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Tine Tricot et al.
Cells, 9(3) (2020-03-04)
Acute and chronic liver failure is a highly prevalent medical condition with high morbidity and mortality. Currently, the therapy is orthotopic liver transplantation. However, in some instances, chiefly in the setting of metabolic diseases, transplantation of individual cells, specifically functional
Guodong Song et al.
Life sciences, 223, 9-21 (2019-03-14)
Severe acute pancreatitis (SAP) is an acute disease of the digestive system accompanied by pancreatic necrosis. We have found that bone marrow-derived mesenchymal stem cells (BMSCs) can attenuate SAP, but the underlying mechanism remains unclear. The present study was conducted
M C García et al.
Food & function, 7(11), 4693-4701 (2016-10-27)
Stones from olives and Prunus genus fruits are cheap and sustainable sources of proteins and could be potential sources of bioactive peptides. The main limitation to the use of these seeds is the presence of amygdalin. This work proposes to
Inha Heo et al.
Nature microbiology, 3(7), 814-823 (2018-06-28)
Stem-cell-derived organoids recapitulate in vivo physiology of their original tissues, representing valuable systems to model medical disorders such as infectious diseases. Cryptosporidium, a protozoan parasite, is a leading cause of diarrhoea and a major cause of child mortality worldwide. Drug
Haiyu Qi et al.
Molecular medicine reports, 16(5), 6306-6312 (2017-08-30)
Acute pancreatitis (AP) is a common non‑bacterial disease compromising pancreatic tissues. Adipocyte‑derived leptin is closely associated with the severity and clinical outcome of pancreatitis. The potential protective effects of exogenous leptin administration on a rat model of severe AP (SAP)
Jiarun Mo et al.
Digestive diseases and sciences, 58(10), 2903-2907 (2013-08-21)
Neuronostatin is encoded in the preprosomatostatin gene and exerts important physiological actions on neuronal and cardiovascular regulation and metabolism in diverse tissues. An intraperitoneal injection of neuronostatin can induce c-Jun expression in the periphery of pancreatic islets. Because of the
Iram Shahzadi et al.
Journal of colloid and interface science, 531, 253-260 (2018-07-24)
It was the aim of this study to prepare trypsin decorated mucus permeating self-emulsifying drug delivery systems (SEDDS). Lipophilicity of enzyme was increased by hydrophobic ion pairing (HIP) with the anionic surfactants sodium dodecyl sulfate (SDS), sodium taurocholate (ST) and
Takashi Yoshikado et al.
Molecular pharmacology, 83(2), 552-562 (2012-12-12)
The antiplatelet drug, ticlopidine (TIC), reportedly causes cholestatic liver injuries. The present study analyzed the effect of TIC on bile formation, revealing that the biliary secretion of phospholipids was significantly decreased in TIC-administered Sprague Dawley (SD) rats. However, the effect
Haniyeh Etezadi et al.
International journal of pharmaceutics, 590, 119918-119918 (2020-10-09)
The objective of the present study was the development of self-emulsifying drug delivery systems (SEDDS) for oral delivery of therapeutic proteins providing storage stability. Horseradish peroxidase (HRP) serving as model protein was ion paired with docusate and incorporated into three
Ammonia uptake by transmembrane pH gradient poly(isoprene)-block-poly(ethylene glycol) polymersomes.
Aaron C Schmidt et al.
Soft matter, 16(11), 2725-2735 (2020-03-03)
Transmembrane pH gradient poly(isoprene)-block-poly(ethylene glycol) (PI-b-PEG) polymersomes were investigated for their potential use in the detoxification of ammonia, a metabolite that is excessively present in patients suffering from urea cycle disorders and advanced liver diseases, and which causes neurotoxic effects
Denise Frediani Barbeiro et al.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 16(1), 52-56 (2015-11-28)
The clinical course of acute pancreatitis can vary from mild to severe. In its most severe manifestation, acute pancreatitis is associated with an exacerbated systemic inflammatory response and high mortality rates. The severe form of acute pancreatitis is more frequent
Marc J Tol et al.
Autophagy, 14(3), 437-449 (2018-02-20)
In recent years, the lysosome has emerged as a highly dynamic, transcriptionally regulated organelle that is integral to nutrient-sensing and metabolic rewiring. This is coordinated by a lysosome-to-nucleus signaling nexus in which MTORC1 controls the subcellular distribution of the microphthalmia-transcription
Clostridium difficile in retail baskets, trolleys, conveyor belts, and plastic bags in Saudi Arabia.
Mohammed A Alqumber
Saudi medical journal, 35(10), 1274-1277 (2014-10-16)
To determine Clostridium difficile (C. difficile) prevalence on retail surfaces and shoppers plastic bags. From 20 June to 10 August 2011, in a cross-sectional epidemiological study, 17 supermarkets from 2 cities, Albaha and Altaif, Saudi Arabia were sampled. A total
Atcharaporn Ontawong et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 52, 187-197 (2019-01-03)
Coffea arabica pulp (CP) is the first by-product obtained from coffee berries during coffee processing. The major constituents of CP, including chlorogenic acid, caffeine, and epicatechin exhibit anti-hyperlipidemic effects in in vitro and in vivo models. Whether Coffea arabica pulp
TRPM2-mediated extracellular Ca2+ entry promotes acinar cell necrosis in biliary acute pancreatitis.
Júlia Fanczal et al.
The Journal of physiology, 598(6), 1253-1270 (2020-01-10)
Acute biliary pancreatitis is a significant clinical challenge as currently no specific pharmaceutical treatment exists. Intracellular Ca2+ overload, increased reactive oxygen species (ROS) production, mitochondrial damage and intra-acinar digestive enzyme activation caused by bile acids are hallmarks of acute biliary
Apurva Kanneganti et al.
The Journal of experimental medicine, 215(6), 1519-1529 (2018-05-26)
Pyroptosis is an inflammasome-induced lytic cell death mode, the physiological role of which in chronic inflammatory diseases is unknown. Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disease worldwide, affecting an estimated 150,000 patients. The disease is caused
Xiaohong Wang et al.
International immunopharmacology, 24(2), 285-298 (2014-12-24)
To observe the protecting effects of Acanthopanax and Ulinastatin against severe acute pancreatitis (SAP)-induced brain injury in rats. SAP-modeled rats were equally randomized into three groups: model group, Acanthopanax-treated group and Ulinastatin-treated group. A sham-operation group was used as negative
Christian Carlucci et al.
Scientific reports, 9(1), 885-885 (2019-01-31)
Many cases of Clostridioides difficile infection (CDI) are poorly responsive to standard antibiotic treatment strategies, and often patients suffer from recurrent infections characterized by severe diarrhea. Our group previously reported the successful cure of two patients with recurrent CDI using
Xingwang Zhang et al.
Journal of pharmaceutical sciences, 103(6), 1711-1719 (2014-04-05)
Oral delivery of anticancer drugs remains challenging because of limited water-solubility and/or poor permeability. Here, we aimed to enhance the oral bioavailability of tripterine (TRI, a plant-derived anticancer compound) using lipid nanospheres (LNs) and to determine the mechanisms of oral
Silvia Pichardo et al.
Toxicology in vitro : an international journal published in association with BIBRA, 38, 142-149 (2016-10-01)
Cylindrospermopsin (CYN) is a cyanotoxin produced by various cyanobacterial species. It is a water soluble zwitterion, stable at extreme temperatures and pH. Despite the main route of exposure to CYN is through drinking water and food, there is a lack
Mariona Jové et al.
Cardiovascular research, 97(4), 642-652 (2012-12-18)
Atherosclerosis is the main pathological process contributing to cardiovascular disease, with diet being the most important factor involved. Although the lipidome of atheromatous plaque has been studied previously, the use of comparative lipidomics and metabolomics in plasma in early atherogenesis
Laetitia Delort et al.
Frontiers in cell and developmental biology, 8, 571948-571948 (2021-01-29)
Breast cancer is the most common cancer among women worldwide. Overweight and obesity are now recognized as established risk factors for this pathology in postmenopausal women. These conditions are also believed to be responsible for higher recurrence and mortality rates.
Bowen Xiao et al.
Ecotoxicology and environmental safety, 194, 110454-110454 (2020-03-17)
The wide application of silver nanoparticles (AgNPs) has inevitably led to their release into the natural aquatic environment. Natural organic matter (NOM) is ubiquitous and would influence the fate and effects of these nanoparticles in such aquatic environments. Here we
Marjorie Buttet et al.
PloS one, 11(1), e0145626-e0145626 (2016-01-05)
The metabolic syndrome (MetS) greatly increases risk of cardiovascular disease and diabetes and is generally associated with abnormally elevated postprandial triglyceride levels. We evaluated intestinal synthesis of triglyceride-rich lipoproteins (TRL) in a mouse model of the MetS obtained by feeding
Hong Wang et al.
Scientific reports, 9(1), 14541-14541 (2019-10-12)
Necrotic enteritis (NE) caused by Clostridium perfringens infection has reemerged as a prevalent poultry disease worldwide due to reduced usage of prophylactic antibiotics under consumer preferences and regulatory pressures. The lack of alternative antimicrobial strategies to control this disease is
Yu Zhou et al.
Molecular medicine reports, 17(5), 6576-6584 (2018-03-08)
Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine involved in many acute and chronic inflammatory diseases. However, its role in acute lung injury associated with acute pancreatitis in pregnancy (APIP) has not yet been elucidated. The present study was
Taiki Kida et al.
The Journal of pharmacology and experimental therapeutics, 348(1), 125-130 (2013-10-23)
Bile acids are end products of cholesterol metabolism, and they constantly exist at high concentrations in the blood. Since vascular endothelial cells express G protein-coupled bile acid receptor (GPBAR), bile acids potentially modulate endothelial function. Here, we investigated whether and
Mitesh Patel et al.
The Journal of pharmacology and experimental therapeutics, 370(2), 269-277 (2019-06-09)
Cabotegravir, a novel integrase inhibitor under development for treatment and prevention of HIV, is primarily metabolized by UDP-glucuronosyltransferase (UGT)1A1 and UGT1A9 to a direct ether glucuronide metabolite. The aim of these studies was to elucidate the mechanistic basis of cabotegravir-glucuronide
Doreen Braun et al.
Endocrinology, 156(12), 4720-4730 (2015-09-15)
Monocarboxylate transporter 8 (MCT8) is a thyroid hormone transmembrane transporter expressed in many cell types, including neurons. Mutations that inactivate transport activity of MCT8 cause severe X-linked psychomotor retardation in male patients, a syndrome originally described as the Allan-Herndon-Dudley syndrome.
Raluca Ica et al.
Journal of mass spectrometry : JMS, 55(5), e4502-e4502 (2020-01-22)
We have developed here a superior approach based on high-resolution (HR) mass spectrometry (MS) for monitoring the changes occurring with development and aging in the composition and structure of cerebellar gangliosidome. The experiments were focused on the comparative screening and
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