R0300000

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DEVTA: results from the biggest clinical trial ever.

Paul Garner et al.

Lancet (London, England), 381(9876), 1439-1441 (2013-03-19)

Lemon (Citrus limon, Burm.f.) essential oil enhances the trans-epidermal release of lipid-(A, E) and water-(B6, C) soluble vitamins from topical emulsions in reconstructed human epidermis.

L Valgimigli et al.

International journal of cosmetic science, 34(4), 347-356 (2012-04-21)

Topical bioavailability of lipid- and water-soluble vitamins is a critical issue for protecting or anti-ageing formulations. Using 17-day-old SkinEthic(®) reconstructed human epidermis, we investigated (at 34°C) the role of lemon EO in enhancing the penetration of α-tocopherol (E) and retinyl

Preparation, in vitro and in vivo evaluation of solid-state self-nanoemulsifying drug delivery system (SNEDDS) of vitamin A acetate.

Ehab I Taha et al.

Journal of drug targeting, 17(6), 468-473 (2009-06-02)

Vitamin A self-nanoemulsifying drug delivery system (SNEDDS), which comprises soybean oil, Cremophor EL, and Capmul MCM-C8, was prepared and mixed with different grades of Avicel to produce homogenized powders. The resultant powders were compressed into tablets. The prepared tablets were

Retinoid production using metabolically engineered Escherichia coli with a two-phase culture system.

Hui-Jeong Jang et al.

Microbial cell factories, 10, 59-59 (2011-08-02)

Retinoids are lipophilic isoprenoids composed of a cyclic group and a linear chain with a hydrophilic end group. These compounds include retinol, retinal, retinoic acid, retinyl esters, and various derivatives of these structures. Retinoids are used as cosmetic agents and

Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance.

Tadao Maeda et al.

Investigative ophthalmology & visual science, 50(10), 4917-4925 (2009-06-06)

Evaluate the efficacy of potential therapeutics in Rdh8(-/-)Abca4(-/-) mice, a rodent model of human age-related macular degeneration (AMD). Therapeutic efficacy of several antioxidant agents (ascorbic acid, alpha-lipoic acid, alpha-tocopherol, Mn(III)-tetrakis(4-benzoic acid)-porphyrin, and butylated hydroxytoluene), an immunosuppressive agent with antivascular endothelial

Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis.

Ling Zhang et al.

Nature, 464(7291), 1058-1061 (2010-03-30)

Cancer chemoprevention uses natural, synthetic, or biological substances to reverse, suppress, or prevent either the initial phase of carcinogenesis or the progression of neoplastic cells to cancer. It holds promise for overcoming problems associated with the treatment of late-stage cancers.

Retinyl acetate-loaded nanoparticles: dermal penetration and release of the retinyl acetate.

Sunatda Arayachukeat et al.

International journal of pharmaceutics, 404(1-2), 281-288 (2010-11-26)

Retinyl acetate (RA) loaded polymeric nanoparticle (NP) carriers were prepared using two different single polymers, ethyl cellulose (EC) and poly (ethylene glycol)-4-methoxycinnamoylphthaloylchitosan (PCPLC). The stability of RA to aqueous solution and UVA light was significantly improved when encapsulated with PCPLC

Vitamin A is systemically bioavailable after intratracheal administration with surfactant in an animal model of newborn respiratory distress.

Avash J Singh et al.

Pediatric research, 67(6), 619-623 (2010-03-11)

Chronic lung disease (CLD) is a major cause of long-term morbidity in extremely LBW infants with respiratory distress syndrome. Parenteral vitamin A administration decreases the risk of CLD. We tested the hypothesis that intratracheal vitamin A administration with surfactant is

Simultaneous determination of retinol acetate, retinol palmitate, cholecalciferol, α-tocopherol acetate and alphacalcidol in capsules by non-aqueous reversed-phase HPLC and column backflushing

Wielinski S and Olszanowski A

Chromatographia, 50(1-2), 109-112 (1999)

Simultaneous analysis for water- and fat-soluble vitamins by a novel single chromatography technique unifying supercritical fluid chromatography and liquid chromatography.

Kaori Taguchi et al.

Journal of chromatography. A, 1362, 270-277 (2014-09-10)

Chromatography techniques usually use a single state in the mobile phase, such as liquid, gas, or supercritical fluid. Chromatographers manage one of these techniques for their purpose but are sometimes required to use multiple methods, or even worse, multiple techniques

Golden Rice is an effective source of vitamin A.

Guangwen Tang et al.

The American journal of clinical nutrition, 89(6), 1776-1783 (2009-04-17)

Genetically engineered "Golden Rice" contains up to 35 microg beta-carotene per gram of rice. It is important to determine the vitamin A equivalency of Golden Rice beta-carotene to project the potential effect of this biofortified grain in rice-consuming populations that

Accelerator mass spectrometry can be used to assess vitamin A metabolism quantitatively in boys in a community setting.

Emmanuel K Aklamati et al.

The Journal of nutrition, 140(9), 1588-1594 (2010-07-28)

A survey indicated that high-dose vitamin A (HD-VA) supplements had no apparent effect on vitamin A (VA) status, assessed by serum retinol concentrations, of Zambian children lt 5 y of age. To explore possible reasons for the lack of response

Application of an allosteric model to describe the interactions among retinol binding protein 4, transthyretin, and small molecule retinol binding protein 4 ligands.

Peter Coward et al.

Analytical biochemistry, 384(2), 312-320 (2008-10-28)

Retinol binding protein 4 (RBP4) is a serum protein that serves as the major transport protein for retinol (vitamin A). Recent reports suggest that elevated levels of RBP4 are associated with insulin resistance and that insulin sensitivity may be improved

Nanoscale domains with nematic order in supercooled vitamin-A acetate: molecular dynamics studies.

Z Wojnarowska et al.

Physical review. E, Statistical, nonlinear, and soft matter physics, 83(5 Pt 1), 051502-051502 (2011-07-07)

Vitamin-A acetate is one of the most versatile vitamins. It is applied in medicine because of its antioxidative properties, in tumor therapy because of its cytostatic activity, and in cosmetics because of its nutritional additives. Herein, using broadband dielectric spectroscopy

An optimized and validated RP-HPLC/UV detection method for simultaneous determination of all-trans-retinol (vitamin A) and alpha-tocopherol (vitamin E) in human serum: comparison of different particulate reversed-phase HPLC columns.

Abad Khan et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(25), 2339-2347 (2010-08-11)

A novel, simple and fast reversed-phase HPLC/UV method was developed, optimized for various chromatographic conditions, and validated according to international guidelines for simultaneous determination of all-trans-retinol and alpha-tocopherol in human serum using retinyl acetate as internal standard in the concentration

Small quantities of carotenoid-rich tropical green leafy vegetables indigenous to Africa maintain vitamin A status in Mongolian gerbils ( Meriones unguiculatus).

Richard A Ejoh et al.

The British journal of nutrition, 103(11), 1594-1601 (2010-04-24)

Leafy vegetables are important sources of provitamin A carotenoids. Information on their ability to provide vitamin A is often misleading because of the methodology used to assess bioefficacy. Mongolian gerbils were used to evaluate the bioefficacy of provitamin A carotenoids

Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate.

Tadao Maeda et al.

Human molecular genetics, 18(12), 2277-2287 (2009-04-03)

Inactivating mutations in the retinoid isomerase (RPE65) or lecithin:retinol acyltransferase (LRAT) genes cause Leber congenital amaurosis (LCA), a severe visual impairment in humans. Both enzymes participate in the retinoid (visual) cycle, the enzymatic pathway that continuously generates 11-cis-retinal, the chromophore

Quantification of β-carotene, retinol, retinyl acetate and retinyl palmitate in enriched fruit juices using dispersive liquid-liquid microextraction coupled to liquid chromatography with fluorescence detection and atmospheric pressure chemical ionization-mass spectrometry.

Pilar Viñas et al.

Journal of chromatography. A, 1275, 1-8 (2013-01-08)

A detailed optimization of dispersive liquid-liquid microextraction (DLLME) was carried out for developing liquid chromatographic (HPLC) techniques, using both fluorescence and atmospheric pressure chemical ionization mass spectrometric (APCI-MS) detection, for the simultaneous analysis of preforms of vitamin A: retinol (R)

Population deworming every 6 months with albendazole in 1 million pre-school children in North India: DEVTA, a cluster-randomised trial.

Shally Awasthi et al.

Lancet (London, England), 381(9876), 1478-1486 (2013-03-19)

In north India many pre-school children are underweight, many have intestinal worms, and 2-3% die at ages 1·0-6·0 years. We used the state-wide Integrated Child Development Service (ICDS) infrastructure to help to assess any effects of regular deworming on mortality.

Development and validation of a dissolution test method for vitamin A in dietary supplement tablets.

Natalia Davydova et al.

Journal of pharmaceutical and biomedical analysis, 53(3), 295-301 (2010-04-30)

A dissolution test method and an analytical procedure by HPLC were developed and validated for evaluation of the dissolution behavior of dietary supplements tablets containing vitamin A in the forms of retinyl acetate or retinyl palmitate. Seven different commercially available

Plasma turnover of 3,4-didehydroretinol (vitamin A2) increases in vitamin A-deficient rats fed low versus high dietary fat.

Anne L Escaron et al.

Journal of lipid research, 50(4), 694-703 (2008-12-02)

Relationships between increased adiposity and fat-soluble vitamin storage and metabolism are poorly understood. To examine these associations, 6% or 21% dietary fat was fed to rats for 11 weeks and tissue vitamin A storage determined. Two levels of supplemental vitamin

Vitamin A supplementation every 6 months with retinol in 1 million pre-school children in north India: DEVTA, a cluster-randomised trial.

Shally Awasthi et al.

Lancet (London, England), 381(9876), 1469-1477 (2013-03-19)

In north India, vitamin A deficiency (retinol <0·70 μmol/L) is common in pre-school children and 2-3% die at ages 1·0-6·0 years. We aimed to assess whether periodic vitamin A supplementation could reduce this mortality. Participants in this cluster-randomised trial were

Triple-fortified rice containing vitamin A reduced marginal vitamin A deficiency and increased vitamin A liver stores in school-aged Thai children.

Siwaporn Pinkaew et al.

The Journal of nutrition, 144(4), 519-524 (2014-02-07)

Vitamin A (VA)-fortified rice is a potential intervention strategy to prevent VA deficiency in at-risk populations. Hot-extruded, triple-fortified rice grains with added VA, zinc, and iron were produced by hot extrusion technology and their ability to improve VA status was

Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice.

Tadao Maeda et al.

Investigative ophthalmology & visual science, 50(9), 4368-4378 (2009-05-02)

Mice lacking retinal pigment epithelium-specific 65-kDa protein (RPE65) develop retinopathy and blindness resembling Leber congenital amaurosis. Effects of 9-cis-retinyl acetate (9-cis-R-Ac) on visual function and retinopathy progression were tested in Rpe65(-/-) mice. Young C57Bl/6 mice were given 9-cis-R-Ac in each

Oral doses of α-retinyl ester track chylomicron uptake and distribution of vitamin A in a male piglet model for newborn infants.

Napaporn Riabroy et al.

The Journal of nutrition, 144(8), 1188-1195 (2014-06-20)

α-Retinol has utility in determining chylomicron trafficking of vitamin A to tissues given that it will not be recirculated in blood on retinol binding protein (RBP). In this study, α-retinol was used as a chylomicron tag to investigate short-term uptake

Simultaneous determination of 13-cis and all-trans vitamin A palmitate (retinyl palmitate), vitamin A acetate (retinyl acetate), and total vitamin E (alpha-tocopherol and DL-alpha-tocopherol acetate) in infant formula and adult nutritionals by normal phase HPLC: first action 2012.10.

Adrienne McMahon et al.

Journal of AOAC International, 96(5), 1073-1081 (2013-11-29)

This HPLC method, with both variable UV and fluorescence detection, allows for the simultaneous determination of vitamin A palmitate, vitamin A acetate, and total vitamin E in infant, pediatric, and adult nutritional formulas. The concentration of each vitamin form is

Cosmeceuticals: the evidence behind the retinoids.

Kajal Babamiri et al.

Aesthetic surgery journal, 30(1), 74-77 (2010-05-06)

A wide range of cosmeceutical products are available on the market currently, but evidence to support their use is often lacking in the literature. Specifically, there is a substantial amount of evidence supporting the efficacy of tretinoin in photoaging, but

[Effect of vitamin A provision on antineoplastic resistance in rats].

M M Marchenko et al.

Voprosy pitaniia, 77(6), 4-8 (2009-02-21)

While studying Guerin's carcinoma development under conditions of different vitamin A provision in the period of tumor growth and before it appearance, it was established, that strengthened saturation of an organism with a tumor by vitamin A hyper doses can

Involvement of all-trans-retinal in acute light-induced retinopathy of mice.

Akiko Maeda et al.

The Journal of biological chemistry, 284(22), 15173-15183 (2009-03-24)

Exposure to bright light can cause visual dysfunction and retinal photoreceptor damage in humans and experimental animals, but the mechanism(s) remain unclear. We investigated whether the retinoid cycle (i.e. the series of biochemical reactions required for vision through continuous generation

Protective effect of two yeast based feed additives on pigs chronically exposed to deoxynivalenol and zearalenone.

Alexandra C Weaver et al.

Toxins, 6(12), 3336-3353 (2014-12-24)

To evaluate the effects of the mycotoxins deoxynivalenol (DON) and zearalenone (ZEA) on pigs and the benefits of two mycotoxin mitigation strategies, gilts (n = 84, 9.1 ± 0.1 kg) were allotted to four treatments: CON (control); MT (4.8 mg/kg

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