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Type 1 (insulin-dependent) diabetes mellitus and gastric emptying: role of blood glucose concentration and dopamine D2 receptors.
P Melga et al.
Diabetes, nutrition & metabolism, 17(1), 62-65 (2004-05-28)
Eun Hee Ahn et al.
BMB reports, 44(5), 329-334 (2011-05-28)
Many proteins with poor transduction efficiency were reported to be delivered to cells by fusion with protein transduction domains (PTDs). In this study, we investigated the effect of levosulpiride on the transduction of PEP-1 ribosomal protein S3 (PEP-1-rpS3), and examined
Raúl León-Barúa et al.
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru, 28(3), 267-269 (2008-10-30)
We expose, this time, our ideas and findings on the etiopathogenesis, diagnosis and treatment of the dyspeptic syndrome.
Vaneeta Jindal et al.
Journal of pharmacology & pharmacotherapeutics, 2(2), 80-84 (2011-07-21)
To investigate the effect of ethanolic extract of fruit pulp of Tamarindus indica Linn. (Family: Caesalpiniaceae) on obesity in rats using cafeteria diet-induced obesity and antipsychotic drug (sulpiride)-induced obesity. Cafeteria dietwas administered for 40 successive days to male Wistar rats
Julia Fedotova
ISRN pharmacology, 2012, 305645-305645 (2012-04-25)
The aim of the present study was to explore the hedonic effects of D(2) receptor agonist, quinpirole and D(2) receptor antagonist, and sulpiride alone or in combination with a low dose of 17β-E(2)-estradiol (17β-E(2)) in the adult ovariectomized female rats
Su-Eon Jin et al.
Journal of pharmaceutical and biomedical analysis, 35(4), 929-936 (2004-06-15)
A rapid and simple high performance liquid chromatography (HPLC) method was developed and validated for determination of levosulpiride in human plasma. After extraction with ethylacetate/methylene chloride (5:1, v/v), analysis of levosulpiride in plasma samples was carried out using a reverse
Levosulpiride: a new solution for premature ejaculation?
E Greco et al.
International journal of impotence research, 14(4), 308-309 (2002-08-02)
Andrew G Yee et al.
Journal of neurochemistry, 148(4), 462-479 (2018-09-12)
Despite the importance of somatodendritic dopamine (DA) release in the Substantia Nigra pars compacta (SNc), its mechanism remains poorly understood. Using a novel approach combining fast-scan controlled-adsorption voltammetry (FSCAV) and single-unit electrophysiology, we have investigated the mechanism of somatodendritic release
M Tonini et al.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 35(4), 244-250 (2003-06-13)
The dopamine D2 receptor antagonist levosulpiride is a substituted benzamide derivative, whose gastrokinetic properties are exploited clinically for the management of functional dyspepsia. However, for other benzamide derivatives, such as cisapride and mosapride, agonism towards serotonin 5-HT4 receptors is considered
Levosulpiride-induced resting orolingual tremor.
Han-Joon Kim et al.
Movement disorders : official journal of the Movement Disorder Society, 24(11), 1700-1701 (2009-05-20)
P Melga et al.
Diabetes care, 20(1), 55-58 (1997-01-01)
We evaluated the effect of chronic administration of levosulpiride, a prokinetic drug that is a selective antagonist for D2 dopamine receptors, on the glycemic control of IDDM subjects. The study was performed on 40 long-standing IDDM subjects with clinical signs
F Demarosi et al.
Minerva stomatologica, 56(1-2), 21-26 (2007-02-09)
This paper evaluated the efficacy of the systemic administration of levosulpiride, an antipsychotic and antidepressant drug, in the management of burning mouth syndrome. Forty-four subjects suffering from idiopathic burning mouth syndrome were enrolled in the study. Patients underwent a thorough
Sergio Agosti et al.
The American journal of emergency medicine, 31(11), 1624-1624 (2013-07-31)
We report the case of an 89-year-old female patient who presented to the emergency department after out-of-hospital cardiac arrest due to polymorphic ventricular tachycardia treated by public access defibrillation. The admission electrocardiogram (ECG) showed extreme QT prolongation (650 milliseconds) with
Hyuk Lee et al.
Journal of gastroenterology and hepatology, 22(11), 1741-1747 (2007-10-05)
This prospective study was conducted to characterize the clinical features of adult rumination syndrome, in the absence of psychiatric illness, by applying newly modified clinical criteria, and to elucidate factors influencing outcomes after treatment. Twenty-one adult patients diagnosed with rumination
Wilda Orisme et al.
Cellular signalling, 22(3), 447-456 (2009-11-06)
Partitioning of cellular components is a critical mechanism by which cells can regulate their activity. In rod photoreceptors, light induces a large-scale translocation of arrestin from the inner segments to the outer segments. The purpose of this project is to
H Y Cho et al.
International journal of clinical pharmacology and therapeutics, 42(3), 174-180 (2004-03-31)
To evaluate the bioequivalence of a single oral 25 mg dose of 2 levosulpiride preparations in healthy male Korean volunteers. The study was conducted as a randomized, 2-period crossover design in 28 healthy male Korean volunteers who received a single
Jin-Hee Park et al.
Biomedical chromatography : BMC, 23(12), 1350-1356 (2009-06-03)
A rapid and validated method for analysis of levosulpiride in human plasma using liquid chromatography coupled to tandem mass spectrometry was developed. Levosulpiride and tiapride (IS, internal standard) were extracted from alkalized plasma samples with ethylacetate and separation by RP-HPLC.
C Mansi et al.
Alimentary pharmacology & therapeutics, 14(5), 561-569 (2000-05-03)
The efficacy of several prokinetic drugs on dyspeptic symptoms and on gastric emptying rates are well-established in patients with functional dyspepsia, but formal studies comparing different prokinetic drugs are lacking. To compare the effects of chronic oral administration of cisapride
Prasad B Phapale et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(24), 2280-2285 (2010-07-27)
An improved method for determining levels of levosulpiride in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed and validated. The protein precipitation method was used for plasma sample preparation. Levosulpiride and an internal standard (IS) were isocratically
Jordi Serra
Gastroenterologia y hepatologia, 33(8), 586-590 (2010-09-21)
Levosulpiride is a sulpiride isomer that exerts its prokinetic action through a dual mechanism: 1) as a D(2) dopamine receptor antagonist and 2) as a serotonin 5HT(4) receptor agonist, conferring this drug with a cholinergic effect. At a dosage of
Syed Javid Hussain et al.
Journal of Ayub Medical College, Abbottabad : JAMC, 22(4), 124-126 (2010-10-01)
Premature ejaculation is one of the most common sexual disorders. A large number of treatment options have been used so far for the treatment of this dysfunction and still a large number of experts are doing research in this field.
Jong Sam Baik et al.
Movement disorders : official journal of the Movement Disorder Society, 23(5), 746-748 (2008-01-11)
We describe three patients who presented with 4 to 5 Hz tremors of the suprahyoid region of the neck. Two developed their tremors in association with levosulpiride treatment. When they opened their mouths, the neck tremors disappeared; no tongue tremors
D Zanetti et al.
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 24(2), 49-57 (2004-10-08)
L-sulpiride is the levorotatory enantiomer of sulpiride, a neuroleptic of the family of benzamide derivatives; it has a characteristic antagonist effect on central DA2 dopaminergic receptors and dopamine DA1 "autoreceptors". Its efficacy in the symptomatic control of acute vertigo spells
José M Entrena et al.
Psychopharmacology, 205(1), 21-33 (2009-03-28)
We evaluated the effects of haloperidol and its metabolites on capsaicin-induced mechanical hypersensitivity (allodynia) and on nociceptive pain induced by punctate mechanical stimuli in mice. Subcutaneous administration of haloperidol or its metabolites I or II (reduced haloperidol) dose-dependently reversed capsaicin-induced
Hyeo-Il Ma et al.
Journal of the neurological sciences, 284(1-2), 140-143 (2009-05-27)
To investigate if diabetes is more common in drug-induced parkinsonism patients. We performed a hospital-based retrospective case-control study on 44 drug-induced parkinsonism (DIP) patients, 177 Parkinson disease patients, and 176 acute stroke patients matched for age and sex who were
Jonathan T Perelmuter et al.
Current biology : CB, 29(13), 2190-2198 (2019-06-18)
Dopamine is integral to attentional and motivational processes, but studies are largely restricted to the central nervous system. In mammals [1, 2] and fishes [3, 4], central dopaminergic neurons project to the inner ear and could modulate acoustic signals at
Pieter Janssen et al.
The American journal of gastroenterology, 108(9), 1382-1391 (2013-09-06)
The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this paper we examined the study-specific correlations between SI and GE, and we
H Y Cho et al.
Neuroscience, 169(1), 378-387 (2010-05-05)
The purposes of this study were to clarify the involvement of P-glycoprotein in the absorption of levosulpiride in knockout mice that lack the Abcb1a/ 1b gene, and to evaluate the relationship between genetic polymorphisms in ABCB1 (exon 12, 21 and
G Okugawa et al.
Journal of neuroendocrinology, 11(11), 887-895 (1999-10-16)
Since the glucocorticoid receptor (GR) and/or mineralocorticoid receptor (MR) in the hippocampus have been implicated in cortisol feedback of the hypothalamus-pituitary-adrenal (HPA) axis, abnormalities in those receptors might underlie the hyperactivity of the HPA axis described in patients with major
K László et al.
Hormones and behavior, 124, 104777-104777 (2020-05-23)
Neuropeptide oxytocin (OT) is involved in the regulation of social and non-social behaviour. The central nucleus of amygdala (CeA), part of the limbic system, plays an important role in learning, memory, anxiety and reinforcing mechanisms. CeA has been shown to
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