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显示 1-30 共 687 条结果 关于 "Q4951" 范围 论文
Xi Chu et al.
PloS one, 10(12), e0143797-e0143797 (2015-12-02)
Tannic acid presents in varying concentrations in plant foods, and in relatively high concentrations in green teas and red wines. Human ether-à-go-go-related gene (hERG) channels expressed in multiple tissues (e.g. heart, neurons, smooth muscle and cancer cells), and play important
Ji Tian et al.
Scientific reports, 5, 12228-12228 (2015-07-21)
Red leaf color is an attractive trait of Malus families, including crabapple (Malus spp.); however, little is known about the molecular mechanisms that regulate the coloration. Dihydroflavonols are intermediates in the production of both colored anthocyanins and colorless flavonols, and
Cory M Dungan et al.
Aging cell, 21(1), e13528-e13528 (2021-12-15)
Systemic deletion of senescent cells leads to robust improvements in cognitive, cardiovascular, and whole-body metabolism, but their role in tissue reparative processes is incompletely understood. We hypothesized that senolytic drugs would enhance regeneration in aged skeletal muscle. Young (3 months) and
Eszter Riethmüller et al.
Journal of pharmaceutical and biomedical analysis, 107, 159-167 (2015-01-17)
Corylus maxima Mill. (Betulaceae) leaves have been used in traditional medicine both internally and externally, nevertheless phytochemical exploration of the plant remains incomplete. In this study, the in vitro antioxidant activity and polyphenolic composition of the ethyl acetate and methanolic
You-Shin Shim et al.
Journal of AOAC International, 96(5), 1059-1064 (2013-11-29)
A rapid method for the simultaneous determination of flavonol aglycones in food using ultra-high-performance LC (u-HPLC) coupled with a heating-block acidic hydrolysis method was validated in terms of precision, accuracy, and linearity. The u-HPLC separation was performed on an RP
Marisa Granato et al.
Viruses, 11(1) (2018-12-28)
Previous studies have indicated that cytotoxic treatments may induce or not activate viral lytic cycle activation in cancer cells latently infected by Kaposi's sarcoma-associated herpesvirus (KSHV). To investigate the molecular mechanisms responsible for such an effect, we compared two cytotoxic
Ji-Hong Moon et al.
Oncology reports, 34(1), 375-381 (2015-05-23)
Quercetin is a potent cancer therapeutic agent and dietary antioxidant present in fruit and vegetables. Quercetin prevents tumor proliferation by inducing cell cycle arrest and is a well known cancer therapeutic agent and autophagy mediator. We investigated whether quercetin enhances
Ghadeer M Albadrani et al.
Saudi journal of biological sciences, 28(5), 2772-2782 (2021-05-21)
This study investigated the anti-remodeling and anti-fibrotic and effect of quercetin (QUR) in the remote non-infarcted of rats after myocardial infarction (MI). Rats were divided as control, control + QUR, MI, and MI + QUR. MI was introduced to the rats by ligating the
Rafidah Lani et al.
Scientific reports, 5, 11421-11421 (2015-06-17)
The mosquito-borne chikungunya virus (CHIKV) causes chikungunya fever, with clinical presentations such as severe back and small joint pain, and debilitating arthritis associated with crippling pains that persist for weeks and even years. Although there are several studies to evaluate
Jaquelini Luber et al.
Anais da Academia Brasileira de Ciencias, 87(2), 903-913 (2015-05-21)
Guava (Psidium guajava L.) is a plant often employed in popular medicine. Recently several studies have alerted about the toxicity of substances present in medicinal plants, which can pose risks to the human health. In this sense, the present work
Systemic induction of senescence in young mice after single heterochronic blood exchange.
Jeon, et al.
Nature metabolism, 4, 995-1006 (2023)
S Harris et al.
Food chemistry, 187, 135-139 (2015-05-16)
Post-harvest treatment can influence levels of secondary metabolites in fruits and vegetables. Onions contain high levels of quercetin but are commonly heat-treated before consumption. Hence, the objective of this study was to examine the effect of cooking treatments on the
Joanna Jakubowicz-Gil et al.
Toxicology and applied pharmacology, 273(3), 580-589 (2013-10-16)
The aim of the present study was to investigate whether silencing of Hsp27 or Hsp72 expression in glioblastoma multiforme T98G and anaplastic astrocytoma MOGGCCM cells increases their sensitivity to programmed cell death induction upon temozolomide and/or quercetin treatment. Transfection with
Catarina Cardoso et al.
PloS one, 9(8), e104201-e104201 (2014-08-16)
Strigolactones (SLs) trigger germination of parasitic plant seeds and hyphal branching of symbiotic arbuscular mycorrhizal (AM) fungi. There is extensive structural variation in SLs and plants usually produce blends of different SLs. The structural variation among natural SLs has been
Vincent Deruelle et al.
Nature communications, 12(1), 4024-4024 (2021-07-01)
Pseudomonas aeruginosa can cause nosocomial infections, especially in ventilated or cystic fibrosis patients. Highly pathogenic isolates express the phospholipase ExoU, an effector of the type III secretion system that acts on plasma membrane lipids, causing membrane rupture and host cell
Abolfazl Ghaniei et al.
Journal of animal physiology and animal nutrition, 103(3), 713-722 (2019-03-01)
Current study was carried out to examine the protective effects of quercetin against toxicity induced by hydrogen peroxide in rooster semen in vitro. Semen samples were collected from ten roosters (Ross 308 broiler breeder males, 32 weeks old) twice a week
Shreya Banerjee et al.
Frontiers in microbiology, 13, 951716-951716 (2022-08-20)
Rotavirus (RV) is the leading cause of acute gastroenteritis and watery diarrhea in children under 5 years accounting for high morbidity and mortality in countries with poor socioeconomic status. Although vaccination against RV has been implemented in more than 100
Zhe Gao et al.
Biochemical pharmacology, 92(2), 358-368 (2014-09-15)
Strategy on activated T cells is an effective treatment for T cell mediated diseases. By using a synthesized chromone derivative, we examined its effects on the activated T cells. This compound, (Z)-1,3-dihydroxy-9-methyl-13H-benzo[b]chromeno[3,2-f][1,4]oxazepin-13-one (neochromine S5), exhibited immunosuppressive activity in vitro and
Alper Gökbulut et al.
Natural product communications, 8(4), 475-478 (2013-06-07)
Three Inula species, I. viscosa, I. helenium ssp. turcoracemosa and I. montbretiana, collected from different locations of Anatolia were investigated for their antioxidant and antimicrobial potential, and their total phenolic content and phenolic composition. Antioxidant activities of various extracts of
Ke-Ke Jia et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 103, 1415-1428 (2018-06-06)
Depression is a mental illness comorbid risk factor for glucose intolerance worldwide. Chaihu-shugan san, a 'Shu-Gan' formula in traditional Chinese medicine, is clinically used in the treatment of depression. The aim of this study was to investigate whether Chaihu-shugan san
Liping Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1227-1234 (2014-04-30)
Nitidine chloride (NC), a quaternary ammonium alkaloid, has numerous pharmacological effects, such as anticancer activity. However, it was found that NC also has hepatocellular toxicity. Because organic cation transporters 1 and 3 (OCT1 and OCT3) might mediate the influx of
Hakki Mevlut Ozcan et al.
Artificial cells, nanomedicine, and biotechnology, 42(4), 256-261 (2013-02-01)
In this study, a novel fresh broad (Vicia faba) tissue homogenate-based biosensor for determination of phenolic compounds was developed. The biosensor was constructed by immobilizing tissue homogenate of fresh broad (Vicia faba) on to glassy carbon electrode. For the stability
Mira Rosenblat et al.
BioFactors (Oxford, England), 41(4), 273-288 (2015-08-01)
Atherogenesis is associated with macrophage cholesterol and oxidized lipids accumulation and foam cell formation. However, two other major lipid-metabolizing cell classes, namely intestinal and liver cells, are also associated with atherogenesis. This study demonstrates that manipulations of cellular oxidative stress
Mustafa Hoca et al.
Nutrition and cancer, 72(7), 1231-1242 (2019-10-10)
Resveratrol and quercetin are phytochemicals that are found in a variety of plants. The aim of this study was to investigate the effect of resveratrol and quercetin on epithelial-mesenchymal transition (EMT) of CD133+ and CD133- pancreatic cancer cells. Cancer stem
J A Hernández-Herrero et al.
Food chemistry, 173, 495-500 (2014-12-04)
Model juices at pH 3.7 were prepared with different combinations of ascorbic acid, rutin (quercetin 3-rutinoside) and concentrated anthocyanin extract of plums (cv. Black Gold). The anthocyanins in the concentrated extract were cyanidin 3-glucoside and cyanidin 3-rutinoside, in a proportion
Hubert Fleury et al.
Nature communications, 10(1), 2556-2556 (2019-06-13)
Senescence is a tumor suppression mechanism defined by stable proliferation arrest. Here we demonstrate that the known synthetic lethal interaction between poly(ADP-ribose) polymerase 1 inhibitors (PARPi) and DNA repair triggers p53-independent ovarian cancer cell senescence defined by senescence-associated phenotypic hallmarks
Brett Fleisher et al.
Journal of pharmaceutical sciences, 104(1), 266-275 (2014-11-25)
Small molecule tyrosine kinase inhibitors (TKIs) are a group of highly novel and target-specific anticancer drugs. Recently, most TKIs are found to be substrates of P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). However, little information is available regarding the
Maria Russo et al.
Biochemical pharmacology, 83(1), 6-15 (2011-08-23)
Biochemical and genetic studies on cellular and animal models on the mechanism(s) of action of phytochemicals provide a functional explanation of how and why a diet rich in fruits and vegetables is considered healthy. It is not unusual to find
Dilem Tanriseven et al.
Food chemistry, 305, 125505-125505 (2019-10-14)
Shalgam is a beverage which is produced by lactic acid fermentation of black carrot juice. Two commercial methods (traditional method - TM and direct method - DM) used to produce shalgams were compared with respect to their effects on the
Pavitra Ranawat et al.
Phytotherapy research : PTR, 27(6), 802-810 (2012-08-14)
Dietary bioflavonoids represent a large class of polyphenolic compounds found in most plants. A significant number of flavonoids are reported to have beneficial health effects. Quercetin is one such flavonoid which has been reported to possess strong antioxidant properties. However
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