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S4751
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Xiaobing Yang et al.
Bioresource technology, 193, 557-562 (2015-07-15)
Microbial lipids produced by oleaginous yeasts serve as promising alternatives to traditional oils and fats for the production of biodiesel and oleochemicals. To improve its techno-economics, it is pivotal to use wastes and produce high quality lipids of special fatty
Sarah E E Berry et al.
The Proceedings of the Nutrition Society, 64(2), 205-212 (2005-06-18)
Exaggerated postprandial lipaemia may increase the risk of CHD by contributing to both thrombotic and atherogenic processes. Previous research has focused on the quantity and composition of dietary fat, whereas the effect of triacylglycerol (TAG) structure on postprandial lipaemia and
Chun-Ying Qu et al.
International journal of nanomedicine, 10, 3911-3920 (2015-06-20)
The first-line chemotherapy treatment protocol for gastric cancer is combination chemotherapy of 5-fluorouracil (5-FU) and cisplatin (CDDP). The aim of this study was to engineer prodrug-based nanostructured lipid carriers (NLC) platform for codelivery of 5-FU and CDDP to enhance therapy
E Zamora-Rojas et al.
Meat science, 95(3), 503-511 (2013-06-25)
A handheld micro-electro-mechanical system (MEMS) based spectrometer working in the near infrared region (NIR) (1600-2400nm) was evaluated for in-situ and non-destructive prediction of main fatty acids in Iberian pig (IP) carcasses. 110 IP carcasses were measured. Performance of the instrument
Mohamad Navab et al.
Journal of lipid research, 56(4), 871-887 (2015-02-04)
We previously reported that i) a Western diet increased levels of unsaturated lysophosphatidic acid (LPA) in small intestine and plasma of LDL receptor null (LDLR(-/-)) mice, and ii) supplementing standard mouse chow with unsaturated (but not saturated) LPA produced dyslipidemia
Friederike Folttmann et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 931-938 (2014-12-03)
A spatial filtering velocimetry (SFV) probe was applied to monitor the increase in particle size during pellet Wurster coating processes in-line. Accuracy of the in-line obtained pellet sizes was proven by at-line performed digital image analysis (DIA). Regarding particle growth
J C Hoak
The American journal of clinical nutrition, 60(6 Suppl), 1050S-1053S (1994-12-01)
Stearic acid causes hypercoagulability of the blood by activation of factor XII and by aggregation of blood platelets. Injection of unbound stearic acid (sodium salt) into the systemic circulation of dogs was followed by massive generalized thrombosis and sudden death.
Liliya Vinarova et al.
Food & function, 6(4), 1319-1330 (2015-03-17)
Quillaja saponin extracts are known to reduce plasma cholesterol levels in humans. Here we study the mechanism of this effect with Quillaja Dry saponin extract (QD). In vitro model of triglyceride lipolysis is used to quantify the effect of QD
Claire Valotteau et al.
ACS applied materials & interfaces, 7(32), 18086-18095 (2015-08-08)
Classical antibacterial surfaces usually involve antiadhesive and/or biocidal strategies. Glycosylated surfaces are usually used to prevent biofilm formation via antiadhesive mechanisms. We report here the first example of a glycosylated surface with biocidal properties created by the covalent grafting of
Dietary stearic acid and risk of cardiovascular disease: intake, sources, digestion, and absorption.
Penny M Kris-Etherton et al.
Lipids, 40(12), 1193-1200 (2006-02-16)
Individual FA have diverse biological effects, some of which affect the risk of cardiovascular disease (CVD). In the context of food-based dietary guidance designed to reduce CVD risk, fat and FA recommendations focus on reducing saturated FA (SFA) and trans
Tatiana Shioji Tiuman et al.
BMC microbiology, 14, 152-152 (2014-06-11)
Leishmania amazonensis infection results in diverse clinical manifestations: cutaneous, mucocutaneous or visceral leishmaniasis. The arsenal of drugs available for treating Leishmania infections is limited. Therefore, new, effective, and less toxic leishmaniasis treatments are still needed. We verified cell death in
Paul A Turner et al.
Tissue engineering. Part A, 21(11-12), 1837-1847 (2015-03-18)
To improve treatment of obesity, a contributing factor to multiple systemic and metabolic diseases, a better understanding of metabolic state and environmental stress at the cellular level is essential. This work presents development of a three-dimensional (3D) in vitro model
Heverton Silva Camargos et al.
PloS one, 9(8), e104429-e104429 (2014-08-08)
Although many terpenes have shown antitumor, antibacterial, antifungal, and antiparasitic activity, the mechanism of action is not well established. Electron paramagnetic resonance (EPR) spectroscopy of the spin-labeled 5-doxyl stearic acid revealed remarkable fluidity increases in the plasma membrane of terpene-treated
Faiezah A A Mohamed et al.
Drug development and industrial pharmacy, 41(4), 623-630 (2014-02-26)
Extended release (ER) of water-soluble drugs from hydroxypropylmethylcellulose (HPMC) matrix mini-tablets (mini-matrices) is difficult to achieve due to the large surface area to volume ratio of the mini matrices. Therefore, the aims of this study were to control the release
Hypoxia potentiates palmitate-induced pro-inflammatory activation of primary human macrophages
Snodgrass Ryan G, et al.
The Journal of Biological Chemistry, 291(1), 413-424 (2016)
Hongming Miao et al.
Scientific reports, 5, 13092-13092 (2015-08-15)
The biomechanics stress and chronic inflammation in obesity are causally linked to osteoarthritis. However, the metabolic factors mediating obesity-related osteoarthritis are still obscure. Here we scanned and identified at least two elevated metabolites (stearic acid and lactate) from the plasma
Zulfiqar Ali Mirani et al.
Pakistan journal of pharmaceutical sciences, 26(2), 383-389 (2013-03-05)
In the present study a vancomycin resistant Staphylococcus aureus (S. aureus) (VRSA) (Labeled as CP2) was isolated from the blood of a post-operative cardiac patient is described. It harbors a plasmid which carry vanA gene and exhibited low-level vancomycin resistance
Tae Hwan Kim et al.
Journal of chromatographic science, 53(7), 1100-1106 (2014-12-20)
Chloroacetamide (CAA) is a preservative used in various cosmetic, personal care and household products. Due to the hazard potential for allergic reaction and reproductive toxicity, CAA is being considered a high priority for screening assessment and toxicological re-evaluation. This study
Marie Guhmann et al.
Drug development and industrial pharmacy, 41(4), 540-551 (2014-02-06)
Fast onset of action is prerequisite for acute pain medication. A palatable orodispersible medicine of diclofenac providing rapid analgesic effect should improve patient compliance and treatment. In the present study, diclofenac taste-masked orodispersible tablets (ODTs) with fast release characteristics were
Anthony Tomlinson et al.
Molecular pharmaceutics, 12(11), 3805-3815 (2015-10-01)
Polysorbate 20 (PS20), a commonly used surfactant in biopharmaceuticals, showed degradation upon long-term (∼18-36 months) storage of two monoclonal antibody (mAb, mAb-A, and mAb-B) drug products at 2-8 °C. The PS20 degradation resulted in the accumulation of free fatty acids
Hemlata Patil et al.
International journal of pharmaceutics, 496(1), 33-41 (2015-04-12)
The objective of the present study was to develop pH-independent/dependent sustained release (SR) tablets of ondansetron HCl dihydrate (OND), a selective 5-HT3 receptor antagonist that is used for prevention of nausea and vomiting caused by chemotherapy, radiotherapy and postoperative treatment.
Ram Jee Sharma et al.
Natural product communications, 10(6), 969-976 (2015-07-23)
Eugenia jambolana, commonly known as 'jamun' or Indian blackberry, is an important source of bioactive compounds. All parts of the plant like stem bark, leaves, flower, fruit pulp and seeds are traditionally used for many diseases. Metabolite profiling in medicinally
Michael C Rudolph et al.
Journal of lipid research, 55(6), 1052-1065 (2014-04-29)
Thyroid hormone responsive protein Spot 14 has been consistently associated with de novo fatty acid synthesis activity in multiple tissues, including the lactating mammary gland, which synthesizes large quantities of medium chain fatty acids (MCFAs) exclusively via FASN. However, the
Azmat Ali Khan et al.
Anticancer research, 33(6), 2517-2524 (2013-06-12)
Chemical synthesis and characterization of a lipophilic ester conjugate, propofol stearate and evaluation of its anticancer efficacy on human breast cancer cell lines MDA-MB-361, MCF-7 and MDA-MB-231. The chemical structure of the synthesized conjugate was characterized by spectroscopic studies. Its
Yuji Katsuta et al.
The Journal of investigative dermatology, 124(5), 1008-1013 (2005-04-28)
Abnormal follicular keratinization is involved in comedogenesis in acne vulgaris. We recently demonstrated that calcium influx into epidermal keratinocytes is associated with impaired skin barrier function and epidermal proliferation. Based on these results, we hypothesized that sebum components affect calcium
Zhanguo Gao et al.
Molecular endocrinology (Baltimore, Md.), 18(8), 2024-2034 (2004-05-15)
Insulin receptor substrate (IRS) has been suggested as a molecular target of free fatty acids (FFAs) for insulin resistance. However, the signaling pathways by which FFAs lead to the inhibition of IRS function remain to be established. In this study
A Olejnik et al.
International journal of cosmetic science, 37(4), 401-407 (2015-02-24)
The aim of this work was to investigate the long-term stability of four emulsions (creams and ointments) developed for carrying hyaluronic acid (HA) for dermal penetration. The stability of obtained formulations was analysed by multiple light scattering and laser diffraction
Meng He et al.
ACS applied materials & interfaces, 5(3), 585-591 (2013-01-08)
A novel, highly hydrophobic cellulose composite film (RCS) with biodegradability was fabricated via solvent-vaporized controllable crystallization of stearic acid in the porous structure of cellulose films (RC). The interface structure and properties of the composite films were investigated with wide-angle
Sindhuri Maddineni et al.
AAPS PharmSciTech, 16(2), 444-454 (2014-11-02)
The objective of the present study was to investigate the effects of processing variables and formulation factors on the characteristics of hot-melt extrudates containing a copolymer (Kollidon® VA 64). Nifedipine was used as a model drug in all of the
G Hoffmann et al.
Clinical chemistry, 35(4), 587-595 (1989-04-01)
This new method for qualitative and quantitative determination of organic acids, aldehydes, and ketones in biological samples is effective for use with urine, plasma, and amniotic fluid, and it requires no deproteinization. Isolation by batch-wise liquid partition chromatography on silicic
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