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Claudia Fiorini et al.
Biochimica et biophysica acta, 1843(5), 976-984 (2014-02-04)
Among the large number of variants belonging to the pancreatic-type secretory ribonuclease (RNase) superfamily, bovine pancreatic ribonuclease (RNase A) is the proto-type and bovine seminal RNase (BS-RNase) represents the unique natively dimeric member. In the present manuscript, we evaluate the
Magali Solé et al.
FEBS letters, 587(6), 737-742 (2013-02-12)
Unfolding by chemical denaturants and the linear extrapolation method are widely used to determine the free energy of proteins. Ribonuclease 3 from bullfrog shows an extraordinary behavior in guanidinium hydrochloride in comparison to its homologues ribonuclease A and onconase with
Downregulation of the long non-coding RNA taurine-upregulated gene 1 inhibits glioma cell proliferation and invasion and promotes apoptosis
Zhao Z, et al.
Oncology Letters, 15(3), 4026-4032 (2018)
Virginie Bottero et al.
Journal of virology, 87(21), 11806-11820 (2013-08-30)
Angiogenin (ANG) is a 14-kDa multifunctional proangiogenic secreted protein whose expression level correlates with the aggressiveness of several tumors. We observed increased ANG expression and secretion in endothelial cells during de novo infection with Kaposi's sarcoma-associated herpesvirus (KSHV), in cells
Kyoung Woo Kim et al.
Investigative ophthalmology & visual science, 54(9), 6355-6362 (2013-08-31)
Angiogenin (ANG) originally was identified as an angiogenic tumor factor, and recently its biologic activity is extended to stimulating cell proliferation. With viewing pterygium as a tumorigenic mimicry, we investigated ANG profiles within pterygia. Expression levels of ANG were assessed
Marka van Blitterswijk et al.
PloS one, 7(11), e48983-e48983 (2012-11-17)
Progressive muscular atrophy (PMA) and amyotrophic lateral sclerosis (ALS) are devastating motor neuron diseases (MNDs), which result in muscle weakness and/or spasticity. We compared mutation frequencies in genes known to be associated with MNDs between patients with apparently sporadic PMA
Yuen Lai Shek et al.
Biochemistry, 52(4), 672-680 (2013-01-09)
We report the first application of volume and compressibility measurements to characterization of interactions between cosolvents (osmolytes) and globular proteins. Specifically, we measure the partial molar volumes and adiabatic compressibilities of cytochrome c, ribonuclease A, lysozyme, and ovalbumin in aqueous
Zhijun Zhao et al.
Oncology letters, 15(3), 4026-4032 (2018-02-23)
Expression of the long non-coding RNA taurine-upregulated gene 1 (TUG1) is associated with various aggressive tumors. The present study aimed to investigate the biological function of TUG1 in regulating apoptosis, proliferation, invasion and cell cycle distribution in human glioma U251
Adriano Chiò et al.
Neurology, 79(19), 1983-1989 (2012-10-27)
To assess the frequency and clinical characteristics of patients with mutations of major amyotrophic lateral sclerosis (ALS) genes in a prospectively ascertained, population-based epidemiologic series of cases. The study population includes all ALS cases diagnosed in Piemonte, Italy, from January
Srinivasan Damodaran
Biochemistry, 52(46), 8363-8373 (2013-10-26)
Cosolvents affect structural stability of proteins in aqueous solutions. A clear understanding of the mechanism by which cosolvents impact protein stability is critical to understanding protein folding in a biological milieu. In this study, we investigated the Lifshitz-van der Waals
Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1)
Sukackaite R, et al.
Scientific Reports, 7(1), 2119-2119 (2017)
Imidazole C-2 hydrogen/deuterium exchange reaction at histidine for probing protein structure and function with matrix-assisted laser desorption ionization mass spectrometry.
Naoka Hayashi et al.
Biochemistry, 53(11), 1818-1826 (2014-03-13)
Ribonucleases: From Prototypes to Therapeutic Targets
Loverix S and Steyaert J
Current Medicinal Chemistry, 10(9), 779-785 (2003)
The crystal structure of ribonuclease A in complex with thymidine-3?-monophosphate provides further insight into ligand binding
Doucet N, et al.
Proteins: Structure, Function, and Bioinformatics, 78(11), 2459-2468 (2010)
Cholpon S Djuzenova et al.
BMC cancer, 19(1), 299-299 (2019-04-05)
Most tumor cells show aberrantly activated Akt which leads to increased cell survival and resistance to cancer radiotherapy. Therefore, targeting Akt can be a promising strategy for radiosensitization. Here, we explore the impact of the Akt inhibitor MK-2206 alone and
Yifei Kong et al.
Nanoscale, 5(3), 1009-1017 (2012-12-20)
Ultra-small gold nanoclusters (AuNCs) have unique size-dependent optical, electrical and chemical properties. They have emerged as a new nanomaterial with broad applications in optoelectronics, catalysis, biosensing, and bioimaging. Several strategies have been exploited to prepare AuNCs of different "magic number"
Panote Prapansilp et al.
Malaria journal, 12, 50-50 (2013-02-07)
Plasma angiopoietin (Ang)-2 is associated with disease severity and mortality in adults and children with falciparum malaria. However the mechanism of action of the angiopoietins in fatal malaria is unclear. This study aimed to determine whether the expression of Ang-1
B Schmidt et al.
Journal of chromatography. A, 944(1-2), 149-159 (2002-02-08)
A novel type of linear polyelectrolyte, namely poly-DADMAC [poly(diallyldimethylammonium chloride)], was prepared and studied as a displacer for cation-exchange displacement chromatography of proteins. In contrast to the commercially available polymers of that chemistry, the novel type of poly-DADMAC introduced here
Andrea Pica et al.
Acta crystallographica. Section D, Biological crystallography, 69(Pt 10), 2116-2123 (2013-10-09)
The deletion of five residues in the loop connecting the N-terminal helix to the core of monomeric human pancreatic ribonuclease leads to the formation of an enzymatically active domain-swapped dimer (desHP). The crystal structure of desHP reveals the generation of
Lakshmanane Premkumar et al.
The Journal of biological chemistry, 289(5), 2563-2576 (2013-12-07)
The multidrug resistance-encoding IncA/C conjugative plasmids disseminate antibiotic resistance genes among clinically relevant enteric bacteria. A plasmid-encoded disulfide isomerase is associated with conjugation. Sequence analysis of several IncA/C plasmids and IncA/C-related integrative and conjugative elements (ICE) from commensal and pathogenic
Alessandro Vergara et al.
Inorganic chemistry, 52(19), 10714-10716 (2013-10-08)
A Raman-assisted crystallographic study on the adduct between AziRu, a Ru(III) complex with high antiproliferative activity, and RNase A is presented. The protein structure is not perturbed significantly by the Ru label. The metal coordinates to ND atoms of His105
Marko Premzl
Molecular genetics and genomics : MGG, 289(2), 161-167 (2013-12-18)
The present study attempted to update comprehensive eutherian ribonuclease A gene data sets, using public eutherian genomic sequence data sets and new genomics and molecular evolution tests. Among 448 ribonuclease A potential coding sequences, the present analysis annotated 255 complete
Shalini Iyer et al.
The FEBS journal, 280(1), 302-318 (2012-11-23)
Angiogenin (Ang) is a potent inducer of neovascularization. Point mutations in human Ang have been linked to cancer progression and two neurodegenerative diseases: amyotrophic lateral sclerosis and Parkinson's disease. Intensive structural and functional analyses of Ang have been paramount in
Ulla-Britt Jönsson et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(4), 283-291 (2014-04-17)
Previous studies showed that the biological activity and the eosinophil content of eosinophil cationic protein (ECP, RNase 3) are determined by single-nucleotide polymorphisms (SNPs) in the ECP (RNase3) gene. In this study, we report the prevalence of a common SNP
Tamara Granner et al.
The British journal of ophthalmology, 97(3), 371-374 (2013-01-08)
Age-related macular degeneration (AMD) is currently the leading cause of blindness in developed countries. Bevacizumab is a widely used anti-VEGF agent that is a commonly applied therapy for neovascular AMD; however, a consequence of bevacizumab therapy may be the activation
Back to the future: ribonuclease A
Marshall GR, et al.
Pept. Sci., 90(3), 259-277 (2008)
Chunju Li et al.
Journal of biotechnology, 162(2-3), 283-288 (2012-09-25)
Ribonuclease A (RNase A) is a therapeutic enzyme with cytotoxic action against tumor cells. Its clinical application is limited by the short half-life and insufficient stability. Conjugation of albumin can overcome the limitation, whereas dramatically decrease the enzymatic activity of
Elin Enervald et al.
The EMBO journal, 40(24), e105862-e105862 (2021-11-18)
The onset of random X chromosome inactivation in mouse requires the switch from a symmetric to an asymmetric state, where the identities of the future inactive and active X chromosomes are assigned. This process is known as X chromosome choice.
Anna On-Yee Chan et al.
Chemical communications (Cambridge, England), 49(14), 1428-1430 (2013-01-17)
A new approach for selective modification of cysteine-containing peptides through gold-mediated oxidative allene-thiol coupling reaction in aqueous medium is developed.
Donald Gagné et al.
The Journal of biological chemistry, 287(53), 44289-44300 (2012-11-09)
Conformational flexibility between structural ensembles is an essential component of enzyme function. Although the broad dynamical landscape of proteins is known to promote a number of functional events on multiple time scales, it is yet unknown whether structural and functional
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