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Diana A T Nijholt et al.
Journal of Alzheimer's disease : JAD, 46(1), 227-238 (2015-03-05)
Increased levels of pregnancy zone protein (PZP) were found in the serum of persons who later developed Alzheimer's disease (AD) in comparison to controls who remained dementia free. We suggested that this increase is due to brain derived PZP entering
Christian Kukat et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(36), 11288-11293 (2015-08-26)
Mammalian mitochondrial DNA (mtDNA) is packaged by mitochondrial transcription factor A (TFAM) into mitochondrial nucleoids that are of key importance in controlling the transmission and expression of mtDNA. Nucleoid ultrastructure is poorly defined, and therefore we used a combination of
Camelia Ungureanu et al.
Bioelectrochemistry (Amsterdam, Netherlands), 107, 14-24 (2015-09-29)
Implant-associated infections are a major cause of morbidity and mortality. This study was performed using titanium samples coated by anodization with a titanium dioxide (TiO2) shielded nanotube layer. TiO2/Ti surface was modified by simple immersion in torularhodin solution and by
Lei Wu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(23), 2798-2806 (2015-02-18)
A surface enhanced Raman scattering (SERS)-assisted 3D barcode chip has been developed for high-throughput biosensing. The 3D barcode is realized through joint 2D spatial encoding with the Raman spectroscopic encoding, which stores the SERS fingerprint information in the format of
Onju Ham et al.
Cell transplantation, 24(7), 1329-1341 (2014-05-16)
Mesenchymal stem cells (MSCs) have the potential to repair and regenerate ischemic heart tissue; however, the poor viability of transplanted MSCs in the ischemic region is a major obstacle to their therapeutic use. This cell death is caused by Fas
Dave J Koss et al.
Cellular and molecular life sciences : CMLS, 72(23), 4613-4632 (2015-06-14)
Patients suffering from tauopathies including frontotemporal dementia (FTD) and Alzheimer's disease (AD) present with intra-neuronal aggregation of microtubule-associated protein Tau. During the disease process, Tau undergoes excessive phosphorylation, dissociates from microtubules and aggregates into insoluble neurofibrillary tangles (NFTs), accumulating in
Hannah H Lee et al.
Molecular cancer therapeutics, 14(4), 994-1003 (2015-02-20)
The antimicrotubular agent docetaxel is a widely used chemotherapeutic drug for the treatment of multiple solid tumors and is predominantly dependent on hepatic disposition. In this study, we evaluated drug uptake transporters capable of transporting radiolabeled docetaxel. By screening an
Deborah Michel et al.
Journal of pharmaceutical and biomedical analysis, 107, 229-235 (2015-01-27)
A simple, fast and sensitive quantification method for the drug metformin in dog serum was developed using flow injection analysis (FIA)-tandem mass spectrometry (MS/MS). The method was fully validated according to industry standards. It is the first time that FIA-MS/MS
Jing Li et al.
Journal of cellular and molecular medicine, 19(9), 2118-2127 (2015-06-19)
Malignant ascites is one of the common complication at the late stage of abdominal cancers, which may deteriorate the environment of abdominal cavity and lead to potential damage of functional cells. Interstitial cells of Cajal (ICCs) are mesoderm-derived mesenchymal cells
Hye Jin Kang et al.
The Journal of biological chemistry, 289(43), 29961-29974 (2014-09-07)
To define the upstream and downstream signaling specificities of metabotropic glutamate receptors (mGluR), we have examined the ability of representative mGluR of group I, II, and III to be activated by endogenous amino acids and catalyze activation of G proteins
Jean-Louis Vincent et al.
Critical care medicine, 43(1), 57-64 (2014-08-02)
To compare the effectiveness and safety of the hemoglobin-based nitric oxide scavenger, pyridoxalated hemoglobin polyoxyethylene, against placebo in patients with vasopressor-dependent distributive shock. Multicenter, randomized, placebo-controlled, open-label study. Sixty-one participating ICUs in six European countries (Austria, Belgium, Germany, the Netherlands
Benita Sjögren et al.
PloS one, 10(5), e0123581-e0123581 (2015-05-15)
The ubiquitin-proteasome system for protein degradation plays a major role in regulating cell function and many signaling proteins are tightly controlled by this mechanism. Among these, Regulator of G Protein Signaling 2 (RGS2) is a target for rapid proteasomal degradation
Kangdong Liu et al.
Molecular carcinogenesis, 54(9), 751-760 (2014-04-05)
Phosphatase and tensin homolog (PTEN) loss or mutation consistently activates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling pathway, which contributes to the progression and invasiveness of prostate cancer. Furthermore, the PTEN/PI3-K/Akt and Ras/MAPK pathways cooperate to promote the epithelial-mesenchymal transition (EMT) and
Shan Yu et al.
Cell research, 25(12), 1352-1367 (2015-11-28)
Biofilms are surface-associated communities of microorganism embedded in extracellular matrix. Exopolysaccharide is a critical component in the extracellular matrix that maintains biofilm architecture and protects resident biofilm bacteria from antimicrobials and host immune attack. However, self-produced factors that target the
Manuel Valero et al.
Nature neuroscience, 18(9), 1281-1290 (2015-07-28)
Sharp-wave ripples represent a prominent synchronous activity pattern in the mammalian hippocampus during sleep and immobility. GABAergic interneuronal types are silenced or fire during these events, but the mechanism of pyramidal cell (PC) participation remains elusive. We found opposite membrane
Yi Zhang et al.
PloS one, 10(6), e0129945-e0129945 (2015-06-20)
Complement factor H (CFH) is one of the most important soluble complement regulatory proteins and is closely associated with age-related macular degeneration (AMD), the leading cause of irreversible central vision loss in the elderly population in developed countries. Our study
Meng Lu et al.
Scientific reports, 5, 12608-12608 (2015-08-01)
In this study, we explored the potential roles of miRNA-133 in regulating TLR pathways in the sea cucumber Apostichopus japonicus. Target screening of RNA-Seq data successfully identified interleukin-1 receptor-associated kinase (AjIRAK-1) as a putative target of miR-133. This result was
Alba Hykollari et al.
Electrophoresis, 35(15), 2116-2129 (2014-02-28)
In this study, we have performed the first mass spectrometric analysis of N-glycans of the M31 mutant strain of the cellular slime mould Dictyostelium discoideum, previously shown to have a defect in glucosidase II. Together with glucosidase I, this enzyme
Hala E Hussein et al.
Parasites & vectors, 8, 618-618 (2015-12-03)
Ticks are blood-feeding arthropods that can affect human and animal health both directly by blood-feeding and indirectly by transmitting pathogens. The cattle tick Rhipicephalus (Boophilus) microplus is one of the most economically important ectoparasites of bovines worldwide and it is
Rui Xue et al.
Steroids, 94, 51-59 (2015-01-04)
Non-small cell lung cancer is the most common type of lung cancer and the most common cause of cancer-related death in humans. TXA9, which is a natural product separated from an anti-tumor-active fraction of the roots of Streptocaulon juventas, may
Irena Antic et al.
Nature communications, 6, 7396-7396 (2015-06-09)
Ras (Rat sarcoma) protein is a central regulator of cell growth and proliferation. Mutations in the RAS gene are known to occur in human cancers and have been shown to contribute to carcinogenesis. In this study, we show that the
Taoguang Huo et al.
Biomedical chromatography : BMC, 28(9), 1254-1262 (2014-09-23)
An online microdialysis (MD)–dansyl chloride (Dns) derivatization–high-performance liquid chromatography (HPLC) and fluorescence detection (FD) system was developed for simultaneous determination of eight extracellular amino acid neurotransmitters in hippocampus. The MD probe was implanted in hippocampal CA1 region. Dialysate and Dns
Widya Mulyasasmita et al.
Tissue engineering. Part A, 20(15-16), 2102-2114 (2014-02-05)
Peptide mimics of growth factors represent an emerging class of therapeutic drugs due to high biological specificity and relative ease of synthesis. However, maintaining efficacious therapeutic dosage at the therapy site has proven challenging owing to poor intestinal permeability and
Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells.
Kerri-Ann Norton et al.
OncoTargets and therapy, 7, 1571-1582 (2014-09-18)
Angiogenesis, the formation of new blood vessels, is an essential step for cancer progression, but antiangiogenic therapies have shown limited success. Therefore, a better understanding of the effects of antiangiogenic treatments on endothelial cells is necessary. In this study, we
Florian Ulrich Seifert et al.
Acta crystallographica. Section F, Structural biology communications, 71(Pt 6), 752-757 (2015-06-10)
Together with the Rad50 ATPase, the Mre11 nuclease forms an evolutionarily conserved protein complex that plays a central role in the repair of DNA double-strand breaks (DSBs). Mre11-Rad50 detects and processes DNA ends, and has functions in the tethering as
Martin Lochner et al.
The Journal of pharmacology and experimental therapeutics, 351(3), 674-684 (2014-10-04)
Proguanil is an antimalarial prodrug that is metabolized to 4-chlorophenyl-1-biguanide (CPB) and the active metabolite cycloguanil (CG). These compounds are structurally related to meta-chlorophenyl biguanide (mCPBG), a 5-hydroxytryptamine 3 (5-HT3) receptor agonist. Here we examine the effects of proguanil and
Sung-Woo Kim et al.
Biomedical chromatography : BMC, 29(7), 990-997 (2014-11-18)
Following quick, easy, cheap, effective, rugged and safe (QuEChERS) and LC/MS/MS analysis, pyridaben residual levels were determined in unprocessed and processed hot pepper fruit and leaves. The linearities were satisfactory with determination coefficients (R(2)) in excess of 0.995 in processed
E Railey White et al.
ACS chemical biology, 10(5), 1198-1208 (2015-02-06)
Many intracellular protein-protein interactions are mediated by the phosphorylation of serine, and phosphoserine-containing peptides can inhibit these interactions. However, hydrolysis of the phosphate by phosphatases, and the poor cell permeability associated with phosphorylated peptides has limited their utility in cellular
Sabrina Haag et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2539-2550 (2015-02-13)
Rheumatoid arthritis (RA) is associated with amino acid variants in multiple MHC molecules. The association to MHC class II (MHC-II) has been studied in several animal models of RA. In most cases these models depend on T cells restricted to
Swati S Vyas et al.
Biosensors & bioelectronics, 70, 254-260 (2015-04-02)
Presence of bacteria such as Brucella spp. in dairy products is an immense risk to public health. Point of care immunoassays are rapid in that they can quickly screen various samples in a relatively short amount of time, are sensitive
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