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S7152
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K Yang et al.
Bone, 114, 40-49 (2018-06-09)
Osteoporosis is a serious health problem worldwide. Semaphorins (Sema) have been described as key molecules involved in the cross-talk between bone cells (osteoblasts/osteoclasts). In this study, we investigated whether plasmid containing Sema3a could ameliorate bone loss in an ovariectomized (OVX)
Dequn Niu et al.
In vitro cellular & developmental biology. Animal, 55(4), 243-251 (2019-03-20)
This study determined the effects of miR-338-3p on osteoclast (OC) differentiation and activation. The change levels of miR-338-3p in differentiated OCs were investigated by microRNA microarray assay and quantitative real-time PCR analysis. The effects of miR-338-3p on the differentiation and
Marzena Wyganowska-Swiatkowska et al.
Experimental and therapeutic medicine, 13(1), 160-168 (2017-01-27)
Enamel matrix derivative (EMD) can mimic odontogenic effects by inducing the proliferation and differentiation of connective tissue progenitor cells, stimulating bone growth and arresting epithelial cells migration. To the best of our knowledge, there is no data indicating that any
Jochen Kroner et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 32(12), 2431-2444 (2017-08-05)
Mast cells, important sensor and effector cells of the immune system, may influence bone metabolism as their number is increased in osteoporotic patients. They are also present during bone fracture healing with currently unknown functions. Using a novel c-Kit-independent mouse
Hyun-Seok Jin et al.
PloS one, 10(8), e0135285-e0135285 (2015-08-11)
To identify novel susceptibility variants for osteoporosis in Korean postmenopausal women, we performed a genome-wide association analysis of 1180 nonsynonymous single nucleotide polymorphisms (nsSNPs) in 405 individuals with osteoporosis and 722 normal controls of the Korean Association Resource cohort. A
Mo Zhu et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(4), 739-751 (2018-12-07)
Cannabinoid receptor 2 (CB2) has been implicated as an important clinical regulator of inflammation and malignant osteolysis. Here, we observed that CB2 expression was markedly higher in the collagen-induced arthritis (CIA) mice synovium and bone tissues than in the noninflamed
Hidetaka Ideguchi et al.
Clinical oral investigations, 23(2), 821-827 (2018-06-08)
We aimed to evaluate molecular imaging as a novel diagnostic tool for mice periodontitis model induced by ligature and Porphyromonas gingivalis (Pg) inoculation. Twelve female mice were assigned to the following groups: no treatment as control group (n = 4); periodontitis group
Anne Bernhardt et al.
Tissue engineering. Part A, 26(11-12), 647-655 (2019-11-28)
Osteoclasts are pivotal cells for bone remodeling and their activity is coordinated by osteocytes that reside inside the bone matrix. In vitro co-cultures of osteocytes and osteoclasts are therefore advantageous to analyze the crosstalk between these cell species. In this
Lingsen You et al.
International journal of molecular sciences, 21(7) (2020-04-09)
Growing evidence suggests an adverse impact of gut microbiota dysbiosis on human health. However, it remains unclear whether embryonic osteogenesis is affected by maternal gut dysbacteriosis. In this study, we observed that elevated lipopolysaccharide (LPS) levels led to skeletal developmental
Yi Feng et al.
Plant, cell & environment, 42(2), 424-436 (2018-07-11)
Plants experiencing salt-induced stress often reduce cytokinin levels during the early phases of stress-response. Interestingly, we found that the cytokinin content in the apple rootstock "robusta" was maintained at a high level under salt stress. Through screening genes involved in
Lavinia Raimondi et al.
Cancers, 12(8) (2020-08-08)
Bone disease severely affects the quality of life of over 70% of multiple myeloma (MM) patients, which daily experience pain, pathological fractures, mobility issues and an increased mortality. Recent data have highlighted the crucial role of the endoplasmic reticulum-associated unfolded
Camila Alessandra Pazzini et al.
Archives of oral biology, 79, 30-34 (2017-03-11)
The aim of the present study was to investigate the effect of probiotic (Bacillus Subtilis) supplementation on bone remodelling induced by mechanical loading. C57BL/6 mice were divided in two groups: (1) Probiotic and (2) Vehicle (water). The probiotic (1.5×10 OTM
Huan Qin et al.
Frontiers in pharmacology, 11, 581049-581049 (2021-03-13)
Traditional herb pair Salvia miltiorrhiza Bunge-Radix Puerariae (DG) owns various biological activities including anti-inflammatory and anti-oxidative stress. Oxidative stress is one high-risk factor for osteoporosis, then effect of DG on osteoporosis and underlying mechanisms was explored both in vivo and
Nicole Cheng et al.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 54(6), 687-698 (2017-01-18)
Bone grafts in patients with cleft lip and palate can undergo a significant amount of resorption. The aim of this study was to investigate the effects of bisphosphonates (BPs) on the success of bone grafts in rats. Thirty-five female 15-week-old
Falk Wehrhan et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 47(10), 1600-1607 (2019-08-08)
Surgical treatment of medication-related osteonecrosis of the jaw (MRONJ) consists of necrotic bone removal followed by dense mucosal closure. Fluorescence-guided surgery has become a promising tool to intraoperatively distinguish between healthy and necrotic bone. Until now, there has been a
Michael A Rieger et al.
Cell reports, 33(12), 108531-108531 (2020-12-29)
CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we define its CNS targets, which are
Louvy Lynn Punzalan et al.
Cell chemical biology, 27(6), 708-718 (2020-05-14)
Pharmacophore-focused chemical libraries are continuously being created in drug discovery programs, yet screening assays to maximize the usage of such libraries are not fully explored. Here, we report a chemical proteomics approach to reutilizing a focused chemical library of 1,800
Satoshi Takagi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(10), 2430-2439 (2018-02-15)
Purpose: Tumor cell-platelet interactions contribute to tumor progression and metastasis in solid tumors. However, the role of platelets in hematological malignancies is not clear. We investigated the association of platelet activation status with clinical stages in multiple myeloma (MM) patients
Dawei Liu et al.
Cell research, 28(9), 918-933 (2018-07-22)
In the human body, 50-70 billion cells die every day, resulting in the generation of a large number of apoptotic bodies. However, the detailed biological role of apoptotic bodies in regulating tissue homeostasis remains unclear. In this study, we used
Christian S Thudium et al.
Calcified tissue international, 95(1), 83-93 (2014-05-20)
Osteopetrosis due to lack of acid secretion by osteoclasts is characterized by abolished bone resorption, increased osteoclast numbers, but normal or even increased bone formation. In contrast, osteoclast-poor osteopetrosis appears to have less osteoblasts and reduced bone formation, indicating that
Da Liu et al.
Clinical and experimental pharmacology & physiology, 42(2), 202-212 (2014-11-27)
Acute spinal cord injury (SCI) leads to permanent functional deficits via mechanical injury and secondary mechanisms, but the therapeutic strategy for SCI is limited. Carvedilol has been shown to possess multiple biological and pharmacological properties. The of the present study
Lin Ren et al.
Biochemical and biophysical research communications, 508(1), 138-144 (2018-11-27)
Age-related skeletal changes is closely associated with imbalanced bone remodeling characterized by elevated osteocyte apoptosis and osteoclast activation. Since osteocytes are the commander of bone remodeling, attenuating increased osteocyte apoptosis may improve age-related bone loss. Exosomes, derived from mesenchymal stem
Eva Svandova et al.
Journal of anatomy, 235(2), 256-261 (2019-05-31)
FASL (CD178) is known for its role in triggering apoptosis, mostly in relation with immune cells but additional functions have been reported more recently, including those in bone development. Examination of postnatal FasL-deficient mice (gld) showed an increased bone deposition
Dongliang Xiao et al.
Journal of cellular biochemistry, 121(11), 4542-4557 (2020-02-13)
Perturbations in the balanced process of osteoblast-mediated bone formation and osteoclast-mediated bone resorption leading to excessive osteoclast formation and/or activity is the cause of many pathological bone conditions such as osteoporosis. The osteoclast is the only cell in the body
Jong-Ho Lee et al.
Arthritis research & therapy, 19(1), 163-163 (2017-07-21)
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by uncontrolled joint inflammation and destruction of bone and cartilage. We previously reported that C-X-C motif chemokine 10 (CXCL10; also called IP-10) has important roles in joint inflammation and bone destruction
Jesus Delgado-Calle et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(5), 2878-2890 (2018-02-07)
Parathyroid hormone (PTH) affects the skeleton by acting on osteocytes (Ots) in bone through yet unclear mechanisms. We report that matrix metalloproteinase 14 (MMP14) expression/activity are increased in bones from mice with genetic constitutive activation (ca) of the PTH receptor
Daimel Castillo-González et al.
Journal of chemical information and modeling, 55(10), 2094-2110 (2015-09-12)
Telomeres and telomerase are key players in tumorogenesis. Among the various strategies proposed for telomerase inhibition or telomere uncapping, the stabilization of telomeric G-quadruplex (G4) structures is a very promising one. Additionally, G4 stabilizing ligands also act over tumors mediated
Ji Ye Kwon et al.
Scientific reports, 8(1), 13832-13832 (2018-09-16)
Osteoarthritis (OA) is a major degenerative joint condition that causes articular cartilage destruction. It was recently found that enhancement of chondroclasts and suppression in Treg cell differentiation are involved in the pathogenesis of OA. Kartogenin (KGN) is a small drug-like
Gang Wu et al.
Menopause (New York, N.Y.), 26(7), 785-792 (2019-05-15)
Osteoporosis is a prevalent condition among postmenopausal women, and lacks satisfactory therapeutic options. Hydrogen (H2) has been shown to be effective in alleviating many diseases. This study aimed to investigate the effects of H2 on inhibiting osteoclastogenesis and bone loss
Ae Ri Kim et al.
Journal of translational medicine, 16(1), 306-306 (2018-11-11)
Diabetes induces long bone loss and aggravation of periodontitis-induced alveolar bone loss. Simvastatin (SIM), which is a lipid-lowering agent is known to have an anabolic effect on bone. Therefore, we investigated effect of SIM on tibial and alveolar bone loss
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