R4127

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Experimental TLR4 inhibition improves intestinal microcirculation in endotoxemic rats.

Juan Zhou et al.

Microvascular research, 101, 33-37 (2015-06-28)

Toll like receptor 4 (TLR4) represents a critical cellular link for endotoxin-induced pathology. The aim of this study was to evaluate the potential role of TLR4 inhibition on the intestinal microcirculation during experimental endotoxemia. The intestinal microcirculation was studied by

A fluorescent and chemiluminescent difunctional mesoporous silica nanoparticle as a label for the ultrasensitive detection of cancer cells.

Liang Tao et al.

Analytica chimica acta, 761, 194-200 (2013-01-15)

A new kind of ultrabright fluorescent and chemiluminescent difunctional mesoporous silica nanoparticle (FCMSN) is reported. A luminescent dye, Rhodamine 6G or tris(2,2'-bipyridyl)dichlororuthenium(II) hexahydrate (Rubpy), is doped inside nanochannels of a silica matrix. The hydrophobic groups in the silica matrix avoid

Performance-enhancing methods for Au film over nanosphere surface-enhanced Raman scattering substrate and melamine detection application.

Jun Feng Wang et al.

PloS one, 9(6), e97976-e97976 (2014-06-03)

A new high-performance surface-enhanced Raman scattering (SERS) substrate with extremely high SERS activity was produced. This SERS substrate combines the advantages of Au film over nanosphere (AuFON) substrate and Ag nanoparticles (AgNPs). A three order enhancement of SERS was observed

Superresolution imaging with optical fluctuation using speckle patterns illumination.

MinKwan Kim et al.

Scientific reports, 5, 16525-16525 (2015-11-18)

Superresolution fluorescence microscopy possesses an important role for the study of processes in biological cells with subdiffraction resolution. Recently, superresolution methods employing the emission properties of fluorophores have rapidly evolved due to their technical simplicity and direct applicability to existing

Facile fabrication of SERS arrays through galvanic replacement of silver onto electrochemically deposited copper micropatterns.

Xi Ke et al.

Chemphyschem : a European journal of chemical physics and physical chemistry, 13(17), 3786-3789 (2012-09-28)

Scatter me: A fast and cost-effective approach for the fabrication of surface-enhanced Raman scattering (SERS) arrays is developed. The method applied combines microcontact printing, electrodeposition, and galvanic replacement without the need for expensive instruments and intricate processing. The as-prepared arrays

Designing and fabricating of surface-enhanced Raman scattering substrate with high density hot spots by polyaniline template-assisted self-assembly.

Kai Qian et al.

Nanoscale, 4(20), 6449-6454 (2012-09-08)

In general, the procedures for producing a high density hot spots structure should be stable, inexpensive, and easy to make. It still remains a grand challenge to assemble silver or gold nanoparticles (Au NPs) with well-defined hot spots for SERS

An intravaginal ring for the sustained delivery of antibodies.

Manjula Gunawardana et al.

Journal of pharmaceutical sciences, 103(11), 3611-3620 (2014-09-19)

Human monoclonal antibodies (mAbs) based on IgG and IgA have shown promise as topical microbicide candidates to protect women from HIV infection. Application of mAbs has been limited, however, by the inability of vaginal gels and conventional intravaginal ring (IVR)

A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole.

Shaoji Cheng et al.

Antimicrobial agents and chemotherapy, 51(5), 1855-1858 (2007-02-28)

We showed that a Candida albicans petite mutant in which oxidative phosphorylation is uncoupled was eightfold more resistant to fluconazole and voriconazole than SC5314 but equally susceptible to ketoconazole, itraconazole, and amphotericin B. Strain P5 significantly overexpressed MDR1, which likely

Antimicrobial efficacy of tobramycin polymeric nanoparticles for Pseudomonas aeruginosa infections in cystic fibrosis: formulation, characterisation and functionalisation with dornase alfa (DNase).

Jill Deacon et al.

Journal of controlled release : official journal of the Controlled Release Society, 198, 55-61 (2014-12-08)

Inhaled antibiotics, such as tobramycin, for the treatment of Pseudomonas aeruginosa pulmonary infections are associated with the increase in life expectancy seen in cystic fibrosis (CF) patients over recent years. However, the effectiveness of this aminoglycoside is still limited by

IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice.

R Guabiraba et al.

Mucosal immunology, 7(5), 1079-1093 (2014-01-16)

Intestinal damage and severe diarrhea are serious side effects of cancer chemotherapy and constrain the usage of most such therapies. Here we show that interleukin-33 (IL-33) mediates the severe intestinal mucositis in mice treated with irinotecan (CPT-11), a commonly used

H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF.

Kunihiko Nishino et al.

Antimicrobial agents and chemotherapy, 53(8), 3541-3543 (2009-06-10)

Screening of Salmonella mutants for the ability to increase beta-lactam resistance has led to the identification of a mutation in hns, which codes for the histone-like nucleoid structuring protein (H-NS). In this study, we report that H-NS modulates multidrug resistance

Development of nanovesicular systems for dermal imiquimod delivery: physicochemical characterization and in vitro/in vivo evaluation.

Man Ma et al.

Journal of materials science. Materials in medicine, 26(6), 191-191 (2015-05-21)

The aim of the current investigation was to develop and statistically evaluate nanovesicular systems for dermal imiquimod delivery. To this purpose, transethosomes were prepared with phospholipid, ethanol and different permeation enhancers. Conventional ethosomes, with soy phospholipid and ethanol, were used

In vitro uptake of 140 kDa Bacillus thuringiensis nematicidal crystal proteins by the second stage juvenile of Meloidogyne hapla.

Fengjuan Zhang et al.

PloS one, 7(6), e38534-e38534 (2012-06-28)

Plant-parasitic nematodes (PPNs) are piercing/sucking pests, which cause severe damage to crops worldwide, and are difficult to control. The cyst and root-knot nematodes (RKN) are sedentary endoparasites that develop specialized multinucleate feeding structures from the plant cells called syncytia or

Prevention of bacterial adhesion and biofilm formation on a vitamin E-blended, cross-linked polyethylene surface with a poly(2-methacryloyloxyethyl phosphorylcholine) layer.

Masayuki Kyomoto et al.

Acta biomaterialia, 24, 24-34 (2015-06-09)

In the construction of artificial hip joint replacements, the surface and substrate of a cross-linked polyethylene (CLPE) liner are designed to achieve high wear resistance and prevent infection by bacteria. In this study, we fabricated a highly hydrophilic and antibiofouling

Decelerated vascularization in tissue-engineered constructs in association with diabetes mellitus in vivo.

Paul Schumann et al.

Journal of diabetes and its complications, 29(7), 855-864 (2015-07-22)

Rapid blood vessel ingrowth in transplanted tissue engineering constructs is the key factor for successful incorporation, but many potential patients who may use engineered tissues suffer from widespread diseases that limit the capacity of neovascularization (e.g. diabetes). Thus, in vivo

Optical and electrical detection of single-molecule translocation through carbon nanotubes.

Weisi Song et al.

ACS nano, 7(1), 689-694 (2012-12-20)

Ion current through a single-walled carbon nanotube (SWCNT) was monitored at the same time as fluorescence was recorded from charged dye molecules translocating through the SWCNT. Fluorescence bursts generally follow ion current peaks with a delay time consistent with diffusion

Graphene from sugar and its application in water purification.

Soujit Sen Gupta et al.

ACS applied materials & interfaces, 4(8), 4156-4163 (2012-07-14)

This paper describes a green method for the synthesis of graphenic material from cane sugar, a common disaccharide. A suitable methodology was introduced to immobilize this material on sand without the need of any binder, resulting in a composite, referred

A facile one-pot synthesis of starch functionalized graphene as nano-carrier for pH sensitive and starch-mediated drug delivery.

Kunping Liu et al.

Colloids and surfaces. B, Biointerfaces, 128, 86-93 (2015-03-04)

A fast, green and facile method was developed to prepare starch functionalized graphene nanosheets (starch-GNS) via the reduction of exfoliated graphene oxides by soluble starch, which acted both as a reductant and as a functionalization reagent for capping graphene nanosheets

Newborn boys and girls differ in the lipid composition of vernix caseosa.

Radka Míková et al.

PloS one, 9(6), e99173-e99173 (2014-06-10)

Vernix caseosa protects the skin of a human fetus during the last trimester of pregnancy and of a newborn after the delivery. Besides its cellular and proteinaceous components, an important constituent and functional agent is a complex lipid fraction, implicated

Noncovalent binding of xanthene and phthalocyanine dyes with graphene sheets: the effect of the molecular structure revealed by a photophysical study.

Xian-Fu Zhang et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 113, 92-99 (2013-05-30)

The fluorescence and absorption properties of several xanthene and phthalocyanine dyes were measured in the presence and absence of chemically derived graphene (CDG) sheets. The interaction of pyronine Y (PYY) with graphene sheets was compared with that of rhodamine 6G

Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance.

Sarah Tsao et al.

Antimicrobial agents and chemotherapy, 53(4), 1344-1352 (2009-02-19)

Candida albicans frequently develops resistance to treatment with azole drugs due to the acquisition of gain-of-function mutations in the transcription factor Tac1p. Tac1p hyperactivation in azole-resistant isolates results in the constitutive overexpression of several genes, including CDR1 and CDR2, which

Gold Nanocluster Embedded Albumin Nanoparticles for Two-Photon Imaging of Cancer Cells Accompanying Drug Delivery.

Rumi Khandelia et al.

Small (Weinheim an der Bergstrasse, Germany), 11(33), 4075-4081 (2015-05-06)

Gold nanoclusters in albumin nanoparticles (nanovehicles) are used for single-photon and two-photon imaging of cancer cells following the delivery of doxorubicin through the nanovehicle. NIR excitation and emission wavelengths in the biological window (650-900 nm) make the nanovehicle an ideal

Induction of P-Glycoprotein by Antiretroviral Drugs in Human Brain Microvessel Endothelial Cells

Gary N.Y. Chan

Antimicrobial Agents and Chemotherapy, 57(9) (2013)

Selective inhibition of PKR improves vascular inflammation and remodelling in high fructose treated primary vascular smooth muscle cells.

Jaspreet Kalra et al.

Biochimica et biophysica acta. Molecular basis of disease, 1866(3), 165606-165606 (2019-11-20)

Double-stranded RNA dependent protein kinase (PKR) is reported to play a critical role in the pathogenesis of diabetes and associated vascular complications. Increased PKR activity is observed in metabolic disorders. Increased PKR activity is reported to induce inflammation and oxidative

Microfluidic surface-enhanced Raman scattering sensor with monolithically integrated nanoporous gold disk arrays for rapid and label-free biomolecular detection.

Ming Li et al.

Journal of biomedical optics, 19(11), 111611-111611 (2014-07-24)

We present a microfluidic surface-enhanced Raman scattering (SERS) sensor for rapid and label-free biomolecular detection. Our sensor design mitigates a common limiting factor in microfluidic SERS sensors that utilize integrated nanostructures: low-efficiency transport of biomolecules to nanostructured surface which adversely

Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals.

Monika Sharma et al.

Antimicrobial agents and chemotherapy, 53(8), 3256-3265 (2009-05-28)

Curcumin (CUR), a natural product of turmeric, from rhizomes of Curcuma longa, is a known agent of reversal of drug resistance phenotypes in cancer cells overexpressing ATP-binding cassette (ABC) transporters, viz., ABCB1, ABCG2, and ABCC1. In the present study, we

Desmopressin improves intestinal functional capillary density and decreases leukocyte activation in experimental endotoxemia.

K Wafa et al.

Microvascular research, 97, 98-104 (2013-09-17)

Blood flow to the intestine is decreased in sepsis in favor of vital organs resulting in ischemic damage of the gut mucosa. Once the mucosa is damaged, increased translocation of intestinal bacteria to the systemic circulation may occur. This in

Halloysite nanotubule clay for efficient water purification.

Yafei Zhao et al.

Journal of colloid and interface science, 406, 121-129 (2013-06-29)

Halloysite clay has chemical structure similar to kaolinite but it is rolled in tubes with diameter of 50 nm and length of ca. 1000 nm. Halloysite exhibits higher adsorption capacity for both cationic and anionic dyes because it has negative

Analysis of 1,2-diol diesters in vernix caseosa by high-performance liquid chromatography - atmospheric pressure chemical ionization mass spectrometry.

Lenka Šubčíková et al.

Journal of chromatography. A, 1378, 8-18 (2015-01-04)

Fatty acid diesters of long-chain 1,2-diols (1,2-DDE), or type II wax diesters, were analyzed in the vernix caseosa of a newborn girl. 1,2-DDE were isolated from the total lipid extract by the semipreparative TLC using plates coated with silica gel.

No Dynamic Changes in Inflammation-related Microcirculatory Parameters in Developing Rats During Local Cortex Exposure to Microwaves.

Hiroshi Masuda et al.

In vivo (Athens, Greece), 29(5), 561-567 (2015-09-12)

The biological effects of exposing the developing brain to radiofrequency electromagnetic fields (RF) are still unclear. Our experiments investigated whether three inflammation-related, microcirculatory parameters in juvenile and young adult rats were modified during local cortex exposure to RF under non-thermal

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