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显示 1-30 共 53 条结果 关于 "RAB0602" 范围 论文
Xinmei Wang et al.
PloS one, 13(6), e0198552-e0198552 (2018-06-08)
Hepatocellular carcinoma (HCC) remains one of the major causes of cancer related deaths. Although ultrasonography (US), computed tomography (CT) and/or high-cost magnetic resonance imaging (MRI) have been shown to improve early detection of liver cancer and mortality rates in high-risk
Novel photoelectrochemical immunosensor for disease-related protein assisted by hemin/G-quadruplex-based DNAzyme on gold nanoparticles to enhance cathodic photocurrent on p-CuBi2O4 semiconductor.
Lv S, et al.
Biosensors And Bioelectronics, 96, 317-323 (2017)
Joseph L Jilek et al.
Molecular therapy. Nucleic acids, 14, 498-508 (2019-02-13)
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths, warranting better therapies. Restoration of tumor-suppressive microRNAs depleted in hepatocellular carcinoma represents a new therapeutic strategy. Herein, we sought to identify a potent microRNA (miRNA) agent that could alleviate HCC
Aya O Balbaa et al.
Nanomedicine (London, England), 14(5), 515-528 (2019-02-27)
Cells electrical fields have a significant role in cell function. The current study examined the effects of nanoscale electric fields generated by magneto-electric nanoparticles (MENs) on precancerous liver tissue. A total of 30 nm MENs synthesized by sol-gel method were tested in
Arnaud Carpentier et al.
The Journal of clinical investigation, 124(11), 4953-4964 (2014-10-09)
The demonstrated ability to differentiate both human embryonic stem cells (hESCs) and patient-derived induced pluripotent stem cells (hiPSCs) into hepatocyte-like cells (HLCs) holds great promise for both regenerative medicine and liver disease research. Here, we determined that, despite an immature
Proliferating infantile hemangioma promotes α-fetoprotein production by HepG2 cells.
Bede van Schaijik et al.
Pediatric research, 87(1), 3-6 (2019-08-15)
Lejia Sun et al.
Frontiers in oncology, 10, 878-878 (2020-06-26)
The existing in vitro models for antitumor drug screening have great limitations. Many compounds that inhibit 2D cultured cells do not exhibit the same pharmacological effects in vivo, thereby wasting human and material resources as well as time during drug
Gianluigi Giannelli et al.
PloS one, 15(3), e0222259-e0222259 (2020-03-27)
Transforming growth factor beta (TGF-β) signalling is involved in the development of hepatocellular carcinoma (HCC). We followed changes in biomarkers during treatment of patients with HCC with the TGF-βRI/ALK5 inhibitor galunisertib. This phase 2 study (NCT01246986) enrolled second-line patients with
Asmaa A Hassan et al.
Pakistan journal of pharmaceutical sciences, 31(4), 1191-1201 (2018-07-24)
Daflon is a phlebotonic drug widely used in chronic venous or lymphatic insufficiency. This study designed to investigate the relation of daflon with hyaluronan as a mediator for the hepatoprotective effect against Carbon tetrachloride (CCl4) and/or γ-radiation induced liver damage.
Z Macek-Jilkova et al.
Bulletin of experimental biology and medicine, 170(3), 340-344 (2021-01-17)
We evaluated the possibility of using an experimental model of hepatocellular carcinoma to study oncomarkers of primary liver cancer and compared the diagnostic efficacy of alpha-fetoprotein and osteopontin in the experiment and in clinical practice. Experimental studies were performed on
Dabin Liu et al.
Science translational medicine, 10(437) (2018-04-20)
Nonalcoholic fatty liver disease (NAFLD)-induced hepatocellular carcinoma (HCC) is an emerging malignancy in the developed world; however, mechanisms that contribute to its formation are largely unknown, and targeted therapy is currently not available. Our RNA sequencing analysis of NAFLD-HCC samples
Rui Xi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 88, 242-251 (2017-01-23)
Actein is isolated from the rthizomes of Cimicifuga foetida, which is a triterpene glycoside, displaying suppressive effects on breast cancer cells proliferation. However, the effects of actein treatment on liver injury, tending to cancer, have little to be known. Thus
Rune Busk Damgaard et al.
Cell death and differentiation, 27(5), 1457-1474 (2020-04-02)
Methionine-1 (M1)-linked polyubiquitin chains conjugated by the linear ubiquitin chain assembly complex (LUBAC) control NF-κB activation, immune homoeostasis, and prevents tumour necrosis factor (TNF)-induced cell death. The deubiquitinase OTULIN negatively regulates M1-linked polyubiquitin signalling by removing the chains conjugated by
Yu Sun et al.
Journal of hepatology, 73(3), 603-615 (2020-07-01)
Obesity is an independent risk factor for malignancies, including hepatocellular carcinoma (HCC). However, it remains unknown whether maternal obesity affects the incidence of HCC in offspring. Thus, we aimed to investigate this association and its underlying mechanisms. Diethylnitrosamine (DEN) was
Zeinab Salah et al.
Current gene therapy, 19(5), 342-354 (2019-11-09)
MicroRNA modulation therapy has shown great promise to treat hepatocellular carcinoma (HCC), however Efficient tissue-specific and safe delivery remains a major challenge. We sought to develop an inorganic-organic hybrid vehicle for the systemic delivery of the tumor suppressor miR-34a, and
Surachate Siripongsakun et al.
Journal of gastroenterology and hepatology, 29(1), 157-164 (2013-12-21)
The performance of alpha-fetoprotein (AFP) in the detection of hepatocellular carcinoma (HCC) recurrence after radiofrequency ablation was analyzed. One hundred and forty-six solitary HCC lesions treated by radiofrequency ablation were evaluated. Using the AFP cutoff level at ≥ 20 ng/mL, tumors were
Jianmin Qin et al.
Oncology letters, 15(5), 6137-6146 (2018-05-08)
In vitro and in vivo studies have demonstrated that brucine is able to inhibit the proliferation of liver cancer cells and growth of animal tumors, and may be a promising anticancer drug. However, high toxicity, poor water solubility, short half-life
Kenya Kamimura et al.
Cancers, 12(2) (2020-02-23)
Hepatocellular carcinoma (HCC) is a major global malignancy, responsible for >90% of primary liver cancers. Currently available therapeutic options have poor performances due to the highly heterogeneous nature of the tumor cells; recurrence is highly probable, and some patients develop
Gerda de Vries et al.
Scientific reports, 10(1), 18938-18938 (2020-11-05)
Testicular cancer (TC) is the most common solid tumour in young men. While cisplatin-based chemotherapy is highly effective in TC patients, chemoresistance still accounts for 10% of disease-related deaths. Pre-clinical models that faithfully reflect patient tumours are needed to assist
Miao Lu et al.
BMC cancer, 19(1), 887-887 (2019-09-07)
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80-90% of cases. Mutations are commonly found in the signaling regulating the PI3K/Akt pathway, leading to oncogenic cell proliferation and survival. Key transcription factors that are negatively regulated
Yuan Cheng et al.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 23(12), 2354-2361 (2019-02-26)
A growing body of research indicates that the monitoring of circulating tumor cells (CTCs) may have great significance to the diagnosis of malignant tumors, assessment of condition, selection of treatment methods, and evaluation of prognosis and has a broad range
Mahmoud A Mansour et al.
Journal of biochemical and molecular toxicology, 28(9), 400-406 (2014-05-28)
The antineoplastic effect of carfilzomib (CFZ) against chemically induced hepatocarcinogenesis was studied. A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each group. Rats in group 1 (control group) were given dimethylsulphoxide
Abdel Hady A Abdel Wahab et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 22(7), 621-628 (2016-10-30)
The incidence rate of hepatocellular carcinoma (HCC) is higher in developing countries, and most cases are associated with chronic hepatitis C virus (HCV) infection. To evaluate the circulating proteins as liver biomarkers for the identification of HCC associated with HCV
Qirong Xiong et al.
Nature communications, 9(1), 1743-1743 (2018-05-03)
Microfluidic biochips hold great potential for liquid analysis in biomedical research and clinical diagnosis. However, the lack of integrated on-chip liquid mixing, bioseparation and signal transduction presents a major challenge in achieving rapid, ultrasensitive bioanalysis in simple microfluidic configurations. Here
Alyaa Farouk Hessin et al.
Indian journal of pharmacology, 49(4), 282-289 (2018-01-13)
Liver fibrosis is a global health problem that causes approximately 1.4 million deaths per year. It is associated with inflammation, oxidative stress, necrosis and ends with cirrhosis, liver cancer, or liver failure. Therefore, the present study was constructed to investigate
Lilin Ge et al.
Biosensors & bioelectronics, 132, 210-216 (2019-03-16)
A simple and feasible electrochemical immunosensing protocol with glucometer readout was designed for the detection of low-abundance disease-related biomarker (alpha-fetoprotein; AFP) on the basis of backfilling rolling cycle amplification (RCA) with invertase-DNA2 conjugates on the detection antibody. The assay consisted
Hong Liu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(2), 478-488 (2016-08-19)
The majority of tumor-specific antigens are intracellular and/or secreted and therefore inaccessible by conventional chimeric antigen receptor (CAR) T-cell therapy. Given that all intracellular/secreted proteins are processed into peptides and presented by class I MHC on the surface of tumor
Nicole Prior et al.
Development (Cambridge, England), 146(12) (2019-05-31)
During mouse embryogenesis, progenitors within the liver known as hepatoblasts give rise to adult hepatocytes and cholangiocytes. Hepatoblasts, which are specified at E8.5-E9.0, have been regarded as a homogeneous progenitor population that initiate differentiation from E13.5. Recently, scRNA-seq analysis has
Association between serum alpha-fetoprotein levels and fatty liver disease: a cross-sectional study.
Ping Xu et al.
World journal of gastroenterology, 20(33), 11865-11870 (2014-09-11)
To investigate the association between serum alpha-fetoprotein (AFP) levels and fatty liver disease (FLD) in a Chinese population. A cross-sectional study was performed among subjects who presented for a health examination at the First Affiliated Hospital, College of Medicine, Zhejiang
Jihan Hussein et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 90, 880-887 (2017-04-26)
The present study aimed to compare the therapeutic efficiency of nano-encapsulated and nano-emulsion carvacrol administration on liver injury in thioacetamide (TAA) treated rats. To fulfill our target, we used sixty male albino rats classified into six groups as follow: control
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