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PHR1481
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Esmer Jongedijk et al.
Yeast (Chichester, England), 32(1), 159-171 (2014-08-29)
Monoterpene olefins such as limonene are plant compounds with applications as flavouring and fragrance agents, as solvents and potentially also in polymer and fuel chemistry. We engineered baker's yeast Saccharomyces cerevisiae to express a (-)-limonene synthase from Perilla frutescens and
Valentino Ruggieri et al.
BMC plant biology, 14, 337-337 (2014-12-04)
Genome Wide Association Studies (GWAS) have been recently used to dissect complex quantitative traits and identify candidate genes affecting phenotype variation of polygenic traits. In order to map loci controlling variation in tomato marketable and nutritional fruit traits, we used
Arne Trettin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 71-81 (2014-04-29)
Paracetamol (acetaminophen) is a widely used safe analgesic drug when administered at therapeutic doses. Given the chemical reactivity of its phenolic group towards electrophilic species, we assumed that detection of paracetamol metabolites distinctly different from its known phase I metabolite
Jeremy G Owen et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(14), 4221-4226 (2015-04-02)
In molecular evolutionary analyses, short DNA sequences are used to infer phylogenetic relationships among species. Here we apply this principle to the study of bacterial biosynthesis, enabling the targeted isolation of previously unidentified natural products directly from complex metagenomes. Our
Hwang Eui Cho et al.
Biomedical chromatography : BMC, 28(12), 1624-1632 (2014-05-02)
A sensitive and specific high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the determination of Grayanotoxin I (GTX I) and Grayanotoxin III (GTX III) in rat whole blood. Grayanotoxins (GTXs) and clindamycin as internal standard (IS) were extracted
Màrius Tarrés et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(48), 15808-15815 (2014-10-09)
This paper presents a novel and unique feature of metallacarboranes, consisting of the linkage of this redox electro-active site to a stretchable polymer. This is based on polyTHF, a known and applied material. This hybrid material has the two ends
Seok-Hwi Park et al.
Organic & biomolecular chemistry, 13(15), 4539-4550 (2015-03-18)
Concise and stereocontrolled syntheses of (+)-hyacinthacine A2 and sphingofungin B were achieved via a diastereomerically enriched oxazine intermediate. The key strategies include palladium(0)-catalyzed intramolecular oxazine formation and diastereoselective nucleophilic addition to an aldehyde. (+)-Hyacinthacine A2 was synthesized in 13 steps
Nađa Kostić et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 962, 102-108 (2014-06-09)
This paper presents a LC-MS/MS method for the determination of antiepileptic drug vigabatrin in dried plasma spots (DPS). Due to its zwitterionic chemical structure, a pre-column derivatization procedure was performed, aiming to yield enhanced ionization efficiency and improved chromatographic behaviour.
Kohji Abe et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(12), 1907-1913 (2014-09-18)
To assess reactive oxygen species (ROS) production by detecting the fluorescent oxidation product, hydroethidine has been used extensively. The present study was undertaken to evaluate the potential of the hydroethidine derivative as a radiotracer to measure in vivo brain ROS
Iain M McIntyre et al.
Journal of analytical toxicology, 39(2), 152-155 (2014-12-18)
A 24-year-old man whose medical history was significant for alcohol abuse and depression was found unresponsive in bed. He had several prior suicide attempts with 'pills' and had also been hospitalized for an accidental overdose on a previous occasion. Autopsy
Gulsen Tel et al.
Pharmaceutical biology, 53(6), 824-830 (2015-02-28)
Recently, mushrooms are interesting natural products to be investigated due to exhibiting various bioactivities. This study determines the antioxidant and anticholinesterase activities of various extracts of five wild mushroom species. In addition, the total bioactive contents, namely, ascorbic acid, β-carotene
Maria Celeiro et al.
Journal of chromatography. A, 1344, 1-14 (2014-04-29)
An effective, simple and low cost sample preparation method based on matrix solid-phase dispersion (MSPD) followed by gas chromatography-mass spectrometry (GC-MS) or gas chromatography-triple quadrupole-mass spectrometry (GC-MS/MS) has been developed for the rapid simultaneous determination of 38 cosmetic ingredients, 25
Iain M McIntyre et al.
Journal of analytical toxicology, 39(2), 156-159 (2014-11-29)
A 20-year-old man, a college student, became unresponsive in front of his girlfriend. He was known to consume alcohol and take an unknown drug at some point while in attendance at a local music festival earlier in the day/evening. Upon
Philippe Haouzi et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(2), 493-504 (2014-07-13)
Hydrogen sulphide (H2S), a chemical hazard in oil and gas production, has recently become a dreadful method of suicide, posing specific risks and challenges for the first responders. Currently, there is no proven effective treatment against H2S poisoning and its
Marina G Pintado-Herrera et al.
Analytica chimica acta, 851, 1-13 (2014-12-03)
This work presents the development, optimization and validation of a multi-residue method for the simultaneous determination of 102 contaminants, including fragrances, UV filters, repellents, endocrine disruptors, biocides, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and several types of pesticides in
Rubén del Barrio-Galán et al.
Food chemistry, 179, 116-126 (2015-02-28)
The effect of high levels of the polysaccharide Saccharomyces cerevisiae yeast strain (HPS) and another conventional yeast strain (FERM) on the polysaccharide and phenolic composition of Syrah red wines during alcoholic fermentation and subsequent aging on lees, with or without
Silici Sibel et al.
Journal of ethnopharmacology, 156, 155-161 (2014-09-07)
Rhododendron honey, locally known as "mad honey", contains gryanotoksin (GTX) and thus induces toxic effects when consumed in large amounts. But, it is still popularly used for treating medical conditions such as high blood pressure or gastro-intestinal disorders. The aim
Konstantinos A Aliferis et al.
PloS one, 9(11), e111930-e111930 (2014-11-05)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key
Michael A Gardner et al.
Journal of analytical toxicology, 39(2), 118-125 (2014-12-11)
Fentanyl is a synthetic narcotic anesthetic ∼80-100 times more potent than morphine. Owing to the potential for its abuse, the drug may be included in a forensic toxicology work-up, which requires fast, precise and accurate measurements. Here, the stability of
Magdalena Golasik et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 28(3), 338-343 (2014-05-29)
Chronic exposure even to low doses of manganese may lead to development of neurological syndrome similar to parkinsonism. The aim of this research is to assess the possibility of manganese poisoning based on the level of metal in the urine
Qinghong Su et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 119-123 (2015-02-14)
A simple, rapid and sensitive high-performance liquid chromatography tandem mass-spectrometric method (LC-MS/MS) for the novel multiple tyrosine kinase inhibitor (TKI) cabozantinib was developed and validated using erlotinib as internal standard (IS). Plasma samples were pre-treated by liquid-liquid extraction with ethyl
Janclei P Coutinho et al.
Talanta, 134, 256-263 (2015-01-27)
In this work a multivariate statistical tool (Derringer and Suich optimization) was proposed for the separation of seventeen capsinoids (natural and synthetic) using the UHPLC-DAD chromatography. Capsinoids were analyzed at 280 nm. The variables optimized were the mobile phase (water
Yinyue Deng et al.
Applied and environmental microbiology, 81(8), 2861-2868 (2015-02-15)
Plant pathogen Xanthomonas campestris pv. campestris produces cis-11-methyl-2-dodecenoic acid (diffusible signal factor [DSF]) as a cell-cell communication signal to regulate biofilm dispersal and virulence factor production. Previous studies have demonstrated that DSF biosynthesis is dependent on the presence of RpfF
Cheong Hoon Lee et al.
Talanta, 129, 552-559 (2014-08-17)
Because of the high stability and potential toxic effects of non-steroidal anti-inflammatory drugs (NSAIDs), it is important to closely monitor their concentrations in the environment using a sensitive analytical method. In this study, a simple, rapid, efficient, and sensitive analytical
Christopher A Lear et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(4), R387-R395 (2014-06-20)
Perinatal exposure to infection is highly associated with adverse outcomes. Experimentally, acute, severe exposure to gram-negative bacterial lipopolysaccharide (LPS) is associated with increased fetal heart rate variability (FHRV). It is unknown whether FHRV is affected by subclinical infection with or
Luísa K Pilz et al.
Chronobiology international, 32(2), 248-254 (2014-10-07)
Circadian rhythm disturbances are among the risk factors for depression, but specific animal models are lacking. This study aimed to characterize the effects of acute rhythm disruption in mice and investigate the effects of imipramine and N-acetylcysteine (NAC) on rhythm
Naiyu Zheng et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 66-74 (2015-03-10)
Apixaban (Eliquis™) was developed by Bristol-Myers Squibb (BMS) and Pfizer to use as an antithrombotic/anticoagulant agent and has been recently approved for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. A clinical study of apixaban
Lingchen Yang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 74, 120-130 (2014-10-09)
The T-2 and HT-2 toxins, the main metabolites of Fusarium poae, induce toxicity in broilers and accumulate in tissues. Consequently, during the breeding process of broilers, diets are frequently supplemented with physical adsorbents to protect birds against the toxicity induced
Aimin Qiao et al.
Fitoterapia, 98, 137-142 (2014-08-05)
Sour jujube is a common fruit and traditional medicine in China. Bioactivity-guided fractionation of sour jujube was used to determine the chemical identity of potent antiproliferative and antioxidant constituents. Four novel ursane-type triterpenoids, together with 8 known were isolated and
Mylène Ratelle et al.
Toxicology letters, 232(2), 369-375 (2014-12-17)
Permethrin is a widely used pyrethroid insecticide for which the toxicokinetics of exposure biomarkers in humans is not fully documented. The time courses of key biomarkers of permethrin exposure were thus assessed in accessible biological matrices of orally exposed volunteers.
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