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显示 31-60 共 466 条结果 关于 "S4375" 范围 论文
Zev A Wainberg et al.
Cancer chemotherapy and pharmacology, 76(1), 61-67 (2015-05-15)
Our study was designed to evaluate the efficacy and safety of everolimus in patients with pre-treated metastatic gastric and esophagus cancers in a US-based population focusing on biomarker correlation. Patients with advanced upper GI adenocarcinomas who progressed after 1-2 prior
Vassiliki Saloura et al.
Molecular cancer research : MCR, 13(2), 293-304 (2014-10-05)
Squamous cell carcinoma of the head and neck (SCCHN) is a relatively common malignancy with suboptimal long-term prognosis, thus new treatment strategies are urgently needed. Over the last decade, histone methyltransferases (HMT) have been recognized as promising targets for cancer
Junichi Yasutake et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(8), 1315-1321 (2015-06-26)
Galactose-deficient IgA1 (Gd-IgA1) is a critical effector molecule in the pathogenesis of IgA nephropathy (IgAN). Although many researchers have measured serum levels of Gd-IgA1 using snail helix aspersa agglutinin (HAA) lectin-based assay, the lectin-dependent assay has some serious problems in
Samar A Sultan et al.
Journal of cellular physiology, 230(11), 2695-2705 (2015-03-27)
Gestational diabetes mellitus (GDM) is known to be associated with fetal endothelial dysfunction, however, the mechanisms are not fully understood. This study examines the effect of maternal diabetes on fetal endothelial function and gene expression under physiological glucose conditions (5 mM).
Ying Ao et al.
PloS one, 9(6), e100417-e100417 (2014-06-21)
Hepatocyte transplantation is considered to be a promising therapy for patients with liver diseases. Induced pluripotent stem cells (iPSCs) provide an unlimited source for the generation of functional hepatocytes. In this study, we generated iPSCs from porcine ear fibroblasts (PEFs)
Christian Gerecke et al.
Journal of cancer research and clinical oncology, 141(12), 2097-2107 (2015-04-24)
Epigenetic silencing of tumor suppressor genes is involved in early transforming events and has a high impact on colorectal carcinogenesis. Likewise, colon cancers that derive from chronically inflamed bowel diseases frequently exhibit epigenetic changes. But there is little data about
Satoshi Ishishita et al.
Scientific reports, 5, 9435-9435 (2015-03-25)
Hybrid sterility plays an important role in the maintenance of species identity and promotion of speciation. Male interspecific hybrids from crosses between Campbell's dwarf hamster (Phodopus campbelli) and the Djungarian hamster (P. sungorus) exhibit sterility with abnormal spermatogenesis. However, the
Mélanie Bourque et al.
Neurobiology of aging, 35(10), 2347-2356 (2014-04-15)
Raloxifene, used in the clinic, is reported to protect brain dopaminergic neurons in mice. Raloxifene was shown to mediate an effect through the G protein-coupled estrogen receptor 1 (GPER1). We investigated if raloxifene neuroprotective effect in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated male mice
Siying Ye et al.
Journal of virology, 89(5), 2672-2683 (2014-12-19)
Highly pathogenic avian influenza virus infection is associated with severe mortality in both humans and poultry. The mechanisms of disease pathogenesis and immunity are poorly understood although recent evidence suggests that cytokine/chemokine dysregulation contributes to disease severity following H5N1 infection.
Kim Tardif et al.
Cardiovascular diabetology, 13, 119-119 (2014-08-21)
Nestin was reported to directly contribute to cell proliferation and the intermediate filament protein was detected in vascular smooth muscle cells. In experimental type I diabetes, nestin downregulation in the heart was identified as an incipient pathophysiological event. The following
Angela C O Menegatti et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(1), 61-75 (2014-11-06)
Serine/threonine protein phosphatases have been described in many pathogenic bacteria as essential enzymes involved in phosphorylation-dependent signal transduction pathways and frequently associated with the virulence of these organisms. An inspection of Mycoplasma synoviae genome revealed the presence of a gene
Takashi Kawahara et al.
American journal of cancer research, 5(10), 2959-2968 (2015-12-23)
Silodosin, a selective α1A-adrenergic blocker prescribed for the symptomatic treatment of benign prostatic hyperplasia, was previously shown to decrease the expression of ELK1, a c-fos proto-oncogene regulator and a well-described downstream target of the PKC/Raf-1/ERK pathway, in human prostate smooth
Carola Hedberg Oldfors et al.
BMC genetics, 16, 80-80 (2015-07-15)
Several reports indicate a commonly deleted chromosomal region independent from, and distal to the TP53 locus in a variety of human tumors. In a previous study, we reported a similar finding in a rat tumor model for endometrial carcinoma (EC)
April L Darrow et al.
Cardiovascular diabetology, 14, 73-73 (2015-06-07)
Diabetes promotes maladaptive changes in the endothelium that lead to its dysfunction and contribute to the vascular pathology of diabetes. We have previously reported the up-regulation of galectin-3, a β-galactoside-binding lectin, in the endothelium and sera of diabetic mice, implicating
Elizabeth Valdivieso et al.
Parasites & vectors, 8, 399-399 (2015-07-29)
Serine proteinase inhibitors (serpins) finely regulate serine proteinase activity via a suicide substrate-like inhibitory mechanism. In parasitic nematodes, some serpins interact with host physiological processes; however, little is known about these essential molecules in Anisakis. This article reports the gene
Benjamin L Parker et al.
Science signaling, 8(380), rs6-rs6 (2015-06-11)
A major goal in signaling biology is the establishment of high-throughput quantitative methods for measuring changes in protein phosphorylation of entire signal transduction pathways across many different samples comprising temporal or dose data or patient samples. Data-independent acquisition (DIA) mass
André L Mencalha et al.
BMC cancer, 14, 866-866 (2014-11-25)
Signal transducer and activator of transcription 3 (STAT3) is an important transcriptional factor frequently associated with the proliferation and survival of a large number of distinct cancer types. However, the signaling pathways and mechanisms that regulate STAT3 activation remain to
Leila Gobejishvili et al.
Clinical immunology (Orlando, Fla.), 161(2), 291-299 (2015-09-27)
Dysregulated cytokine metabolism plays a critical role in the pathogenesis of many forms of liver disease, including alcoholic and non-alcoholic liver disease. In this study we examined the efficacy of Misoprostol in modulating LPS-inducible TNFα and IL-10 expression in healthy
Jo-Il Kim et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2427-2436 (2014-10-11)
The solid matrices used for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) enable the analysis of small molecules by preventing fragmentations of organic matrix molecules in the low mass-to-charge ratio (m/z) range. In this work, a nylon nanoweb with TiO(2)
Jeremy S Toma et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(3), 1291-1306 (2015-01-23)
Induced pluripotent cell-derived motoneurons (iPSCMNs) are sought for use in cell replacement therapies and treatment strategies for motoneuron diseases such as amyotrophic lateral sclerosis (ALS). However, much remains unknown about the physiological properties of iPSCMNs and how they compare with
Hyunjin Noh et al.
Stem cells (Dayton, Ohio), 32(9), 2443-2453 (2014-05-09)
We reported a functional incompetence in mesenchymal stem cells (MSCs) under uremia, but the mechanisms have not been explored. To study the mechanisms of dysfunctional MSCs induced by uremia, we characterized insulin signaling in MSCs and investigated the effect of
J Dhanda et al.
British journal of cancer, 111(11), 2114-2121 (2014-10-01)
Extracapsular spread (ECS) in cervical lymph nodes is the single-most prognostic clinical variable in oral squamous cell carcinoma (OSCC), but diagnosis is possible only after histopathological examination. A promising biomarker in the primary tumour, alpha smooth muscle actin (SMA) has
Elizabeth Stansell et al.
PloS one, 10(4), e0124784-e0124784 (2015-04-29)
As HIV-1-encoded envelope protein traverses the secretory pathway, it may be modified with N- and O-linked carbohydrate. When the gp120s of HIV-1 NL4-3, HIV-1 YU2, HIV-1 Bal, HIV-1 JRFL, and HIV-1 JRCSF were expressed as secreted proteins, the threonine at
Zuyi Weng et al.
The Journal of allergy and clinical immunology, 135(4), 1044-1052 (2014-12-17)
Mast cells (MCs) are hematopoietic cells that mature in tissues and are involved in allergy, immunity, and inflammation by secreting multiple mediators. The natural flavone luteolin has anti-inflammatory actions and inhibits human mast cells (MCs). We sought to investigate the
Aaron C Koppel et al.
American journal of physiology. Cell physiology, 306(10), C899-C909 (2014-03-07)
Proline-rich protein tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family. We used Pyk2 knockout (Pyk2-KO) mice to study the role of Pyk2 in cutaneous wound repair. We report that the rate of wound closure was
Vanessa R da Silva et al.
American journal of physiology. Endocrinology and metabolism, 307(1), E93-101 (2014-05-16)
Low vitamin B-6 nutritional status is associated with increased risk for cardiovascular disease and certain cancers. Pyridoxal 5'-phosphate (PLP) serves as a coenzyme in many cellular processes, including several reactions in one-carbon (1C) metabolism and the transsulfuration pathway of homocysteine
Romain Lambrot et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(11), 4402-4416 (2015-08-06)
Little is known of the fundamental processes governed by epigenetic mechanisms in the supplier cells of spermatogenesis, the spermatogonial stem cells (SSCs). The histone H3 lysine demethylase KDM1A is expressed in spermatogonia. We hypothesized that KDM1A serves in transcriptional regulation
Mayra Denisse Ramírez-Quijas et al.
Microbial pathogenesis, 87, 1-12 (2015-07-19)
In order for Candida species to adhere and colonize human host cells they must express cell wall proteins (CWP) and adapt to reactive oxygen species (ROS) generated by phagocytic cells of the human host during the respiratory burst. However, how
Riet van der Meer et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(12), 3211-3221 (2014-04-29)
To identify genes whose depletion is detrimental to Pim1-overexpressing prostate cancer cells and to validate this finding in vitro and in vivo. RNAi screening was used to identify genes whose depletion is detrimental to Pim1-overexpressing cells. Our finding was validated
Shiping Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(40), 14460-14465 (2014-09-24)
Lineage-specific microRNAs (miRNAs) may contribute to functions specific to hematophagous mosquitoes and, as such, have potential for contributing to the development of future mosquito control approaches. Here we report that the mosquito- and gut-specific miRNA, miR-1174, is required for proper
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