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Children with severe asthma have unique oxidative stress-associated metabolomic profiles.
Anne M Fitzpatrick et al.
The Journal of allergy and clinical immunology, 133(1), 258-261 (2013-12-29)
Massimiliano Calabrese et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 21(5), 580-589 (2014-11-30)
Although cognitive dysfunction is a relevant aspect of multiple sclerosis (MS) from the earliest disease phase, cognitive onset is unusual thus jeopardizing early and accurate diagnosis. Here we describe 12 patients presenting with cognitive dysfunction as primary manifestation of MS
H C Curtius et al.
Journal of chromatography, 112, 523-531 (1975-10-29)
A specific and very sensitive method for the determination of 5-hydroxy-tryptophol (5-HTOL) and 5-methoxytryptophol (5-MTOL) in extracts from human cerebrospinal fluid (CSF) involving the use of mass fragmentography and pentafluoropriopionyl derivatives is described. 5-HTOL and 5-MTOL were determined in human
Wolfram Gronwald et al.
Kidney international, 79(11), 1244-1253 (2011-03-11)
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based
Grace Kwan et al.
Applied and environmental microbiology, 81(3), 861-873 (2014-11-25)
Salmonella enterica is a member of the plant microbiome. Growth of S. enterica in sprouting-seed exudates is rapid; however, the active metabolic networks essential in this environment are unknown. To examine the metabolic requirements of S. enterica during growth in
Seok-Min Kang et al.
Clinical biochemistry, 44(4), 293-299 (2010-12-21)
We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with
Carolin F Manthey et al.
American journal of physiology. Cell physiology, 307(2), C180-C189 (2014-05-23)
Enteropathogenic Escherichia coli (EPEC) and Citrobacter rodentium are attaching-and-effacing (A/E) pathogens that cause intestinal inflammation and diarrhea. The bacteria adhere to the intestinal epithelium, destroy microvilli, and induce actin-filled membranous pedestals but do not invade the mucosa. Adherence leads to
Amy A Boaro et al.
FEMS microbiology ecology, 90(3), 802-815 (2014-10-08)
Integrated 'omics have been used on pure cultures and co-cultures, yet they have not been applied to complex microbial communities to examine questions of perturbation response. In this study, we used integrated 'omics to measure the perturbation response of a
Se Jin Park et al.
Biological & pharmaceutical bulletin, 37(7), 1207-1213 (2014-07-06)
Alzheimer's disease, a neurodegenerative disorder, is characterized by progressive cognitive impairment associated with the disruption of cholinergic neurotransmission. The aim of the present study was to evaluate the effect of α- or β-amyrin, a type of pentacyclic triterpene, on the
Yulia V Bertsova et al.
Biochimica et biophysica acta, 1837(7), 1122-1129 (2013-12-24)
The Klebsiella pneumoniae genome contains genes for two putative flavin transferase enzymes (ApbE1 and ApbE2) that add FMN to protein Thr residues. ApbE1, but not ApbE2, has a periplasm-addressing signal sequence. The genome also contains genes for three target proteins
Bo Peng et al.
Molecular bioSystems, 11(1), 105-114 (2014-10-18)
The cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized endogenous inhibitor of the phosphatase activity of protein phosphatase 2A (PP2A), which extends the half-life of oncogenic protein c-myc and promotes in vivo tumor growth. The function of
Selom K Doamekpor et al.
RNA (New York, N.Y.), 21(1), 113-123 (2014-11-22)
mRNA capping enzymes are directed to nascent RNA polymerase II (Pol2) transcripts via interactions with the carboxy-terminal domains (CTDs) of Pol2 and transcription elongation factor Spt5. Fission yeast RNA triphosphatase binds to the Spt5 CTD, comprising a tandem repeat of
Akihiro Sugai et al.
Journal of virology, 88(2), 1140-1149 (2013-11-08)
Measles virus nucleoprotein is the most abundant viral protein and tightly encapsidates viral genomic RNA to support viral transcription and replication. Major phosphorylation sites of nucleoprotein include the serine residues at locations 479 and 510. Minor phosphorylation residues have yet
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio
Junko Sugatani et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1708-1718 (2014-07-31)
The human pregnane X receptor (hPXR) is recognized as a xenobiotic-sensing nuclear receptor that transcriptionally regulates the gene expression of drug-metabolizing enzymes and transporters. Our study elucidates the mechanism by which the localization of hPXR is regulated through threonine-290. A
Jian-Xu Li et al.
The Biochemical journal, 451(3), 417-426 (2013-02-27)
Most TPSs (terpene synthases) contain plasticity residues that are responsible for diversified terpene products and functional evolution, which provide a potential for improving catalytic efficiency. Artemisinin, a sesquiterpene lactone from Artemisia annua L., is widely used for malaria treatment and
Ci-Di Chen et al.
Journal of molecular neuroscience : MN, 55(1), 76-90 (2014-06-09)
Klotho functions as an aging suppressor, which, in mice, extends lifespan when overexpressed and accelerates development of aging-like phenotypes when disrupted. Klotho is mainly expressed in brain and kidney and is secreted into the serum and CSF. We have previously
Jaesung Jung et al.
Journal of virology, 88(16), 8754-8767 (2014-05-23)
Phosphorylation of serines 157, 164, and 172 within the carboxyl-terminal SPRRR motif of the hepatitis B virus (HBV) core (C) protein modulates HBV replication at multiple stages. Threonine 162 and serines 170 and 178, located within the carboxyl-terminal conserved RRRS/T
H Nørrelund et al.
Journal of internal medicine, 260(1), 11-21 (2006-06-23)
It is well known that chronic heart failure (CHF) is associated with insulin resistance and cachexia, but little is known about the underlying substrate metabolism. The present study was undertaken to identify disturbances of basal glucose, lipid and protein metabolism.
HPLC-fluorescence determination of amino acids in pharmaceuticals after pre-column derivatization with phanquinone
Gatti.R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 35(2), 339-348 (2004)
G Alfredsson et al.
Psychopharmacology, 99(3), 322-327 (1989-01-01)
Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (starting with 400, 800 or 1200 mg) according to a double blind randomized administration schedule. The
Daniel H Ebert et al.
Nature, 499(7458), 341-345 (2013-06-19)
Rett syndrome (RTT) is an X-linked human neurodevelopmental disorder with features of autism and severe neurological dysfunction in females. RTT is caused by mutations in methyl-CpG-binding protein 2 (MeCP2), a nuclear protein that, in neurons, regulates transcription, is expressed at
Tomoko Kurata et al.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 23(10), 2580-2590 (2014-09-23)
In addition to reducing the level of blood pressure (BP), telmisartan was expected to show the long-term neuroprotective effects preventing accumulation of cellular amyloid beta peptide (Aβ) and phosphorylated tau (pτ) by ameliorating neuroinflammation. We examined effects of telmisartan on
Laurel M Mastro et al.
American journal of veterinary research, 75(7), 658-667 (2014-06-25)
To compare whole-body phenylalanine kinetics and the abundance of factors in signaling pathways associated with skeletal muscle protein synthesis and protein breakdown between horses with pituitary pars intermedia dysfunction (PPID) and age-matched control horses without PPID. 12 aged horses (6
Jonel Trebicka et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1393-1402 (2014-06-11)
Patients with cirrhosis display hypocontractility of splanchnic vessels because of dysregulation of vasoactive proteins, such as decreased effect of RhoA/ROCK and increased activity of β-Arrestin-2 and eNOS. However, it is unknown whether the dysregulation of vasoactive proteins is displayed in
E L Wils-Plotz et al.
Poultry science, 92(3), 735-745 (2013-02-26)
Coccidiosis is a major contributor to economic losses in the poultry industry due to its detrimental effects on growth performance and nutrient utilization. We hypothesized that the combined effects of supplemental dietary Thr and purified fiber may modulate the intestinal
Yanmei Si et al.
The Analyst, 139(21), 5466-5471 (2014-09-02)
A simple, rapid, sensitive, selective, and field-deployable detection protocol has been initially proposed for the early warning and diagnosis of exposure to organophosphates (OPs) by electrochemically monitoring the direct biomarkers of free OPs in blood. Phosphorylation-sensitive tyrosine (Tyr), which was
X Li et al.
Journal of internal medicine, 275(4), 418-427 (2013-11-19)
Biochemical changes in the cerebrospinal fluid (CSF) could reflect pathophysiological processes in Alzheimer's disease (AD). However, it is still not clear how these processes correlate with grey matter (GM) volume and microstructural changes in the brain. To assess the relationship
Nahla Elgohary et al.
International journal of oncology, 46(2), 597-606 (2014-11-19)
The mammalian timeless (TIM) protein interacts with proteins of the endogenous clock and essentially contributes to the circadian rhythm. In addition, TIM is involved in maintenance of chromosome integrity, growth control and development. Thus, we hypothesized that TIM may exert
Anna Walter et al.
Neurobiology of aging, 25(10), 1299-1303 (2004-10-07)
Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble metabolites of phosphatidylcholine (PtdCho), in human cerebrospinal fluid (CSF).
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