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Rebecca Marcus et al.
Cancers, 13(22) (2021-11-28)
Intrahepatic cholangiocarcinoma (ICC) is a primary biliary malignancy that harbors a dismal prognosis. Oncogenic mutations of KRAS and loss-of-function mutations of BRCA1-associated protein 1 (BAP1) have been identified as recurrent somatic alterations in ICC. However, an autochthonous genetically engineered mouse
Greg J Duncan et al.
Nature communications, 9(1), 3066-3066 (2018-08-05)
Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte
Parallel evolution and phenotypic divergence in lichenized fungi: a case study in the lichen-forming fungal family Graphidaceae (Ascomycota: Lecanoromycetes: Ostropales).
Rivas Plata E
Molecular Phylogenetics and Evolution, 61(1), 45-63 (2011)
Jessica Wallingford et al.
Frontiers in molecular neuroscience, 10, 268-268 (2017-09-14)
Astrocyte dysfunction has been indicated in many neurodevelopmental disorders, including Fragile X Syndrome (FXS). FXS is caused by a deficiency in fragile X mental retardation protein (FMRP). FMRP regulates the translation of numerous mRNAs and its loss disturbs the composition
Erica Bresciani et al.
Blood, 124(1), 70-78 (2014-05-23)
CBFβ and RUNX1 form a DNA-binding heterodimer and are both required for hematopoietic stem cell (HSC) generation in mice. However, the exact role of CBFβ in the production of HSCs remains unclear. Here, we generated and characterized 2 zebrafish cbfb
Daniel Fil et al.
Human molecular genetics, 26(4), 686-701 (2017-01-04)
The recent identification of profilin1 mutations in 25 familial ALS cases has linked altered function of this cytoskeleton-regulating protein to the pathogenesis of motor neuron disease. To investigate the pathological role of mutant profilin1 in motor neuron disease, we generated
Nitya Bhaskaran et al.
Scientific reports, 8(1), 13764-13764 (2018-09-15)
Elevated Microsatellite Alterations at Selected Tetranucleotide repeats (EMAST) occur in up to 60% of colorectal cancers and may associate with aggressive and advanced disease in patients. Although EMAST occurs in many cancer types, current understanding is limited due to the
Eimy Rivas Plata et al.
Molecular phylogenetics and evolution, 61(1), 45-63 (2011-05-25)
A molecular phylogeny of combined mtSSU, nuLSU, and RPB2 data revealed previously unrecognized levels of parallel evolution and phenotypic divergence in the lichen family Graphidaceae. Five clades were supported within the family: the Fissurina, Ocellularia, Graphis, Topeliopsis, and Thelotrema clades
Shamsudheen Moidunny et al.
British journal of pharmacology, 177(24), 5658-5676 (2020-10-21)
A significant number of HIV-1 patients on antiretroviral therapy develop HIV-associated neurocognitive disorders (HAND). Evidence indicate that biological sex may regulate HAND pathogenesis, but the mechanisms remain unknown. We investigated synaptic mechanisms associated with sex differences in HAND, using the
Lauren N Beloate et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(38), 9949-9961 (2016-09-23)
Experience with sexual behavior causes cross-sensitization of amphetamine reward, an effect dependent on a period of sexual reward abstinence. We previously showed that ΔFosB in the nucleus accumbens (NAc) is a key mediator of this cross-sensitization, potentially via dopamine receptor
Amelia R Hofstetter et al.
PloS one, 11(2), e0149864-e0149864 (2016-02-26)
The role of the reactive oxygen species-producing NADPH oxidase family of enzymes in the pathology of influenza A virus infection remains enigmatic. Previous reports implicated NADPH oxidase 2 in influenza A virus-induced inflammation. In contrast, NADPH oxidase 1 (Nox1) was
K D Kuhn et al.
Molecular and cellular neurosciences, 103, 103467-103467 (2020-02-01)
During neural development, complex organisms rely on progressive and regressive events whereby axons, synapses, and neurons are overproduced followed by selective elimination of a portion of these components. Tumor necrosis factor α (TNFα) together with its cognate receptor (Tumor necrosis
Altered developmental expression of the astrocyte-secreted factors hevin and SPARC in the fragile X mouse model
Wallingford J, et al.
Frontiers in Molecular Neuroscience, 10, 268-268 (2017)
Renée J H A Tillie et al.
Cells, 10(7) (2021-08-08)
Platelet-derived growth factor B (PDGF-B) is a mitogenic, migratory and survival factor. Cell-associated PDGF-B recruits stabilizing pericytes towards blood vessels through retention in extracellular matrix. We hypothesized that the genetic ablation of cell-associated PDGF-B by retention motif deletion would reduce
Phylogenetic placement, species delimitation, and cyanobiont identity of endangered aquatic Peltigera species (lichen-forming Ascomycota, Lecanoromycetes).
Miadlikowska J
American Journal of Botany, 101(7), 1141-1156 (2014)
Claudia Sigl et al.
Applied and environmental microbiology, 77(3), 972-982 (2010-12-15)
In filamentous fungi, secondary metabolism is often linked with developmental processes such as conidiation. In this study we analyzed the link between secondary metabolism and conidiation in the main industrial producer of the β-lactam antibiotic penicillin, the ascomycete Penicillium chrysogenum.
Christina Lisk et al.
Frontiers in immunology, 12, 624197-624197 (2021-04-06)
Vaccines have played a pivotal role in improving public health, however, many infectious diseases lack an effective vaccine. Controlling the spread of infectious diseases requires continuing studies to develop new and improved vaccines. Our laboratory has been investigating the immune
Darinka Gjorgieva et al.
BioMed research international, 2013, 276417-276417 (2013-07-19)
Heavy metals have the potential to interact and induce several stress responses in the plants; thus, effects of heavy metal stress on DNA damages and total antioxidants level in Urtica dioica leaves and stems were investigated. The samples are sampled
Rasmus H Jensen et al.
Journal of clinical microbiology, 49(2), 549-556 (2010-12-15)
Candida palmioleophila has previously been misidentified as C. famata or C. guilliermondii. We have investigated traditional and modern identification methods for the identification of this and related species. Forty-one clinical isolates previously identified as C. famata or C. guilliermondii and
Gil Benedek et al.
PLoS neglected tropical diseases, 15(10), e0009821-e0009821 (2021-10-19)
Nodding syndrome (NS) is a catastrophic and enigmatic childhood epilepsy, accompanied by multiple neurological impairments and neuroinflammation. Of all the infectious, environmental and psychological factors associated with NS, the major culprit is Onchocerca Volvulus (Ov)-a parasitic worm transmitted to human
Ventral tegmental area dopamine cell activation during male rat sexual behavior regulates neuroplasticity and d-amphetamine cross-sensitization following sex abstinence
Beloate LN, et al.
The Journal of Neuroscience, 36, 9949-9961 (2016)
Targeted mutagenesis in the progeny of maize transgenic plants.
Yang M
Plant Molecular Biology, 70(6), 669-679 (2009)
Prescott T Leach et al.
eNeuro, 3(1) (2016-03-30)
Fragile X syndrome is a neurodevelopmental disorder characterized by mild-to-severe cognitive deficits. The complete absence of Fmr1 and its protein product in the mouse model of fragile X (Fmr1 KO) provides construct validity. A major conundrum in the field is
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