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S7152
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Yu-Si Chen et al.
Clinical and experimental pharmacology & physiology, 44(4), 500-508 (2017-01-12)
Growth Differentiation Factor 8 (GDF8), also called myostatin, is a member of the transforming growth factor (TGF)-β super-family. As a negative regulator of skeletal muscle growth, GDF8 is also associated with bone metabolism. However, the function of GDF8 in bone
Libo Zhao et al.
Frontiers in pharmacology, 8, 928-928 (2018-01-10)
Dihydromyricetin (DMY), the main flavonoid component of
Rui Pei et al.
Mini reviews in medicinal chemistry, 21(5), 554-575 (2020-11-11)
Rhein, an anthraquinone derivative, has been employed widely, especially for the treatment of intractable diseases like diabetic nephropathy, arthritis, and cancer in a unique action mechanism. In the last decades, considerable efforts have been made in structural modification of rhein.
Yaxian Ma et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, fj201700983RR-fj201700983RR (2018-05-18)
The receptor activator of NF-κB ligand-induced osteoclast differentiation has a critical role in the process of bone metabolism. Overactivation of osteoclastogenesis may result in a series of diseases. Irisin, a novel myokine, which was first reported in 2012, has been
Hye-Yeon Jang et al.
Archives of oral biology, 122, 105029-105029 (2021-01-03)
The flower of chrysanthemum, used worldwide as a medicinal and edible product, has shown various bioactivities, such as anti-inflammatory, antioxidant, anti-tumorigenic, and hepatoprotective activities, as well as cardiovascular protection. However, the effect of Chrysanthemum morifolium Ramat. on the regulation of
Li-Li Jiang et al.
Chinese medicine, 10, 33-33 (2015-11-14)
Deer tendons are believed more effective than cattle tendons in tonifying kidney yang (shen yang) and enhancing bone and tendons. This study aims to differentiate the two types of tendons by a loop-mediated isothermal amplification (LAMP) test and bone remodeling
N Ogasawara et al.
Osteoarthritis and cartilage, 28(6), 831-841 (2020-04-10)
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease characterized by progressive cartilage degeneration, abnormal bone remodeling, and chronic pain. In this study, we aimed to investigate effective therapies to reverse or suppress TMJOA progression. To this end, we performed intravenous
Ting Yu et al.
BioMed research international, 2019, 9042542-9042542 (2019-02-06)
This study aimed to explore periodontal and systemic immune response of overweight hosts to periodontitis. Forty C57 BL/6J male mice were divided into high (HF) or low fat (LF) diet groups and fed with the two diets, respectively, for 8
Jiarui Yang et al.
The Analyst, 146(6), 1859-1864 (2021-01-15)
The detection of telomerase is of great significance for monitoring cell canceration. The conventional methods depend on the extension of telomerase towards its primer to conduct signal transduction. Herein, a specific and reliable detection strategy based on stepwise recognition was
Monika J Tomecka et al.
Disease models & mechanisms, 12(9) (2019-08-07)
Reduced bone quality or mineral density predict susceptibility to fracture and also attenuate subsequent repair. Bone regrowth is also compromised by bacterial infection, which exacerbates fracture site inflammation. Because of the cellular complexity of fracture repair, as well as genetic
Jiang Wang et al.
Pathogens and disease, 78(7) (2020-08-30)
Periodontitis is an inflammatory disease that causes damages to periodontium and alveolar bone. Overactivation and formation of osteoclasts can cause bone destruction, which contributes to periodontitis development. Receptor activator of nuclear factor κB ligand (RANKL)-mediated NF-κB signaling plays an essential
Dongfeng Zhao et al.
Menopause (New York, N.Y.), 25(12), 1459-1469 (2018-06-27)
This study was to determine the bone protective effects and underlying mechanisms of Osthole (OT) in ovariectomized (OVX) mice. We found that the inhibitory effects of OT on receptor activator of nuclear factor kappa-B ligand (RANKL)-activated osteoclastogenesis are responsible for
Y Wu et al.
Biochimica et biophysica acta, 1497(1), 27-36 (2000-06-06)
Tyrosine kinases, c-Src and Fyn, in their active form, have their C-terminal tyrosine residue dephosphorylated. In this study, we used clone 28, a monoclonal antibody (MoAb) that recognizes dephosphorylated C-terminal tyrosine of c-Src and Fyn, to investigate the mode of
Dongyan Zhang et al.
PloS one, 15(8), e0237354-e0237354 (2020-08-14)
The TCIRG1 gene encodes the a3 isoform of vacuolar H+-ATPase (V-ATPase), which forms a proton transport channel in osteoclasts. Defects in this gene lead to functional impairment of osteoclasts and increased bone mass; however, the molecular mechanisms of TCIRG1 loss
Xiao Chen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(11), 4855-4865 (2017-07-26)
Osteoporosis is a metabolic bone disease characterized by decreased bone density and strength due to excessive loss of bone protein and mineral content. The imbalance between osteogenesis by osteoblasts and osteoclastogenesis by osteoclasts contributes to the pathogenesis of postmenopausal osteoporosis.
Masayoshi Yamaguchi et al.
Experimental and therapeutic medicine, 12(6), 3602-3606 (2017-01-21)
Osteoporosis is induced by the reduction in bone mass through decreased osteoblastic osteogenesis and increased osteoclastic bone resorption, and it is associated with obesity and diabetes. Osteoblasts and adipocytes are derived from bone marrow mesenchymal stem cells. The prevention of
Mingxiang Yu et al.
Biochemical and biophysical research communications, 447(2), 364-370 (2014-04-16)
Osteoclasts, derived from hemopoietic progenitors of the monocyte/macrophage lineage, have a unique role in bone resorption, and are considered a potential therapeutic target in the treatment of such pathologic bone diseases as osteoporosis, rheumatoid arthritis, and periodontitis. In the present
Bo Yan et al.
Pathology, research and practice, 215(6), 152372-152372 (2019-03-12)
Puerarin (PR), a natural isoflavone isolated from Chinese traditional plant pueraria lobata, has attracted considerable attention due to its important biological and pharmacological activities. However, its effects on lesion of peri-implant and related mechanism of action are still not clear
Takaharu Abe et al.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 57(2), 208-217 (2019-08-20)
Cleft lip and palate (CLP) is a common anomaly of the orofacial region. Mesenchymal stem cell (MSC) transplantation has been a focus of regenerative medicine, and its application to the repair of bone defects in patients with CLP is highly
Shiori Nakajima et al.
In vivo (Athens, Greece), 34(6), 3291-3299 (2020-11-05)
The in vivo effect of abiraterone on bone mineral density (BMD) in addition to androgen deprivation therapy was examined using a murine model. The mice were separated into the following groups: control, abiraterone, castration, and castration+abiraterone. The percentage change in
Gaurav Swarnkar et al.
Scientific reports, 6, 29896-29896 (2016-07-21)
The transcription factor NF-κB is central to numerous physiologic processes including bone development, and its activation is controlled by IKKγ (also called NEMO), the regulatory subunit of IKK complex. NEMO is X-linked, and mutations in this gene result in Incontinentia
Wang Zhou et al.
Bone, 66, 267-276 (2014-06-29)
Parathyroid hormone-related protein (PTHrP) has been identified to play a crucial role in osteolysis formation and stromal cell (GCTSC) proliferation in giant cell tumor (GCT). MiR-126-5p is an intronic miRNA identified as tumor suppressor in many tumors, but its role
Elena Orecchini et al.
Frontiers in pharmacology, 11, 593829-593829 (2021-02-09)
Artocarpus tonkinensis (At) leaf decoction, a traditional remedy prepared in North Vietnam by the Hmong ethnic group, is a tea extract rich in bioactive compounds that may have therapeutic effects in arthritis and backache. Indeed, it has been demonstrated that
Loek D Loozen et al.
Tissue engineering. Part A, 21(9-10), 1672-1679 (2015-02-27)
Treatment and reconstruction of large bone defects, delayed unions, and nonunions is challenging and has resulted in an ongoing search for novel tissue-engineered therapies. Bone morphogenetic protein-2 (BMP-2) gene therapy is a promising strategy to provide sustained production of BMP-2
Charis Achilleos et al.
PloS one, 13(4), e0196604-e0196604 (2018-04-27)
High-risk human papillomaviruses (HPVs) have been shown in vitro to impinge on telomere homeostasis in a number of ways. However, the in vivo interaction of viruses with the telomere homeostasis apparatus has not been previously explored. Since E6 and E7
Sung-Hee Yoon et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 34(8), 1473-1486 (2019-06-13)
The absence of functional dystrophin with mutations of the dystrophin-encoding gene in Duchenne muscular dystrophy (DMD) results in muscle inflammation and degeneration, as well as bone fragility. Long-term glucocorticoid therapy delays the muscular disease progression but suppresses growth hormone secretion
Brice Moukengue et al.
EBioMedicine, 53, 102704-102704 (2020-03-11)
Osteosarcoma (OS) is the most common primary malignant bone tumour. Unfortunately, no new treatments are approved and over the last 30 years the survival rate remains only 30% at 5 years for poor responders justifying an urgent need of new
Kyung-Ah Cho et al.
Scientific reports, 7(1), 17114-17114 (2017-12-08)
Human mesenchymal stem cells (MSCs) are adult multipotent cells that have plasticity and inhabit the stroma of diverse tissues. The potential utility of MSCs has been heavily investigated in the fields of regenerative medicine and cell therapy. However, MSCs represent
Mithun Ghosh et al.
Molecules (Basel, Switzerland), 23(3) (2018-03-09)
This study aimed to determine the anti-osteoclastogenic effects of extracts from Aronia melanocarpa 'Viking' (AM) and identify the underlying mechanisms in vitro. Reactive oxygen species (ROS) are signal mediators in osteoclast differentiation. AM extracts inhibited ROS production in RAW 264.7
PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice.
Joo-Hee Choi et al.
Experimental & molecular medicine, 50(8), 111-111 (2018-08-30)
Protein arginine methylation is a novel form of posttranslational modification mediated by protein arginine methyltransferase (PRMTs). PRMT1, a major isoform of the PRMT family, is responsible for various biological functions, including cellular differentiation. Although the important function that PRMT1 plays
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