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关键词:'PHR1321'
显示 31-60 共 4543 条结果 关于 "PHR1321" 范围 论文
Shoude Zhang et al.
BMC cancer, 14, 689-689 (2014-09-23)
Hypericum japonicum Thunb. ex Murray is widely used as an herbal medicine for the treatment of hepatitis and tumours in China. However, the molecular mechanisms of its effects are unclear. Our previous research showed that extracts of H. japonicum can
Yael Pewzner-Jung et al.
EMBO molecular medicine, 6(9), 1205-1214 (2014-08-03)
Cystic fibrosis patients and patients with chronic obstructive pulmonary disease, trauma, burn wound, or patients requiring ventilation are susceptible to severe pulmonary infection by Pseudomonas aeruginosa. Physiological innate defense mechanisms against this pathogen, and their alterations in lung diseases, are
M Lackner et al.
Antimicrobial agents and chemotherapy, 58(7), 3626-3635 (2014-04-16)
Candidemia is the fourth most common kind of microbial bloodstream infection, with Candida albicans being the most common causative species. Echinocandins are employed as the first-line treatment for invasive candidiasis until the fungal species is determined and confirmed by clinical
The physical association of the P2Y12 receptor with PAR4 regulates arrestin-mediated Akt activation.
Aasma Khan et al.
Molecular pharmacology, 86(1), 1-11 (2014-04-12)
It is now well accepted that protease activated receptor (PAR) 1 and PAR4 have differential roles in platelet activation. PAR4, a low-affinity thrombin receptor in human platelets, participates in sustained platelet activation in a P2Y12-dependent manner; however, the mechanisms are
D Albert Joubert et al.
Journal of virology, 89(2), 1377-1388 (2014-11-14)
Wongabel virus (WONV) is an arthropod-borne rhabdovirus that infects birds. It is one of the growing array of rhabdoviruses with complex genomes that encode multiple accessory proteins of unknown function. In addition to the five canonical rhabdovirus structural protein genes
Francesca Cargnin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16650-16661 (2014-12-17)
The RE1 Silencing Transcription Factor (REST) acts as a governor of the mature neuronal phenotype by repressing a large consortium of neuronal genes in non-neuronal cells. In the developing nervous system, REST is present in progenitors and downregulated at terminal
Wei Wang et al.
CNS neuroscience & therapeutics, 21(5), 425-434 (2015-02-04)
Anxiety disorders are characterized by a deficient extinction of fear memory. Evidence is growing that leptin influences numerous neuronal functions. The aims of this study were to investigate the effects and the mechanism of leptin on fear extinction. Leptin (1
Hao-Hsuan Hsu et al.
Cell and tissue research, 357(1), 225-243 (2014-05-21)
The ion regulation mechanisms of fishes have been recently studied in zebrafish (Danio rerio), a stenohaline species. However, recent advances using this organism are not necessarily applicable to euryhaline fishes. The euryhaline species medaka (Oryzias latipes), which, like zebrafish, is
Anke Dahlmann et al.
Kidney international, 87(2), 434-441 (2014-08-08)
We have previously reported that sodium is stored in skin and muscle. The amounts stored in hemodialysis (HD) patients are unknown. We determined whether (23)Na magnetic resonance imaging (sodium-MRI) allows assessment of tissue sodium and its removal in 24 HD
Wei Wu et al.
Molecular pharmacology, 87(3), 401-409 (2014-12-19)
Activation of human ether-a-go-go-related gene 1 (hERG1) K(+) channels mediates repolarization of action potentials in cardiomyocytes. RPR-260243 [(3R,4R)-4-[3-(6-methoxy-quinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluorophenyl)-prop-2-ynyl]-piperidine-3-carboxylic acid] (RPR) slows deactivation and attenuates inactivation of hERG1 channels. A detailed understanding of the molecular mechanism of hERG1 agonists such as
James O Fajemiroye et al.
Journal of psychopharmacology (Oxford, England), 28(10), 923-934 (2014-06-13)
Our study sought to evaluate the anxiolytic and antidepressant activities of oleanolic acid as well as the neural mechanisms involved. Animal models such as barbiturate sleep-induction, light-dark box, elevated plus maze, forced swimming test, tail suspension test and open field
Jesús Tejero et al.
Biochemistry, 54(3), 722-733 (2015-01-03)
Neuroglobin (Ngb) is a six-coordinate globin that can catalyze the reduction of nitrite to nitric oxide. Although this reaction is common to heme proteins, the molecular interactions in the heme pocket that regulate this reaction are largely unknown. We have
Giulia Pavani et al.
Blood, 124(7), 1157-1165 (2014-06-25)
Recombinant activated human factor VII (rhFVIIa) is an established hemostatic agent in hemophilia, but its mechanism of action remains unclear. Although tissue factor (TF) is its natural receptor, rhFVIIa also interacts with the endothelial protein C receptor (EPCR) through its
Todd J Cohen et al.
Nature communications, 6, 5845-5845 (2015-01-06)
TDP-43 pathology is a disease hallmark that characterizes amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). Although a critical role for TDP-43 as an RNA-binding protein has emerged, the regulation of TDP-43 function is poorly understood. Here, we identify
Yoshihiro Egashira et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(8), 3701-3710 (2015-02-27)
During synaptic vesicle (SV) recycling, the vacuolar-type H(+) ATPase creates a proton electrochemical gradient (ΔμH(+)) that drives neurotransmitter loading into SVs. Given the low estimates of free luminal protons, it has been envisioned that the influx of a limited number
G Dehghan et al.
Acta biologica Hungarica, 64(2), 207-217 (2013-06-07)
The effect of increasing NaCl concentrations on biomass, hydrogen peroxide (H2O2), ascorbic acid (ASC), proline and total thiol, and the activity of some antioxidant enzymes in alfalfa (Medicago sativa L. cv. Gara-Yonjeh) were investigated. The dry weights of roots and
Minghui Yao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12039-12048 (2014-09-05)
Previous studies have shown that the Hippo pathway effector yes-associated protein (YAP) plays an important role in maintaining stem cell proliferation. However, the precise molecular mechanism of YAP in regulating murine embryonic neural stem cells (NSCs) remains largely unknown. Here
R Galatola et al.
Biochimica et biophysica acta, 1848(2), 392-407 (2014-12-03)
The interaction between a peptide sequence from GB virus C E1 protein (E1P8) and its structural analogs (E1P8-12), (E1P8-13), and (E1P8-21) with anionic lipid membranes (POPG vesicles and POPG, DPPG or DPPC/DPPG (2:1) monolayers) and their association with HIV-1 fusion
Quantitative proteomic profiling reveals differentially regulated proteins in cystic fibrosis cells.
Navin Rauniyar et al.
Journal of proteome research, 13(11), 4668-4675 (2014-05-14)
The most prevalent cause of cystic fibrosis (CF) is the deletion of a phenylalanine residue at position 508 in CFTR (ΔF508-CFTR) protein. The mutated protein fails to fold properly, is retained in the endoplasmic reticulum via the action of molecular
Jeongyub Kim et al.
Stem cells and development, 24(3), 284-295 (2014-09-18)
There is a growing body of evidence that small subpopulations of cells with stem cell-like characteristics within most solid tumors are responsible for the malignancy of aggressive cancer cells and that targeting these cells might be a good therapeutic strategy
Mélanie Carquin et al.
Journal of lipid research, 55(7), 1331-1342 (2014-05-16)
We recently reported that trace insertion of exogenous fluorescent (green BODIPY) analogs of sphingomyelin (SM) into living red blood cells (RBCs), partially spread onto coverslips, labels submicrometric domains, visible by confocal microscopy. We here extend this feature to endogenous SM
Chelsea L Edwards et al.
European journal of immunology, 45(1), 130-141 (2014-10-17)
Type I IFN signaling suppresses splenic T helper 1 (Th1) responses during blood-stage Plasmodium berghei ANKA (PbA) infection in mice, and is crucial for mediating tissue accumulation of parasites and fatal cerebral symptoms via mechanisms that remain to be fully
Ana Franco-Villanueva et al.
Human molecular genetics, 23(16), 4383-4395 (2014-04-05)
We identify Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) as a novel component of neuronal synapses whose absence increases dendritic spine size and filamentous actin levels in an N-WASP/Arp2/3-independent, RhoA/ROCK/profilinIIa-dependent manner. These effects depend on the reduction of membrane sphingomyelin (SM)
Rachel M Smith et al.
Tissue engineering. Part A, 20(21-22), 3021-3030 (2014-05-08)
The cryopreservation and autotransplantation of ovarian tissue is emerging as a powerful approach for preserving fertility. However, for cancer patients, it may not be possible to transplant ovarian tissue due to the risk of re-seeding disease. We investigated strategies for
Julia C Meier et al.
Cancer medicine, 4(2), 253-267 (2014-12-11)
Molecular mechanisms underlying the development of resistance to platinum-based treatment in patients with ovarian cancer remain poorly understood. This is mainly due to the lack of appropriate in vivo models allowing the identification of resistance-related factors. In this study, we
Paulo A Silva et al.
PloS one, 9(7), e100410-e100410 (2014-07-02)
Several studies have correlated protein restriction associated with other nutritional deficiencies with the development of cardiovascular and renal diseases. The driving hypothesis for this study was that Ang II signaling pathways in the heart and kidney are affected by chronic
Elena Buelow et al.
The Journal of antimicrobial chemotherapy, 69(8), 2215-2223 (2014-04-09)
Selective digestive decontamination (SDD) is an infection prevention measure for critically ill patients in intensive care units (ICUs) that aims to eradicate opportunistic pathogens from the oropharynx and intestines, while sparing the anaerobic flora, by the application of non-absorbable antibiotics.
Reetika Bhardwaj et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2862-2870 (2015-02-15)
The secreted protein, YKL-40, has been proposed as a biomarker of a variety of human diseases characterized by ongoing inflammation, including chronic neurologic pathologies such as multiple sclerosis and Alzheimer's disease. However, inflammatory mediators and the molecular mechanism responsible for
A mathematical proof of how the outgrowth angle of hair follicles influences the injury to the donor area in FUE harvesting.
Georgios Zontos et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 40(10), 1147-1150 (2014-09-26)
Enrique Gomez-Barrena et al.
The Journal of bone and joint surgery. American volume, 96(23), 1937-1944 (2014-12-05)
Abundant literature regarding the use of intravenous tranexamic acid (TXA) in primary total knee replacement is available. Randomized controlled trials have confirmed the efficacy of topical TXA compared with placebo, but the comparison between topical and intravenous TXA is unclear.
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