CN
Search Within
s4375
应用筛选条件
关键词:'s4375'
显示 1-30 共 466 条结果 关于 "s4375" 范围 论文
M Zhao et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(1), 72-77 (2014-11-06)
Revascularisation of transplanted islets is an essential prerequisite for graft survival and function. However, current islet isolation procedures deprive the islets of endothelial tubulets. This may have a detrimental effect on the revascularisation process of islets following transplantation. We hypothesise
Kine S N Dervola et al.
Neurotoxicology, 50, 38-45 (2015-07-29)
Polychlorinated biphenyls (PCBs) are present as ortho- and non-ortho-substituted PCBs, with most of the ortho-substituted congeners being neurotoxic. The present study examined effects of the ortho-substituted PCB 153 on dopamine, serotonin and amino acid neurotransmitters in the neostriatum of both
Julien Robitaille et al.
PloS one, 10(9), e0136815-e0136815 (2015-09-04)
CHO cell culture high productivity relies on optimized culture medium management under fed-batch or perfused chemostat strategies enabling high cell densities. In this work, a dynamic metabolic model for CHO cells was further developed, calibrated and challenged using datasets obtained
Guo-Shi Lin et al.
International journal of clinical and experimental pathology, 7(6), 3141-3149 (2014-07-18)
Besides STAT3 tyrosine 705 phosphorylation (pTyr705-STAT3), phosphorylation of STAT3 at serine 727 (pSer727-STAT3) is shown to contribute to tumorigenesis and be closely related with resistance to radiotherapy and chemotherapy in glioma, but there is currently no study regarding its relevance
Abdullah A Osman et al.
Cancer research, 75(7), 1205-1215 (2015-02-19)
TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC), with mutations occurring in over two thirds of cases; however, the predictive response of these mutations to cisplatin-based therapy remains elusive. In the current study
Qing-Guo Ren et al.
Journal of molecular neuroscience : MN, 56(2), 500-508 (2015-02-18)
To investigate the effect of escitalopram (a widely used and highly efficacious antidepressant from the SSRI class) on tau hyperphosphorylation, HEK293/tau441 cells were pretreated with 4 μM of forskolin for 2 h. Then we treated the cells with different doses
Mitsuaki Ojima et al.
PloS one, 10(2), e0116645-e0116645 (2015-02-28)
We determined the frequencies of dicentric chromosomes per cell in non-dividing confluent normal human fibroblasts (MRC-5) irradiated with a single 1 Gy dose or a fractionated 1 Gy dose (10X0.1 Gy, 5X0.2 Gy, and 2X0.5 Gy). The interval between fractions
Jingjiao Ma et al.
Journal of virology, 89(5), 2831-2841 (2014-12-30)
At least 10 different genotypes of novel reassortant H3N2 influenza viruses with 2009 pandemic H1N1 [A(H1N1)pdm09] gene(s) have been identified in U.S. pigs, including the H3N2 variant with a single A(H1N1)pdm09 M gene, which has infected more than 300 people.
Merrell A Johnson et al.
The Journal of membrane biology, 248(4), 695-703 (2015-02-19)
We show that the interaction of aromatic amino acids with lipid bilayers can be characterized by conventional 1D [Formula: see text]H NMR spectroscopy using reference spectra obtained in isopropanol-d8/D[Formula: see text]O solutions. We demonstrate the utility of this method with
Liu Chunlei et al.
Pakistan journal of pharmaceutical sciences, 28(4 Suppl), 1449-1456 (2015-10-04)
Total proteins of Changbai Mountain hazelnut were extracted and then enzymolysed in solution. The mixture of peptides was separated on chromatograph and identified by shotgun proteomics approach. The identified proteins were analyzed by bioinformatics, 303 proteins were identified, of which
Rekha Kar et al.
Biochemical and biophysical research communications, 459(3), 393-397 (2015-03-04)
Neuronal nitric oxide synthase (nNOS) plays a critical role in regulating cardiomyocyte function. nNOS was reported to decrease superoxide production in the myocardium by inhibiting the function of xanthine oxidoreductase. However, the effect of oxidative stress on nNOS in cardiomyocytes
Kazuhiro Yamamoto et al.
Phytotherapy research : PTR, 29(5), 707-713 (2015-02-04)
Cordyceps militaris (CM) is gaining attention as a traditional medicinal food, but its molecular biological mechanisms for anti-cancer activity are not identified or clarified. We aimed to elucidate the synthesizing apoptotic effects of CM extracts and to determine the biological
Young Seok Lee et al.
Cancer genomics & proteomics, 12(3), 153-166 (2015-05-16)
Despite great effort to elucidate the process of acquired gefitinib resistance (AGR) in order to develop successful chemotherapy, the precise mechanisms and genetic factors of such resistance have yet to be elucidated. We performed a cross-platform meta-analysis of three publically
Christopher M Schaupp et al.
Chemico-biological interactions, 234, 154-161 (2014-12-03)
Doxorubicin is highly effective at inducing DNA double-strand breaks in rapidly dividing cells, which has led to it being a widely used cancer chemotherapeutic. However, clinical administration of doxorubicin is limited by off-target cardiotoxicity, which is thought to be mediated
Manish Tandon et al.
Breast cancer research : BCR, 16(1), R16-R16 (2014-02-01)
The Runt-related transcription factor Runx2 is critical for skeletal development but is also aberrantly expressed in breast cancers, and promotes cell growth and invasion. A de-regulated serine/threonine kinase Akt signaling pathway is implicated in mammary carcinogenesis and cell survival; however
Carlos Spichiger et al.
Physiological genomics, 47(12), 621-633 (2015-10-01)
Recent reports account for altered metabolism in adult offspring from pregnancy subjected to abnormal photoperiod, suggesting fetal programming of liver physiology. To generate a pipeline of subsequent mechanistic experiments addressing strong candidate genes, here we investigated the effects of constant
Yira Bermudez et al.
Cancer prevention research (Philadelphia, Pa.), 8(8), 720-728 (2015-06-03)
The incidence of skin cancer is higher than all other cancers and continues to increase, with an average annual cost over $8 billion in the United States. As a result, identifying molecular pathway alterations that occur with UV exposure to
Anna L Illert et al.
PloS one, 9(11), e112318-e112318 (2014-11-27)
ABL tyrosine kinase inhibitors (TKI) like Imatinib, Dasatinib and Nilotinib are the gold standard in conventional treatment of CML. However, the emergence of resistance remains a major problem. Alternative therapeutic strategies of ABL TKI-resistant CML are urgently needed. We asked
Dmitriy Smolensky et al.
BMC cancer, 15, 927-927 (2015-11-26)
Doxorubicin (Dox) is widely used to treat progressed bladder cancer after transurethral resection. The use of Dox-chemotherapy has been limited due to induced drug resistance and cumulative cardiotoxic effects. N-benzyladriamycin-14-valerate (AD198), a novel derivative of Dox, has a potential to
Zhen Lin et al.
Cellular signalling, 26(11), 2436-2445 (2014-07-23)
The transcriptional cofactor CITED1 inhibits osteoblastic differentiation and blunts the stimulation of osteoblastic differentiation by parathyroid hormone (PTH). In the MC3T3-E1 osteoblastic cell line, we found that CITED1 was located predominantly in the cytoplasm and that hPTH(1-34) increased translocation of
Buxin Chen et al.
Molecular pharmacology, 88(1), 95-105 (2015-05-03)
Thrombin, the key effector protease of the coagulation cascade, drives fibrin deposition and activates human platelets through protease-activated receptor-1 (PAR1). These processes are critical to the progression of thrombotic diseases. Thrombin is the main target of anticoagulant therapy, and major
Mathieu Méquinion et al.
American journal of physiology. Endocrinology and metabolism, 308(3), E241-E255 (2014-12-04)
In restrictive-type anorexia nervosa (AN) patients, physical activity is usually associated with food restriction, but its physiological consequences remain poorly characterized. In female mice, we evaluated the impact of voluntary physical activity with/without chronic food restriction on metabolic and endocrine
Samya Bekri et al.
Journal of chromatography. A, 1399, 80-87 (2015-05-16)
The present work aims at studying the influence of the nature of the polyelectrolytes used in successive multiple ionic polymers on the performances of protein separation in acetic acid volatile background electrolyte. A broad library of polyelectrolyte multilayers was compared
Dorte E Kristensen et al.
The Journal of physiology, 593(8), 2053-2069 (2015-02-03)
AMP-activated protein kinase (AMPK) is a regulator of energy homeostasis during exercise. Studies suggest muscle fibre type-specific AMPK expression. However, fibre type-specific regulation of AMPK and downstream targets during exercise has not been demonstrated. We hypothesized that AMPK subunits are
Jacob T Bjerrum et al.
Inflammatory bowel diseases, 20(12), 2340-2352 (2014-10-31)
It is unknown why patients with extensive ulcerative colitis (UC) have a higher risk of colorectal cancer compared with patients with left-sided UC. This study characterizes the inflammatory processes in left-sided UC, pancolitis, and UC-associated dysplasia at the transcriptional level
Pirjo Pärnänen et al.
Biochemical and biophysical research communications, 457(4), 676-680 (2015-01-27)
We set out to identify the Candida glabrata cell wall attached proteases which may play a role as virulence factors in candidosis, particularly in the immunocompromized host. We studied a clinical C. glabrata strain T-1639, which was isolated from a
Yi-Fang Chang et al.
Oncotarget, 6(1), 85-100 (2014-11-22)
Angiogenesis, one of the major routes for tumor invasion and metastasis represents a rational target for therapeutic intervention. Recent development in drug discovery has highlighted the diverse biological and pharmacological properties of hydroxamate derivatives. In this study, we characterized the
Bo-Young Lee et al.
Comparative biochemistry and physiology. Part D, Genomics & proteomics, 14, 33-41 (2015-03-10)
Rotifers (phylum Rotifera) are the most common non-arthropod animal. Species in the monogonont rotifer Brachionus are widely distributed in coastal areas and play an important role in aquatic food webs as secondary producers. Brachionus koreanus is currently being developed as
Hua Zhang et al.
Journal of autoimmunity, 53, 67-77 (2014-04-05)
Spinal cord pathology with inflammatory, demyelinating lesions spanning three or more vertebral segments is a characteristic feature of neuromyelitis optica (NMO). NMO pathogenesis is thought to involve binding of immunoglobulin G anti-aquaporin-4 autoantibodies (NMO-IgG) to astrocytes, causing complement-dependent cytotoxicity (CDC)
Kazuaki Kawaura et al.
Behavioural brain research, 278, 186-192 (2014-10-11)
Glutamatergic dysfunction, particularly the hypofunction of N-methyl-D-aspartate (NMDA) receptors, is involved in the pathophysiology of schizophrenia. The positive modulation of the glycine site on the NMDA receptor has been proposed as a novel therapeutic approach for schizophrenia. However, its efficacy
1/16