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Katie L Bidne et al.
Journal of animal science, 97(10), 4314-4322 (2019-08-03)
Heat stress (HS) occurs when heat dissipation mechanisms are insufficient to maintain euthermia, and it is associated with seasonal infertility (SI), which manifests as smaller litters, longer wean-to-estrus interval, increased abortions, and reduced conception rates. To understand HS-induced mechanisms underlying
Xinhui Tian et al.
Scientific reports, 5, 16982-16982 (2015-11-21)
Merrillianoid (1), a racemic neolignan possessing the characteristic benzo-2,7-dioxabicyclo[3.2.1]octane moiety, was isolated from the branches and leaves of Illicium merrillianum. Chiral separation of 1 gave two enantiomers (+)-1 and (-)-1. The structure of 1 was established by comprehensive spectroscopic analysis
Tuan Hoang et al.
Bioscience reports, 35(4) (2015-07-17)
Mitochondrial inner membrane uncoupling proteins (UCPs) facilitate transmembrane (TM) proton flux and consequently reduce the membrane potential and ATP production. It has been proposed that the three neuronal human UCPs (UCP2, UCP4 and UCP5) in the central nervous system (CNS)
Yan Sun et al.
Oncology letters, 9(6), 2750-2756 (2015-07-03)
Cervical cancer is the third most common malignancy worldwide, accounting for 250,000 mortalities annually. Notch1, an important regulator of cell-fate decisions and differentiation, has been found to be overexpressed in certain types of cancer. However, the role of Notch1 in
Linbin Zhang et al.
PLoS genetics, 11(3), e1005073-e1005073 (2015-03-31)
Biological diversity on Earth depends on the multiplication of species or speciation, which is the evolution of reproductive isolation such as hybrid sterility between two new species. An unsolved puzzle is the exact mechanism(s) that causes two genomes to diverge
Chun-Chang Yeh et al.
BMC anesthesiology, 15, 92-92 (2015-06-17)
The application of pulsed radiofrequency (PRF) close to the dorsal root ganglia, or peripheral nerves, has been demonstrated to be effective for the treatment of chronic neuropathic pain conditions. The goal of this study was to investigate the analgesic effect
Brenda C O'Connell et al.
PloS one, 9(12), e115228-e115228 (2014-12-30)
HSP90 inhibitors are currently undergoing clinical evaluation in combination with antimitotic drugs in non-small cell lung cancer (NSCLC), but little is known about the cellular effects of this novel drug combination. Therefore, we investigated the molecular mechanism of action of
Niamh E Goulding et al.
Frontiers in physiology, 6, 192-192 (2015-07-16)
Chronic kidney disease (CKD) is often associated with a disturbed cardiovascular homeostasis. This investigation explored the role of the renal innervation in mediating deranged baroreflex control of renal sympathetic nerve activity (RSNA) and renal excretory function in cisplatin-induced renal failure.
Lykke Blaabjerg et al.
Journal of molecular endocrinology, 53(3), 417-427 (2014-10-18)
During the development of diabetes β-cells are exposed to elevated concentrations of proinflammatory cytokines, TNFα and IL1β, which in vitro induce β-cell death. The class B G-protein-coupled receptors (GPCRs): corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 are expressed in pancreatic
Lauren A McGinnis et al.
Biology of reproduction, 92(6), 146-146 (2015-04-24)
Vertebrate eggs are arrested at metaphase of meiosis II, a state classically known as cytostatic factor arrest. Maintenance of this arrest until the time of fertilization and then fertilization-induced exit from metaphase II are crucial for reproductive success. Another key
N Okaniwa et al.
Free radical research, 49(1), 35-44 (2014-10-21)
We reported that deficiency of the eNOS protein exacerbates colitis induced by dextran sodium sulfate (DSS-induced colitis). However, the role of eNOS in colitis remains controversial. Therefore, we studied how over-expression of eNOS affected this inflammatory condition, using vascular endothelial
Takashi Hotta et al.
Current biology : CB, 31(4), 900-907 (2021-01-23)
Detyrosination of the α-tubulin C-terminal tail is a post-translational modification (PTM) of microtubules that is key for many biological processes.1 Although detyrosination is the oldest known microtubule PTM,2-7 the carboxypeptidase responsible for this modification, VASH1/2-SVBP, was identified only 3 years
Daniel E Vazquez et al.
Innate immunity, 21(5), 477-489 (2014-09-18)
Sepsis is a major healthcare problem and a leading cause of death worldwide. There is no dependable diagnosis, and treatment for this condition remains mainly supportive. The etiology of sepsis is related to an overwhelming inflammatory response. In this regard
Hideaki Mabashi-Asazuma et al.
Insect biochemistry and molecular biology, 65, 20-27 (2015-07-15)
The silkworm silk glands are powerful secretory organs that can produce and secrete proteins at high levels. As such, it has been suggested that the biosynthetic and secretory power of the silk gland can be harnessed to produce and secrete
Jinggeng Zhou et al.
Journal of experimental botany, 66(11), 3353-3366 (2015-04-16)
Regulating the intensity and duration of immune responses is crucial to combat infections without deleterious side effects. Arabidopsis FLS2, the receptor for bacterial flagellin, activates immune signalling by association with its partner BAK1. Upon flagellin (flg22) perception, the plant U-box
Pankaj Kumar et al.
Veterinary research, 46, 79-79 (2015-07-15)
Turkey adenovirus 3 (TAdV-3) causes high mortality and significant economic losses to the turkey industry. However, little is known about the molecular determinants required for viral replication and pathogenesis. Moreover, TAdV-3 does not grow well in cell culture, thus detailed
Priyadarsini Kumar et al.
PloS one, 10(8), e0135089-e0135089 (2015-08-13)
Trophoblast differentiation during early placental development is critical for successful pregnancy and aberrant differentiation causes preeclampsia and early pregnancy loss. During the first trimester, cytotrophoblasts are exposed to low oxygen tension (equivalent to~2%-3% O2) and differentiation proceeds along an extravillous
Sandra Blanchet et al.
Nucleic acids research, 43(6), 3298-3308 (2015-03-05)
In eukaryotes, translation termination is performed by eRF1, which recognizes stop codons via its N-terminal domain. Many previous studies based on point mutagenesis, cross-linking experiments or eRF1 chimeras have investigated the mechanism by which the stop signal is decoded by
Eric Lam et al.
Journal of virology, 88(24), 14426-14439 (2014-10-10)
The cGAS/STING DNA sensing complex has recently been established as a predominant pathogen recognition receptor (PRR) for DNA-directed type I interferon (IFN) innate immune activation. Using replication-defective adenovirus vectors and replication-competent wild-type adenovirus, we have modeled the influence of the
Van B Lu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(20), 8021-8034 (2015-05-23)
Under physiological conditions, the voltage-gated sodium channel Nav1.8 is expressed almost exclusively in primary sensory neurons. The mechanism restricting Nav1.8 expression is not entirely clear, but we have previously described a 3.7 kb fragment of the Scn10a promoter capable of
Daniela A Parodi et al.
Reproductive toxicology (Elmsford, N.Y.), 54, 66-75 (2014-12-30)
Early life exposure to estrogens and estrogen like contaminants in the environment is thought to contribute to the early onset of puberty and consequently increases the risk of developing breast cancer in the exposed female. The results of this study
Joana Fernandes et al.
PloS one, 9(6), e99958-e99958 (2014-06-25)
Transient global cerebral ischemia induces profound changes in the transcriptome of brain cells, which is partially associated with the induction or repression of genes that influence the ischemic response. However, the mechanisms responsible for the selective vulnerability of hippocampal neurons
Rukmali Athurupana et al.
The Journal of reproduction and development, 61(3), 205-210 (2015-03-11)
Cryopreservation of boar semen is still considered suboptimal due to lower fertility as compared with fresh samples when glycerol, a permeating cryoprotectant, is used. Trehalose is a non-permeable cryoprotectant and nonreducing disaccharide known to stabilize proteins and biologic membranes. The
Rajesh Lakshmanan et al.
Nanomedicine (London, England), 10(23), 3451-3467 (2015-11-27)
The aim of the study is to develop scaffolds that mimic native tissue properties for effective regeneration of the myocardium, which is affected by the gradual thinning of left ventricular tissue after an infarction. Heterogenous nanofibrous scaffolds made of poly(lactide-co-caprolactone)
Qian Geng et al.
Journal of food science and technology, 52(9), 5874-5881 (2015-09-08)
In the present study, influences of nine probiotics and tea polyphenols on the production of acetic, butyric, and lactic acid from simulated colonic fermentation of maize resistant starch (RS) were investigated. RS was fermented by fecal extracts of healthy adults
Daniel T Radoff et al.
eLife, 3 (2014-11-11)
The presynaptic protein complexin (CPX) is a critical regulator of synaptic vesicle fusion, but the mechanisms underlying its regulatory effects are not well understood. Its highly conserved central helix (CH) directly binds the ternary SNARE complex and is required for
Yasin Shaifta et al.
Cardiovascular research, 106(1), 121-130 (2015-02-11)
Sphingosylphosphorylcholine (SPC) elicits vasoconstriction at micromolar concentrations. At lower concentrations (≤1 µmol/L), however, it does not constrict intrapulmonary arteries (IPAs), but strongly potentiates vasoreactivity. Our aim was to determine whether this also occurs in a systemic artery and to delineate
Jian-Zhuang Tan et al.
Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)
The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:
Jieli Li et al.
American journal of physiology. Heart and circulatory physiology, 307(11), H1618-H1625 (2014-09-28)
Mature cardiac myocytes are terminally differentiated, and the heart has limited capacity to replace lost myocytes. Thus adaptation of myocyte size plays an important role in the determination of cardiac function. The hypothesis tested is that regulation of the dynamic
Marilena Briglia et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(2), 768-778 (2015-09-12)
The JAK1/JAK2 tyrosine kinase inhibitor ruxolitinib is widely used for the treatment of myeloproliferative neoplasm-associated myelofibrosis and other malignancies. Most important side effects include anemia. A common cause of anemia is accelerated suicidal death of erythrocytes or eryptosis, which is
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