PHR1131

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关键词:'PHR1131'

显示 1-30 共 101 条结果关于 "PHR1131" 范围论文

Effects of verapamil on the immediate-early gene expression of bone marrow mesenchymal stem cells stimulated by mechanical strain in vitro.

Runguang Li et al.

Medical science monitor basic research, 19, 68-75 (2013-02-26)

To study the effects of verapamil on the immediate-early genes (IEGs) expression of bone marrow mesenchymal stem cells (MSCs) stimulated by cyclic mechanical strain, in order to deduce the role of calcium ion channel in the cell signaling responses of

Blood-brain barrier pharmacoproteomics-based reconstruction of the in vivo brain distribution of P-glycoprotein substrates in cynomolgus monkeys.

Yasuo Uchida et al.

The Journal of pharmacology and experimental therapeutics, 350(3), 578-588 (2014-06-21)

The aim of this study was to investigate whether in vivo drug distribution in brain in monkeys can be reconstructed by integrating four factors: protein expression levels of P-glycoprotein (P-gp)/multidrug resistance protein 1 at the blood-brain barrier (BBB), in vitro

Combination therapy to reduce conjunctival scarring after glaucoma surgery.

Marco A Zarbin

JAMA ophthalmology, 131(9), 1123-1123 (2013-07-13)

Acceleration of tuberculosis treatment by adjunctive therapy with verapamil as an efflux inhibitor.

Shashank Gupta et al.

American journal of respiratory and critical care medicine, 188(5), 600-607 (2013-06-29)

A major priority in tuberculosis (TB) is to reduce effective treatment times and emergence of resistance. Recent studies in macrophages and zebrafish show that inhibition of mycobacterial efflux pumps with verapamil reduces the bacterial drug tolerance and may enhance drug

A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport.

Lucy C Stott et al.

Aquatic toxicology (Amsterdam, Netherlands), 159, 127-137 (2014-12-30)

The gill is the principle site of xenobiotic transfer to and from the aqueous environment. To replace, refine or reduce (3Rs) the large numbers of fish used in in vivo uptake studies an effective in vitro screen is required that

Depression biased non-Hebbian spike-timing-dependent synaptic plasticity in the rat subiculum.

Anurag Pandey et al.

The Journal of physiology, 592(16), 3537-3557 (2014-06-08)

The subiculum is a structure that forms a bridge between the hippocampus and the entorhinal cortex (EC), and plays a major role in the memory consolidation process. Here, we demonstrate spike-timing-dependent plasticity (STDP) at the proximal excitatory inputs on the

High-throughput liquid chromatography/mass spectrometry method for the quantitation of small molecules using accurate mass technologies in supporting discovery drug screening.

Xiao Ding et al.

Rapid communications in mass spectrometry : RCM, 27(3), 401-408 (2013-01-03)

Drug discovery samples are routinely analyzed using liquid chromatography/tandem mass spectrometry (LC/MS/MS) methods on triple quadrupole mass spectrometers employing multiple reaction monitoring (MRM). In order to improve analysis throughput, quantitation of small molecules on a quadrupole time-of-flight (QqTOF) instrument using

Acute respiratory distress syndrome after verapamil intoxication: case report and literature review.

S Izdes et al.

Acta clinica Belgica, 69(2), 116-119 (2014-04-15)

Verapamil intoxication is a life-threatening condition that often presents with severe hemodynamic instability and requires vasopressor support. There are also documented case reports of the development of non-cardiogenic pulmonary oedema after verapamil overdose. However, the exact mechanisms responsible for pulmonary

Two cases of cluster headache effectively treated with levetiracetam.

Antonio Palermo et al.

Functional neurology, 28(1), 63-64 (2013-06-05)

Pharmacological basis for the medicinal use of Wrightia tinctoria in hypertension and dyslipidemia.

Hasan Salman Siddiqi et al.

Journal of cardiovascular pharmacology, 64(2), 151-163 (2014-04-01)

This study was aimed to offer a possible pharmacological basis regarding the remedial utilization of Wrightia tinctoria in hypertension and dyslipidemia in certain South Asian traditional systems of medicine, using in vivo and in vitro assays. The aqueous methanolic extract

The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval.

Lei Zhang et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 5006-5016 (2013-03-15)

In rodents, adrenergic signaling by norepinephrine (NE) in the hippocampus is required for the retrieval of intermediate-term memory. NE promotes retrieval via the stimulation of β1-adrenergic receptors, the production of cAMP, and the activation of both protein kinase A (PKA)

Vaginal expression of efflux transporters and the potential impact on the disposition of microbicides in vitro and in rabbits.

Carolien Grammen et al.

Molecular pharmaceutics, 11(12), 4405-4414 (2014-10-21)

In order to reach sufficiently high tissue concentrations and thus be effective, vaginally applied anti-HIV microbicides that are active at the level of the immune cells must permeate across the cervicovaginal mucosal layer. Cellular efflux transporters, such as Pgp, BCRP

Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.

Yasuhiro Horita et al.

Antimicrobial agents and chemotherapy, 58(6), 3168-3176 (2014-03-26)

Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS coinfection cases. We evaluated

A complex rhythm treated simply: fascicular ventricular tachycardia.

Timothy Canan et al.

The American journal of medicine, 127(7), 601-604 (2013-12-10)

Potential role for human P-glycoprotein in the transport of lacosamide.

Chunbo Zhang et al.

Epilepsia, 54(7), 1154-1160 (2013-04-05)

Antiepileptic drugs (AEDs) do not effectively treat 30-40% of patients with epilepsy. Export of AEDs by P-glycoprotein (Pgp, ABCB1, or MDR1), which is overexpressed in the blood-brain barrier in drug-resistant patients, may be a mechanism for resistance to AEDs. For

Circumvention of inherent or acquired cytotoxic drug resistance in vitro using combinations of modulating agents.

David Cadagan et al.

Anticancer research, 33(10), 4381-4387 (2013-10-15)

Modulating agents are used to circumvent drug resistance in the clinical setting. However achievable serum concentrations are often lower than those which are optimal in vitro. Combination of modulating agents with non-overlapping toxicities may overcome this obstacle. We have investigated

Mechanism of synergistic interactions and its influence on drug release from extended release matrices manufactured using binary mixtures of polyethylene oxide and sodium carboxymethylcellulose.

Dasha Palmer et al.

Colloids and surfaces. B, Biointerfaces, 104, 174-180 (2013-01-15)

The ability of anionic polymer sodium carboxymethylcellulose to influence the release of four model cationic drugs (chlorpheniramine maleate, venlafaxine hydrochloride, propranolol hydrochloride and verapamil hydrochloride) from extended release (ER) hydrophilic matrices based on non-ionic polymer polyethylene oxide was investigated by

Cells with hematopoietic activity in the mouse placenta reside in side population.

Ahmed Ramadan et al.

Genes to cells : devoted to molecular & cellular mechanisms, 15(9), 983-994 (2010-08-20)

The discovery of a major hematopoietic stem cell pool in midgestation mouse embryo has defined the placenta as an important hematopoietic anatomical site. In this study, we examined the flow cytometric pattern of mouse placenta cells on embryonic days (E)

Metformin as adjunct antituberculosis therapy.

Amit Singhal et al.

Science translational medicine, 6(263), 263ra159-263ra159 (2014-11-21)

The global burden of tuberculosis (TB) morbidity and mortality remains immense. A potential new approach to TB therapy is to augment protective host immune responses. We report that the antidiabetic drug metformin (MET) reduces the intracellular growth of Mycobacterium tuberculosis

ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1.

Masato Ishigami et al.

Biochimica et biophysica acta, 1831(4), 683-690 (2013-01-12)

Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports

Vascular-promoting therapy reduced tumor growth and progression by improving chemotherapy efficacy.

Esther Bridges et al.

Cancer cell, 27(1), 7-9 (2015-01-15)

In this issue of Cancer Cell, Wong and colleagues describe a novel approach of increasing the number of functional blood vessels in tumors using a low-dose therapy regimen of Cilengtide and Verapamil. This method enhanced gemcitabine delivery, uptake, and metabolism

A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating.

Tianxing Wang et al.

Biosensors & bioelectronics, 49, 9-13 (2013-05-28)

Drug-induced cardiotoxicity greatly endangers the human health and results in resource waste. Also, it is a leading attribution to drug withdrawal and late-stage attrition in pharmaceutical industry. In the study, a dual function cardiomyocyte-based biosensor was introduced for rapid drug

Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges".

Yoonseok Kam et al.

International journal of cancer, 136(4), E188-E196 (2014-08-27)

ATP-binding cassette (ABC) drug transporters consuming ATPs for drug efflux is a common mechanism by which clinical cancers develop multidrug resistance (MDR). We hypothesized that MDR phenotypes could be suppressed by administration of "ersatzdroges," nonchemotherapy drugs that are, nevertheless, ABC

Comparative study of the sensitivities of cancer cells to doxorubicin, and relationships between the effect of the drug-efflux pump P-gp.

Golam Kibria et al.

Biological & pharmaceutical bulletin, 37(12), 1926-1935 (2014-12-03)

Multi-drug resistance (MDR) of cancers to chemotherapy including doxorubicin (DOX) is mediated by several factors. To design an effective therapy for the treatment of chemotherapy-resistant cancers, it is essential to explore the elements responsible for mediating MDR. However, exploring these

Comparison of the permeability of metoprolol and labetalol in rat, mouse, and Caco-2 cells: use as a reference standard for BCS classification.

Tuba Incecayir et al.

Molecular pharmaceutics, 10(3), 958-966 (2013-01-19)

The purpose of this study was to investigate labetalol as a potential high permeability reference standard for the application of Biopharmaceutics Classification Systems (BCS). Permeabilities of labetalol and metoprolol were investigated in animal intestinal perfusion models and Caco-2 cell monolayers.

Functional impact of ABCB1 variants on interactions between P-glycoprotein and methadone.

Chin-Chuan Hung et al.

PloS one, 8(3), e59419-e59419 (2013-03-26)

Methadone is a widely used substitution therapy for opioid addiction. Large inter-individual variability has been observed in methadone maintenance dosages and P-glycoprotein (P-gp) was considered to be one of the major contributors. To investigate the mechanism of P-gp's interaction with

Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition.

Alice Ban Ke et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(3), 437-446 (2013-01-30)

Through PET imaging, our laboratory has studied the dynamic biodistribution of (11)C-verapamil, a P-gp substrate, in the nonhuman primate Macaca nemestrina. To gain detailed insight into the kinetics of verapamil transport across the blood-brain barrier (BBB) and the blood-placental barrier

Keratinocyte growth factor-2 stimulates P-glycoprotein expression and function in intestinal epithelial cells.

Seema Saksena et al.

American journal of physiology. Gastrointestinal and liver physiology, 304(6), G615-G622 (2013-01-19)

Intestinal P-glycoprotein (Pgp/multidrug resistance 1), encoded by the ATP-binding cassette B1 gene, is primarily involved in the transepithelial efflux of toxic metabolites and xenobiotics from the mucosa into the gut lumen. Reduced Pgp function and expression has been shown to

Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using felodipine and hesperetin in combination in Wistar rats and everted rat gut sacs in vitro.

V Sridhar et al.

Phytotherapy research : PTR, 28(5), 699-705 (2013-07-25)

The effects of hesperetin on the pharmacokinetics and the role of P-glycoprotein (P-gp) in the transport of felodipine were investigated in rats and in vitro. Felodipine was administered orally (10 mg/kg) without or with hesperetin (25, 50 and 100 mg/kg) to rats

Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center.

Michael Levine et al.

Annals of emergency medicine, 62(3), 252-258 (2013-05-07)

Verapamil or diltiazem overdose can cause severe morbidity and death, and there exist limited human data describing management and outcome of a large number of such patients. This article describes the management and outcome of patients with nondihydropyridine calcium-channel blocker

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