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A Taniguchi et al.
Journal of lipid research, 28(5), 490-494 (1987-05-01)
Relative lipolytic activity of human parathyroid hormone-(1-34) (hPTH-(1-34], hPTH-(3-34), desamino-Ser1-hPTH-(1-34), and rat PTH-(1-34) was compared in human subcutaneous adipose tissues in vitro. Human PTH-(1-34), rat PTH-(1-34), and desamino-Ser1-hPTH-(1-34) stimulated in vitro lipolysis significantly above basal level at the concentration of
María Teresa Rivera-García et al.
Psychopharmacology, 232(20), 3797-3808 (2015-08-10)
Toluene is a misused inhalant with hallucinogenic properties and complex effects. Toluene blocks N-methyl-D-aspartate (NMDA) receptors, releases dopamine (DA), and modifies several neurotransmitter levels; nonetheless, the mechanism by which it produces hallucinations is not well characterized. This study aims (a)
Eric J Dimise et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(40), 15311-15316 (2008-10-04)
Bacteria belonging to the order Actinomycetales have proven to be an important source of biologically active and often therapeutically useful natural products. The characterization of orphan biosynthetic gene clusters is an emerging and valuable approach to the discovery of novel
Brandon L Blakely et al.
Nature methods, 11(12), 1229-1232 (2014-10-13)
We developed molecular tension probes (TPs) that report traction forces of adherent cells with high spatial resolution, can in principle be linked to virtually any surface, and obviate monitoring deformations of elastic substrates. TPs consist of DNA hairpins conjugated to
Yan Luo et al.
Oncotarget, 6(6), 4286-4298 (2015-03-05)
Current knowledge indicates that the mammalian target of rapamycin (mTOR) functions as two complexes, mTORC1 and mTORC2, regulating cell growth, proliferation, survival, differentiation, and motility. Recently mSin1 has been identified as a critical component of mTORC2, which is essential for
Leila Khamzina et al.
Endocrinology, 146(3), 1473-1481 (2004-12-18)
The mammalian target of rapamycin (mTOR) pathway integrates insulin and nutrient signaling in numerous cell types. Recent studies also suggest that this pathway negatively modulates insulin signaling to phosphatidylinositol 3-kinase/Akt in adipose and muscle cells. However, it is still unclear
Elaine F Walker et al.
Neuropsychiatry, neuropsychology, and behavioral neurology, 15(1), 10-17 (2002-03-06)
To examine plasma cortisol, adrencorticotropin hormone, and indicators of catecholamine activity in monozygotic twins discordant for schizophrenia or major affective disorders. Previous research has suggested that catecholamines play a role in the etiology of major mental illness. Several findings have
Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats.
Wang XQ
BMC Neuroscience, 16, 14-14 (2015)
Fan Zheng et al.
Journal of molecular biology, 427(2), 491-510 (2014-12-03)
Reagents that target protein-protein interactions to rewire signaling are of great relevance in biological research. Computational protein design may offer a means of creating such reagents on demand, but methods for encoding targeting selectivity are sorely needed. This is especially
A Hinek et al.
American journal of human genetics, 66(3), 859-872 (2000-03-11)
Costello syndrome is characterized by mental retardation, loose skin, coarse face, skeletal deformations, cardiomyopathy, and predisposition to numerous malignancies. The genetic origin of Costello syndrome has not yet been defined. Using immunohistochemistry and metabolic labeling with [3H]-valine, we have established
Hong-Fei Wang et al.
Antonie van Leeuwenhoek, 107(3), 835-843 (2015-01-09)
A white bacterial strain, designated EGI 650022(T), was isolated from the roots of Salsola affinis C. A. Mey, collected from Urumqi City, Xinjiang, north-western China. The strain was found to be aerobic, Gram-stain positive, oxidase-positive and catalase-positive. Cells were non-motile
J D Hooper et al.
Cancer research, 59(13), 3199-3205 (1999-07-09)
We have cloned and characterized a cDNA encoding a new human serine proteinase, testisin, that is abundantly expressed only in the testis and is lost in testicular tumors. The testisin cDNA was identified by homology cloning using degenerate primers directed
Ji-Young Moon et al.
Pharmacological research, 100, 353-364 (2015-09-01)
We have previously demonstrated that activation of the spinal sigma-1 receptor (Sig-1R) plays an important role in the development of mechanical allodynia (MA) via secondary activation of the N-methyl-d-aspartate (NMDA) receptor. Sig-1Rs have been shown to localize to astrocytes, and
Tiago G Araújo et al.
Lasers in medical science, 30(7), 2003-2008 (2014-06-02)
The liver regeneration is an important clinical issue after major hepatectomies. Unfortunately, many organs (including the liver) exhibit age-related impairments regarding their regenerative capacity. Recent studies found that low-power laser irradiation (LPLI) has a stimulatory effect on the liver regeneration
K Q Do et al.
Journal of neurochemistry, 65(6), 2652-2662 (1995-12-01)
HPLC and gas chromatography-mass spectrometry analyses of 18 amino acids, N-acetylaspartate, N-acetylaspartylglutamate, and 5-hydroxyindoleacetic acid, derived from serotonin, and homovanillic acid, derived from dopamine, were performed in CSF collected from a group of patients with schizophrenia who either had been
K Kobayashi et al.
No to shinkei = Brain and nerve, 34(8), 769-774 (1982-08-01)
Using reversed-phase high-performance liquid chromatography and electrochemical detection with a rapid one-step purification on Sephadex G-10 column, we have developed a sensitive technique to measure p-hydroxyphenylacetic acid (PHPA), the oxidatively deaminated metabolite of p-tyramine, in cerebrospinal fluid (CSF). The method
Uriel Heresco-Levy et al.
Schizophrenia research, 91(1-3), 14-21 (2007-02-06)
Prepulse inhibition (PPI) of the startle reflex, a measure of sensorimotor gating, is decreased in schizophrenia. The validity of a glutamatergic, N-methyl-d-aspartate receptor (NMDAR)-mediated model of PPI disruption is presently equivocal. The NMDAR antagonist ketamine disrupts PPI in rodents, but
Dorottya Kalapis et al.
PLoS biology, 13(11), e1002291-e1002291 (2015-11-07)
Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was engineered to translate a
J F Strauss et al.
Recent progress in hormone research, 54, 369-394 (1999-11-05)
Stimulation of steroid-producing cells of the gonads and adrenals with tropic hormone results in a marked increase in steroid hormone synthesis within minutes. The rate-limiting step in this acute steroidogenic response is the transport of cholesterol from the outer to
A Paju et al.
The American journal of pathology, 157(6), 2011-2021 (2000-12-07)
Trypsinogen is a serine proteinase produced mainly by the pancreas, but it has recently been found to be expressed also in several cancers such as ovarian and colon cancer and in vascular endothelial cells. In this study, we found that
Kelli Lauderdale et al.
ASN neuro, 7(5) (2015-10-23)
Cellular edema (cell swelling) is a principal component of numerous brain disorders including ischemia, cortical spreading depression, hyponatremia, and epilepsy. Cellular edema increases seizure-like activity in vitro and in vivo, largely through nonsynaptic mechanisms attributable to reduction of the extracellular space. However
Ewan A Ross et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 265-276 (2015-05-24)
In myeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phosphorylated in response to LPS. To investigate the role of two specific phosphorylations, at serines 52 and 178, we created a mouse strain in which those residues were
Ji Hyun Jang et al.
Basic research in cardiology, 110(3), 21-21 (2015-03-26)
Angiotensin II (Ang II), a potent precursor of hypertrophy and heart failure, upregulates neuronal nitric oxide synthase (nNOS or NOS1) in the myocardium. Here, we investigate the involvement of type 1 and 2 angiotensin receptors (AT1R and AT2R) and molecular
Angelica Dessì et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 27 Suppl 2, 34-38 (2014-10-07)
The objective of our study was to evaluate the capability of the metabolomics approach to identify the variations of urine metabolites over time related to the neonatal fungal septic condition. The study population included a clinical case of a preterm
F Brugger et al.
European journal of pharmacology, 191(1), 29-38 (1990-11-20)
We present a comparative study of the modulation of the N-methyl-D-aspartate (NMDA) receptor at the strychnine-insensitive glycine site in the spinal cord and in the cortex. The excitatory effect of NMDA was potentiated by D-serine (a glycine mimetic) in the
C W Franzke et al.
The Journal of biological chemistry, 271(36), 21886-21890 (1996-09-06)
The stratum corneum chymotryptic enzyme (SCCE) has been previously purified from human stratum corneum and resembles a chymotryptic serine endopeptidase involved in physiological detachment of corneocytes from human stratum corneum. From human stratum corneum two inhibitory activities of SCCE could
Peggy L Olive et al.
Cancer research, 64(15), 5363-5369 (2004-08-04)
We reported recently that exposure of hamster V79 fibroblasts to 6 drugs that varied in their ability to produce DNA double-strand breaks stimulated formation of phosphorylated histone H2AX (serine 139 phosphorylated histone H2AX; gammaH2AX). Using flow cytometry to analyze gammaH2AX
Priyanka Saini et al.
Oncotarget, 6(15), 13072-13087 (2015-05-13)
The therapeutic efficacy of nucleoside analogues, e.g. gemcitabine, against cancer cells can be augmented by inhibitors of checkpoint kinases, including Wee1, ATR, and Chk1. We have compared the chemosensitizing effect of these inhibitors in cells derived from pancreatic cancer, a
Keiichirou Nemoto et al.
The Journal of biological chemistry, 290(27), 16665-16677 (2015-05-15)
Protein phosphorylation on Tyr residues is a key post-translational modification in mammals. In plants, recent studies have identified Tyr-specific protein phosphatase and Tyr-phosphorylated proteins in Arabidopsis by phosphoproteomic screenings, implying that plants have a Tyr phosphorylation signal pathway. However, little
Sung Hwa Shin et al.
PloS one, 10(6), e0127784-e0127784 (2015-06-09)
Uncoordinated 51-like kinase 2 (ULK2), a member of the serine/threonine kinase family, plays an essential role in the regulation of autophagy in mammalian cells. Given the role of autophagy in normal cellular homeostasis and in multiple diseases, improved mechanistic insight
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