger (Zingiber officinale R.)-juice from fresh rhizome, essential oil, and extracts (oleoresin)-were studied and compared with the properties of synthetic antioxidant ionol (butylatedhydroxy-toluene, BHT). Reaction antioxidants with stable free 2,2-diphenyl-1-picrylhydrozyl radicals were used

Human placental eXpanded (PLX) mesenchymal-like adherent stromal cells confer neuroprotection to nerve growth factor (NGF)-differentiated PC12 cells exposed to ischemia by secretion of IL-6 and VEGF.

Adi Lahiani et al.

Biochimica et biophysica acta, 1853(2), 422-430 (2014-12-03)

Mesenchymal stem cells are potent candidates in stroke therapy due to their ability to secrete protective anti-inflammatory cytokines and growth factors. We investigated the neuroprotective effects of human placental mesenchymal-like adherent stromal cells (PLX) using an established ischemic model of

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