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显示 1-30 共 142 条结果 关于 "RAB0117" 范围 论文
Alfonso Benítez-Páez et al.
mSystems, 5(2) (2020-03-27)
Cross-sectional studies conducted with obese and control subjects have suggested associations between gut microbiota alterations and obesity, but the links with specific disease phenotypes and proofs of causality are still scarce. The present study aimed to profile the gut microbiota
Ling Wang et al.
FEBS letters, 594(1), 153-160 (2019-08-01)
Bromhexine was reported to relieve the symptoms of Sjogren Syndrome at an early stage. However, the underlying mechanism remains unclear. Here, we administered bromhexine at low doses in human primary conjunctival fornix epithelial cells, and found it stimulated MUC5AC secretion
Yi-Hsuan Lin et al.
Cells, 9(4) (2020-04-16)
Interleukin 26 (IL-26) is a new member of the IL-10 family that is highly expressed in rheumatoid arthritis (RA). However, the functions of IL-26 produced by macrophages in RA have not been elucidated. In the present work, we evaluated the
Rosaria Greco et al.
The journal of headache and pain, 21(1), 122-122 (2020-10-18)
Migraine can manifest with an episodic or a chronic pattern in a continuum of disease severity. Multiple factors are associated with the progression of the pattern from episodic to chronic. One of the most consistently reported factors is the overuse
Mahesh Chandra Patra et al.
Cells, 9(7) (2020-07-15)
Toll-like receptors (TLRs) play a fundamental role in the inflammatory response against invading pathogens. However, the dysregulation of TLR-signaling pathways is implicated in several autoimmune/inflammatory diseases. Here, we show that a novel small molecule TLR-inhibitor (TAC5) and its derivatives TAC5-a
Wen Wen et al.
Experimental and therapeutic medicine, 19(1), 85-94 (2019-12-20)
Migraine, characterized by hyperalgesia of the trigeminovascular system, is a severe condition that leads to severe reductions in the quality of life. Upon external stimulation, the levels of various neurotransmitters, including aspartic acid (Asp), glutamic acid (Glu), γ-amino butyric acid
Su Cheol Baek et al.
Foods (Basel, Switzerland), 9(3) (2020-03-07)
Hippophae rhamnoides L. (Elaeagnaceae; commonly known as "sea buckthorn" and "vitamin tree"), is a spiny deciduous shrub whose fruit is used in foods and traditional medicines. The H. rhamnoides fruit (berry) is rich in vitamin C, with a level exceeding
Luca Ferrari et al.
Comparative immunology, microbiology and infectious diseases, 72, 101523-101523 (2020-08-08)
This study evaluated the early modulation of the phenotype and cytokine secretion in swine immune cells treated with an engineered killer peptide (KP) based on an anti-idiotypic antibody functionally mimicking a yeast killer toxin. The influence of KP on specific
Clara Domínguez Vivero et al.
Toxins, 12(8) (2020-08-01)
Previous studies have reported increased brain deposits of iron in patients with chronic migraine (CM). This study aims to determine the relation between iron deposits and outcome after treatment with OnabotulinumtoxinA (OnabotA). Demographic and clinical data were collected for this
Yingzheng Zhao et al.
Toxicology letters, 323, 57-66 (2020-02-06)
Oxidative stress and inflammatory processes are proposed to mediate the development of silicosis. However, antioxidant therapy has not produced consistent results during the treatment of silicosis. α-Lipoic acid synthesized by lipoic acid synthase is a powerful anti-oxidant and helps protect
Xiaoxu Chen et al.
Scientific reports, 10(1), 21494-21494 (2020-12-11)
Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo. This study was performed to evaluate serum levels of inflammatory factors and changes in B-mode carotid ultrasound findings in patients with BPPV. The study population consisted of 90
Gabriela M Escalante et al.
Vaccines, 8(2) (2020-04-10)
Primary infection with Epstein-Barr virus (EBV) is associated with acute infectious mononucleosis, whereas persistent infection is associated with chronic diseases such as autoimmune diseases and various types of cancer. Indeed, approximately 2% of all new cancer cases occurring annually worldwide
Friederike Cordes et al.
Inflammatory bowel diseases, 26(3), 391-406 (2019-09-29)
The inhibition of Janus kinases (JAKs) and subsequent signal transducers and activators of transcription (STATs) by tofacitinib represents a new therapeutic strategy in inflammatory bowel diseases (IBD) as clinical trials have led to approval of tofacitinib for ulcerative colitis (UC)
Alexandre Póvoa Barbosa et al.
Life sciences, 241, 117132-117132 (2019-12-15)
This study aimed to verify the effects of cigarette smoke exposure in bone mineralization and fibrillar matrix composition as well as in bone healing after tibial fracture induction. C57Bl/6 Mice were assigned according to exposure and surgery: C room air;
Ahmad Alkhatib et al.
Nutrients, 12(4) (2020-04-25)
The study tested whether anserine (beta-alanyl-3-methyl-l-histidine), the active ingredient of chicken essence affects exercise-induced oxidative stress, cell integrity, and haematology biomarkers. In a randomized placebo-controlled repeated-measures design, ten healthy men ingested anserine in either a low dose (ANS-LD) 15 mg.kg-1.bw-1
Yun Kyong Lim et al.
Food science and biotechnology, 29(4), 539-548 (2020-04-17)
The purpose of this study was to determine the anti-inflammatory and in vitro bone formation effects of Garcinia mangostana L. (mangosteen) and propolis extracts. Immortalized human gingival fibroblasts (hTERT-hNOF) cells were treated with Porphyromonas gingivalis KCOM 2804 lipopolysaccharide followed by
CXCL1 contributes to host defense in polymicrobial sepsis via modulating T cell and neutrophil functions.
Jin L
Journal of Immunology, 193(7), 3549-3558 (2014)
Xiaoping Luo et al.
Pharmaceutical biology, 58(1), 886-897 (2020-09-04)
Obacunone, a limonoid abundantly found in Citrus fruits, exhibits a variety of bioactivities. To investigate the effects of obacunone on a colorectal cancer (CRC) mouse model, and clarify its potential molecular mechanisms. The male Balb/c mice were induced with azoxymethane
Mohsin Sulaiman et al.
Molecular biology reports, 47(11), 8701-8710 (2020-11-02)
Sulfated polysaccharide ascophyllan from marine brown algae has been identified to have burn wound healing properties. Thus, we examined the effects of ascophyllan fraction (AF3) on the inflammatory response and oxidative damage in burn wounds. Full-thickness burn wounds in rats
Javid Sadri Nahand et al.
International immunopharmacology, 88, 106913-106913 (2020-09-06)
The aim of this study was to determine the presence of HPV in patients with Prostate cancer (PCa) and its possible association with cancer progression. In this case-control study, fresh prostate tissues and blood samples were collected from 90 individuals
Alfred K Njamnshi et al.
The American journal of tropical medicine and hygiene, 103(6), 2244-2252 (2020-10-21)
Human African trypanosomiasis (HAT) remains a serious public health problem with diagnostic and treatment challenges in many African countries. The absence of a gold-standard biomarker has been a major difficulty for accurate disease staging and treatment follow-up. We therefore attempted
Peilang Yang et al.
Journal of cell science, 133(19) (2020-09-04)
Besides regulating glucose levels, insulin has been reported to participate actively in many other functions, including modulating inflammatory reactions. In this study we investigated how topical insulin application would affect the diabetic wound healing process. We found that the excessive
Peng Yu et al.
International journal of pharmaceutics, 593, 120171-120171 (2020-12-16)
Osteoporosis therapy consists of inhibiting the osteoclasts' activity and promoting osteoblasts' osteogenesis. Salmon calcitonin (sCT) could realize both requirements, however, it is limited by the low bioavailability caused by fibrillation. Supramolecular assembly of sCT and biocompatible agents into nanoassemblies provides
Soo Youn Choi et al.
International journal of ophthalmology, 13(7), 1023-1030 (2020-07-21)
To investigate the therapeutic effect of natural extract eye drops containing bee venom, musk, and deer antlers in dry eye disease (DED) animal models. Scopolamine-injected DED rats and lacrimal gland-excised rats were allocated into control, saline, and natural extract groups
Ji Hun Suh et al.
Journal of clinical medicine, 9(2) (2020-02-23)
Colorectal cancer (CRC) is one of the leading causes of world cancer deaths. To improve the survival rate of CRC, diagnosis and post-operative monitoring is necessary. Currently, biomarkers are used for CRC diagnosis and prognosis. However, these biomarkers have limitations
Andreas Kupz et al.
Scientific reports, 10(1), 13115-13115 (2020-08-06)
Toxoplasmic encephalitis is an AIDS-defining condition. The decline of IFN-γ-producing CD4+ T cells in AIDS is a major contributing factor in reactivation of quiescent Toxoplasma gondii to an actively replicating stage of infection. Hence, it is important to characterize CD4-independent
Seiji Saito et al.
Protein science : a publication of the Protein Society, 29(5), 1186-1195 (2020-03-07)
IgG2 subclass antibodies have unique properties that include low effector function and a rigid hinge region. Although some IgG2 subclasses have been clinically tested and approved for therapeutic use, they have a higher propensity than IgG1 for aggregation, which can
Sima Nazarpour et al.
Biological trace element research, 194(2), 348-359 (2019-07-31)
Iodine is essential for the production of thyroid hormones, and its deficiency during pregnancy may be associated with poor obstetric outcomes. The aim of this study was to investigate the relationship between maternal iodine statuses with pregnancy outcomes among pregnant
Ahmad H Alghadir et al.
Clinical interventions in aging, 15, 1271-1283 (2020-08-22)
Poor daily life physical activities among older people were related to depressive mood especially memory loss. In addition to that, the change in physical ability is significantly associated with the score of depression among older age. The present study aimed
Lucia M Moreira et al.
Nature, 587(7834), 460-465 (2020-11-06)
Atrial fibrillation, the most common cardiac arrhythmia, is an important contributor to mortality and morbidity, and particularly to the risk of stroke in humans1. Atrial-tissue fibrosis is a central pathophysiological feature of atrial fibrillation that also hampers its treatment; the underlying molecular
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