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关键词:'S7152'
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Wei Hong et al.
Acta pharmacologica Sinica, 36(12), 1487-1496 (2015-11-26)
Apolipoprotein E (ApoE) plays an important role in the transport and metabolism of lipids. Recent studies show that bone mass is increased in young apoE(-/-) mice. In this study we investigated the bone phenotype and metabolism in aged apoE(-/-) mice.
Kyung-Hyun Park-Min et al.
Nature communications, 5, 5418-5418 (2014-11-14)
Emerging evidence suggests that RANKL-induced changes in chromatin state are important for osteoclastogenesis, but these epigenetic mechanisms are not well understood and have not been therapeutically targeted. In this study, we find that the small molecule I-BET151 that targets bromo
Wang Zhou et al.
Bone, 66, 267-276 (2014-06-29)
Parathyroid hormone-related protein (PTHrP) has been identified to play a crucial role in osteolysis formation and stromal cell (GCTSC) proliferation in giant cell tumor (GCT). MiR-126-5p is an intronic miRNA identified as tumor suppressor in many tumors, but its role
Gaurav Swarnkar et al.
Scientific reports, 6, 29896-29896 (2016-07-21)
The transcription factor NF-κB is central to numerous physiologic processes including bone development, and its activation is controlled by IKKγ (also called NEMO), the regulatory subunit of IKK complex. NEMO is X-linked, and mutations in this gene result in Incontinentia
Mingxiang Yu et al.
Biochemical and biophysical research communications, 447(2), 364-370 (2014-04-16)
Osteoclasts, derived from hemopoietic progenitors of the monocyte/macrophage lineage, have a unique role in bone resorption, and are considered a potential therapeutic target in the treatment of such pathologic bone diseases as osteoporosis, rheumatoid arthritis, and periodontitis. In the present
Yongming Xi et al.
Experimental cell research, 389(2), 111930-111930 (2020-03-03)
Tissue inhibitor of metalloproteinase 1 (TIMP1) has various biological activities including the regulation of cell growth and differentiation. However, its role in bone homeostasis and remodeling remains poorly understood. In this study, we investigate the effects of TIMP1 on osteoblast
Ciro Menale et al.
Stem cells translational medicine, 8(1), 22-34 (2018-09-06)
Biomimetic scaffolds are extremely versatile in terms of chemical composition and physical properties, which can be defined to accomplish specific applications. One property that can be added is the production/release of bioactive soluble factors, either directly from the biomaterial, or
Mieke Sinnesael et al.
Molecular and cellular endocrinology, 411, 198-206 (2015-05-11)
Androgen deficiency or androgen receptor knockout (ARKO) causes high-turnover osteopenia, but the target cells for this effect remain unclear. To examine whether AR in osteoclasts directly suppresses bone resorption, we crossed AR-floxed with cathepsin K-Cre mice. Osteoclast-specific ARKO (ocl-ARKO) mice
John P Leach et al.
Nature, 550(7675), 260-264 (2017-10-05)
Mammalian organs vary widely in regenerative capacity. Poorly regenerative organs, such as the heart are particularly vulnerable to organ failure. Once established, heart failure commonly results in mortality. The Hippo pathway, a kinase cascade that prevents adult cardiomyocyte proliferation and
Atsushi Yasumoto et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1068-1069, 98-104 (2017-10-17)
Eicosanoid mediators play important roles in maintaining the physiological and pathophysiological homeostasis in the body. Their measurements, however, are rarely performed in clinical practice. In the present study, we analyzed 30 varieties of eicosanoid mediators that were detectable in human
Roberto Dinami et al.
Oncotarget, 8(56), 95674-95691 (2017-12-10)
The catalytic subunit of the telomerase complex, hTERT, ensures unlimited proliferative potential of cancer cells by maintaining telomere function and protecting from apoptosis. Using a miRNA screening approach we identified miR-296-5p and miR-512-5p as miRNAs that target hTERT in breast
Yuyun Wu et al.
Archives of oral biology, 102, 39-46 (2019-04-09)
It has been suggested that degenerative conditions of the temporomandibular joint (TMJ), such as osteoarthritis (OA) and progressive condylar resorption, are caused by multiple etiological factors, such as hormonal imbalance and excessive mechanical stress. However, it is unclear whether these
Lubinda Mbundi et al.
Nanomaterials (Basel, Switzerland), 8(6) (2018-06-06)
The control of osteoblast/osteoclast cross-talk is crucial in the bone remodelling process and provides a target mechanism in the development of drugs for bone metabolic diseases. Osteoprotegerin is a key molecule in this biosignalling pathway as it inhibits osteoclastogenesis and
Yu-Wei Ge et al.
Oxidative medicine and cellular longevity, 2020, 1404915-1404915 (2020-06-27)
Aseptic loosening caused by wear particles is one of the common complications after total hip arthroplasty. We investigated the effect of the recombinant protein ephB4-Fc (erythropoietin-producing human hepatocellular receptor 4) on wear particle-mediated inflammatory response. In vitro, ephrinB2 expression was
Ji-Young Yoon et al.
Tissue engineering and regenerative medicine, 15(3), 333-340 (2019-01-04)
Remifentanil is commonly used in operating rooms and intensive care units for the purpose of anesthesia and sedation or analgesia. Although remifentanil may significantly affect the bone regeneration process in patients, there have been few studies to date on the
Liqiang Zhang et al.
Stem cell research & therapy, 11(1), 269-269 (2020-07-06)
Bone mass loss in aging is linked with imbalanced lineage differentiation of bone marrow mesenchymal stem cells (BMMSCs). Recent studies have proved that histone deacetylases (HDACs) are regarded as key regulators of bone remodeling. However, HDACs involve in regulating BMMSC
Jing Wu et al.
Food & function, 11(7), 6251-6264 (2020-07-01)
Collagen-induced arthritis (CIA) is a widely used animal model for studying rheumatoid arthritis (RA), which manifests serious joint dysfunction, progressive bone erosion and articular cartilage destruction. Considering that joint damage in RA is caused by systemic inflammation and dihydromyricetin (DMY)
Jiaxin Zhan et al.
Aging, 8(12), 3298-3310 (2016-11-28)
Both HIV and antiretroviral therapy could induce vascular aging with unclear mechanisms. In this study, via microarray analysis, we identified, for the first time, that miR-34a expression was significantly increased in both HIV-infected, and antiretroviral agents-treated vessels and vascular endothelial
Muriel Babey et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(6), 1064-1076 (2014-12-17)
The primary goal of this study was to determine whether the IGF1R in mature osteoblasts and osteocytes was required for the catabolic actions of continuous parathyroid hormone (cPTH). Igf1r was deleted from male and female FVN/B mice by breeding with
Jennifer L Krauss et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(33), 10455-10460 (2015-08-05)
The alternative or noncanonical nuclear factor kappa B (NF-κB) pathway regulates the osteoclast (OC) response to receptor activator of nuclear factor kappa B ligand (RANKL) and thus bone metabolism. Although several lines of evidence support the emerging concept that nucleotide-binding
Kyong-Oh Shin et al.
Archives of pharmacal research, 37(9), 1183-1192 (2014-04-02)
Ginsenoside compound K (CK) is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer (Araliaceae), has long been used to treat against the development of cancer, inflammation, allergies, and diabetes. This study examined the anti-angiogenic properties of CK
Chia-Jung Hsieh et al.
International journal of oncology, 46(2), 555-562 (2014-11-26)
The bone is the most common metastatic site of breast cancer. Bone metastasis causes pain, pathologic fractures, and severely reduces the quality of life. Breast cancer causes osteolytic bone metastasis, which is dependent on osteoclast-mediated bone resorption. While current treatments
Takenobu Ishii et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(7), 4016-4030 (2018-03-14)
Cell fusion-mediated formation of multinuclear osteoclasts (OCs) plays a key role in bone resorption. It is reported that 2 unique OC-specific fusogens [ i.e., OC-stimulatory transmembrane protein (OC-STAMP) and dendritic cell-specific transmembrane protein (DC-STAMP)], and permissive fusogen CD9, are involved
Min Zhou et al.
Acta pharmacologica Sinica, 36(11), 1388-1394 (2015-10-27)
S100A4, also known as fibroblast-specific protein 1 or metastasin 1, is not only highly expressed in growth-stimulated cultured cells and metastatic tumor cells, but also in the periodontal ligament. The aim of this study was to investigate the roles of
Fuping Gao et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(7), 1801671-1801671 (2019-04-17)
Super-small nanoclusters may intrinsically trigger specific molecular pathway for disease treatment in vitro/vivo. To prove the hypothesis the super-small nanoclusters, e.g., Au clusters, are directly used to treat rheumatoid arthritis (RA) in vitro/vivo. RA is a chronic autoimmune disease that
Ana Paula Lazzari Marques Peron et al.
The Angle orthodontist, 87(1), 118-124 (2016-11-02)
To compare the histological responses in corticotomy- and corticision-assisted tooth movement. Ninety Wistar rats were divided into three groups: C (control-tooth movement only), CT (tooth movement + corticotomy), and CI (tooth movement + corticision). Surgeries were performed on the vestibular
Min Jiang et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(2), 361-374 (2018-10-16)
Osteoporosis, an osteolytic disease that affects millions of people worldwide, features a bone remodeling imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Identifying dual target-directed agents that inhibit excessive bone resorption and increase bone formation is considered
Tomoyuki Mukai et al.
PloS one, 9(8), e105518-e105518 (2014-08-22)
SH3BP2 is a signaling adapter protein which regulates immune and skeletal systems. Gain-of-function mutations in SH3BP2 cause cherubism, characterized by jawbone destruction. This study was aimed to examine the role of SH3BP2 in inflammatory bone loss using a collagen-induced arthritis
Ingrid Nyhus Moen et al.
Cell death discovery, 7(1), 36-36 (2021-02-21)
Elevated activity of bone-degrading osteoclasts (OC) contributes to pathological bone degradation in diseases such as multiple myeloma. Several proinflammatory cytokines, including TNF, contribute to osteoclastogenesis. The receptor-interacting protein kinase 1 (RIPK1) regulates inflammation and cell death. It is recruited to
Cheng-Wei Lai et al.
Oncotarget, 8(5), 7357-7369 (2017-01-07)
The AKR1A1 protein is a member of the aldo-keto reductase superfamily that is responsible for the conversion of D-glucuronate to L-gulonate in the ascorbic acid (vitamin C) synthesis pathway. In a pCAG-eGFP transgenic mouse line that was produced by pronuclear
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