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RES6003H-B7
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Juan He et al.
Nephrology (Carlton, Vic.), 20(9), 591-600 (2015-04-25)
Micro-vesicles (MVs) from bone mesenchymal stem cells (MSCs) have been shown to contribute to the recovery of damaged kidney. The aims of the present study are to investigate the biological effects and repair mechanisms of MVs. Micro-vesicles were obtained from
V A Bozhedomov et al.
Journal of reproductive immunology, 112, 95-101 (2015-09-27)
Autoimmune reactions against the sperm cells play an ambiguous role in fertility impairment. The objective of this study was to characterize functional deficit of sperm conditioned by antisperm immune response in normozoospermic men. This was a multi-centric, cross-sectional, сase-control study.
Ashish Gurav et al.
The Biochemical journal, 469(2), 267-278 (2015-05-20)
Mammalian colon harbours trillions of bacteria under physiological conditions; this symbiosis is made possible because of a tolerized response from the mucosal immune system. The mechanisms underlying this tolerogenic phenomenon remain poorly understood. In the present study we show that
Gabriel A Knudsen et al.
Toxicology and applied pharmacology, 289(2), 323-329 (2015-09-22)
Tetrabromobisphenol A (TBBPA) is currently the world's highest production volume brominated flame retardant. Humans are frequently exposed to TBBPA by the dermal route. In the present study, a parallelogram approach was used to make predictions of internal dose in exposed
Kailash C Chadha et al.
The Prostate, 75(12), 1285-1299 (2015-05-13)
PSA is a biomarker for diagnosis and management of prostate cancer. PSA is known to have anti-tumorigenic activities, however, the physiological role of PSA in prostate tumor progression is not well understood. Five candidate peptides identified based upon computer modeling
Cristina Martínez-Ramos et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(6), 1249-1257 (2014-10-29)
Cancer research focuses increasingly on cancer stem cell study as those cells are thought to be the root of chemo and radioresistance of the most aggressive cancer types. Nevertheless, two-dimensional (2D) cell culture and even three-dimensional (3D) spheroid models, with
Norbert Orgovan et al.
Advances in colloid and interface science, 211, 1-16 (2014-05-23)
This paper gives an overview of the advantages and associated caveats of the most common sample handling methods in surface-sensitive chemical and biological sensing. We summarize the basic theoretical and practical considerations one faces when designing and assembling the fluidic
Genyan Liu et al.
Journal of agricultural and food chemistry, 63(28), 6304-6312 (2015-06-30)
The insect GABA receptor (GABAR), which is composed of five RDL subunits, represents an important target for insecticides. A series of 4,5-disubstituted 3-isoxazolols, including muscimol analogues, were synthesized and examined for their activities against four splice variants (ac, ad, bc
Divya K Rao et al.
The Journal of biological chemistry, 289(45), 31397-31410 (2014-09-26)
This paper introduces a strategy to kill selectively multidrug-resistant cells that express the ABCG2 transporter (also called breast cancer resistance protein, or BCRP). The approach is based on specific stimulation of ATP hydrolysis by ABCG2 transporters with subtoxic doses of
Mahmood M Alam et al.
Nature communications, 6, 7285-7285 (2015-07-08)
Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By employing chemical and genetic tools in combination with quantitative global
Fanny Tzelepis et al.
The Journal of clinical investigation, 125(2), 752-768 (2015-01-07)
The phagocytosis of apoptotic cells and associated vesicles (efferocytosis) by DCs is an important mechanism for both self tolerance and host defense. Although some of the engulfment ligands involved in efferocytosis have been identified and studied in vitro, the contributions
Shankar Munusamy et al.
American journal of physiology. Renal physiology, 309(8), F731-F743 (2015-08-21)
We investigated obesity-induced changes in kidney lipid accumulation, mitochondrial function, and endoplasmic reticulum (ER) stress in the absence of hypertension, and the potential role of leptin in modulating these changes. We compared two normotensive genetic mouse models of obesity, leptin-deficient
Sun Mi Gu et al.
Journal of neuroinflammation, 12, 124-124 (2015-06-27)
Accumulation of beta-amyloid and neuroinflammation trigger Alzheimer's disease. We previously found that lipopolysaccharide (LPS) caused neuroinflammation with concomitant accumulation of beta-amyloid peptides leading to memory loss. A variety of anti-inflammatory compounds inhibiting nuclear factor kappaB (NF-κB) activation have showed efficacy
Dominika Wrobel et al.
Biochimica et biophysica acta, 1848(7), 1490-1501 (2015-04-07)
The influence of maltose-modified poly(propylene imine) (PPI) dendrimers on dimyristoylphosphatidylcholine (DMPC) or dimyristoylphosphatidylcholine/dimyristoylphosphatidylglycerol (DMPC/DMPG) (3%) liposomes was studied. Fourth generation (G4) PPI dendrimers with primary amino surface groups were partially (open shell glycodendrimers - OS) or completely (dense shell glycodendrimers
Katharina Leitmeyer et al.
BioMed research international, 2015, 925890-925890 (2015-04-29)
Rapamycin is an antifungal agent with immunosuppressive properties. Rapamycin inhibits the mammalian target of rapamycin (mTOR) by blocking the mTOR complex 1 (mTORC1). mTOR is an atypical serine/threonine protein kinase, which controls cell growth, cell proliferation, and cell metabolism. However
Nathella P Kumar et al.
Immunology, 144(4), 677-686 (2014-11-05)
Type 2 diabetes mellitus (DM) is associated with expanded frequencies of mycobacterial antigen-specific CD4(+) T helper type 1 (Th1) and Th17 cells in individuals with active pulmonary tuberculosis (TB). No data are available on the role of CD8(+) T and
Rafaëlle Rossignol et al.
PloS one, 9(8), e105996-e105996 (2014-08-26)
Visual sensory impairments are common in Mental Deficiency (MD) and Autism Spectrum Disorder (ASD). These defects are linked to cerebral dysfunction in the visual cortical area characterized by the deregulation of axon growth/guidance and dendrite spine immaturity of neurons. However
Ahmed Rezk et al.
BMC complementary and alternative medicine, 15, 364-364 (2015-10-17)
Rhododendron leaf extracts were previously found to exert antimicrobial activities against a range of Gram-positive bacteria. In this study, we investigated which of the extracts with these antimicrobial properties would be best suited for further exploitation. Specifically, the project aims
Katia Falasca et al.
Nutrients, 7(10), 8335-8347 (2015-10-02)
Inflammation persists in patients infected with HIV. Reduction of inflammatory cytokines and microbial translocation might be one way that this could be managed. The anti-inflammatory properties of certain probiotic strains prompted us to investigate whether a probiotic could reduce the
Ajit G Thomas et al.
PloS one, 10(8), e0127785-e0127785 (2015-08-08)
The cystine-glutamate antiporter (system xc-) is a Na+-independent amino acid transporter that exchanges extracellular cystine for intracellular glutamate. It is thought to play a critical role in cellular redox processes through regulation of intracellular glutathione synthesis via cystine uptake. In
Shibin He et al.
PloS one, 9(5), e97364-e97364 (2014-05-14)
Recent advances demonstrate that epigenome changes can also cause phenotypic diversity and can be heritable across generations, indicating that they may play an important role in evolutionary processes. In this study, we analyzed the chromosomal distribution of several histone modifications
Yu Liu et al.
European journal of pharmacology, 735, 193-201 (2014-04-23)
Hesperetin (HSP, one of the most common flavonoids in Citrus) has been reported to possess many benificial effects and is indicated for many diseases both as a therapeutic drug and as a supplement. Although its vascular effects have been extensively
Guanghua Yang et al.
Scientific reports, 5, 17166-17166 (2015-11-28)
Endothelial progenitor cells (EPC) are able to migrate to tumor vasculature. These cells, if genetically modified, can be used as vehicles to deliver toxic material to, or express anticancer proteins in tumor. To test this hypothesis, we developed several single
Nikolaus P Dittrich et al.
International immunopharmacology, 29(1), 166-172 (2015-08-20)
Fluid homeostasis mediated by the airway epithelium is required for proper lung function, and the CFTR (cystic fibrosis transmembrane conductance regulator) Cl(-) channel is crucial for these processes. Luminal acetylcholine (ACh) acts as an auto-/paracrine mediator to activate Cl(-) channels
Wen-Yih Jeng et al.
Acta crystallographica. Section D, Biological crystallography, 68(Pt 7), 829-838 (2012-07-04)
NkBgl, a β-glucosidase from Neotermes koshunensis, is a β-retaining glycosyl hydrolase family 1 enzyme that cleaves β-glucosidic linkages in disaccharide or glucose-substituted molecules. β-Glucosidases have been widely used in several applications. For example, mutagenesis of the attacking nucleophile in β-glucosidase
Kinue Kurihara et al.
Oncology reports, 34(2), 771-778 (2015-06-06)
Epithelial-mesenchymal transition (EMT) is a crucial event required for the invasion and progression of carcinogenesis, inducing stem-like properties in epithelial cells. In the present study, the expression of BMI1, which controls self-renewal in stem cells, as well as that of
Marie Boegh et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 227-235 (2014-01-15)
Oral delivery of drugs, including peptide and protein therapeutics, can be impeded by the presence of the mucus surface-lining the intestinal epithelium. The aim of the present project was to design and characterize biosimilar mucus compatible with Caco-2 cell monolayers
Jong-Hee Kim et al.
Experimental gerontology, 69, 122-128 (2015-06-10)
Apoptosis plays an important role in atrophy and sarcopenia in skeletal muscle. Recent evidence suggests that insufficient heat shock proteins (HSPs) may contribute to apoptosis and muscle wasting. In addition, long-term caloric restriction (CR) and lifelong wheel running exercise (WR)
Alastair Mak et al.
Chemical research in toxicology, 28(8), 1567-1573 (2015-07-15)
The mechanism of idiosyncratic drug-induced liver injury (IDILI) remains poorly understood, in part due to the lack of a valid animal model. Clinical evidence suggests that most IDILI is immune mediated, and the major factor preventing liver injury in most
Hong Zhang et al.
Virology, 482, 32-40 (2015-03-31)
Vaccination is the most effective way to prevent and control infection by influenza viruses, and a cell-culture-based vaccine production system is preferred as the future choice for the large-scale production of influenza vaccines. As one of the WHO-recommended cell lines
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