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Q4951
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Lucia Račková et al.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 84(5-6), 295-309 (2014-01-01)
Current evidence has demonstrated the immunomodulatory efficacy of omega-3 polyunsaturated fatty acids (PUFAs) in glial cells, suggesting their therapeutic potential for diseases in the central nervous system (CNS). However, conjugated omega-5 PUFAs have also attracted considerable attention because of their
Zhengzong Wu et al.
Food chemistry, 194, 671-679 (2015-10-17)
The application of attenuated total reflectance infrared spectroscopy (ATR-IR), Raman spectroscopy (RS) and combination of ATR-IR and RS for measurements of total antioxidant capacity (TAC) and total phenolic content (TPC) of Chinese rice wine (CRW) were investigated in this study.
Kirana P Mugaranja et al.
Heliyon, 6(7), e04392-e04392 (2020-07-17)
A phenolic rich fraction purified from Simarouba glauca leaves was effective in alpha glucosidase inhibition. The purified fraction named 'fraction-14' had shown significant inhibition of yeast alpha glucosidase enzyme activity (IC50 = 2.4 ± 0.4 μg/mL) when compared to anti-diabetic
Ahmed A Morsi et al.
Environmental toxicology, 37(2), 310-321 (2021-11-10)
Although several studies have reported a toxic effect of diesel exhaust particles (DEP) exposure on the kidney tissues, the involvement of autophagy/NF-kB signaling as encountered mechanisms and the protective effects of a natural flavonoid, quercetin on DEP remains unclear. Thirty-two
Shoji Ohgami et al.
Plant physiology, 168(2), 464-477 (2015-04-30)
Tea plants (Camellia sinensis) store volatile organic compounds (VOCs; monoterpene, aromatic, and aliphatic alcohols) in the leaves in the form of water-soluble diglycosides, primarily as β-primeverosides (6-O-β-D-xylopyranosyl-β-D-glucopyranosides). These VOCs play a critical role in plant defenses and tea aroma quality
Quercetin protects radiation-induced DNA damage and apoptosis in kidney and bladder tissues of rats.
H Özyurt et al.
Free radical research, 48(10), 1247-1255 (2014-07-22)
Ionizing radiation (IR) can induce cell damage and cell death through the reactive oxygen species generated by radiolytic hydrolysis. The present study was aimed to determine the possible protective effects of quercetin, a well-known antioxidant agent, against IR-induced bladder and
Hyeju Lee et al.
International journal of molecular sciences, 23(21) (2022-11-12)
In sepsis, the persistence of uncontrolled inflammatory response of infected host cells eventually leads to severe lung and organ failure and, ultimately, death. Carbapenem-resistant Acinetobacter baumannii (CRAB), causative bacteria of sepsis and lung failure in acute cases, belongs to a
Takashi Matsumoto et al.
Molecules (Basel, Switzerland), 20(10), 18031-18046 (2015-10-06)
Most orally administered polyphenols are metabolized, with very little absorbed as aglycones and/or unchanged forms. Metabolic and pharmacokinetic studies are therefore necessary to understand the pharmacological mechanisms of polyphenols. Jumihaidokuto (JHT), a traditional Japanese medicine, has been used for treatment
Kenneth K W To et al.
Experimental cell research, 338(2), 222-231 (2015-09-20)
Colorectal cancer (CRC) is a major cause of mortality and morbidity worldwide. While surgery remains the mainstay of treatment for early stage CRC, adjuvant chemotherapy is usually given to reduce the risk of recurrence after colectomy. Overexpression of a multidrug
Miriam S N Hohmann et al.
Phytotherapy research : PTR, 29(7), 1097-1101 (2015-04-09)
Hypericum perforatum is a medicinal plant with anti-inflammatory and antioxidant properties, which is commercially available for therapeutic use in Brazil. Herein the effect of H. perforatum extract on paracetamol (acetaminophen)-induced hepatotoxicity, lethality, inflammation, and oxidative stress in male swiss mice
Ju-Ye Ro et al.
SpringerPlus, 4, 17-17 (2015-01-30)
The effects of onion peel extract (OPE) in collagen (5 μg/mL)-stimulated washed rat platelet aggregation were investigated. OPE inhibited platelet aggregation via inhibition of aggregation-inducing molecules, intracellular Ca(2+) and thromboxane A2 (TXA2) by blocking cyclooxygenase-1 (COX-1) and TXA2 synthase (TXAS) activities
Khushwant S Bhullar et al.
Food chemistry, 168, 595-605 (2014-08-31)
Partridgeberry (Vaccinium vitis-idaea) is a polyphenol-rich berry of the Ericaceous family, grown in Newfoundland and Labrador province of Canada. The aims of this study were to identify extraction solvents for the maximum recovery of polyphenols, to establish fractionation technique for
Dhiraj Patil et al.
Journal of enzyme inhibition and medicinal chemistry, 30(2), 229-239 (2014-06-19)
Asthma is multifaceted disease where many targets contribute towards its development and progression. Among these, adenosine receptor subtypes play a major role. MCD-KV-10, a novel thiazolo-thiophene was designed and evaluated pre-clinically for its implication in management of asthma. This compound
Ji Hun Paek et al.
Archives of pharmacal research, 37(10), 1271-1279 (2014-01-16)
A method combining enzyme assay-guided high-performance liquid chromatography (HPLC) micro-fractionation and elution-extrusion counter-current chromatography (EECCC) was developed to screen and separate aldose reductase (AR) inhibitory activities from those of the ethyl acetate (EtOAc) fraction of Nardostachys chinensis. Under the target-guidance
Hao Yang et al.
Phytotherapy research : PTR, 33(12), 3140-3152 (2019-08-28)
Multiphase pathological processes involve in Type 2 diabetes (T2DM)-induced nonalcoholic fatty liver disease (NAFLD). However, the therapies are quite limited. In the present study, the hepatoprotective effects and underlying mechanisms of quercetin in T2DM-induced NAFLD were investigated. T2DM-induced NAFLD and
N Singh et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 968, 105-111 (2014-04-08)
SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that modulate SIRT6 activity could be of great therapeutic importance. We have
Hyun-Bok Kim et al.
Plants (Basel, Switzerland), 11(22) (2022-11-27)
The aim of this study is to compare the functions of the physiologically active compounds of three types of mulberry leaf by cultivar, and to confirm the changes using hot-melt extrusion (HME-ML). The active components of mulberry leaf were analyzed
Alicia P Cárdenas-Castro et al.
International journal of food sciences and nutrition, 71(7), 826-838 (2020-03-07)
"Serrano" pepper is extensively used in Mexican cuisine. The aim of this study was to identify the bioaccessible phenolic compounds (PC) of "Serrano" pepper as well as short-chain fatty acids (SCFA) produced and PC bioconverted using an in vitro step-wise gastromimetic
Zohreh Sajadi Hezaveh et al.
Complementary therapies in medicine, 46, 24-28 (2019-09-15)
The aim of this study was to determine whether quercetin can reduce iron overload and inflammation in thalassemic patients. Eighty four patients were recruited to this study and randomly assigned to two groups: 42 patients received a 500 mg/day quercetin tablet
José Antonio Curiel et al.
Journal of agricultural and food chemistry, 57(14), 6224-6230 (2009-07-16)
Tannase is an enzyme with important biotechnological applications in the food industry. Previous studies have identified the tannase encoding gene in Lactobacillus plantarum and also have reported the description of the purification of recombinant L. plantarum tannase through a protocol
Cory M Dungan et al.
GeroScience, 44(4), 1925-1940 (2022-03-25)
With aging, skeletal muscle plasticity is attenuated in response to exercise. Here, we report that senescent cells, identified using senescence-associated β-galactosidase (SA β-Gal) activity and p21 immunohistochemistry, are very infrequent in resting muscle, but emerge approximately 2 weeks after a bout
Akari Ishisaka et al.
Archives of biochemistry and biophysics, 557, 11-17 (2014-06-04)
In recent years, many papers have suggested that dietary flavonoids may exert beneficial effects in the brain tissue for the protection of neurons against oxidative stress and inflammation. However, the bioavailability of flavonoids across the blood-brain barrier and the localization
Eva Tvrdá et al.
International journal of molecular sciences, 23(24) (2022-12-24)
The aim of this study was to investigate the effects of quercetin (QUE) on the testicular architecture as well as markers of oxidative, inflammatory, and apoptotic profile of male gonads in Zucker diabetic fatty (ZDF) rats suffering from Type 2
Verena Kallhoff-Munoz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(44), 11421-11431 (2008-10-31)
Cell cycle markers have been shown to be upregulated and proposed to lead to apoptosis of postmitotic neurons in Alzheimer's disease (AD). Presenilin (PS) plays a critical role in AD pathogenesis, and loss-of-function studies in mice established a potent effect
Mateja Sirše et al.
Molecules (Basel, Switzerland), 25(20) (2020-10-15)
Several plant polyphenols have been shown to reduce osteoarthritis symptoms due to their antioxidant, anti-inflammatory and immunomodulatory properties. We investigated the effects of two different polyphenolic extracts (Belinal, Pycnogenol) and two different polyphenols (resveratrol, quercetin) on the chondrogenic potential of
Jean Paul Dzoyem et al.
Journal of ethnopharmacology, 156, 1-8 (2014-08-26)
Culinary herbs and spices are widely used ethnomedically across Africa. They are traditionally employed in the treatment of several ailments including inflammation disorders, pain alleviation and infectious diseases. Pharmacological studies are necessary to provide a scientific basis to substantiate their
Ali Rezaei-Golmisheh et al.
Iranian journal of basic medical sciences, 18(7), 691-699 (2015-09-12)
The current study was aimed to determine the bioactive constituents and biological effects of the Crataegus monogyna ethanolic extracts from bark, leaves and berries on hypercholesterolemia. Oleanolic acid, ursolic acid, quercetin and lupeol concentrations were quantified by HPLC. Total phenol
Lijana Dienaitė et al.
Foods (Basel, Switzerland), 9(10) (2020-10-11)
Defatted by supercritical CO2, Viburnum opulus berry pomace (VOP) was subjected to consecutive extraction with pressurized ethanol (E) and water (W) and yielded 23% of VOP-E and 8% of VOP-W, respectively. The major phytochemical groups covering 42 identified and quantified
Ansgar Bruning
Anti-cancer agents in medicinal chemistry, 13(7), 1025-1031 (2013-01-01)
Quercetin is an abundant micronutrient in our daily diet. Several beneficial health effects are associated with the dietary uptake of this bioflavonoid, including alleviating effects on chronic inflammation and atherosclerosis. A variety of in vitro data indicate a possible use
JiHoon Kang et al.
The Journal of biological chemistry, 288(38), 27343-27357 (2013-08-02)
Radioresistance is a major cause of decreasing the efficiency of radiotherapy for non-small cell lung cancer (NSCLC). To understand the radioresistance mechanisms in NSCLC, we focused on the radiation-induced Notch-1 signaling pathway involved in critical cell fate decisions by modulating
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